CN106103425A - 用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂 - Google Patents

用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂 Download PDF

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Publication number
CN106103425A
CN106103425A CN201580014031.5A CN201580014031A CN106103425A CN 106103425 A CN106103425 A CN 106103425A CN 201580014031 A CN201580014031 A CN 201580014031A CN 106103425 A CN106103425 A CN 106103425A
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alkyl
inhibitor
piperidin
acid
methyl
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CN201580014031.5A
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Chinese (zh)
Inventor
S·卡布拉尔
二木建太郎
D·赫普沃斯
K·瓦尔
D·W-S·孔
S·T·M·奥尔
K·宋
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Pfizer Inc
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Pfizer Inc
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201580014031.5A 2014-03-17 2015-03-03 用于治疗代谢及相关病症的二酰甘油酰基转移酶2抑制剂 Pending CN106103425A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954351P 2014-03-17 2014-03-17
US61/954,351 2014-03-17
PCT/IB2015/051560 WO2015140658A1 (en) 2014-03-17 2015-03-03 Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders

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CN106103425A true CN106103425A (zh) 2016-11-09

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US (3) US9440949B2 (tr)
EP (1) EP3119757B1 (tr)
JP (1) JP6152229B2 (tr)
KR (1) KR101772836B1 (tr)
CN (1) CN106103425A (tr)
AP (1) AP2016009407A0 (tr)
AR (1) AR099768A1 (tr)
AU (1) AU2015233094B2 (tr)
CA (1) CA2942759C (tr)
CL (1) CL2016002169A1 (tr)
CR (1) CR20160405A (tr)
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DO (1) DOP2016000248A (tr)
EA (1) EA032356B1 (tr)
EC (1) ECSP16072034A (tr)
ES (1) ES2674240T3 (tr)
GE (1) GEP20186864B (tr)
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HU (1) HUE039446T2 (tr)
IL (1) IL247809A0 (tr)
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PH (1) PH12016501654A1 (tr)
PL (1) PL3119757T3 (tr)
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SI (1) SI3119757T1 (tr)
SV (1) SV2016005279A (tr)
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TW (1) TWI551596B (tr)
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WO (1) WO2015140658A1 (tr)

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CN110305966A (zh) * 2019-06-18 2019-10-08 广西壮族自治区水产科学研究院 一种罗非鱼肝脏dgat2基因表达的调控方法
CN114846013A (zh) * 2019-12-23 2022-08-02 株式会社Lg化学 可用作二酰基甘油酰基转移酶2抑制剂的新的氨基芳基衍生物及其用途
CN114901653A (zh) * 2019-12-23 2022-08-12 株式会社Lg化学 可用作二酰基甘油酰基转移酶2抑制剂的新的酰胺衍生物及其用途
CN116056706A (zh) * 2020-09-04 2023-05-02 株式会社Lg化学 可用作二酰基甘油酰基转移酶2抑制剂的新的联芳基衍生物及其用途
CN116139138A (zh) * 2016-11-11 2023-05-23 3-V生物科学股份有限公司 脂质合成的杂环调节剂

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ES2674240T3 (es) 2014-03-17 2018-06-28 Pfizer Inc. Inhibidores de diacilglicerol aciltransferasa 2 para su uso en el tratamiento de trastornos metabólicos y relacionados
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
JP6811489B2 (ja) * 2016-10-17 2021-01-13 学校法人慶應義塾 未分化幹細胞除去剤、及び未分化幹細胞除去方法
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
WO2021161222A1 (en) * 2020-02-11 2021-08-19 Inorbit Therapeutics Ab Compounds useful in inhibiting diacylglycerol o-acyltransferase and methods of making and using the same
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
WO2021236405A1 (en) 2020-05-18 2021-11-25 Merck Sharp & Dohme Corp. Novel diacylglyceride o-acyltransferase 2 inhibitors
CN116685577A (zh) 2020-10-08 2023-09-01 默沙东有限责任公司 作为新型二酰基甘油酯o-酰基转移酶2抑制剂的苯并咪唑酮衍生物的制备
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
WO2024118858A1 (en) 2022-12-02 2024-06-06 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors

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CN102203280A (zh) * 2008-10-30 2011-09-28 维尔制药公司 二酰甘油酰基转移酶抑制剂
WO2012024179A1 (en) * 2010-08-18 2012-02-23 Merck Sharp & Dohme Corp. Substituted amide derivatives as dgat-1 inhibitors
WO2012164071A1 (en) * 2011-06-02 2012-12-06 Intervet International B.V. Imidazole derivatives
WO2013068328A1 (en) * 2011-11-07 2013-05-16 Intervet International B.V. Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors
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