CN104147173A - Chinese medicinal composition for treating acute alcoholism - Google Patents
Chinese medicinal composition for treating acute alcoholism Download PDFInfo
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- CN104147173A CN104147173A CN201410367681.5A CN201410367681A CN104147173A CN 104147173 A CN104147173 A CN 104147173A CN 201410367681 A CN201410367681 A CN 201410367681A CN 104147173 A CN104147173 A CN 104147173A
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Abstract
The invention belongs to the technical field of Chinese medicaments and in particular discloses a Chinese medicinal composition for treating acute alcoholism. The Chinese medicinal composition is prepared from the following raw materials in parts by weight: 5-15 parts of rhubarb, 10-15 parts of kudzuvine root, 10-15 parts of hawthorn, 5-15 parts of oriental wormwood, 3-10 parts of bupleurum, 10-30 parts of hyacinth bean, 5-15 parts of polygala and 10-15 parts of wild jujube seeds. The composition disclosed by the invention has the effects of expelling toxin, detoxifying, strengthening spleen, soothing liver and tranquilizing mind by nourishing the heart, and can be used for effectively relieving acute alcoholism and a continuous harm of remaining alcohol to the body.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of acute alcoholism.
Background technology
Alcoholism: be an excessive consumption of alcohol, cause that central nervous system is transferred to the state of inhibition by excitement.Motherland's medical science is recorded in " property of medicine opinion ": Radix Puerariae: " controlling the upper gas of day row, vomiting whetting the appetite, principal solution alcoholism ".Its pathomechanism is: excessively excessive drinking, and addiction to greasy and sweet foods savoury, impairing the spleen and stomach, makes dysfunction of the spleen in transportation, and accumulatively wet raise phlegm is turbid, due to the turbid illiteracy key of expectorant or Phlegm to hinder collaterals.Clinical condition is shown in: words are many, think highly of oneself, and irritability, instability of gait, clumsy in one's movement, severe patient pale complexion, blurred vision, speaking incoherently, nauseating, vomiting, hyponoia, the symptoms such as stupor.
Doctor trained in Western medicine conventional therapy and symptomatic therapy, can only alleviate partial symptoms, continues the carry over effect to body damage but can not remove remaining ethanol in body.
Summary of the invention
For overcoming the deficiencies in the prior art part, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of acute alcoholism, said composition has: the merit of toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart, can efficient solution remove acute alcoholism and the continuity detrimental effect of remaining ethanol to body.
For achieving the above object, the technical scheme that the present invention takes is as follows:
Treat a Chinese medicine composition for acute alcoholism, made by each crude drug of following portions by weight: Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part.
Further, the parts by weight of described each crude drug are preferably: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Puerariaes, 15 parts of Fructus Crataegis, 15 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 30 parts, Seem Lablab Album, 10 parts of Radix Polygalaes, 15 parts of Semen Ziziphi Spinosaes.
Described Chinese medicine composition routinely technique is made decoct, pill or capsule.
Preparation method and using method:
Acute stage, with decoct: in parts by weight, take: Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part, then, this eight tastes Chinese medicine is put into marmite, first decocts 600 parts by volume that add water, soak 30 minutes, after first boiling with high heat, then use 30 minutes at a simmer, taking liquid approximately 350 parts by volume; Second decocts 500 parts by volume that add water, and after first boiling with high heat, then uses 25 minutes at a simmer, taking liquid approximately 350 parts by volume; Boil medicine after liquid mixes and take at twice two, morning and evening service once, decoction being taken warmly or nasal feeding; Wherein, weight portion is with g timing, and parts by volume is in ml.
Catabasis, with pill or capsule: in parts by weight, take Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part, then after these eight kinds of Chinese medicines being pulverized, cross 100 mesh sieves and make superfine medicated powder, then make: 1. pill: medicated powder and honey are made to honeyed pill by the weight ratio of 1:1.5, every ball 3g, each serving 6g, takes secondary every day; Or 2. capsule: pack medicated powder into Capsules, every 0.3g, each serving 6, takes three times every day.
Pharmacology of the present invention is as follows:
Radix Et Rhizoma Rhei: this product bitter cold is removed heat by catharsis, has stronger relieving constipation by purgation, cleanses the stagnant effect of the intestines and stomach, is the key medicine of heat and toxic materials clearing away, can promote the excretion of food and drink in stomach, intestinal, to reduce the absorption of ethanol.
Radix Puerariae: record in Shennong's Herbal: " can separate all poison "." property of medicine opinion " records " principal solution alcoholism ".Modern pharmacological research proves: " Radix Puerariae has beta-receptor retardation widely, can treat the heart rate causing because of alcoholism and accelerate, and reduces myocardial oxygen consumption, increases oxygen supply ".
Fructus Crataegi: this product acid is sweet, tepor, and merit is apt to promoting digestion and removing stagnation, can control various eating accumulations, particularly digests the key medicine of greasy meat stagnation.The product that can treat food and drink delicious food savoury, the impairment of the spleen is upset one's stomach.
Herba Artemisiae Scopariae: this product is apt to the wet of sharp liver and gall and jaundice eliminating, and hardship can be fallen and be let out again, cold with heat clearing away, therefore especially kind removing damp-heat from the liver and the gallbladder makes it to go out from urine.Modern pharmacological research proves: " this product protects the liver the effect of regulating liver-QI induction of drug enzyme ".Can treat the rising of the serum bilirubin and the Aspartate aminotransferase etc. that cause because of alcoholism.
Radix Bupleuri: the pungent row hardship of this product is let out, the kind bar of property reaches irritability, dispersing the stagnated live-QI to relieve the stagnation of QI.Modern pharmacological research proves: " Radix Bupleuri has the effects such as good anti-fatty liver, anti-liver injury, function of gallbladder promoting, reduction transaminase, gastric acid secretion inhibiting, antiulcer, coordinates Herba Artemisiae Scopariae, Radix Puerariae, Seem Lablab Album to strengthen the effect that protects the liver and promote alcohol metabolism.
Seem Lablab Album: the sweet tepor of this product, can air making-up and spleen enlivening, holding concurrently again can removing dampness, the conventional disease of controlling damp-retention due to hypofunction of the spleen.Modern pharmacological research proves: " vomiting, acute gastroenteritis etc. that this product causes alimentary toxicosis have Detoxication, still have the effects such as alcoholic intoxication ".
Radix Polygalae: this product toil temperature, main enter heart kidney channel, gas and mind calming god happily, can lead to kidney qi again and by force will do not forget, be the good merchantable brand of restoring normal coordination between the heart and kidney, mind tranquilizing and the heart calming, the strong will of Fructus Alpiniae Oxyphyllae." medicine justice " is recorded: this product enters the heart has one's ideas straightened out, all sputum volt hearts, and the thinking of being jammed, causes motive excess-heat, not peaceful for dossing, and slow-witted for decrepit and muddleheaded god, aphasia, is afraid of for dimly frightened ... with this eliminating phlegm profit key, make the motive open-minded temporarily, the state of mind is from peaceful.
Semen Ziziphi Spinosae: this product sweet in the mouth, enter conscience warp, to be longer than and to calm the nerves, the double cloudy blood that can nourish the heart, liver, is the key medicine of tranquilizing by nourishing the heart.Modern pharmacological research proves: the water of Semen Ziziphi Spinosae and alcohol extract, have antiarrhythmic effect.Coordinate Radix Polygalae to increase the effect of the diseases such as treatment cardiopalmus, excitement, irritability.
All medicine compatibilities are played altogether above: the merit of toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart.Be used for the treatment of because the words due to alcoholism are many, think highly of oneself, irritability, instability of gait, clumsy in one's movement, severe patient pale complexion, blurred vision, speaking incoherently, feels sick, vomiting, hyponoia, the symptoms such as stupor, and continuity infringement to internal organs such as the heart, brain, livers etc.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is done to introduce in detail further, but protection scope of the present invention is not limited to this.
Embodiment 1
In parts by weight, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Radix Puerariaes, 10 parts of Fructus Crataegis, 15 parts of Herba Artemisiae Scopariaes, 7 parts of Radix Bupleuri, 10 parts, Seem Lablab Album, 15 parts of Radix Polygalaes, 10 parts of Semen Ziziphi Spinosaes.
Preparation method and using method:
Acute stage, with decoct: this eight tastes Chinese medicine is put into marmite, and first decocts 600 parts by volume that add water, soak 30 minutes, after first boiling with high heat, then use 30 minutes at a simmer, taking liquid approximately 350 parts by volume; Second decocts 500 parts by volume that add water, and after first boiling with high heat, then uses 25 minutes at a simmer, taking liquid approximately 350 parts by volume; Boil medicine after liquid mixes and take at twice two, morning and evening service once, decoction being taken warmly or nasal feeding; Wherein, weight portion is with g timing, and parts by volume is in ml.
Catabasis, with pill or capsule: cross 100 mesh sieves after these eight kinds of Chinese medicines are pulverized and make superfine medicated powder, then make: 1. pill: medicated powder and honey are made to honeyed pill by the weight ratio of 1:1.5, and every ball 3g, each serving 6g, takes secondary every day; Or 2. capsule: pack medicated powder into Capsules, every 0.3g, each serving 6, takes three times every day.
Embodiment 2
In parts by weight, 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Puerariaes, 15 parts of Fructus Crataegis, 15 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 30 parts, Seem Lablab Album, 10 parts of Radix Polygalaes, 15 parts of Semen Ziziphi Spinosaes.
Preparation method and using method are with embodiment 1.
Embodiment 3
In parts by weight, 15 parts of Radix Et Rhizoma Rhei, 10 parts of Radix Puerariaes, 12 parts of Fructus Crataegis, 5 parts of Herba Artemisiae Scopariaes, 3 parts of Radix Bupleuri, 20 parts, Seem Lablab Album, 5 parts of Radix Polygalaes, 12 parts of Semen Ziziphi Spinosaes.
Preparation method and using method are with embodiment 1.
clinical trial
1.1 physical data
From year June in August, 2009 to 2014, filter out and accept patients with acute alcoholism totally 70 examples for medical treatment.All cases is all made a definite diagnosis through multiple inspections such as health check-up and electrocardiogram, liver functions, and without dysfunctions such as liver, kidney, the hearts.Being divided at random treatment group 35 examples, is all male, age 16-68 year, 36 years old mean age; Matched group 35 examples, are all male, age 17-66 year, 35 years old mean age; Two groups at aspects such as sex, age, the state of an illness all without significant difference (p>0.05), there is comparability, refer to table 1.
1.2 diagnostic criteria
1. excessive drinking history once; 2. excitation period; Blood concentration of alcohol reaches 11mmol/L, and performance words are many, conceited, irritability, have discourtesy etc.; 3. the ataxia phase: blood concentration of alcohol reaches 33mmol/L, performance instability of gait, clumsy in one's movement, speaking incoherently, feel sick, vomiting etc.; 4. coma stage: blood concentration of alcohol reaches 54mmol/L, performance hyponoia, lethargy, stupor etc. even; 5. continue symptom and can have headache, dizziness, weak, nauseating etc.
1.3 Therapeutic Method
Matched group: by doctor trained in Western medicine conventional therapy, give Allylnoroxymorphone, vitamin B
1deng, equilibrium electrolyte and symptomatic treatment.
Treatment group: only take Chinese medicine composition embodiment 2 prescriptions of the present invention and preparation method thereof, using method.
Treat respectively after 2 weeks for two groups, before and after two groups of treatments, all carry out electrocardiogram, liver function test, observation experiment chamber check result and clinical symptoms are improved situation.
1.4 therapeutic evaluation
1.4.1 effective: clinical symptom disappearance, blood concentration of alcohol, electrocardiogram and liver function recovery are normal.
1.4.2 effective: clinical symptoms disappears substantially, blood concentration of alcohol, electrocardiogram or liver function normal.
1.4.3 invalid: clinical symptoms is not improved, blood concentration of alcohol, electrocardiogram or liver function are still without changing.
1.5 statistical method
Data represent by rate, adopt X
2inspection, has statistical significance taking p<0.05 as difference.
1.6 result
1.6.1 before and after treatment, two groups of symptoms are improved situation comparison
Treatment group is only taken clinical symptoms improvement rate (97%) after Chinese medicine composition of the present invention, clinical symptoms improvement rate (70%) after treating with routine of western medicine merely with matched group, there were significant differences, the curative effect when clinical efficacy that Chinese medicine composition of the present invention is described is better than the symptomatic treatment alcoholism such as Western medicine Allylnoroxymorphone.Especially heart damage carry over effect after alcoholism being produced and the therapeutic effect comparison to liver function injury, the Chinese medicine composition of the present invention clinical efficacy that is better than the Western medicine such as Allylnoroxymorphone evident in efficacy, p<0.05.Refer to table 2.
1.6.2 untoward reaction
Matched group has 3 examples to occur that both hands tremble, and has 6 examples to increase the weight of to feel sick, vomit; Treatment group have 2 routine patients occur diarrhoea, more than have no other untoward reaction.
model case
Case 1
Lee so-and-so, man, 60 years old, peasant, was North Street people from village, area just outside a city gate town, on June 9th, 2013, carrys out inventor locate to go to a doctor with " acute alcoholism ".Its lover tells in generation, after three hours the excessive drink Chinese liquor of cause (about 600ml), occur nervous, chest pain, pareordia constriction, feels sick, vomiting, dysphoria, therefore emergency inventor place.Indagation finding: complexion, pale, nervous, the uncomfortable in chest pain of lip, pareordia constriction, pale tongue with white fur, thready and rapid pulse.Blood concentration of alcohol: 46 mmol/L, electrocardio diagram: 115 beats/min of hole rates, V2-3 T wave height is alarmmed, S-T section changes, and liver function is shown: glutamate pyruvate transaminase 60mmol/L.
Diagnosis: acute alcoholism (syndrome of deficiency of both qi and yin, the turbid impatency of expectorant).
The rule for the treatment of: dispelling toxicity, detoxicating, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart.
Side's medicine: the embodiment of the present invention 2 Chinese medicine composition prescriptions and preparation method thereof, using method.
After medication, regained consciousness the same day gradually, and complexion, lip gradually ruddy, vomiting disappear, and gait is normal, and lamprophonia is still felt nervous after activity, pain uncomfortable in chest, abdominal discomfort, took medicine after 7 days, and nervous, uncomfortable in chest pain disappears, following the service was used after 2 weeks, and electrocardiogram is often become a full member, and liver function recovery is normal, recovery from illness.
Case 2
Zhang, man, 40 years old, enterpriser, was moderately well-off people from village in West Street, area just outside a city gate town, carrys out inventor locate to go to a doctor on October 8th, 2012 with " acute alcoholism ".Lover patient tells in generation, and before 2 hours, because of after excessive consumption of alcohol (about 700ml Chinese liquor), walking is unstable, and slurred speech, is sent back home by companion, and having palpitation then appears in mad dry uneasiness, and chest pain, feels oppressed, irregular respiration, emergency inventor place.Indagation finding: flushed face, cyanotic lips, rough breath is irregular, nervous, pain uncomfortable in chest, lethargy, red tongue, yellow and greasy fur, slippery and rapid pulse knot generation.The concentration of alcohol of having a blood test: alcoholic strength 50mmlo/L, electrocardiogram: 120 beats/min of hearts rate, frequent premature ventricular beats.Liver function: glutamate pyruvate transaminase 68mmol/L.
Diagnosis: acute alcoholism (expectorant stasis of blood impatency venation).
The rule for the treatment of: toxin expelling, removing toxic substances, invigorating the spleen and relieving depression of liver-QI, tranquilizing by nourishing the heart.
Side's medicine: the embodiment of the present invention 2 Chinese medicine composition prescriptions and preparation method thereof, using method.
After medication, regained consciousness the same day, and complexion is often become a full member, eupnea, and gait is steady, still feels pain nervous, uncomfortable in chest, electrocardio diagram: frequent premature ventricular beats disappears substantially.Take medicine after 5 days, nervous, chest pain, disappearance uncomfortable in chest, clothes after 2 weeks, electrocardiogram, liver function is all recovered normally, fully recovers.
Case 3
Pan so-and-so, man, 40 years old, peasant, Xi Sizhuan township Yue Cun people, carrys out inventor on June 15th, 2010 with " acute alcoholism " and locates to go to a doctor, in lover patient generation, tells, before 3 hours because of after excessive consumption of alcohol (about 500ml Chinese liquor), instability of gait, feel sick, vomiting, is delivered in family by companion,, then there is chest pain in manic uneasiness, feels oppressed, irregular respiration, emergency inventor place.Indagation finding: pale complexion, cyanotic lips, rough breath, irregular, uncomfortable in chest, breathe hard, feel sick, vomiting, lethargy, dysphoria, red tongue, yellow and greasy fur, slippery and rapid pulse.Blood alcohol concentration 41mmol/L, electrocardio diagram: 108 beats/min of hearts rate, V2-3 T ripple changes, II. III .avF S-T section changes.Liver function: glutamate pyruvate transaminase 56mmol/L.
Diagnosis: acute alcoholism.
The rule for the treatment of: symptomatic treatment.
Prescription: 1. 5% Glucose Liquid 250ml+ Allylnoroxymorphone 0.8mg, intravenous drip, once-a-day; 2. 5% Glucose Liquid 500ml+ cimetidine 0.4mg+10% potassium chloride 10ml, intravenous drip, once-a-day; 3. all the other symptomatic treatments.
Medication patient on same day sanity, nausea and vomiting alleviates, but still sense chest pain, breast is felt oppressed, 96 beats/min of hearts rate, and respiratory murmur is thick, agitation.After treating 5 days, above-mentioned all diseases are taken a turn for the better to some extent, and chest pain, breast are felt oppressed and alleviated, breathe steadily, agitation slightly alleviates, after controlling 2 weeks, chest pain, breast is felt oppressed, and still exists, vexed, insomnia, when rise morning, feel sick, electrocardio diagram: 86 beats/min of hearts rate, V2-3 T ripple changes and II. the change of III .avF S-T section is not improved.Liver function: glutamate pyruvate transaminase 50mmol/L, continues to give symptomatic treatment.
Claims (3)
1. treat a Chinese medicine composition for acute alcoholism, it is characterized in that being made by each crude drug of following portions by weight: Radix Et Rhizoma Rhei 5-15 part, Radix Puerariae 10-15 part, Fructus Crataegi 10-15 part, Herba Artemisiae Scopariae 5-15 part, Radix Bupleuri 3-10 part, Seem Lablab Album 10-30 part, Radix Polygalae 5-15 part, Semen Ziziphi Spinosae 10-15 part.
2. the Chinese medicine composition for the treatment of acute alcoholism as claimed in claim 1, is characterized in that the parts by weight of described each crude drug are: 10 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Puerariaes, 15 parts of Fructus Crataegis, 15 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 30 parts, Seem Lablab Album, 10 parts of Radix Polygalaes, 15 parts of Semen Ziziphi Spinosaes.
3. the Chinese medicine composition for the treatment of acute alcoholism as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition routinely technique is made decoct, pill or capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104740478A (en) * | 2015-04-03 | 2015-07-01 | 邰贵刚 | Traditional Chinese medicine pill for emergency treatment of alcoholism and preparation method thereof |
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| CN1070825A (en) * | 1992-06-23 | 1993-04-14 | 余朋千 | The prescription of anti-intoxication alcohol neutralizing oral agents and manufacture method |
| CN101352493A (en) * | 2008-08-07 | 2009-01-28 | 华中科技大学同济医学院附属同济医院 | Chinese medicine with functions for reducing fat and clearing liver and preparation method thereof |
| CN102580046A (en) * | 2012-03-23 | 2012-07-18 | 南宁市品迪生物工程有限公司 | Zhuang ethnic group medical recipe for preventing alcoholism and sobering up |
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2014
- 2014-07-30 CN CN201410367681.5A patent/CN104147173B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1070825A (en) * | 1992-06-23 | 1993-04-14 | 余朋千 | The prescription of anti-intoxication alcohol neutralizing oral agents and manufacture method |
| CN101352493A (en) * | 2008-08-07 | 2009-01-28 | 华中科技大学同济医学院附属同济医院 | Chinese medicine with functions for reducing fat and clearing liver and preparation method thereof |
| CN102580046A (en) * | 2012-03-23 | 2012-07-18 | 南宁市品迪生物工程有限公司 | Zhuang ethnic group medical recipe for preventing alcoholism and sobering up |
Non-Patent Citations (1)
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| 季昌群等，: "《解酒护肝宜吃的食物》", 29 February 2012, 金盾除湿痹 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104740478A (en) * | 2015-04-03 | 2015-07-01 | 邰贵刚 | Traditional Chinese medicine pill for emergency treatment of alcoholism and preparation method thereof |
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