CN104474417A - Medicinal-edible homologous traditional Chinese medicine composition and use thereof and grape wine and preparation method of grape wine - Google Patents
Medicinal-edible homologous traditional Chinese medicine composition and use thereof and grape wine and preparation method of grape wine Download PDFInfo
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- CN104474417A CN104474417A CN201410650455.8A CN201410650455A CN104474417A CN 104474417 A CN104474417 A CN 104474417A CN 201410650455 A CN201410650455 A CN 201410650455A CN 104474417 A CN104474417 A CN 104474417A
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- A61K36/9062—Alpinia, e.g. red ginger or galangal
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Abstract
The present invention relates to the field of grape wine, and in particular relates to a medicinal-edible homologous traditional Chinese medicine composition and use thereof and grape wine and a preparation method of the grape wine, and the medicinal-edible homologous traditional Chinese medicine composition includes Chinese wolfberry, poria cocos, chrysanthemum, polygonatum, cinnamon and alpinia oxyphylla. The medicinal-edible homologous traditional Chinese medicine composition has the effects of tonifying kidney, reinforcing essence and blood, resisting fatigue, nourishing liver and kidney, strengthening bones and muscles, softening blood vessels, beautifying, nourishing face, enhancing immunity, and delaying senescence. The grape wine not only keeps the original grape wine mellow, fragrant and rich taste, also has the effects of tonifying kidney, reinforcing essence and blood, resisting fatigue, nourishing liver and kidney, strengthening bones and muscles, softening blood vessels, beautifying, nourishing face, enhancing immunity, and delaying senescence.
Description
Technical field
The present invention relates to field of grape wine, particularly integration of edible and medicinal herbs Chinese medicine composition and uses thereof, wine and preparation of wine.
Background technology
Along with the continuous quickening of rhythm of life, social pressure constantly increases, and the crowd that suffers from a deficiency of the kidney being in sub-health state constantly rises, and has a strong impact on its work and life.Suffer from a deficiency of the kidney and mostly be long term accumulation and become the one of the sub-health state of disease to show, modern science proves, when people suffers from a deficiency of the kidney, no matter deficiency of the kidney yin or insufficiency of kidney-YANG, all can cause the reduction of the immunocompetence of people, have more evidence to show, suffer from a deficiency of the kidney occur time, the immunocompetence of kidney reduces, and the microcirculqtory system of kidney also can be blocked, and kidney network presents obstructed.Generally speaking, suffering from a deficiency of the kidney is the Etiological of subhealth state.Suffer from a deficiency of the kidney and not only concentrate on male, along with socioeconomic development, women is more and more large under pressure, bear work and family's double liability also increases gradually, thus cause women's YANG QI deficiency, cloudy gas do not fill, gradually develop into menoxenia, face senilism, climacteric in advance, endocrine disturbance, fear of cold fear a series of diseases of suffering from a deficiency of the kidney such as heat.
But at present corresponding medicine, health product etc. are not fully up to expectations, as the medicine of Western medicine many employings gonadal hormone, blood vessel dilating and angiotensin converting enzyme inhibitor etc., though have certain curative effect, but its effect can not be lasting, simultaneously with side effect, people is even made to produce dependency.And Western medicine is cured the symptoms, not the disease, can not life-time service.And the strengthening yang and invigorating kidney health promoting product on existing market, much all with the addition of the raw material of " viagra " sldenafil constituents, its toxic and side effects is too large, is unfavorable for the health care of long-term warming and recuperating the kidney-YANG.Therefore, for the medicine of western medicine composition and health product, the health promoting wine safety that integration of edible and medicinal herbs Chinese medicine is made is higher, and wine has effects such as " promoting blood circulation; row medicine gesture, warming intestines and stomach, imperial wind and cold ", wine and medicine preparation can strengthen the stability of the efficacy of a drug and each Chinese medicinal components, are particularly suitable for long-term the kidney invigorating.
China just have from ancient times drink medicated wine, tonic wine carrys out health preserving, keep fit, be healthy and strong the tradition that gets rid of illness, but rests on individual workship and family's brewed stage personal from drink always.Until the eighties in last century just proposes, and distinguish with medicated wine.The nineties in 20th century, with the proposition of " subhealth state " and prevailing, health-care and nutritious wine market is rapidly developed.But, above-mentioned health-care and nutritious wine is substantially all the medicinal liquor for strengthening yang of the kidney invigorating yang deficiency, can not the kidney invigorating deficiency of YIN, the health care of its kidney-replenishing medicated wine neither be fairly obvious, all employ the Chinese liquor wine base of 30% to 38%, life-time service can cause damage to human liver, the health promoting wine product that seldom all effective to deficiency of the kidney yin, insufficiency of kidney-YANG and collocation balances, therefore, along with the change of people's care concepts, with the wine of alcoholic strength low for wine base, and with various integration of edible and medicinal herbs Chinese medicine for the new development trend of health-care and nutritious wine for health promoting wine industry prepared by raw material.But it is single that current health preserving wine exists formula, be difficult to reach equilibrium between yin and yang with the effect of mending, cause curative effect not obvious, health care is single, treats greatly differ from each other with differential diagnosis in tcm.And it is to no effect several to the kidney invigorating.Meanwhile, some health promoting wine, in order to pursue the stripping of ingredient, uses the ethanol of the too high number of degrees, though the precipitation of liposoluble constituent can be increased, be unfavorable for the dissolving of water soluble ingredient, and alcoholic strength is too high, long-term drink can cause damage to organs such as livers, has a negative impact to health of masses.Also having part health promoting wine to promote mouthfeel, adding some spice, as aspartame, essence etc., although adding of these materials can promote mouthfeel, having impact to health, reduce drug effectiveness.Therefore, a kind of medicated wine of the kidney invigorating Be very effective is provided, there is far-reaching realistic meaning.
Summary of the invention
In view of this, the invention provides integration of edible and medicinal herbs Chinese medicine composition and uses thereof, wine and preparation of wine.This integration of edible and medicinal herbs Chinese medicine composition has the drug effect of the kidney invigorating, replenishing vital essence and blood, resisting fatigue, liver and kidney tonifying, bone and muscle strengthening, vessel softening, looks improving and the skin nourishing, enhancing immunity, slow down aging.This wine not only maintains the mellow mouthfeel of the strong fragrance of wine script, and has effect of the kidney invigorating, replenishing vital essence and blood, resisting fatigue, liver and kidney tonifying, bone and muscle strengthening, vessel softening, looks improving and the skin nourishing, enhancing immunity, slow down aging.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of integration of edible and medicinal herbs Chinese medicine composition, comprise Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.
As preferably, integration of edible and medicinal herbs Chinese medicine composition provided by the invention, is made up of Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.
Preferred, integration of edible and medicinal herbs Chinese medicine composition provided by the invention, is made up through ethanol extraction of Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.Preferred, be extracted as reflux, extract.More preferably, the number of times of alcohol reflux is 2 times, and the mass ratio of ethanol and integration of edible and medicinal herbs Chinese medicine composition is 4:1, and the mass concentration of ethanol is 50%.
In some embodiments of the invention, integration of edible and medicinal herbs Chinese medicine composition is grouped into by the one-tenth of following weight portion:
As preferably, integration of edible and medicinal herbs Chinese medicine composition is grouped into by the one-tenth of following weight portion:
In some embodiments of the invention, also disclose above-mentioned integration of edible and medicinal herbs Chinese medicine composition and prepare the application in medicine, food or the beverage for the treatment of and suffering from a deficiency of the kidney.As preferably, above-mentioned integration of edible and medicinal herbs Chinese medicine composition has the effect of replenishing vital essence and blood, liver and kidney tonifying, bone and muscle strengthening.Preferred, above-mentioned integration of edible and medicinal herbs Chinese medicine composition is applicable to that body is tired, soreness of waist and knee joint, fear of cold are afraid of cold, the crowd that suffers from a deficiency of the kidney of sexual impotence erectile problem, insomnia and dreamful sleep.
In other embodiments of the present invention, also disclose the application of above-mentioned integration of edible and medicinal herbs Chinese medicine composition in the preparation medicine of resisting fatigue, food or beverage.Fatigue of the present invention is not limited to the fatigue caused owing to suffering from a deficiency of the kidney, and the disease of every fatigue, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned integration of edible and medicinal herbs Chinese medicine composition and preparing the application in the medicine of enhancing immunity, food or beverage.Immunity is the defense mechanism of human body self, is human bioequivalence and any foreign body (virus, antibacterial etc.) eliminating external intrusion; Process is old and feeble, damage, the ability of mutant cell and virus infected cell in the own cells of dead, degeneration and identification and handling body.Immunology Today is thought, immunity is the physiological reaction of human bioequivalence and eliminating " dissident ".What perform this function in human body is immune system, and by multiple method enhancing immunity, dietetic regulation, the useful food of polyphagia, particularly child, needs the enhancing noting immunity more.Every disease being suitable for enhancing immunity definition in immunology, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned integration of edible and medicinal herbs Chinese medicine composition and preparing the application in the medicine of slow down aging, food or beverage.Aging of the present invention, from biologically, be biology As time goes on, spontaneous necessary process, it is complicated natural phenomena, and show as structure and hypofunction, adaptability and resistance go down.Every disease being suitable for biologically old and feeble definition, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned integration of edible and medicinal herbs Chinese medicine composition and preparing the application in the medicine of vessel softening, food or beverage.Sclerosis of blood vessels shows as vessel wall thickening and hardening, and sebaceous cyst (atherosclerosis nest) appears in inwall, this is because cholesterol, platelet adhere to the protuberance caused.So intravascular space narrows, blood circulation is had some setbacks, continue deterioration and go down and will block completely.Everyly meet biologically angiosclerotic disease, all within protection scope of the present invention.
Present invention also offers a kind of wine, it is obtained with integration of edible and medicinal herbs Chinese medicine composition mixing after fermentation by Fructus Vitis viniferae; Described integration of edible and medicinal herbs Chinese medicine composition is made up of Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.
In some embodiments of the invention, wine integration of edible and medicinal herbs used Chinese medicine composition is grouped into by the one-tenth of following weight portion:
In order to keep the mellow mouthfeel of the strong fragrance of wine script, and there is the drug effect of the kidney invigorating, replenishing vital essence and blood, resisting fatigue, liver and kidney tonifying, bone and muscle strengthening, vessel softening, looks improving and the skin nourishing, enhancing immunity, slow down aging, the mass ratio controlling Fructus Vitis viniferae and integration of edible and medicinal herbs Chinese medicine composition is 2000:(14 ~ 30).
In some embodiments of the invention, also disclose above-mentioned wine and prepare the application in medicine, food or the beverage for the treatment of and suffering from a deficiency of the kidney.As preferably, above-mentioned wine has the effect of replenishing vital essence and blood, liver and kidney tonifying, bone and muscle strengthening.Preferred, above-mentioned wine is applicable to that body is tired, soreness of waist and knee joint, fear of cold are afraid of cold, the crowd that suffers from a deficiency of the kidney of sexual impotence erectile problem, insomnia and dreamful sleep.
In other embodiments of the present invention, also disclose the application of above-mentioned middle wine in the preparation medicine of resisting fatigue, food or beverage.Fatigue of the present invention is not limited to the fatigue caused owing to suffering from a deficiency of the kidney, and the disease of every fatigue, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned wine and preparing the application in the medicine of enhancing immunity, food or beverage.Immunity is the defense mechanism of human body self, is human bioequivalence and any foreign body (virus, antibacterial etc.) eliminating external intrusion; Process is old and feeble, damage, the ability of mutant cell and virus infected cell in the own cells of dead, degeneration and identification and handling body.Immunology Today is thought, immunity is the physiological reaction of human bioequivalence and eliminating " dissident ".What perform this function in human body is immune system, and by multiple method enhancing immunity, dietetic regulation, the useful food of polyphagia, particularly child, needs the enhancing noting immunity more.Every disease being suitable for enhancing immunity definition in immunology, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned wine and preparing the application in the medicine of slow down aging, food or beverage.Aging of the present invention, from biologically, be biology As time goes on, spontaneous necessary process, it is complicated natural phenomena, and show as structure and hypofunction, adaptability and resistance go down.Every disease being suitable for biologically old and feeble definition, all within protection scope of the present invention.
In other embodiments of the present invention, also disclose above-mentioned wine and preparing the application in the medicine of vessel softening, food or beverage.Sclerosis of blood vessels shows as vessel wall thickening and hardening, and sebaceous cyst (atherosclerosis nest) appears in inwall, this is because cholesterol, platelet adhere to the protuberance caused.So intravascular space narrows, blood circulation is had some setbacks, continue deterioration and go down and will block completely.Everyly meet biologically angiosclerotic disease, all within protection scope of the present invention.
Present invention also offers a kind of above-mentioned preparation of wine, get described integration of edible and medicinal herbs Chinese medicine composition pulverize, sieve after mix with the Fructus Vitis viniferae after fragmentation, fermentation obtains.
The kinds such as the optional Cabernet Sauvignon of Fructus Vitis viniferae, Cabernet franc, Cabernet Gernischt, grape variety can not affect effect vinous provided by the invention, and any grape variety is all within protection scope of the present invention.
The alcoholic strength that existing a lot of health promoting wine soaks is improper causes unsatisfactory curative effect.Some health promoting wine is pursue the ethanol that the stripping of ingredient uses the too high number of degrees, though it can increase the precipitation of liposoluble constituent, but be unfavorable for the dissolving of water soluble ingredient, if and the too low dissolving being unfavorable for liposoluble constituent of alcoholic strength, thus selecting suitable alcoholic strength to extract will have a significant impact its curative effect.It is too high to there is alcoholic strength in some health preserving wine on the market, and long-term drink can cause damage to organs such as livers, and consumer also easily occurs drunk, unfavorable to the health of masses.Therefore, the present invention controls described alcoholic strength vinous is 7 ° ~ 18 °.
As preferably, the preparation method of the Fructus Vitis viniferae of described fragmentation is: after getting Fructus Vitis viniferae cleaning, fragmentation, with sulfurous acid aqueous solution, then mix with sucrose.
Preferred, the mass percentage of sulfurous acid aqueous solution sulfite is 0.066% ~ 0.117%, makes the mass percentage in the Fructus Vitis viniferae slurry of sulfur dioxide after fragmentation be 0.004% ~ 0.006%.
The process of wine brew is exactly the process of fermentation in fact, and the materials such as the glucose in Fructus Vitis viniferae, fructose are converted into ethanol under the effect of saccharomyces cerevisiae.Usually when brew wine because the pol of Fructus Vitis viniferae own needs not to add sucrose, sucrose decomposition is be converted into ethanol through everfermentation after glucose and fructose.In order to control alcoholic strength vinous, need to add sucrose.General 17g/L sucrose can be converted into the ethanol of 1%.Control at 7 ° ~ 18 ° to make the alcoholic strength after fermentation.Preferably, the addition of sucrose be after fragmentation Fructus Vitis viniferae slurry in mass percentage be 11.9% ~ 23.4%.
After being mixed with integration of edible and medicinal herbs Chinese medicine composition by said mixture, adjustment sugar content is 18% ~ 25%, and acid content is 0.6% ~ 0.8%, and the wine yeast of inoculation 0.3% ~ 0.5% ferments.
As preferably, the temperature of fermentation is 20 ~ 30 DEG C, stirs 2 ~ 4 every day, and the medicated powder of floating and skin slag are immersed in Sucus Vitis viniferae.
In some embodiments of the invention, the step of fermentation post processing is also comprised.Fermentation post processing is specially: when fermentation liquid residual sugar is down to 0.01% ~ 0.06%, broth temperature controls at 20 ~ 30 DEG C, filters wine liquid separation skin slag and obtains original wine; The sulfur dioxide adding 0.3%-0.5% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 20 ~ 30 days; Wine liquid is crossed 0.45 μm of filter membrane and carry out fine straining, pass into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
As preferably, the wine provided by the invention amount of drinking for each person every day is 50 ~ 100mL.
The invention provides a kind of integration of edible and medicinal herbs Chinese medicine composition, comprise Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.The present invention with " integration of edible and medicinal herbs " Chinese medicine for raw material, the kidney invigorating prescription through comprehensive traditional Chinese medical science ancient prescription, proved recipe and various modern traditional Chinese patent medicine for many years screens, carry out a large amount of comparative experimental research, finally successful integration of edible and medicinal herbs Chinese medicine composition is researched and developed, there is the effect such as replenishing vital essence and blood, resisting fatigue, liver and kidney tonifying, bone and muscle strengthening, vessel softening, looks improving and the skin nourishing, enhancing immunity, slow down aging, be suitable for that body is tired, soreness of waist and knee joint, fear of cold are afraid of cold, the crowd that suffers from a deficiency of the kidney of sexual impotence erectile problem, insomnia and dreamful sleep, its temperature and not dry can long-term taking.
Present invention also offers a kind of health preserving formula vinous and preparation method thereof.The present invention optimizes unicity vinous, selected multiple integration of edible and medicinal herbs Chinese herbal medicine and fresh grape make tonifying kidney and preserving health wine, reach equilibrium between yin and yang with the object of mending, can gentle the kidney invigorating, replenishing vital essence and blood, resisting fatigue, liver and kidney tonifying, bone and muscle strengthening, vessel softening, looks improving and the skin nourishing, strengthen immunity, effect of slow down aging, not only its mouthfeel has unique Chinese medicine fragrance, the strong sweet-smelling that wine is original is not lost yet, both the function of drinking wine itself had been met, there is again the relevant health maintenance effect of Chinese medicine, the wine containing integration of edible and medicinal herbs Chinese medicine composition of current preparation is produced as a trial, after all kinds of crowd is on probation, effect is better, it is suitable popular wine.
Detailed description of the invention
The invention discloses a kind of integration of edible and medicinal herbs Chinese medicine composition and uses thereof, wine and uses thereof, and preparation of wine, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
Integration of edible and medicinal herbs Chinese medicine composition provided by the invention and uses thereof, wine and uses thereof, and in preparation of wine, raw materials used medicine and food materials, preparation all can be buied by market.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 integration of edible and medicinal herbs Chinese medicine composition
Get crude drug Fructus Lycii 50g, Poria 200g, Flos Chrysanthemi 100g, Rhizoma Polygonati 80g, Cortex Cinnamomi 140g, Fructus Alpiniae Oxyphyllae 180g, mix homogeneously, add the ethanol of 4 times amount 50%, heating and refluxing extraction 2 times, each 30min.Merge extractive liquid, filters, to obtain final product.
The preparation of embodiment 2 integration of edible and medicinal herbs Chinese medicine composition
Get crude drug Fructus Lycii 200g, Poria 100g, Flos Chrysanthemi 50g, Rhizoma Polygonati 50g, Cortex Cinnamomi 200g, Fructus Alpiniae Oxyphyllae 50g, mix homogeneously, add the ethanol of 4 times amount 50%, heating and refluxing extraction 2 times, each 30min.Merge extractive liquid, filters, to obtain final product.
The preparation of embodiment 3 integration of edible and medicinal herbs Chinese medicine composition
Get crude drug Fructus Lycii 140g, Poria 50g, Flos Chrysanthemi 200g, Rhizoma Polygonati 140g, Cortex Cinnamomi 50g, Fructus Alpiniae Oxyphyllae 200g, mix homogeneously, add the ethanol of 4 times amount 50%, heating and refluxing extraction 2 times, each 30min.Merge extractive liquid, filters, to obtain final product.
The preparation of embodiment 4 integration of edible and medicinal herbs Chinese medicine composition
Get crude drug Fructus Lycii 80g, Poria 140g, Flos Chrysanthemi 150g, Rhizoma Polygonati 200g, Cortex Cinnamomi 180g, Fructus Alpiniae Oxyphyllae 140g, mix homogeneously, add the ethanol of 4 times amount 50%, heating and refluxing extraction 2 times, each 30min.Merge extractive liquid, filters, to obtain final product.
The preparation of embodiment 5 integration of edible and medicinal herbs Chinese medicine composition
Get crude drug Fructus Lycii 50g, Poria 50g, Flos Chrysanthemi 50g, Rhizoma Polygonati 50g, Cortex Cinnamomi 50g, Fructus Alpiniae Oxyphyllae 50g, mix homogeneously, add the ethanol of 4 times amount 50%, heating and refluxing extraction 2 times, each 30min.Merge extractive liquid, filters, to obtain final product.
Embodiment 6 preparation vinous
According to the preparation of embodiment 5 integration of edible and medicinal herbs Chinese medicine composition, take Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi, each 50 grams of Fructus Alpiniae Oxyphyllae Chinese crude drug respectively, pulverized 14 object sieves, load in fermentation tank, get 20Kg fresh grape in addition, first clean with light water, use washed with de-ionized water again three times, grape harvest by hand or destemming disintegrating machine remove carpopodium, fruit grain fragmentation is obtained Fructus Vitis viniferae slurry, add in fermentation tank; In the Fructus Vitis viniferae slurry of fragmentation, add sulfurous acid 0.066%, make sulfur dioxide concentration reach 0.004%, add 3.6kg sucrose, stir.Adjustment Sucus Vitis viniferae sugar content is 18%, and acid content is 0.6%, and the wine yeast of inoculation 0.3% ferments, and control fermentation temperature between yeast phase at 20 DEG C ~ 30 DEG C, every day stirs 2-4 time, makes the medicated powder of floating and skin slag be pressed in Sucus Vitis viniferae; The 9 angel's fermentation liquid residual sugars that ferment are down to 0.01% ~ 0.06%, and broth temperature controls at 20 DEG C ~ 30 DEG C, filter wine liquid separation skin slag and obtain original wine; The sulfur dioxide adding 0.3% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 28 days; Wine liquid is crossed 0.45 μm of filter membrane and carry out fine straining, pass into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
Embodiment 7 preparation vinous
Take 100g Fructus Lycii, 100g Poria, 100g Flos Chrysanthemi, 50g Rhizoma Polygonati, 25g Cortex Cinnamomi, 50g Fructus Alpiniae Oxyphyllae respectively, pulverized 14 object sieves, load in fermentation tank, get 34Kg fresh grape in addition, first with light water cleaning, then use washed with de-ionized water three times, grape harvest by hand or destemming disintegrating machine remove carpopodium, fruit grain fragmentation is obtained Fructus Vitis viniferae slurry, add in fermentation tank; In the Fructus Vitis viniferae slurry of fragmentation, add sulfurous acid 0.117%, make sulfur dioxide concentration reach 0.007%, add 8.5kg sucrose, stir.Adjustment Sucus Vitis viniferae sugar content is 25%, and acid content is 0.6%, and the wine yeast of inoculation 0.3% ferments, and control fermentation temperature between yeast phase at 20 DEG C ~ 30 DEG C, every day stirs 2-4 time, makes the medicated powder of floating and skin slag be pressed in Sucus Vitis viniferae; The 8 days after fermentation liquid residual sugars that ferment are down to 0.01% ~ 0.06%, and broth temperature controls at 20 DEG C ~ 30 DEG C, filter wine liquid separation skin slag and obtain original wine; The sulfur dioxide adding 0.3% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 28 days; Wine liquid is crossed 0.45 μm of filter membrane and carry out fine straining, pass into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
Embodiment 8 preparation vinous
Take 60g Fructus Lycii, 40g Poria, 80g Flos Chrysanthemi, 50g Rhizoma Polygonati, 25g Cortex Cinnamomi, 45g Fructus Alpiniae Oxyphyllae respectively, pulverized 14 object sieves, load in fermentation tank, get 20Kg fresh grape in addition, first with light water cleaning, then use washed with de-ionized water three times, grape harvest by hand or destemming disintegrating machine remove carpopodium, fruit grain fragmentation is obtained Fructus Vitis viniferae slurry, add in fermentation tank; In the Fructus Vitis viniferae slurry of fragmentation, add sulfurous acid 0.066%, make sulfur dioxide concentration reach 0.004%, add 4kg sucrose, stir.Adjustment Sucus Vitis viniferae sugar content is 20%, and acid content is 0.6%, and the wine yeast of inoculation 0.3% ferments, and control fermentation temperature between yeast phase at 20 DEG C ~ 30 DEG C, every day stirs 2-4 time, makes the medicated powder of floating and skin slag be pressed in Sucus Vitis viniferae; The 9 angel's fermentation liquid residual sugars that ferment are down to 0.01% ~ 0.06%, and broth temperature controls at 20 DEG C ~ 30 DEG C, filter wine liquid separation skin slag and obtain original wine; The sulfur dioxide adding 0.3% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 28 days; Wine liquid is crossed 0.45 μm of filter membrane and carry out fine straining, pass into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
Embodiment 9 preparation vinous
Take 100g Fructus Lycii, 75g Poria, 80g Flos Chrysanthemi, 70g Rhizoma Polygonati, 35g Cortex Cinnamomi, 60g Fructus Alpiniae Oxyphyllae respectively, pulverized 14 object sieves, load in fermentation tank, get 24Kg fresh grape in addition, first with light water cleaning, then use washed with de-ionized water three times, grape harvest by hand or destemming disintegrating machine remove carpopodium, fruit grain fragmentation is obtained Fructus Vitis viniferae slurry, add in fermentation tank; In the Fructus Vitis viniferae slurry of fragmentation, add sulfurous acid 0.1%, make sulfur dioxide concentration reach 0.006%, add 5.2kg sucrose, stir.Adjustment Sucus Vitis viniferae sugar content is 22%, and acid content is 0.6%, and the wine yeast of inoculation 0.3% ferments, and control fermentation temperature between yeast phase at 20 DEG C ~ 30 DEG C, every day stirs 2-4 time, makes the medicated powder of floating and skin slag be pressed in Sucus Vitis viniferae; The 9 days fermentation liquid residual sugars that ferment are down to 0.01% ~ 0.06%, and broth temperature controls at 20 DEG C ~ 30 DEG C, filter wine liquid separation skin slag and obtain original wine; The sulfur dioxide adding 0.3% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 28 days; Wine liquid is crossed 0.45 μm of filter membrane and carry out fine straining, pass into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
Embodiment 10 preparation vinous
Take 160g Fructus Lycii, 110g Poria, 130g Flos Chrysanthemi, 120g Rhizoma Polygonati, 60g Cortex Cinnamomi, 120g Fructus Alpiniae Oxyphyllae respectively, pulverized 14 object sieves, load in fermentation tank, get 56Kg fresh grape in addition, first with light water cleaning, then use washed with de-ionized water three times, grape harvest by hand or destemming disintegrating machine remove carpopodium, fruit grain fragmentation is obtained Fructus Vitis viniferae slurry, add in fermentation tank; In the Fructus Vitis viniferae slurry of fragmentation, add sulfurous acid 0.066%, make sulfur dioxide concentration reach 0.004%, add 10.08kg sucrose, stir.Adjustment Sucus Vitis viniferae sugar content is 18%, and acid content is 0.6%, and the wine yeast of inoculation 0.3% ferments, and control fermentation temperature between yeast phase at 20 DEG C ~ 30 DEG C, every day stirs 2-4 time, makes the medicated powder of floating and skin slag be pressed in Sucus Vitis viniferae; The 9 days after fermentation liquid residual sugars that ferment are down to 0.01% ~ 0.06%, and broth temperature controls at 20 DEG C ~ 30 DEG C, filter wine liquid separation skin slag and obtain original wine; The sulfur dioxide adding 0.3% in original wine carries out after fermentation, and wine is filled liquor storage vessel sealing and preserved, and temperature controls at 18-25 DEG C, and period carries out malic-lactic acid fermentation as required; Then control temperature carries out aging at 10-15 DEG C, relative humidity 85%-90%, and carries out down bucket, bucketful and clarifying treatment; Measure pol, wine degree, the acidity of original wine, adjust to setting respectively according to the physical and chemical index of finished product and carry out blending process, store 28 days; Wine liquid is carried out fine straining, passes into sterilizer 90 DEG C/min quick sterilization, bottling sealing, sterilize 20min in the water of 70 ~ 72 DEG C, is up to the standards and gets final product code, vanning, warehouse-in.
Embodiment 11 safety evaluatio is tested
Get integration of edible and medicinal herbs Chinese medicine composition 1000ml prepared by the embodiment of the present invention 1 to embodiment 5, be evaporated to 50ml as experimental group one; Example 6 to embodiment 10 prepare each 1000ml of wine, be evaporated to 50ml, as the wine test liquid of experimental group two.
Separately get cleaning grade Kunming mouse 60, body weight 20 ± 2 grams, male and female half and half, every day early, evening respectively gives an experimental group one and experimental group two, at every turn for 0.2ml/10g Mus is heavy, successive administration 7 days, observe mice outward appearance, behavior, appetite, all there is not abnormal phenomena in body weight and defecation two clock test liquid, 60 none death of mice, therefore cannot ask and calculate its median lethal dose(LD 50) (LD50), only roughly can calculate that the maximum tolerance of its oral administration is the concentration >40ml/kg body weight of 1:20, it is quantity more than 1000 times, illustrate that this health preserving wine edible safety is without side effect effect.
Embodiment 12 mouse sperm impact test
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method:
Get cleaning grade male mice in kunming 70, body weight 20 ± 2 grams, is divided into 7 groups at random, give above-mentioned matched group, blank group and experimental group respectively, the heavy gavage of 0.1ml/10g Mus, once a day, continuous 7 days, animal was taken off cervical vertebra in the 8th day and put to death, win rapidly epididymis tissue, after scales/electronic balance weighing, be placed in mortar and grind, dilute 15 times with ringer solution, count sperm quantity under the microscope, and observe its activity situation, survival rate, sperm count conversion is ten thousand/10mg epididymis tissue, the results are shown in Table 1.
Table 1 sperm affect result of the test (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
The most directly reacting for male's insufficiency of kidney-YANG is exactly the decline of sexuality, and sperm quantity and survival rate are the important indicators of sexuality, and the raising of these indexs is exactly the lifting of sexuality, are exactly the improvement to insufficiency of kidney-YANG.As shown in Table 1, sperm quantity, the survival rate of experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine group are all higher, and obviously (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can improve sexuality, have significant curative effect to insufficiency of kidney-YANG symptom.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can improve sexuality, have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptom.
Embodiment 13 mice gonad impact test
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method: get cleaning grade male mice in kunming 70, body weight 20 ± 2 grams, is divided into 7 groups at random, give above-mentioned 4 groups of medicated wine and normal saline respectively, the heavy gavage of 0.1m1/10g Mus, once a day, continuous 7 days, animal was taken off cervical vertebra in 8th day to put to death, get each mouse preputial gland, prostate seminal vesicle, the fat that carefully removing tissue is accompanying, liquid on surface is sucked with filter paper, ten thousand/ balance on weigh, and conversion is on average every mouse testis and epididymis tissue wet, the results are shown in Table 2.
Table 2 gonad affect result of the test (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
Impel the growth of sexual organ to be means of enhancing ability, it is exactly the reaction improving male's insufficiency of kidney-YANG that sexuality improves.As shown in Table 2, experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine group can increase testis and epididymis tissue wet, and result remarkable (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine have androgen-like action, the growth of sexual organ can be impelled, have significant curative effect to insufficiency of kidney-YANG symptom.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.There is androgen-like action, the growth of sexual organ can be impelled, have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptom.
Embodiment 14 is on the impact of mice with kidney-yang deficiency body weight, plasma cortisol, adrenal gland's seminal vesicle weights
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method: cleaning grade male mice in kunming 140, body weight about 20 grams, subcutaneous injection 0.5% hydrocortisone 0.2m1//day, continuous 7 days.Visual animal body weight obviously alleviates around here, average out to about 21 grams, have an appointment 30% animal dead, all visible hair of surviving animals loosens, fear of cold, and limbs are sent out cool, inappetence, dispiritedly waits insufficiency of kidney-YANG symptom.Test the 8th day, animal is divided into 7 groups by body weight Stochastic Equilibrium, give the reagent of above-mentioned matched group, blank group and experimental group respectively, the heavy gavage of 0.1ml/10g Mus, once a day, continuous 12 days, duration of test, every 4 days record body weight once.Test the 21st day, extract eyeball of mouse, get blood by orbital vein, anticoagulant heparin, after centrifugal, quantitatively draw blood plasma, by northern immunoreagent institute method, utilize EJ-2008r immunity enumerator, carry out plasma cortisol mensuration.Group difference is compared by the T method of inspection.Get blood to weigh simultaneously, and win bilateral adrenal glands seminal vesicle, put in Bownis liquid and fix 24 hours, then surface liquid is sucked with filter paper, carefully go out its hetero-organizations such as degrease, ten thousand/balance weighs weight in wet base, and conversion is average every mouse adrenal gland milligram weight in wet base, carry out statistical disposition by the method for inspection, the results are shown in Table 3.
Table 3 testing result
* represent that experimental group has significant difference P < 0.05 compared with matched group
As shown in Table 3, experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can have obviously (P < 0.05) curative effect to mice with kidney-yang deficiency, improve the situation of the body weight because subcutaneous injection hydrocortisone occurs, plasma cortisol, the reduction of adrenal gland's weight, and result remarkable (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine not only have and can correct " yang deficiency " Mouse Weight and the low effect of adrenal gland's endocrine function, and also have the effect promoting the weightening finish of " yang deficiency " animal adrenal gland.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine not only have can correct " yang deficiency " Mouse Weight and the low effect of adrenal gland's endocrine function, and also has the effect promoting the weightening finish of " yang deficiency " animal adrenal gland.
Embodiment 15 mice mating contrast test
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method: get healthy male mice in kunming 70 (body weight 20 ± 2 grams) and mate its acquired experience of 2 angels with female elementization of the same race (only mating front 48h lumbar injection estradiol benzoate 20 μ g/) female mice (body weight 20 ± 2 grams).Take out female Mus, male Mus is had three days off.Male Mus is divided into 7 groups, each group of reagent giving above-mentioned blank group, matched group and experimental group respectively, the heavy gavage of 0.1ml/10g Mus, every day 1 time, continuous 7 days, the 8th day male mice and female Mus mated by 1:5 quantity.Record its mating incubation period (to the time of mice the 1st mating from mating) and 1 hour mating number of times, the results are shown in Table 4.
Table 4 mice mating result of the test (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
The raising of sexual potency improves the most directly embodying of male's insufficiency of kidney-YANG.As shown in Table 4, experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine group are compared with matched group with blank group, significantly (P < 0.05), significantly (P < 0.05) shortens mating incubation period, adds mating number of times.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can improve sexual potency, have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptom.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can improve sexual potency, have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptom.
Embodiment 16 mice anoxia enduring contrast test
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method: get healthy male mice in kunming (body weight 20 ± 2 grams) 70, be divided into 7 groups at random, often organize 10, the each group of reagent giving above-mentioned matched group, blank group and experimental group respectively, the heavy gavage of 0.1mL/10g Mus, every day 1 time, continuous 7 days, after 1 hour, each group of mice is put into respectively in the 8th day gavage the 250mL wide mouthed bottle (putting 1 mice for every bottle) filling 5g sodica calx.With the airtight bottleneck of vaseline, timing immediately, until respiratory arrest.For index, respectively organize hypoxia endurance time with mice time-to-live in airtight wide mouthed bottle, the results are shown in Table 5.
Table 5 mice hypoxia endurance test result (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
Insufficiency of kidney-YANG patient except sexuality goes down, main sign be exactly fatiguability, spirit not good, hypoxia-bearing capability difference causes fatiguability, the not good main cause of spirit, and thus raising mice hypoxia-bearing capability can improve fatiguability, spirit is not good, thus improves insufficiency of kidney-YANG disease.As shown in Table 5, experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine significantly (P < 0.05) increase mice hypoxia endurance time, and be better than matched group and blank group, show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptoms such as fatiguability, spirit are not good.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptoms such as fatiguability, spirit are not good.
Embodiment 17 mice swimming exercise contrast test
Test grouping:
Matched group: be divided into commercially available three animal penes wine group (batch number 20100725), commercially available deer antler wine group (batch number 20100618), commercial glucose wine (batch number 20100813), commercially available strength wine group (batch number 20100821);
Blank group: normal saline group.
Experimental group: the wine of the integration of edible and medicinal herbs Chinese medicine composition being divided into embodiment 1 group to prepare, embodiment 6 preparation;
Test method: get healthy male mice in kunming (body weight 20 ± 2 grams) 70, be divided into 7 groups at random, often organize 10, each group gives above-mentioned blank group, matched group and experimental group respectively, the heavy gavage of 0.1mL/10g Mus, every day 1 time, continuous 7 days, fasten 2 grammes per square metre little iron ring at each mouse tail line in the 8th day gavage after 1 hour, mice is put into the bucket of depth of water 20cm, timing immediately, sinks under water completely no longer till upstream until mice, the results are shown in Table 6.
Table 6 mice swimming exercise result (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
Sportive efforts endurance is the whether vigorous important indicator of reaction health energy, is also that the middle energy of insufficiency of kidney-YANG is not good, the direct performance of fatiguability, bradykinesia etc., and thus raising exercise tolerance and muscle power are also the improved direct embodiments of insufficiency of kidney-YANG.As shown in Table 6, experimental group---integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine group significantly (P < 0.05) increase mice swimming time, and be better than matched group and blank group, show that the insufficiency of kidney-YANG symptoms such as it is not good to energy, fatiguability, bradykinesia have significantly (P < 0.05) curative effect.
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Show that the insufficiency of kidney-YANG symptom such as integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine is not good to energy, fatiguability, bradykinesia has significantly (P < 0.05) curative effect.
CAMP, E2, T, Cu in embodiment 18 pairs of deficiency of the kidney yin mice plasma
++, Zn
++the impact of content
20100312), commercially available deer antler wine group (batch number: 20100619), wine group, commercially available strength wine group (batch number 20100821) test grouping: Normal group, Kidney-yin-vacuity matched group, positive controls: comprise commercially available three animal penes wine group (batch number:; Experimental group comprises embodiment 1 group, embodiment 6 groups.
Test method: Kunming mouse 630, male and female half and half, body weight (20 ± 2) g, purchased from Medical University Of Chongqing's Experimental Animal Center.Fasting 12h before experiment, freely drinks water.Laboratory temperature (24 ± 2) DEG C, humidity 60%.Model mice subcutaneous injection hydrocortisone 1mg/ only, the next day 1 time, totally 3 times, present deficiency of the kidney yin symptom.The capacity normal saline such as Normal group injection.2h after injection, by following grouping perfusion respectively.Normal group and Kidney-yin-vacuity matched group (normal saline 20ml/kg); Wine group (20ml/kg), embodiment 1 group (20ml/kg), embodiment 6 groups of (20ml/kg) strength wine group (20ml/kg), three animal penes wine group (20ml/kg), deer antler wine group (20ml/kg), each treated animal gastric infusion every day once, continuous 7 days.Broken end gets blood, separated plasma, with radioimmunology, measures CAMP, E2, T content, with aas determination C u
++, Z n
++content, the results are shown in Table 7.
Table 7 respectively organizes medication to CAMP, E2, T, Cu in mice plasma
++, Zn
++content impact (
n=10)
* represent that experimental group has significant difference P < 0.05 compared with matched group
Table 7 is known, experimental group---and integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can have obviously (P < 0.05) curative effect to kidney yin making a deficient case more deficient mice, take rear CAMP, E2, Cu
++, Z n
+ +content obviously (P < 0.05) reduction, T content obviously (P < 0.05) rising, significant difference is remarkable.
Wine prepared by prepare by embodiment 2 to embodiment 5 respectively and embodiment 7 to embodiment 10 carries out above-mentioned experiment, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank integration of edible and medicinal herbs Chinese medicine composition matched group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can improve sexuality, have significantly (P < 0.05) curative effect to insufficiency of kidney-YANG symptom.
Embodiment 19 engulfs the impact of phagocyte imdex, test for humoral immunity to deficiency of the kidney yin mice
Test grouping:
20100312), commercially available deer antler wine group (batch number: 20100619), wine group, commercially available strength wine group (batch number 20100821) test grouping: Normal group, Kidney-yin-vacuity matched group, positive controls: comprise commercially available three animal penes wine group (batch number:; Experimental group comprises embodiment 1 group, embodiment 6 groups.
Test method: by embodiment 18 method to deficiency of the kidney yin mouse model.
By following grouping perfusion respectively.Normal group and Kidney-yin-vacuity matched group (normal saline 20ml/kg); Wine group (20ml/kg); Embodiment 1 group (20ml/kg); Embodiment 6 groups of (20ml/kg) strength wine group (20ml/kg), three animal penes wine group (20ml/kg), deer antler wine group (20ml/kg), each treated animal gastric infusion every day once, continuous 7 days.
1, carbon granules test is engulfed: get male mice 80, be divided into 8 groups at random, often organize 10,2h after last administration, (stock solution is centrifugal with front 2000rmp for tail vein injection 50% india ink 0.1ml/10g, discard precipitate, dilute 2 times with 0.9%N.S) afterwards 2,10min, get blood 25ul from optical fundus respectively, be dissolved in 2ml distilled water, with normal mouse blood for blank, survey absorbance (OD) at 72 type spectrophotometer 600nm wavelength places.Index K is cleaned up in calculating, K=1/8 × lg (OD
2/ OD
10), OD
2, OD
10be respectively 2min and 10min OD value.
2, test for humoral immunity: get male mice 80, be divided into 8 groups at random, often organize 10, administration mouse peritoneal on the 1st is injected 5% sheep red blood cell (SRBC) (SRBC) 0.2ml and is carried out initial immunity, within the 5th day after immunity, extracts eyeball and gets blood, separation of serum.Get 1:5000 dilute serum 1ml, 5%SRBC 0.5ml, guinea pig serum 1ml, mixing, blank pipe replaces mice serum with NS, and other is the same.37 DEG C of water-bath 10min, after water-bath cessation reaction, the centrifugal 10min of 2000rmp, gets supernatant 1ml, adds Dou Shi reagent 3.25ml erythrocyte HD50 control tube, gets SRBC 0.25ml, add 4ml Dou Shi reagent, fully shake up.Place 10min, in 540nm place, measure each pipe absorbance respectively.Calculate half hemolysis value (HC50).
Half hemolysis value=sample light absorption value/SRBC HD50 light absorption value * extension rate
Statistical analysis adopts NDST, and measurement data t checks, and enumeration data X2 checks, and analyzes the significance between each group, and contrasts between two, and significance level is P=0.05.Result is as shown in table 8:
Table 8 is cleaned up exponential sum and is calculated HD50 Data-Statistics after respectively organizing medication
* represent that experimental group has significant difference P < 0.05 compared with matched group
Found that, deficiency of the kidney yin mice engulfs phagocyte imdex and HC50 obviously reduces, and integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine obviously can strengthen deficiency of the kidney yin mice phagocyte imdex and antibody-producing capacity, than commercially available health promoting wine and wine Be very effective (P < 0.05).
Above-mentioned experiment is carried out respectively with wine prepared by integration of edible and medicinal herbs Chinese medicine composition and embodiment 7 to the embodiment 10 of embodiment 2 to embodiment 5 preparation, experimental result is close with the experimental result of embodiment 1, embodiment 6 respectively, and all significantly (P < 0.05) is better than matched group and blank group.Show that integration of edible and medicinal herbs Chinese medicine composition provided by the invention and wine can obviously strengthen deficiency of the kidney yin mice phagocyte imdex and antibody-producing capacity, than commercially available health promoting wine and wine Be very effective (P < 0.05).
Embodiment 20 clinical trial
1, slowly certain, man, 40 years old, to be consciously at ordinary times short of physical strength, sexual impotence erectile problem, breathes hard, physical work lethargy.Through tcm diagnosis for for suffering from a deficiency of the kidney.The integration of edible and medicinal herbs Chinese medicine composition that drinking the embodiment of the present invention 2 provides carries out taking good care of and treating, and every day drinks 50 milliliters after supper, drinks 3 months continuously, and muscle power is restored, energetic, sexual impotence transference cure, supports and hard.Think after TCM pulse diagnosis, its renal function reaches the same with normal person.Confirm that its disease obtains medical treatment, muscle power and energy are restored.Prove that integration of edible and medicinal herbs Chinese medicine composition provided by the invention is to suffering from a deficiency of the kidney effectively.
2, Lee, man, 38 years old, conscious dampness of scrotum, the empty hyperhidrosis of body, erected ineffective.Think through tcm diagnosis, insufficiency of kidney-YANG.The wine that drinking the embodiment of the present invention 7 provides is nursed one's health, every day 1 time, each 80 milliliters, drinks after supper.Through drinking 45 days, treating shape and disappearing.Scrotum is no longer moist, erects rapidly with strong, consciously feels full of physical strength.Prove the effect that wine provided by the invention creates treatment and regulates.
3, Zhu, man, 47 years old, conscious weak all over, breathe hard, night sweat.Think through tcm diagnosis, caused by suffering from a deficiency of the kidney.The integration of edible and medicinal herbs Chinese medicine composition that the embodiment of the present invention 3 is drunk in suggestion to be provided is taken good care of.Drink 50 milliliters at every turn, respectively drink 1 time after every day supper and before sleep, drink every day with 100 milliliters.After drinking through 2 months, from head to foot effectively, phenomenon of breathing hard disappear, night sweat stop to.Prove, integration of edible and medicinal herbs Chinese medicine composition provided by the invention creates the effect of conditioning.
4, Lee, man, 52 years old, conscious gas lost, and head cloud, sexual impotence, can not having sexual intercourse thing.Think through tcm diagnosis, seriously suffer from a deficiency of the kidney and held back.The wine that drinking the embodiment of the present invention 8 provides carries out treating and nurses one's health.Drink 50 milliliters every day, drink after supper, after drinking 3 months, feel and no longer lose gas, vital capacity increases, and dizziness disappears, no longer sexual impotence, and during having sexual intercourse, positive tool is powerful and vigorous, proves that wine provided by the invention creates treatment and opsonic action.
5, money, man, 56 years old, having sexual intercourse difficulty, sexual impotence sometimes, sometimes premature ejaculation, perplexed its orthobiosis often.Think insufficiency of kidney-YANG through tcm diagnosis, sexual disorder, suggestion the kidney invigorating method is treated, integration of edible and medicinal herbs Chinese medicine composition every day of taking that the embodiment of the present invention 4 provides 60 milliliters, after drinking 2 months, shut out certain with a smile in whereabouts doctor explain the situation, say that having sexual intercourse is as adolescent, is in a cheerful frame of mind.Prove, integration of edible and medicinal herbs Chinese medicine composition provided by the invention weakens successful to treatment man sexual function.
6, Zhao, man, 63 years old, within 2006, suffer from sexual dysfunction, with suffering from a deficiency of the kidney, soreness of the waist and knees disease, through hospitalize poor effect, start to drink from October, 2008 wine that the embodiment of the present invention 10 provides, after half a year, the state of an illness takes a turn for the better gradually, after this adheres to every night drinking this wine 50 milliliters, so far more than 6 years, not only cure and suffered from a deficiency of the kidney and the disease such as sexual dysfunction, and agerasia, hale and hearty, look as 50 how old people.
7, Lee, man, 42 years old, suffers from night sweat, lumbago due to renal deficiency, the not normal disease of sexual function, and control little more for a long time, bad during fashion, the wine that taking the embodiment of the present invention 9 provides was clearly better after 3 months, returned to one's perfect health after half a year, and still adhering to taking at present, body constitution is become better and better.
8, river, man, 49 years old, suffer from deficiency of the liver and kindey, waist knee joint was weak, blockage of main and collateral channels disease.Physical weakness, lassitude, very micro-through in many ways curing curative effect.Start to take the integration of edible and medicinal herbs Chinese medicine composition that the embodiment of the present invention 5 provides in May, 2009, October, sb.'s illness took a favorable turn, and the first half of the year in 2010 is almost recovered, and clothes are to now, and health is good.
9, certain is shut out, man, 60 years old, after patient tumbles for 2008 by motorcycle, waist bar is sprained and is not fully recovered always, and often show lumbago, find that traumatic injury position goes out the obvious hyperosteogeny of item in November, 2010, its trick in winter is ice-cold, fear of cold is afraid of cold, the tired power of waist, insomnia and dreamful sleep, sexual impotence erectile problem.Work the wine starting to take embodiment 10 preparation on August 26th, 2011,70 milliliters are taken every night during supper, after serveing on 15 days, lumbago obviously alleviates, and took 45 days continuously afterwards, lumbago disappears completely, hyperosteogeny is obviously eliminated to go hospital's photo to find, sleep is good and dream is few, and trick is warmed up, and body is strengthened, energetic, positive tool is sturdy strong in 30 years old young man.
10, Zheng, female, 52 years old, suffers from rheumatism, rheumatoid, arthritis, whenever raining, all can knee pain when the change of weather, very micro-through in many ways curing curative effect.Start to take wine prepared by embodiment 6 in October, 2010, connect drink 15 days, painful area has and obviously alleviates, and drink 2 months continuously, during drinking, disease sites is without obvious pain.
11, Huang, female, 47 years old, suffer from frequent micturition, urgent micturition, the symptom such as frequently to get up in the night to urinate, take wine 7-15 days prepared by the embodiment of the present invention 6, frequency of getting up in the night to urinate obviously reduces, and urine urgency-frequency is also improved, and connects drink 1-2 month, without getting up in the night to urinate symptom, does not also rebound after stopping drinking.
12, wear certain, female, 36 years old, suffer from soreness of the waist and knees, two skelasthenia, vertigo and tinnitus, insomnia and dreamful sleep, originally thinking what oneself each side's pressure caused greatly, is deficiency of the kidney yin through tcm diagnosis.Take wine 15-25 days prepared by the embodiment of the present invention 8, body constitution is obviously improved, and sleep quality significantly improves, and connect drink more than 2 months, disease does not occur substantially, and the symptom that also do not rebound during stopping drink occurs.
13, for certain, female, 28 years old, suffers from infrequent menstruation, emaciated physique, hectic fever night sweat.Take the embodiment of the present invention 9 wine 2-3 month (stopping using during menstrual period), symptom has clear improvement, and connects drink 3 months, and occur without disease, body constitution is also significantly improved and improves.
The evaluation test of embodiment 21 mouthfeel
As everyone knows, the quality of wine quality, the main method by sense organ taste and physical and chemical index analysis is determined.Current China regulation, sense organ taste vinous is mainly judged from color and luster, fragrance, taste, style four aspects, and judge the impact of the factor such as hobby, custom, emotion, age, experience being often subject to commenting wine personnel, evaluate the subjectivity and uncertainty that often have to a certain degree, this makes the reliability of scoring be affected.So, how to process above-mentioned fuzzy factors, utilize the fuzzy comprehensive evoluation in fuzzy mathematics to be comparatively effective method.
The mathematical model that this experiment fuzzy comprehensive evoluation adopts: known facts collection: U={u
1, u
2u
n) (u
i: represent each influence factor), evaluate collection: V={V
1v
2... .v
n) (v
irepresent various possible general comment result) in wine organoleptic analysis, according to the regulation of Taste of Wine grade form, choose affect sense organ taste four factors as set of factors U, U={ outward appearance, fragrance, taste, style), evaluate and integrate excellent as V={, good, in, poor).Again according in grade form to the scoring ratio of outward appearance, fragrance, taste, style, i.e. outward appearance 20 points, fragrance 20 points, taste 40 points, style 10 points, weight selection collection is: R=(0.2,0.3,0.4,0.1) now the result of Taste of Wine of the present invention is added up as table 9.
Table 9 mouthfeel evaluation result
Note: above-mentioned statistics is the percentage calculation by the number of trial test, and No. 1 sample is that hundred profits give birth to and bring up raw wine, No. 2 samples are an abundant claret, and No. 3 samples are experimental group---wine prepared by embodiment 6 to embodiment 10.
The matrix that No. 1 sample is is:
The Comprehensive Evaluation that No. 1 sample is is:
From above result, in l sample, every maximum be 0.33, illustrates that Comprehensive Evaluation obtains during result is; Every that maximum is 0.4 in No. 2 samples, it is good for illustrating that Comprehensive Evaluation obtains result; Maximum every in No. 3 samples is 0.33, illustrates that the result of Comprehensive Evaluation is excellent, so the ranking of sample is: experimental group, and changyu wine group, hundred sharp raw wines.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (12)
1. an integration of edible and medicinal herbs Chinese medicine composition, is characterized in that, comprises integration of edible and medicinal herbs Chinese medicine composition Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.
2. integration of edible and medicinal herbs Chinese medicine composition according to claim 1, is characterized in that, is grouped into by the one-tenth of following weight portion:
3. integration of edible and medicinal herbs Chinese medicine composition according to claim 1 and 2 treats the application in medicine, food or the beverage of suffering from a deficiency of the kidney in preparation.
4. integration of edible and medicinal herbs Chinese medicine composition according to claim 1 and 2 is preparing the application in the medicine of resisting fatigue, food or beverage.
5. integration of edible and medicinal herbs Chinese medicine composition according to claim 1 and 2 is preparing the application in the medicine of enhancing immunity, food or beverage.
6. integration of edible and medicinal herbs Chinese medicine composition according to claim 1 and 2 is preparing the application in the medicine of slow down aging, food or beverage.
7. integration of edible and medicinal herbs Chinese medicine composition according to claim 1 and 2 is preparing the application in the medicine of vessel softening, food or beverage.
8. a wine, is characterized in that, it is obtained with integration of edible and medicinal herbs Chinese medicine composition mixing after fermentation by Fructus Vitis viniferae; Described integration of edible and medicinal herbs Chinese medicine composition is made up of Fructus Lycii, Poria, Flos Chrysanthemi, Rhizoma Polygonati, Cortex Cinnamomi and Fructus Alpiniae Oxyphyllae.
9. wine according to claim 8, is characterized in that, described integration of edible and medicinal herbs Chinese medicine composition is grouped into by the one-tenth of following weight portion:
10. wine according to claim 8, is characterized in that, the mass ratio of described Fructus Vitis viniferae and described middle integration of edible and medicinal herbs Chinese medicine composition is 2000:(14 ~ 30).
11. 1 kinds of preparation of wine as claimed in claim 8, is characterized in that, get described integration of edible and medicinal herbs Chinese medicine composition pulverize, sieve after mix with the Fructus Vitis viniferae after fragmentation, fermentation obtains.
12. preparation methoies according to claim 11, is characterized in that, described alcoholic strength vinous is 7 ° ~ 18 °.
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| CN106987488A (en) * | 2017-05-24 | 2017-07-28 | 湖北楚波生态农业科技发展有限公司 | A kind of sealwort red wine and preparation method thereof |
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| CN109528926A (en) * | 2018-11-29 | 2019-03-29 | 苏保洲 | A kind of Chinese medicine composition, grape wine and its preparation method and application |
| CN114032151A (en) * | 2021-12-23 | 2022-02-11 | 中国农业科学院郑州果树研究所 | Preparation method of cabernet sauvignon dry red wine |
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