CN104147173B

CN104147173B - A kind of Chinese medicine composition treating acute alcoholism

Info

Publication number: CN104147173B
Application number: CN201410367681.5A
Authority: CN
Inventors: 潘恒鑫; 潘根起
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-07-30
Filing date: 2014-07-30
Publication date: 2016-08-24
Anticipated expiration: 2034-07-30
Also published as: CN104147173A

Abstract

The invention belongs to technical field of Chinese medicines, particularly disclose a kind of Chinese medicine composition treating acute alcoholism.It is made up of each crude drug of following portions by weight: Radix Et Rhizoma Rhei 5 15 parts, Radix Puerariae 10 15 parts, Fructus Crataegi 10 15 parts, Herba Artemisiae Scopariae 5 15 parts, Radix Bupleuri 3 10 parts, 10 30 parts of Seem Lablab Album, Radix Polygalae 5 15 parts, Semen Ziziphi Spinosae 10 15 parts.The present composition has: toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, the merit of tranquilizing by nourishing the heart, efficient solution can remove acute alcoholism and the remaining ethanol continuity detrimental effect to body.

Description

A kind of Chinese medicine composition treating acute alcoholism

Technical field

The invention belongs to technical field of Chinese medicines, particularly to a kind of Chinese medicine composition treating acute alcoholism.

Background technology

Alcoholism: be an excessive consumption of alcohol, causes central nervous system to be transferred to the state of suppression by excitement.Motherland's medical science As far back as described in " property of medicine opinion ": Radix Puerariae: " controlling gas on sky row, vomiting whetting the appetite, principal solution alcoholism ".Its pathomechanism is: excessively Excessive drinking, addiction to greasy and sweet foods savoury, impairing the spleen and stomach, make dysfunction of the spleen in transportation, accumulatively wet raise phlegm is turbid, caused by expectorant turbid illiteracy key or Phlegm to hinder collaterals.Clinical Disease as: words are many, think highly of oneself, irritability, instability of gait, clumsy in one's movement, severe patient pale complexion, blurred vision, speaking incoherently, evil The heart, vomiting, hyponoia, the symptom such as stupor.

Western medicine routine treatment and symptomatic therapy, can only alleviate partial symptoms, but the ethanol that can not release internal remaining continues Carry over effect to body damage.

Summary of the invention

In place of overcoming the deficiencies in the prior art, it is an object of the invention to provide one and treat in acute alcohol The Chinese medicine composition of poison, said composition has: toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, the merit of tranquilizing by nourishing the heart, efficient solution can remove acute wine Essence poisoning and the remaining ethanol continuity detrimental effect to body.

For achieving the above object, the technical scheme that the present invention takes is as follows:

A kind of Chinese medicine composition treating acute alcoholism, is made up of each crude drug of following portions by weight: Radix Et Rhizoma Rhei 5- 15 parts, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, acid Semen Ziziphi Spinosae 10-15 part.

Further, the parts by weight of described each crude drug are preferably: Radix Et Rhizoma Rhei 10 parts, Radix Puerariae 15 parts, Fructus Crataegi 15 parts, Herba Artemisiae Scopariae 15 Part, Radix Bupleuri 10 parts, 30 parts of Seem Lablab Album, Radix Polygalae 10 parts, Semen Ziziphi Spinosae 15 parts.

Described Chinese medicine composition technique routinely makes decoct, pill or capsule.

Preparation method and using method:

Acute stage, with decoct: in terms of parts by weight, weigh: Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, mattress Old 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part, then, put this eight tastes Chinese medicine Entering in marmite, first decocts 600 parts by volume that add water, and soaks 30 minutes, after first boiling with high heat, then decocts 30 minutes with slow fire, gets it filled Liquid about 350 parts by volume；Second decocts 500 parts by volume that add water, and after first boiling with high heat, then decocts 25 minutes with slow fire, taking liquid about 350 Parts by volume；Boil medicine after liquid mixes two and take at twice, morning and evening service once, decoction being taken warmly or nasal feeding；Wherein, weight portion with g timing, Parts by volume is in terms of ml.

Catabasis, with pill or capsule: in terms of parts by weight, weigh Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10- 15 parts, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part, then by these eight kinds Chinese medicine is crossed 100 mesh sieves after pulverizing and is made superfine medicated powder, then makes: 1. pill: medicated powder and honey are made by the weight ratio of 1:1.5 Honeyed pill, every ball 3g, each serving 6g, every day takes secondary；Or 2. capsule: medicated powder is loaded Capsules, every 0.3g, each serving 6, often taken three times per day.

The pharmacology of the present invention is as follows:

Radix Et Rhizoma Rhei: this product bitter cold is removed heat by catharsis, has stronger relieving constipation by purgation, cleanses the effect that the intestines and stomach is stagnant, for heat and toxic materials clearing away it Key medicine, can promote the excretion of food and drink in stomach, intestinal, to reduce the absorption of ethanol.

Radix Puerariae: described in Shennong's Herbal: " all poison can be solved "." property of medicine opinion " records " principal solution alcoholism ".Modern pharmacology Research proves: " Radix Puerariae has beta-receptor retardation widely, can treat the increased heart rate caused because of alcoholism, reduces cardiac muscle Oxygen consumption, increases oxygen supply ".

Fructus Crataegi: this product acid is sweet, tepor, merit is apt to promoting digestion and removing stagnation, can control various eating accumulation, particularly digest greasy meat stagnation Key medicine.Can treat the product of food and drink delicious food savoury, the impairment of the spleen is upset one's stomach.

Herba Artemisiae Scopariae: this product kind profit liver and gall wet and jaundice eliminating, bitter can fall is let out again, trembles with fear with heat clearing away, therefore is especially apt to removing damp-heat from the liver and the gallbladder, makes Go out from urine.Modern pharmacological research proves: " this product protects the liver regulating liver-QI induction of drug enzyme effect ".Can treat because alcoholism draws The rising of the serum bilirubin risen and Aspartate aminotransferase etc..

Radix Bupleuri: this product pungent row hardship is let out, and property is apt to bar and is reached irritability, dispersing the stagnated live-QI to relieve the stagnation of QI.Modern pharmacological research proves: " Radix Bupleuri has preferably Anti-fatty liver, anti-liver injury, function of gallbladder promoting, reduction transaminase, gastric acid secretion inhibiting, the effect such as antiulcer, coordinate Herba Artemisiae Scopariae, Radix Puerariae, Seem Lablab Album strengthens the effect protecting the liver and promoting alcohol metabolism.

Seem Lablab Album: the sweet tepor of this product, can air making-up and spleen enlivening, hold concurrently again can removing dampness, the conventional disease controlling damp-retention due to hypofunction of the spleen.Modern pharmacology grinds Study carefully proof: " vomiting that alimentary toxicosis is caused by this product, acute gastroenteritis etc. have Detoxication, still have the effects such as alcoholic intoxication ".

Radix Polygalae: this product toil temperature, main enter heart kidney channel, can happily gas and mind calming is refreshing, can lead to again kidney qi and by force will do not forget, for Restoring normal coordination between the heart and kidney, mind tranquilizing and the heart calming, the good merchantable brand of the strong will of Fructus Alpiniae Oxyphyllae." medicineization justice " is recorded: this product enters the heart and has one's ideas straightened out, all sputums volt heart, is jammed Thinking, causes motive excess-heat, peaceful for dossing, and stays for decrepit and muddleheaded god, aphasia, is afraid of for the most frightened ... temporarily with this eliminating phlegm profit key, Make the motive open-minded, then the state of mind is from peaceful.

Semen Ziziphi Spinosae: this product sweet in the mouth, enters conscience warp, is longer than and calms the nerves, the double the moon blood that can nourish the heart, liver, wanting for tranquilizing by nourishing the heart Medicine.Modern pharmacological research proves: the water of Semen Ziziphi Spinosae and alcohol extraction thing, has antiarrhythmic effect.Radix Polygalae increase is coordinated to control Treat the effect of the diseases such as cardiopalmus, excitement, irritability.

The most all medicine compatibilities are played altogether: toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, the merit of tranquilizing by nourishing the heart.For treatment because of alcoholism institute If cause many, think highly of oneself, irritability, instability of gait, clumsy in one's movement, severe patient pale complexion, blurred vision, speaking incoherently, feel sick, Vomiting, hyponoia, the symptom such as stupor, and the continuity infringement etc. to internal organs such as the heart, brain, livers.

Detailed description of the invention

Below in conjunction with specific embodiment, technical scheme is discussed in detail further, but the guarantor of the present invention The scope of protecting is not limited thereto.

Embodiment 1

In terms of parts by weight, Radix Et Rhizoma Rhei 5 parts, Radix Puerariae 12 parts, Fructus Crataegi 10 parts, Herba Artemisiae Scopariae 15 parts, Radix Bupleuri 7 parts, 10 parts of Seem Lablab Album, Radix Polygalae 15 parts, Semen Ziziphi Spinosae 10 parts.

Preparation method and using method:

Acute stage, with decoct: this eight tastes Chinese medicine is put into marmite, first decocts 600 parts by volume that add water, and soaks 30 minutes, After first boiling with high heat, then decoct 30 minutes with slow fire, taking liquid about 350 parts by volume；Second decocts 500 parts by volume that add water, and first uses force After fire boils, then decoct 25 minutes with slow fire, taking liquid about 350 parts by volume；Boil medicine two and take at twice after liquid mixing, early, evening each Take once, decoction being taken warmly or nasal feeding；Wherein, weight portion is with g timing, and parts by volume is in terms of ml.

Catabasis, with pill or capsule: cross 100 mesh sieves after being pulverized by these eight kinds of Chinese medicines and make superfine medicated powder, then make Become: 1. pill: by the weight ratio of 1:1.5, medicated powder and honey are made honeyed pill, and every ball 3g, each serving 6g, every day takes secondary；Or 2. glue Wafer: medicated powder is loaded Capsules, every 0.3g, each serving 6, often taken three times per day.

Embodiment 2

In terms of parts by weight, Radix Et Rhizoma Rhei 10 parts, Radix Puerariae 15 parts, Fructus Crataegi 15 parts, Herba Artemisiae Scopariae 15 parts, Radix Bupleuri 10 parts, 30 parts of Seem Lablab Album, remote Will 10 parts, Semen Ziziphi Spinosae 15 parts.

Preparation method and using method are with embodiment 1.

Embodiment 3

In terms of parts by weight, Radix Et Rhizoma Rhei 15 parts, Radix Puerariae 10 parts, Fructus Crataegi 12 parts, Herba Artemisiae Scopariae 5 parts, Radix Bupleuri 3 parts, 20 parts of Seem Lablab Album, Radix Polygalae 5 parts, Semen Ziziphi Spinosae 12 parts.

Preparation method and using method are with embodiment 1.

Clinical trial

1.1 physical data

From in August, 2009 in June, 2014, filter out and accept patients with acute alcoholism totally 70 example for medical treatment.The equal warp of all cases Health check-up and the multiple inspection such as electrocardiogram, liver function are made a definite diagnosis, and without dysfunctions such as liver, kidney, the hearts.It is randomly divided into treatment group 35 example, All male, age 16-68 year, 36 years old mean age；Matched group 35 example, all male, age 17-66 year, average year 35 years old age；Two groups at aspects such as sex, age, the state of an illness all without significant difference (p > 0.05), there is comparability, refer to table 1.

1.2 diagnostic criteria

The most once excessive drinking history；2. excitation period；Blood concentration of alcohol reaches 11mmol/L, and many, conceited, Yi Ji is talked about in performance Invite, have discourtesy etc.；3. the ataxia phase: blood concentration of alcohol reaches 33mmol/L, instability of gait, clumsy in one's movement, language are showed Without coherence, Nausea and vomiting etc.；4. coma stage: blood concentration of alcohol reaches 54mmol/L, show hyponoia, lethargy, even go into a coma Deng；5. continuity symptom can have headache, dizziness, weak, nauseating etc..

1.3 Therapeutic Method

Matched group: by western medicine routine treatment, gives Allylnoroxymorphone, vitamin B₁Deng, equilibrium electrolyte and symptomatic treatment.

Treatment group: only take Chinese medicine composition embodiment 2 prescription of the present invention and preparation method thereof, using method.

After two groups are treated 2 weeks respectively, all carrying out electrocardiogram, liver function test before and after two groups of treatments, observation experiment room checks Result and clinical symptoms improve situation.

1.4 therapeutic evaluation

The most effective: clinical symptom disappearance, blood concentration of alcohol, electrocardiogram and liver function recovery are normal.

The most effective: clinical symptoms disappears substantially, blood concentration of alcohol, electrocardiogram or liver function are normal.

The most invalid: clinical symptoms is not improved, blood concentration of alcohol, electrocardiogram or liver function are still without changing.

1.5 statistical method

Data rate represents, uses X²Inspection, statistically significant with p < 0.05 for difference.

1.6 result

1.6.1 before and after treatment, two groups of symptoms improvement situations compare

Treatment group only takes clinical symptoms improvement rate (97%) after Chinese medicine composition of the present invention, uses merely Western medicine with matched group Clinical symptoms improvement rate (70%) after conventional therapy, there were significant differences, illustrates that the clinical efficacy of Chinese medicine composition of the present invention is better than west Curative effect during the symptomatic treatment alcoholism such as medicine Allylnoroxymorphone.Especially to after alcoholism carry over effect produce heart damage and The therapeutic effect of liver function injury is compared, the Chinese medicine composition of the present invention clinical treatment being better than the Western medicine such as Allylnoroxymorphone evident in efficacy Effect, p < 0.05.Refer to table 2.

1.6.2 untoward reaction

Matched group has 3 examples to occur that both hands tremble, and has 6 examples to increase the weight of Nausea and vomiting；Treatment group has 2 example patients diarrhoea occur, More than have no other untoward reaction.

Model case

Case 1

Lee so-and-so, man, 60 years old, peasant, was North Street people from village, area just outside a city gate town, on June 9th, 2013, with " acute alcoholism " To go to a doctor at inventor.Its lover tells in generation, after three hours cause excess drink Chinese liquor (about 600ml), occurs nervous, chest pain, the heart Proparea constriction, Nausea and vomiting, dysphoria, therefore at emergency inventor.Indagation finding: complexion, lip are pale, nervous, uncomfortable in chest Bitterly, pareordia constriction, pale tongue with white fur, thready and rapid pulse.Blood concentration of alcohol: 46 mmol/L, electrocardio illustrates: hole rate 115 beats/min, V2-3 T wave height is alarmmed, S-T segment changes, and liver function is shown: glutamate pyruvate transaminase 60mmol/L.

Diagnosis: acute alcoholism (syndrome of deficiency of both qi and yin, the turbid impatency of expectorant).

The rule for the treatment of: dispelling toxicity, detoxicating, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart.

Side's medicine: the embodiment of the present invention 2 Chinese medicine composition prescription and preparation method thereof, using method.

After medication, the same day gradually regains consciousness, and complexion, lip are the most ruddy, vomiting disappears, and gait is normal, and lamprophonia, after activity Still feeling nervous, pain uncomfortable in chest, abdominal discomfort, after taking medicine 7 days, nervous, pain uncomfortable in chest disappears, and following the service is with to after 2 weeks, and electrocardiogram is become a full member Often, liver function recovery is normal, recovery from illness.

Case 2

Zhang, man, 40 years old, enterpriser, was West Street, area just outside a city gate town little Khangtsen people, on October 8th, 2012 with " acute alcohol Poisoning " to go to a doctor at inventor.Lover patient generation tell, before 2 hours because of excessive consumption of alcohol (about 700ml Chinese liquor) after, walking shakiness, speech Language obscures, and is sent back home by companion, mad dry uneasiness, followed by occurs nervous, and chest pain is felt oppressed, and irregular respiration, at emergency inventor. Indagation finding: flushed face, cyanotic lips, rough breath is irregular, nervous, pain uncomfortable in chest, lethargy, red tongue, yellow and greasy fur, slippery and rapid pulse Knot generation.Have a blood test concentration of alcohol: alcoholic strength 50mmlo/L, electrocardiogram: heart rate 120 beats/min, frequent premature ventricular beats.Liver function: Gu Bingzhuan Ammonia enzyme 68mmol/L.

Diagnosis: acute alcoholism (expectorant stasis of blood impatency venation).

The rule for the treatment of: toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart.

After medication, the same day regains consciousness, and complexion is often become a full member, eupnea, and gait is steady, still feels pain nervous, uncomfortable in chest, and electrocardio illustrates: Frequent premature ventricular beats disappears substantially.After taking medicine 5 days, nervous, chest pain, disappearance uncomfortable in chest, take after 2 weeks, electrocardiogram, liver function is the most extensive Multiple normal, recovery from illness.

Case 3

Pan so-and-so, man, 40 years old, peasant, Xi Sizhuan township Yue Cun people, on June 15th, 2010 with " acute alcoholism " come Go to a doctor at inventor, lover patient generation tell, before 3 hours because of excessive consumption of alcohol (about 500ml Chinese liquor) after, instability of gait, feel sick, vomit Tell, delivered in family by companion, manic uneasiness, chest pain followed by occurs, feels oppressed, irregular respiration, at emergency inventor.Indagation institute See: pale complexion, cyanotic lips, rough breath, irregularly, uncomfortable in chest, breathe hard, feel sick, vomiting, lethargy, dysphoria, red tongue, Yellow and greasy fur, slippery and rapid pulse.Blood alcohol concentration 41mmol/L, electrocardio illustrates: heart rate 108 beats/min, and V2-3 T ripple changes, and II. III .avF S-T segment changes.Liver function: glutamate pyruvate transaminase 56mmol/L.

Diagnosis: acute alcoholism.

The rule for the treatment of: symptomatic treatment.

Prescription: 1. 5% Glucose Liquid 250ml+ Allylnoroxymorphone 0.8mg, intravenous drip, once-a-day；2. 5% Glucose Liquid 500ml+ cimetidine 0.4mg+10% potassium chloride 10ml, intravenous drip, once-a-day；3. remaining symptomatic treatment.

Medication patient on same day sanity, nausea and vomiting alleviates, but still feels chest pain, and breast is felt oppressed, heart rate 96 beats/min, breathes Sound is thick, irritated.After treatment 5 days, above-mentioned all diseases have been taken a turn for the better, and chest pain, breast are felt oppressed and alleviated, and breathe steadily, and agitation slightly alleviates, warp After controlling 2 weeks, chest pain, breast is felt oppressed, and still suffers from, vexed, insomnia, feels sick when morning rises, and electrocardio illustrates: heart rate 86 beats/min, V2-3 T ripple Change and II. III .avF S-T segment change is not improved.Liver function: glutamate pyruvate transaminase 50mmol/L, continues to give symptomatic treatment.

Claims

1. the Chinese medicine composition treating acute alcoholism, it is characterised in that the parts by weight of described each crude drug are: big Huang 10 parts, Radix Puerariae 15 parts, Fructus Crataegi 15 parts, Herba Artemisiae Scopariae 15 parts, Radix Bupleuri 10 parts, 30 parts of Seem Lablab Album, Radix Polygalae 10 parts, Semen Ziziphi Spinosae 15 parts.

2. the Chinese medicine composition treating acute alcoholism as claimed in claim 1, it is characterised in that: described Chinese medicine composition Technique makes decoct, pill or capsule routinely.