CN108935694A - A kind of healthcare goat milk powder and preparation method thereof with antifatigue simultaneous void of enriching blood - Google Patents

A kind of healthcare goat milk powder and preparation method thereof with antifatigue simultaneous void of enriching blood Download PDF

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Publication number
CN108935694A
CN108935694A CN201810643416.3A CN201810643416A CN108935694A CN 108935694 A CN108935694 A CN 108935694A CN 201810643416 A CN201810643416 A CN 201810643416A CN 108935694 A CN108935694 A CN 108935694A
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China
Prior art keywords
parts
powder
sheep
premix
milk powder
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CN201810643416.3A
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Chinese (zh)
Inventor
朱敏
王文清
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Heilongjiang Feihe Dairy Co Ltd
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Heilongjiang Feihe Dairy Co Ltd
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Priority to CN201810643416.3A priority Critical patent/CN108935694A/en
Publication of CN108935694A publication Critical patent/CN108935694A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/16Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/156Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20Milk; Whey; Colostrum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Abstract

The present invention relates to field of health care food, and in particular to a kind of with antifatigue simultaneous empty healthcare goat milk powder and preparation method thereof of enriching blood.The healthcare goat milk powder is by weight, comprising: 50-130 parts of sheep milk composition, 1-15 parts of ginseng pulverate, 1-15 parts of longan powder, 1-15 parts of Poria cocos powder, 1-10 parts of lotus nut starch;The sheep milk composition is provided by sheep cream and/or sheep milk powder.And sheep cream, ginseng, Poria cocos, lotus seeds, longan are not only creatively combined by the present invention, also by optimization weight proportion, have reached superior technique effect.Compared with the prior art, the present invention has the following advantages: raw material used in the present invention is integration of drinking and medicinal herbs type, safe without toxic side effect, can be used as food or health care product uses, and can be relieved fatigue, it is strengthening the spleen and replenishing qi, promoting production of body fluid and inducing sedation of the mind, have the function of invigorating the spleen and benefiting qi, the anti-labor of qi-restoratives;Proved by pharmacology test, take orally health composition of the present invention can strengthening the spleen and replenishing qi, there is specific alleviation acute fatigue effect.

Description

A kind of healthcare goat milk powder and preparation method thereof with antifatigue simultaneous void of enriching blood
Technical field
The present invention relates to field of health care food, and in particular to it is a kind of with the antifatigue simultaneous healthcare goat milk powder for enriching blood empty and Preparation method.
Background technique
With the development of society, women has been increasingly becoming one of the leading role of society, the dual-pressure of work and life, Already become the key factor for influencing modern female health.The factors such as operating pressure, life stress and individual physiological problem are equal Modern female is set the symptom of fatigue and the deficiency of blood occur.
" the Sub-health State in TCM clinical guidelines " of China Association of Traditional Chinese Medicine's publication were once pointed out: " inferior health refers to that human body is in strong A kind of state between health and disease ", i.e. human body show a degree of vigor reduction, hypofunction, but the disease showed Shape does not meet the clinic or subclinical inflammation standard that modern medicine has related disorders again.With the passing of time over fatigue may develop into " tired Labor syndrome ";And " fatigue syndrome " is the source of many diseases.Therefore over fatigue, which has become, influences the one big of health of masses Risk factor.The correlative study of Fatigue by Traditional Chinese Medicine carry out it is more early, over fatigue is known as more in classical Chinese medicine works " labor ", " tired ", " consumptive disease " etc., it is mainly related with lung, spleen, the dirty functional disturbance of kidney three, with the deficiency of vital energy be its basic interpretation of the cause, onset and process of an illness, with deficiency of spleen-QI and stomach-QI, Transporting is out of strength to be most common, clinically mostly with the dirty basic ideas to relieve fatigue of adjustment of lung, spleen and kidney three.The spleen being the foundation of acquired constitution, Source of generating QI and blood, spleen governing blood, the main syndromes for showing as deficiency of spleen-QI, deficiency of qi and blood after woman's overwork more, therefore woman is tired Labor state mostly to invigorate the spleen and benefit qi, nourishing blood and tranquilization is basic therapy.
Tcm health preserving has a long history in China, and the saying of " integration of drinking and medicinal herbs " just has greatly from ancient medicine ancient books and records The evidence of amount.Chinese medicine formula is combined research with modern preparation method, and there is antifatigue, empty effect of enriching blood health care to eat Product have certain realistic meaning.
Summary of the invention
The present invention provides a kind of healthcare goat milk powder with antifatigue simultaneous void of enriching blood, and is prepared by the following raw material, described Raw material is by weight, comprising:
50-130 parts of sheep milk composition, 1-15 parts of ginseng pulverate, 1-15 parts of longan powder, 1-15 parts of Poria cocos powder, lotus nut starch 1-10 Part.
Wherein the sheep milk composition can be provided by sheep cream (fresh sheep cream) and/or sheep milk powder;
Preferably, the sheep milk composition is made of sheep cream and degreasing sheep milk powder;It is highly preferred that sheep cream and degreasing sheep cream The ratio of powder is (4-8): (1-5).
That is, the present invention is more preferably formulated includes:
Sheep cream: 40-80 parts, degreasing sheep milk powder: 10-50 parts, ginseng pulverate: 1-15 parts, longan powder: 1-15 parts, Poria cocos powder: 1-15 parts, lotus nut starch: 1-10 parts.
It can also further comprise one or more of oligofructose, honey, vegetable fat powder and milk flavour to season And/or as auxiliary material;
Preferably, addition may be selected when adding said components:
10-20 parts of oligofructose, or, 1-10 parts of honey, or, 1-10 parts of vegetable fat powder, or, 1-10 parts of milk flavour.
Preferably, the fat content in the degreasing sheep milk powder is lower than 2.0%.
Preferably, the fat content of the vegetable fat powder is 2-3%, moisture content≤3.0%;The rouge of more preferable vegetable fat powder Fat content is 2.8%.
When preferably as products material, the content of oligofructose is 95% in commodity oligofructose.
Preferably, the honey is the black bee eucalyptus honey in northeast.
Preferably, the milk flavour includes (consisting of the following compositions) tincture of vanilla, 3- hydroxy-2-butanone, in δ-last of the ten Heavenly stems Ester, 5- ethoxy -4- methylthiazol, 4- methyl -5- (2- Acetoxyethyl) thiazole, triacetyl glycerine, Arabic gum, paste Essence.
Further, milk flavour of the present invention includes (composed of the following components): 0.001 part of tincture of vanilla;3- hydroxyl 0.001 part of base -2- butanone;0.001 part of δ-decalactone;0.001 part of methylthiazol of 5- ethoxy -4-;4- methyl -5- (2- acetyl Oxygen ethyl) 0.006 part of thiazole;2 parts of triacetyl glycerine;3 parts of Arabic gum;Dextrin 40 part.It prepares such as this field routine side Method does not do particular determination herein.
As a preferred solution of the present invention, the healthcare goat milk powder by weight, including (composed of the following components):
Sheep cream: 60-70 parts, degreasing sheep milk powder: 20-40 parts, ginseng pulverate: 5-10 parts, longan powder: 3-8 parts, Poria cocos powder: 5- 10, lotus nut starch: 1-5 parts, 15-20 parts of oligofructose, 1-10 parts of honey, 1-5 parts of vegetable fat powder, 1-5 parts of milk flavour.
As most preferably scheme of the invention, the healthcare goat milk powder is in parts by weight, composed of the following components:
It is 60 parts of sheep cream, 3 parts of degreasing sheep milk powder, 8 parts of ginseng pulverate, 6 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch, oligomeric 10 parts of fructose, 8 parts of honey, 4 parts of vegetable fat powder, 2 parts of milk flavour.
Heretofore described ginseng pulverate is Ultramicro-powder flour, needs 400 meshes, longan powder, Poria cocos powder, lotus nut starch are 100 mesh powder.Above-mentioned ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch can be by buying or being prepared, it is only necessary to which meeting partial size needs It asks.
Goat milk and integration of drinking and medicinal herbs raw material are used cooperatively as maximum feature in the formula.Goat milk is full of nutrition with its, is easy to inhale The advantages that receipts, is considered as the treasure in dairy products, is generally acknowledged dairy products closest to human milk in the world, referred to as " king in cream ". Traditional Chinese Medicine thinks that sheep cream has kidney tonifying, grows nourishing effects and the beautifying face and moistering lotions, anti-inflammatory, anti-aging etc. such as lung, stomach invigorating and sharp intestines Health-care efficacy, while modern research shows that sheep cream has certain treatment to tuberculosis, nephrosis, hepatopathy etc. and promotes health benefit.
Ginseng reinforces vital energy, and sheep cream qi-restoratives is moisturized, and one mends a profit, brings out the best in each other, plays the anti-Lao Zhigong of qi-restoratives altogether.Ginseng sweet, Slight bitter puts down, reinforces vital energy, and reinforces the spleen to benefit the lung as monarch, strengthening the spleen and replenishing qi, restores spleen and stomach function, and modern pharmacological research confirms that ginseng can be emerging It puts forth energy central nervous system, enhancing body reduces feeling of fatigue to the adaptability of nonspecific stimulation." the preemergency of the Tang Dynasty SUN Si miao Qianjin Yao Fang " it records, few unsaturated vapor deficient for treating postpartum.
Arillus longan sweet, warm, tonifying heart and spleen, nourishing blood and tranquilization are minister." book on Chinese herbal medicine is looked for the truth " is called it and " is had among tonifying Qi, and more Blood is protected in the power enriched blood, nourishing heart, is heart spleen key medicine ".It, which is longer than, treats because worrying beyond measure, palpitation of palpitating with fear caused by internal lesion caused by overexertion heart spleen, has a sleepless night Amnesia, deficiency of food body are tired and deficiency of the spleen causing weakness of QI, the card such as uterine bleeding of having blood in stool are apt to the related symptoms of the spiritual fatigue of alleviation especially.
Poria cocos is sweet, light, puts down, invigorating the spleen, clearing damp and promoting diuresis, calming heart;Modern pharmacological research Poria cocos can improve humoral immune function, Electrolyte balance is adjusted, organism metabolism is promoted.Poria cocos is sweet, light, puts down, and invigorating the spleen, clearing damp and promoting diuresis, calming heart are assistant, " Japan hanako materia medica " Call its " mending general debility, happy intelligence development ";Modern pharmacological research confirms that Poria cocos can improve humoral immune function, adjusts electrolyte Balance promotes organism metabolism.Poria cocos assists ginseng, arillus longan strengthening the spleen and replenishing qi, establishes Central Region, keeps temper full, qi and blood biochemistry has Source.The disease of the full discomfort for helping to alleviate physical tiredness of temper.
Lotus seeds are sweet, puckery, put down, tonifying spleen and stopping diarrhea, supplementing the kidney to control the nocturnal be make, Compendium of Material Medica describe its " kidney of laying one's heart bear, thick stomach, Gu Vital essence, strengthening the bones and muscles, qi-restoratives damage, only spleen diarrhea protracted dysentery, reddish and whitish turbid urine, all blood of woman's leukorrhagia metrorrhagia are sick ", ginseng, Poria cocos can be assisted to mend Spleen and tonifying kidney;Meanwhile lotus seeds treating spontaneous emission and leukorrhagia, there is the function of astringency inducing, the property of ginseng temperate-dryness can be prevented too.Furthermore arillus longan, Poria cocos, lotus seeds all enter the heart channel of Hang-Shaoyin, energy mental-tranquilization, insomnia, cardio palmus when helping to relieve fatigue state.
Full side's strengthening the spleen and replenishing qi, nourishing blood and tranquilization.Heart spleen, with emphasis on spleen, keeps the prosperous then qi and blood biochemistry of spleen active with controlling, effectively slow Solution muscle rigidity, the fatigue symptoms such as ache;Qi and blood is simultaneously mended, and tonifying Qi is focused on, and the prosperous blood of gas is spontaneous, and hemapodium then supported by the heart, to improvement Irregular menstruation, insomnia, cardio palmus significant effect.Our selection is the article of " integration of drinking and medicinal herbs ", edible safety, with goat milk It is for the effective health-care good product of health with clothes.
The present invention uses Traditional Chinese Medicine and biochemical theory developmental achievement, and product is " integration of drinking and medicinal herbs " raw material composition, Edible safety is for the effective health-care good product of health with goat milk with taking.
Compared with the prior art, the present invention has the following advantages:
1. raw material used in the present invention is integration of drinking and medicinal herbs type, safety, can be used as food or health care product uses, and can delay Solution fatigue, strengthening the spleen and replenishing qi, nourishing blood and tranquilization function.
2. proved by pharmacology test, take orally health composition of the present invention can strengthening the spleen and replenishing qi, the effect of nourishing blood and tranquilization.
The present invention provides the preparation method of any one of the above healthcare goat milk powder together, which comprises
(1) the sheep cream, degreasing sheep milk powder are configured to the first premix, the dry in preferably described first premix Matter concentration is 10-30%;
(2) ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch and first premix are mixed, it is pre- obtains second Mixing;
Preferably, by the first premix obtained in (1) according to (1-10): 100 ratios are divided into two parts, first with 1- in (1) 10% first premix is mixed with ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch, rear and remaining again after sufficiently mixing The first premix mixing, obtains the second premix.
(3) to being sterilized after the second premix homogeneous, being concentrated by evaporation to newborn dry matter concentration is 10~16 ° of B é (Baumes Degree), then through being drying to obtain.
Preferably, when in formula further including one or more of vegetable fat powder, milk flavour, oligofructose or honey, Above-mentioned preparation method includes:
(1) the sheep cream, degreasing sheep milk powder are configured to the first premix, the dry in preferably described first premix Matter concentration is 10-30%;
(2) by one or more of the ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch, vegetable fat powder, milk flavour and The first premix mixing, obtains the second premix;
Preferably, by the first premix obtained in (1) according to (1-10): 100 ratios are divided into two parts, first with 1- in (1) 10% first premix is mixed with ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch, rear and remaining again after sufficiently mixing The first premix mixing, is eventually adding one or more of oligofructose, honey, obtains the second premix.
(3) to being sterilized after the second premix homogeneous, being concentrated by evaporation to newborn dry matter concentration is 10~16 ° of B é (Baumes Degree), then through being drying to obtain.
This field should be appreciated that when in formula without containing certain group timesharing, it is not necessary that the component is added when above-mentioned preparation.
Wherein, in step (3), the homogeneous preferably includes the different homogenization of two steps:
(3.1) preliminary homogenization is carried out to it through colloid mill to second premix;
Preferably, colloid mill gap is controlled when the preliminary homogenization be not more than 1mm;
(3.2) in high pressure homogenizer to (3.1) resulting premix carry out second of homogeneous, homogenization pressure be 12~ 18MPa;
Wherein, in step (3), 30~90s is preferably sterilized in the sterilization at 90~96 DEG C;And/or the evaporation To be evaporated at 50~60 DEG C;And/or the drying is spray drying, it is 150-170 that condition control, which is inlet air temperature, DEG C, temperature of outgoing air is 80-90 DEG C.
After two step homogeneous, solid particle size is uniform in solution, is not in that obvious bulky grain causes to precipitate, thus Generate impurity.
Preparation method of the present invention, for formula of the invention, by the way that sheep cream and sheep milk powder are first prepared into original Material, then by the homogeneous of different condition twice, reach reduction fat floating, the sensibility of fat oxidation is reduced, product wind is enhanced The technical effect of taste and mouthfeel.
Detailed description of the invention
Fig. 1 Fig. 2 Fig. 3 is respectively mouse blood picture test result (P < 0.01 * * and model compared to the blank group in test example 1 Group is compared to ▲ P < 0.05, ▲ ▲ P < 0.01);
Mouse walking weight load test result (P < 0.01 * * compared to the blank group in Fig. 4 test example 1;With model group phase Than ▲ P < 0.05, ▲ ▲ P < 0.01);
Mouse pole-jump test result in Fig. 5 test example 1 (compared to the blank group P < 0.01 * * compared with model group ▲ P < 0.05, ▲▲P<0.01);
Tired mice serum urea nitrogen (BUN) content test result in Fig. 6 test example 1 (compared to the blank group * * P < 0.01;Compared with model group ▲ and P < 0.05, ▲ ▲ P < 0.01);
Full blood lactic content test result (P < 0.05 * compared to the blank group after mouse swimming 10min in Fig. 7 test example 1; Compared with model group ▲ and P < 0.05, ▲ ▲ P < 0.01);
In Fig. 8 test example 1 mouse swimming rest 20min after full blood lactic content test result (compared to the blank group * P < 0.05;Compared with model group ▲ and P < 0.05, ▲ ▲ P < 0.01)
Mouse Ca2+-Mg2+-ATP enzyme activity test result (P < 0.01 * * compared to the blank group in Fig. 9 test example 1;With Model group is compared to ▲ P < 0.05, ▲ ▲ P < 0.01)
Mouse serum N a+-K+-ATP enzyme activity test result (P < 0.01 * * compared to the blank group in Figure 10 test example 1; Compared with model group ▲ and P < 0.05, ▲ ▲ P < 0.01)
Mouse serum lactic dehydrogenase (SLDH) (LDH) vitality test result in Figure 11 test example 1 (compared with model group ▲ P < 0.05,▲▲P<0.01)
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Those skilled in the art it is understood that following " part " as described in the examples be unit of weight, can for " g ", The unit of weights such as " kg ", " t ".
Following milk flavour as described in the examples is composed of the following components: 0.001 part of tincture of vanilla;3- hydroxyl -2- fourth 0.001 part of ketone;0.001 part of δ-decalactone;0.001 part of methylthiazol of 5- ethoxy -4-;4- methyl -5- (2- Acetoxyethyl) 0.006 part of thiazole;2 parts of triacetyl glycerine;3 parts of Arabic gum;Dextrin 40 part.It prepares such as conventional method in that art.
Embodiment 1
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
It is 60 parts of sheep cream, 25 parts of degreasing sheep milk powder, 8 parts of ginseng pulverate, 6 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch, oligomeric 10 parts of fructose, 8 parts of honey, 4 parts of vegetable fat powder, 2 parts of milk flavour.
Embodiment 2
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
It is 40 parts of sheep cream, 30 parts of degreasing sheep milk powder, 5 parts of ginseng pulverate, 8 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch, oligomeric 10 parts of fructose, 5 parts of honey, 3 parts of vegetable fat powder, 3 parts of milk flavour.
Embodiment 3
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
It is 30 parts of sheep cream, 40 parts of degreasing sheep milk powder, 3 parts of ginseng pulverate, 5 parts of longan powder, 3 parts of Poria cocos powder, 5 parts of lotus nut starch, oligomeric 5 parts of fructose, 13 parts of honey, 6 parts of vegetable fat powder, 2 parts of milk flavour.
Embodiment 4
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
It is 40 parts of sheep cream, 25 parts of degreasing sheep milk powder, 8 parts of ginseng pulverate, 3 parts of longan powder, 5 parts of Poria cocos powder, 3 parts of lotus nut starch, oligomeric 10 parts of fructose, 6 parts of honey, 5 parts of vegetable fat powder, 5 parts of milk flavour.
Embodiment 5
The present embodiment provides a kind of healthcare goat milk powder and preparation method thereof, include the following steps:
(1) 60 parts of sheep cream, 25 parts of degreasing sheep milk powder are configured to the first premix, the dry in first premix Matter mass concentration is 15%;
(2) by 8 parts of ginseng pulverate, 6 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch, 4 parts of vegetable fat powder, 2 parts of milk flavour and First premix of part after mixing, then after mixing with remaining first premix, finally adds oligofructose 10 Part, 8 parts of honey, obtain the second premix;
(3) second premix carries out preliminary homogenization to it through colloid mill, and the gap of colloid mill is 1mm;
(4) homogeneous is carried out to the resulting premix of step (3) in high pressure homogenizer, homogenization pressure is 12~18MPa;
(5) it after sterilizing 30s at 96 DEG C to the premix that step (4) obtains, is evaporated at 60 DEG C, and be concentrated into Newborn dry matter concentration is 10 ° of B é (Baume degrees);
(6) in high-pressure pump feeding;
It (7) is 150 DEG C in inlet air temperature, temperature of outgoing air is the spray drying under conditions of 90 DEG C, obtains healthcare goat milk Powder.
Embodiment 6
The present embodiment provides a kind of healthcare goat milk powder and preparation method thereof, include the following steps:
(1) 40 parts of sheep cream, 30 parts of degreasing sheep milk powder are configured to the first premix, the dry in first premix The mass concentration of matter is 18%;
(2) by 5 parts of ginseng pulverate, 8 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch, 3 parts of vegetable fat powder, 3 parts of milk flavour and First premix of part after mixing, then after mixing with remaining first premix, finally adds oligofructose 10 Part, 5 parts of honey, obtain the second premix;
(3) second premix carries out preliminary homogenization to it through colloid mill, and the gap of colloid mill is 1mm;
(4) homogeneous is carried out to the resulting premix of step (3) in high pressure homogenizer, homogenization pressure is 12~18MPa;
(5) it after sterilizing 50s at 90 DEG C to the premix that step (4) obtains, is evaporated at 60 DEG C, and be concentrated into Newborn dry matter concentration is 16 ° of B é (Baume degrees);
(6) in high-pressure pump feeding;
It (7) is 150 DEG C in inlet air temperature, temperature of outgoing air is the spray drying under conditions of 90 DEG C, obtains healthcare goat milk Powder.
Embodiment 7
The present embodiment provides a kind of healthcare goat milk powder and preparation method thereof, include the following steps:
(1) 30 parts of sheep cream, 40 parts of degreasing sheep milk powder are configured to the first premix, the dry in first premix The mass concentration of matter is 20%;
(2) by 3 parts of ginseng pulverate, 5 parts of longan powder, 3 parts of Poria cocos powder, 5 parts of lotus nut starch, 6 parts of vegetable fat powder, 2 parts of milk flavour and First premix of part after mixing, then after mixing with remaining first premix, finally adds oligofructose 5 Part, 13 parts of honey, obtain the second premix;
(3) second premix carries out preliminary homogenization to it through colloid mill, and the gap of colloid mill is 1mm;
(4) homogeneous is carried out to the resulting premix of step (3) in high pressure homogenizer, homogenization pressure is 12~18MPa;
(5) it after sterilizing 90s at 90 DEG C to the premix that step (4) obtains, is evaporated at 50 DEG C, and be concentrated into Newborn dry matter concentration is 12 ° of B é (Baume degrees);
(6) in high-pressure pump feeding;
It (7) is 150 DEG C in inlet air temperature, temperature of outgoing air is the spray drying under conditions of 90 DEG C, obtains healthcare goat milk Powder.
Embodiment 8
The present embodiment provides a kind of healthcare goat milk powder and preparation method thereof, include the following steps:
(1) 25 parts of 40 parts of sheep cream, degreasing sheep milk powder parts are configured to the first premix, it is dry in first premix Material mass concentration is 16%;
(2) by 8 parts of ginseng, 3 parts of longan powder, 5 parts of Poria cocos powder, 3 parts of lotus nut starch, vegetable fat powder 5
Part, 5 parts of milk flavour and the first premix of the part after mixing, then with residue
First premix after mixing, is finally added 10 parts of oligofructose, 6 parts of honey, is obtained
To the second premix;
(3) second premix carries out preliminary homogenization to it through colloid mill, and the gap of colloid mill is 1mm;
(4) homogeneous is carried out to the resulting premix of step (3) in high pressure homogenizer, homogenization pressure is 12~18MPa;
(5) it after sterilizing 30s at 96 DEG C to the premix that step (4) obtains, is evaporated at 60 DEG C, and be concentrated into Newborn dry matter concentration is 16 ° of B é (Baume degrees);
(6) in high-pressure pump feeding;
It (7) is 150 DEG C in inlet air temperature, temperature of outgoing air is the spray drying under conditions of 90 DEG C, obtains healthcare goat milk Powder.
Embodiment 9
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
Sheep cream 60 parts, 25 parts of degreasing sheep milk powder, 8 parts of ginseng pulverate, 6 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch.
Embodiment 10
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
Sheep cream 40 parts, 30 parts of degreasing sheep milk powder, 5 parts of ginseng pulverate, 8 parts of longan powder, 3 parts of Poria cocos powder, 3 parts of lotus nut starch.
Embodiment 11
It is composed of the following components the present embodiment provides a kind of healthcare goat milk powder:
Sheep cream 30 parts, 40 parts of degreasing sheep milk powder, 3 parts of ginseng pulverate, 5 parts of longan powder, 3 parts of Poria cocos powder, 5 parts of lotus nut starch.
Comparative example 1
This comparative example provides a kind of healthcare goat milk powder, composed of the following components:
Sheep cream 50 parts, 25 parts of degreasing sheep milk powder, 8 parts of ginseng pulverate, 4 parts of longan powder, 3 parts of Poria cocos powder, 2 parts of lotus nut starch.
Comparative example 2
This comparative example provides a kind of healthcare goat milk powder, composed of the following components:
Sheep cream 60 parts, 30 parts of degreasing sheep milk powder, 5 parts of ginseng pulverate, 3 parts of fructus lycii, 5 parts of Poria cocos powder, 2 parts of lotus nut starch.
Comparative example 3
This comparative example provides a kind of healthcare goat milk powder, composed of the following components:
Sheep cream 60 parts, 30 parts of degreasing sheep milk powder, 5 parts of ginseng pulverate, 3 parts of gelatin powder, 5 parts of Poria cocos powder, 2 parts of lotus nut starch.
Comparative example 4
This comparative example provides a kind of healthcare goat milk powder and preparation method thereof, and the difference with embodiment 5 is only that, is not related to Step (3).I.e. step (2) obtains directly carrying out step (4) after premix high-pressure homogeneous.
Comparative example 5
This comparative example provides a kind of healthcare goat milk powder and preparation method thereof, and the difference with embodiment 5 is only that, step (5) It is middle that resulting premix is condensed into 25 ° of B é.
Test example 1
Exercise tolerance is that body resisting fatigue ability reinforces best macro manifestations.Swimming with a load attached to the body experiment and Grasping clubglass test Respectively indicate body degree of fatigue in endurance exercise.Energy needed for mouse movement is mainly derived from the sugar of its machine cylinder storage Original, body is long-term or strenuous exercise needs to consume the energy matters such as a large amount of glycogens, and a large amount of generations are accumulated in respiration enhancing in vivo Thank to product, lactic acid, urea nitrogen content are substantially increased therewith in blood tissues, to generate fatigue symptom.Anti-fatigue product is made It is the recovery that product is conducive to the musculature energy with mechanism, the indexs such as lactic acid, urea nitrogen variation in blood tissues, to verify Whether it has anti-fatigue effect.
1 materials and methods
1.1 sample
1.2 experimental animals: female KM mouse
1.3 instruments and reagent: sheet lead, swimming trunk, centrifuge, pressure-even pulp crusher, thermostat water bath, microplate reader, urea nitrogen reagent Box (Nanjing is built up), full Lactic acid Kit (Nanjing is built up), hepatic glycogen kit (Nanjing is built up).
1.4 test method
(1) animal packet
Above-mentioned mouse adaptable fed is after 3 days, is randomly divided into blank group, model group, 2 groups of formula group by weight, i.e., low, Neutralization high dose group, every group 15.
(2) dosage
Blank group, model group: stomach-filling, 0.5% sodium carboxymethyl cellulose solution.
Formula group: stomach-filling, low dose group are the milk power solution of embodiment 1 preparation-obtained 40%, and middle dose group is real The milk power solution of example 1 preparation-obtained 50% is applied, high dose group is the milk power solution of embodiment 1 preparation-obtained 60%.
(3) method for building up of model of blood dificiency
Total totally 4 days, intraperitoneal injection of cyclophosphamide 100mg/kg in administration 26-29, deficiency of blood animal model is prepared.The Start every test after administration in 30 days.(model group as described below is all the model group after establishing model of blood dificiency)
1.4.1 the measurement of walking weight load and musculature ATP enzyme effect of vigor
After last dose 50min, the mouse of 7% weight sheet lead of root of the tail portion load is placed in swimming trunk and is swum.The depth of water 25cm, 28 ± 1.0 DEG C of water temperature, record mouse from swimming to the time of death, i.e. mice burden swimming time.Swimming with a load attached to the body After swimming experiment, hindlimb muscle tissue is taken, 10% homogenate is made in accurate weighing 0.1g, measures by test agent box specification Musculature Na+-K+ATP enzyme and Ca2+-Mg2+ATP enzyme vigor.
1.4.2 pole-climbing time and liver glycogen assay
Start to test after last dose 50min, mouse is put on glass bar, muscle is made to be in static(al) tense situation, remembers Record time for dropping down from glass bar due to muscular fatigue of mouse, experiment is terminated when falling the 3rd time, add up 3 time As the pole-climbing time.Liver 0.05g is taken, filter paper blots after physiological saline rinses, and contains by kit requirement measurement liver glycogen Amount.
1.4.3 the measurement of serum urea nitrogen content, Dehydrogenase Content, blood picture
Start to test after last dose 50min.Being placed on water temperature is not swimming with a load attached to the body 60min in 28 DEG C of swimming cylinders, rest The mouse of 40min, plucks eyeball and takes blood, separate serum, measures blood urea nitrogen (BUN) content, serum lactic by testing cassete specification Dehydrogenase (LDH) vigor, blood picture measurement (number of white blood cells, mean constant of red blood cell and content of hemoglobin).
1.4.4 blood lactase acid measures
Take a blood sample 20 μ L after last dose 30min, and take a blood sample after not swimming with a load attached to the body 10min 20 μ L in 30 DEG C of water, rest Take a blood sample 20 μ L after 20min, and eyeball takes blood, be not added it is anticoagulant, by kit illustrate measure Serum lactic acid content.
2 results
Fig. 1-Figure 11 provided by the present invention, abscissa are group, are followed successively by blank group, model group from left to right (model of blood dificiency group), low dose group, middle dose group and high dose group.
* * shown on Fig. 1-Figure 11 is P < 0.01 compared to the blank group;▲ it is P < 0.05 compared with model group;▲ ▲ it is P < 0.01 compared with model group.
2.1 mouse blood picture test results and analysis
In Fig. 1-Fig. 3, blank group, model of blood dificiency group and prescription low, middle and high dose groups mouse blood picture are measured, point Analyse wherein three number of white blood cells, mean constant of red blood cell and content of hemoglobin index results.Compared to the blank group, model of blood dificiency Group murine interleukin number, mean constant of red blood cell and content of hemoglobin significantly reduce (p < 0.01).With model of blood dificiency group phase Than, it is formulated the apparent increase (p < 0.05 or p < 0.01) of basic, normal, high 3 dosage group red blood cells and content of hemoglobin, it is white thin Born of the same parents have raising trend, but without obvious statistical difference (p > 0.05).2.2 mice burden swimming test results and analysis
In Fig. 4, compared to the blank group, the model of blood dificiency group mice burden swimming time significantly shortens (p < 0.01).With the deficiency of blood Model group is compared, prescription low dosage have the tendency that extend the mice burden swimming time, but without obvious statistical difference (p > 0.05);The middle and high dosage of prescription can be obviously prolonged mice burden swimming time (p < 0.01).
2.3 mouse pole-climbing time test results and analysis
In Fig. 5, compared to the blank group, the model of blood dificiency group mouse pole-climbing time significantly shortens (p < 0.01).With model of blood dificiency Group is compared, and formula low dose group has the tendency that extending the mouse pole-climbing time, but without obvious statistical difference (p > 0.05);Formula Middle and high dosage group can significantly extend the mouse pole-climbing time (p < 0.01).
2.4 mice serum urea nitrogen (BUN) content test results and analysis
In Fig. 6, compared to the blank group, model of blood dificiency group mice serum BUN content significantly increases (p < 0.01).With the deficiency of blood Model group is compared, and the basic, normal, high dosage of prescription can reduce mice serum BUN content (p < 0.05 or p < 0.01).
2.5 Mouse whole blood lactic acid content test results and analysis
2.5.1 full blood lactic content test result after mouse swimming 10min
In Fig. 7, compared to the blank group, model of blood dificiency group Mouse whole blood lactic acid content significantly increases (p < 0.05).With the deficiency of blood Model group is compared, and formula low, middle and high dose groups can significantly reduce Mouse whole blood lactic acid content (p < 0.05 or p < 0.001).
2.5.2 full blood lactic content test result after mouse swimming rest 20min
In Fig. 8, compared to the blank group, model of blood dificiency group Mouse whole blood lactic acid content significantly increases (p < 0.05).With the deficiency of blood Model group is compared, prescription low dosage have the tendency that reduce Mouse whole blood lactic acid content, but without obvious statistical difference (p > 0.05);The middle and high dosage of prescription can significantly reduce Mouse whole blood lactic acid content (p < 0.05 or p < 0.01).
2.5.3 mouse Ca2+-Mg2+ATP enzyme vitality test result and analysis
Ca2+-Mg2+ATP enzyme vigor has increase trend, and the function of skeletal muscle, is conducive to mention when prompting that movement can be improved The convergent force and contraction speed of high skeletal muscle, the generation of resisting fatigue.
In Fig. 9, compared to the blank group, model of blood dificiency group mouse Ca2+-Mg2+ATP enzyme vigor significantly reduces (p < 0.01). Compared with model of blood dificiency group, prescription low dosage is to mouse Ca2+-Mg2+ATP enzyme vigor has increase trend, poor without obvious statistics Different (p > 0.05);The middle and high dosage mouse Ca of prescription2+-Mg2+ATP enzyme vigor significantly increases (p < 0.05 or p < 0.01).
2.5.4 mice serum Na+-K+ATP enzyme vitality test result and analysis
Increase Na+-K+The vigor of ATP enzyme, the function of skeletal muscle when prompting it that can improve movement are conducive to improve bone The convergent force and contraction speed of bone flesh, the generation of resisting fatigue.
In Figure 10, compared to the blank group, model of blood dificiency group mouse Na+-K+ATP enzyme vigor significantly reduces (p < 0.01).With Model of blood dificiency group is compared, prescription low dosage mouse Na+-K+- ATP enzyme activity is without obvious statistical difference (p > 0.05);In prescription, High dose mouse Na+-K+- ATP enzyme activity significantly increases (p < 0.05 or p < 0.01).
2.5.5 mice serum lactic dehydrogenase (LDH) vitality test result and analysis
LDH vigor size directly affects the removing speed of blood lactase acid.Blood lactase acid water is reduced by improving LDH vigor Flat is also the approach for improving body resisting fatigue ability.
In Figure 11, compared to the blank group, model of blood dificiency group mice serum LDH vigor has decreasing trend, but without obvious statistics It learns difference (p > 0.05).Compared with model of blood dificiency group, prescription low dosage mice serum LDH vigor has raising trend, but without obvious Statistical difference (p > 0.05);The middle and high dosage mice serum LDH vigor of group of formula significantly increases (p < 0.01).
In summary results of animal is concluded that according to test result
In the index of antifatigue verification test detection, mice burden swimming time, mouse add up pole-climbing time, serum urine Plain nitrogen (BUN) content, full blood lactic content, Ca2+-Mg2+- ATP enzyme activity, Na+-K+It is ATP enzyme vigor, number of white blood cells, red 9 index experimental results of cell number and content of hemoglobin show model of blood dificiency group compared to the blank group, have obvious Statistical difference illustrates that model of blood dificiency mouse fatigue resistance is decreased obviously, and shows modeling success.
Test result is shown, compared with model group, the middle and high dosage of prescription can be obviously prolonged the weight bearing of model of blood dificiency mouse Swimming time and pole-climbing time increase Ca2+-Mg2+ATP enzyme vigor and Na+-K+ATP enzyme vigor increases LDH vigor;Prescription Basic, normal, high dosage can reduce model of blood dificiency mice serum BUN content, reduce full blood lactic content;Show at middle and high dose Under amount or basic, normal, high dosage, the exercise tolerance of model of blood dificiency mouse is can be improved in prescription, and fatigue when reducing quiet exert oneself improves Aerobic capacity, the function of skeletal muscle when improving movement.
To sum up, be positive according to decision rule, walking weight load and pole-climbing time test result, serum BUN content and Full blood lactic content test result is positive, and can determine that the prescription has function of physical fatigue alleviation for model of blood dificiency mouse Effect.
Test example 2
This test example provides the exercise tolerance test of embodiment 2-4, the preparation-obtained health care sheep milk powder of comparative example 1-3.
According to recorded in test example 1, difference is only that, only does formula middle dose group for test method and statistical method.
Test result is as shown in table 1:
Table 1
The test result and embodiment 1 of goat milk powder provided by embodiment 9 (are verified) no difference of science of statistics by test example 1; Goat milk powder provided by embodiment 10 and embodiment 2, embodiment 11 and embodiment 13 distinguishes no difference of science of statistics.
Test example 3
This test example provides the stability test of the obtained healthcare goat milk powder of preparation method provided by embodiment 5-8.
5-8 of the embodiment of the present invention, the preparation-obtained goat milk powder of comparative example 4-5 are protected under the conditions of room temperature is protected from light respectively The color and structural state of its finished product are observed after depositing 1,2,3,4,5,6 month, evaluation criterion is as shown in table 2:
Table 2, evaluation criterion
Choosing 200 likes the volunteer of dairy products to test and assess, and test result is shown in Table 3.
3 goat milk powder of table reconstitute before sensory evaluation
Test example 4
This test example provides the aesthetic test of the obtained healthcare goat milk powder of preparation method provided by embodiment 5-8 Test.
5-8 of the embodiment of the present invention, the preparation-obtained goat milk powder of comparative example 4-5 are protected from light sealing refrigeration to put after reconstituting Its brew and taste, smell are observed after setting 24 hours, evaluation criterion is as shown in table 4.
Table 4, evaluation criterion
Choosing 200 likes the volunteer of dairy products to test and assess, with average mark as a result, test result is shown in Table 5.
5 goat milk powder of table reconstitutes the sensory evaluation after 24 hours
Evaluation index Embodiment 5 Embodiment 6 Embodiment 7 Embodiment 8 Comparative example 4 Comparative example 5
Flavour 10 10 9 10 7 4
Smell 9 9 9 10 7 4
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail It states, but on the basis of the present invention, it can be made some modifications or improvements, this is aobvious and easy to those skilled in the art See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to that the present invention claims guarantors The range of shield.

Claims (10)

1. a kind of healthcare goat milk powder, which is characterized in that be prepared by the following raw material, the raw material is by weight, comprising:
50-130 parts of sheep milk composition, 1-15 parts of ginseng pulverate, 1-15 parts of longan powder, 1-15 parts of Poria cocos powder, 1-10 parts of lotus nut starch;
The sheep milk composition is provided by sheep cream and/or sheep milk powder.
2. healthcare goat milk powder according to claim 1, which is characterized in that the sheep milk composition is by sheep cream and degreasing sheep milk powder Composition;
Preferably, the ratio of sheep cream and degreasing sheep milk powder is (4-8): (1-5).
3. healthcare goat milk powder according to claim 1 or 2, which is characterized in that further include oligofructose, honey, vegetable fat powder One or more of with milk flavour.
4. healthcare goat milk powder according to claim 3, which is characterized in that the fat content of the vegetable fat powder is 2-3%, water Divide content≤3.0%;
And/or the milk flavour include tincture of vanilla, 3- hydroxy-2-butanone, δ-decalactone, 5- ethoxy -4- methylthiazol, 4- methyl -5- (2- Acetoxyethyl) thiazole, triacetyl glycerine, Arabic gum and dextrin.
5. healthcare goat milk powder according to claim 3 or 4, which is characterized in that the honey is the black bee eucalyptus honey in northeast;
And/or the ginseng pulverate needed 400 meshes, longan powder, Poria cocos powder, lotus nut starch are 100 mesh powder.
6. healthcare goat milk powder according to claim 1-5, which is characterized in that the healthcare goat milk powder is by weight Meter, comprising:
60-70 parts of sheep cream, 20-40 parts of degreasing sheep milk powder, 5-10 parts of ginseng pulverate, 3-8 parts of longan powder, Poria cocos powder 5-10, lotus nut starch 1-5 parts, 15-20 parts of oligofructose, 1-10 parts of honey, 1-5 parts of vegetable fat powder, 1-5 parts of milk flavour.
7. a kind of method for preparing healthcare goat milk powder as claimed in any one of claims 1 to 6, which is characterized in that its step packet It includes:
(1) the sheep cream, degreasing sheep milk powder are configured to the first premix;
(2) ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch, vegetable fat powder, milk flavour and first premix are mixed, Obtain the second premix;
(3) to being sterilized after the second premix homogeneous, being concentrated by evaporation to newborn dry matter concentration is 10~16 ° of B é, then through drying To obtain the final product;
Preferably, described when in formula further including one or more of vegetable fat powder, milk flavour, oligofructose or honey Preparation method includes:
(1) the sheep cream, degreasing sheep milk powder are configured to the first premix;
(2) by one or more of the ginseng pulverate, longan powder, Poria cocos powder, lotus nut starch, vegetable fat powder, milk flavour and described First premix mixing, obtains the second premix;
(3) to being sterilized after the second premix homogeneous, being concentrated by evaporation to newborn dry matter concentration is 10~16 ° of B é, then through drying To obtain the final product.
8. the method according to the description of claim 7 is characterized in that dry substance concentration in first premix be 10~ 30%.
9. method according to claim 7 or 8, which is characterized in that in step (3), the homogeneous includes that two steps are different Homogenization:
(3.1) preliminary homogenization is carried out to it through colloid mill to second premix;
(3.2) second of homogeneous is carried out to (3.1) resulting premix in high pressure homogenizer, homogenization pressure is 12~18Mpa;
Preferably, colloid mill gap is controlled when homogenization described in step (3.1) be not more than 1mm.
10. according to the described in any item methods of claim 7-9, which is characterized in that in step (3), the sterilization for 90~ 30~90s is sterilized at 96 DEG C;
And/or described be evaporated to is evaporated at 50~60 DEG C;
And/or the drying is spray drying, it is 150-170 DEG C that condition control, which is inlet air temperature, and temperature of outgoing air is 80-90 DEG C.
CN201810643416.3A 2018-06-21 2018-06-21 A kind of healthcare goat milk powder and preparation method thereof with antifatigue simultaneous void of enriching blood Pending CN108935694A (en)

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