CN106074635A - Extract for improving skin condition, and its preparation method and application - Google Patents
Extract for improving skin condition, and its preparation method and application Download PDFInfo
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- CN106074635A CN106074635A CN201610517651.7A CN201610517651A CN106074635A CN 106074635 A CN106074635 A CN 106074635A CN 201610517651 A CN201610517651 A CN 201610517651A CN 106074635 A CN106074635 A CN 106074635A
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- extract
- skin condition
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- improving skin
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000011148 porous material Substances 0.000 claims abstract description 32
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 27
- 206010000496 acne Diseases 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 11
- 240000004957 Castanea mollissima Species 0.000 claims description 9
- 235000018244 Castanea mollissima Nutrition 0.000 claims description 9
- 235000006667 Aleurites moluccana Nutrition 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 241000186429 Propionibacterium Species 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 230000001603 reducing effect Effects 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 5
- 241001070941 Castanea Species 0.000 abstract description 4
- 210000003038 endothelium Anatomy 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 4
- 235000014036 Castanea Nutrition 0.000 abstract description 3
- 229930014626 natural product Natural products 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 206010033733 Papule Diseases 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 239000004342 Benzoyl peroxide Substances 0.000 description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000000589 cicatrix Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an extract for improving skin conditions and a preparation method and application thereof, belonging to the technical field of natural products. The extract is prepared by the following method: taking the chestnut endothelium and chestnut pulp as raw materials, adding water as solvent, heating and extracting at 60-100 deg.C, and filtering to obtain filtrate. The extract has effects of treating acne and reducing pores. Experiments prove that the Minimal Inhibitory Concentration (MIC) for inhibiting propionibacterium acnes is 50mg/ml, and the pore reducing effect is obvious.
Description
Technical field
The present invention relates to natural product technical field, particularly relate to a kind of extract for improving skin condition and
Preparation method and purposes.
Background technology
People are in the possible long acne of any age bracket, and acne affects attractive in appearance incessantly, and may leave ugly cicatrix.
The skin change that acne causes is likely to long-term existence after acne disappears, and is difficult to correct.In addition to child, crowd there are about 80%
～the people of 90% suffers from acne or once suffered from acne.
Clinically according to acne lesions character and the order of severity acne is divided into 3 degree, 4 grades: 1 grade (slightly): only have acne；
2 grades (moderate): outside gumming thorn, also have some inflamed papules；3 grades (moderate): outside gumming thorn, the most more inflamed papules or pus
Bleb；4 grades (severe): in addition to having acne, inflamed papules and pustule, goes back nodosity, cyst or cicatrix.
Acne is generally caused by parasteatosis, and the cause of disease is relevant with many factors, including hormone, clogging of pores, heredity
Factor and antibacterial infection etc..Wherein, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, and chemotactic is scorching simultaneously
Disease cell and medium, finally induce and increase the weight of inflammatory reaction.
Local application is the comparatively ideal approach for the treatment of acne.External benzoyl peroxide can effectively treat acne, its mesh
Mainly for removing propionibacterium acnes, be the main force in a lot of anti-acne therapeutic method.But the therapeutic effect of said method
Not ideal, as higher in the concentration required for external benzoyl peroxide, the peroxide of high concentration as used so over the course for the treatment of
Change benzoyl then to produce skin irritation and make skin become dry.Further, when skin becomes dry, people tend to use more moisturizing
Agent, so that clogging of pores, increases the weight of acne further.Therefore, it is extensive that the skin irritation that local topical is treated limits it
Use.It addition, the most often there is the Drug resistance of antibacterial during acne treatment, cause failing to respond to any medical treatment.
It addition, people also treat acne frequently with oral antibiotic.But life-time service antibiotic may cause yeast or
Fungal infection, and severe drug untoward reaction may be caused.It addition, antibiotic can improve people's sensitivity to sunlight, make people
Easily tanned severely.And it may happen that nephrotoxicity.
In addition, oral or topical Retinoids also can play the effect well treating acne, if topical Retinoids is by going
Cutin and dredging pore treat acne, but tretinoin has serious skin irritation, make the product can not life-time service.Oral
Tretinoin is likely to effectively control acne, but has teratogenecity, the most only just can use in the case of very serious.Therefore
Find a kind of effective and bland product, be the problem being eager in acne treatment to solve.
Summary of the invention
Based on this, it is necessary to for the problems referred to above, it is provided that a kind of extract for improving skin condition and preparation side thereof
Method and purposes, use this extract, it is possible to effectively treats acne and has the effect reducing pore.
The preparation method of a kind of extract improving skin condition, comprises the following steps:
Take inner skin of Chinese chestnut with Semen Castaneae sarcocarp as raw material, add water as solvent, heating extraction at 60 DEG C-100 DEG C, mistake
Filter to obtain filtrate, to obtain final product.
Semen Castaneae (Castanea mollissima Blume) belong to Fagaceae Fagaceae Castanea nuts plant, have another name called chestnut,
Semen Castaneae, great Li etc., main product in Guangdong, Guangxi, Yunnan, the ground such as Jiangxi, be the special product plant of China.The medicinal part of Semen Castaneae includes
Root, skin, leaf, flower, outer peel (epicarpium Castaneae), endocarp, involucre (Involucrum Castaneae or acorn-cup) and sarcocarp etc..
Said extracted thing, using the endothelium of Semen Castaneae and sarcocarp as raw material, using water as solvent extraction active component therein,
The extract obtained has treatment acne and has the effect reducing pore.
Wherein in an embodiment, in described raw material, the weight part ratio of inner skin of Chinese chestnut and Semen Castaneae sarcocarp is 0.5-1.5:
1.5-2.5, preferably 0.9-1.1:1.8-2.2.Endothelium and the sarcocarp of Semen Castaneae are coordinated with aforementioned proportion, there is preferable antibacterial effect
Really.
Wherein in an embodiment, described heating extraction is reflux, extract, 4hr-6hr.Extract in the above described manner, have
Preferably extraction efficiency.
Wherein in an embodiment, the addition of described solvent is 3-10 times of raw materials quality.
Wherein in an embodiment, described filtrate also through concentrating, is dried, obtains solids extraction thing.
The invention also discloses the extract that the preparation method of the above-mentioned extract improving skin condition prepares.
This extract obtains by extracting in inner skin of Chinese chestnut and Semen Castaneae sarcocarp, has treatment acne and has the work reducing pore
With.
The invention also discloses said extracted thing for preparing the application in propionibacterium inhibitor.
The invention also discloses said extracted thing and prepare the application in the skin care item improving skin condition.
Wherein in an embodiment, the described skin condition that improves for treatment acne and/or reduces pore.
The invention also discloses a kind of skin care item for improving skin condition, including the said extracted as active component
Acceptable adjuvant on thing, and Dermatology.
The upper acceptable adjuvant of conventional transdermal can be used, these skin care item are prepared as toner/smoothing toner, emulsion, nourishing cream and essence
Various types of skin care item such as Hua Su use.
Compared with prior art, the method have the advantages that
A kind of extract improving skin condition of the present invention, using the endothelium of Semen Castaneae and sarcocarp as raw material, using water as
Solvent extraction active component therein, the extract obtained has treatment acne and has the effect reducing pore.Through experiment card
Real, it is 50mg/ml to the minimal inhibitory concentration (MIC) that propionibacterium acnes is antibacterial, and has and can be reduced significantly pore
Effect.
Detailed description of the invention
For the ease of understanding the present invention, the present invention will be described more fully below.But, the present invention can be to be permitted
The most different forms realizes, however it is not limited to embodiment described herein.On the contrary, providing the purpose of these embodiments is to make
Understanding to the disclosure is more thorough comprehensively.
Unless otherwise defined, all of technology used herein and scientific terminology and the technical field belonging to the present invention
The implication that technical staff is generally understood that is identical.The term used the most in the description of the invention is intended merely to describe tool
The purpose of the embodiment of body, it is not intended that in limiting the present invention.Term as used herein "and/or" includes one or more phase
Arbitrary and all of combination of the Listed Items closed.
Embodiment 1
A kind of extract improving skin condition, is prepared by the following method and obtains:
Take the inner skin of Chinese chestnut that weight part ratio is 1:2 to make as raw material, the distilled water adding 5 times of quality of raw material with Semen Castaneae sarcocarp
For solvent, at 80 DEG C, heating and refluxing extraction 5 hours, filter to get filtrate, concentrating under reduced pressure, after removing solvent, obtain solids extraction
Thing A.
Embodiment 2
A kind of extract improving skin condition, is prepared by the following method and obtains:
Take the inner skin of Chinese chestnut that weight part ratio is 1:1 to make as raw material, the distilled water adding 3 times of quality of raw material with Semen Castaneae sarcocarp
For solvent, at 60 DEG C, heating and refluxing extraction 6 hours, filter to get filtrate, concentrating under reduced pressure, after removing solvent, obtain solids extraction
Thing B.
Embodiment 3
A kind of extract improving skin condition, is prepared by the following method and obtains:
Take inner skin of Chinese chestnut that weight part ratio is 2:1 with Semen Castaneae sarcocarp as raw material, add the distilled water of 10 times of quality of raw material
As solvent, at 100 DEG C, heating and refluxing extraction 4 hours, filter to get filtrate, concentrating under reduced pressure, after removing solvent, obtain solid-state and carry
Take thing C.
Experimental example 1
The extract prepared by above-described embodiment carries out the mensuration of propionibacterium acnes bacteriostasis rate.
One, experimental technique.
1, the preparation of culture medium.
Culture medium is prepared according to a conventional method, and adjusting pH value is 6～8.After cultivating based on good seal in conical flask, put into sterilizing
In Guo at 121 DEG C sterilizing 30min, after cooling, be placed in 4 DEG C of refrigerators and save backup.
2, the preparation of bacteria suspension.
By reference culture (source:11827TM) inoculated and cultured increasing bacterium, under anaerobic culture conditions, cultivate 48h,
Draw bacterium solution, be adjusted to 1 × 10 with culture medium dilution8CFU/mL, continues dilution by bacteria suspension culture medium, uses Maxwell turbidimetry
5 × 10 will be adjusted to5CFU/mL, standby.
3, minimal inhibitory concentration (MIC) measures.
Extract A, B, C are formulated as the extract solution of different gradient concentration, draw said extracted thing solution 1mL, to
Wherein adding 0.1mL concentration is 5 × 105The bacteria suspension of CFU/mL.And set without medicine bacterium solution control tube.After 37 DEG C of Anaerobic culturel 48h
Observed result.
Two, experimental result.
Table 1. minimal inhibitory concentration measurement result
| Liquor strength mg/mL | 3.125 | 6.25 | 12.5 | 25 | 50 | 100 | 200 |
| Extract A | + | + | + | + | - | - | - |
| Extract B | + | + | + | + | + | - | - |
| Extract C | + | + | + | + | + | + | - |
Note: "+" representing long bacterium, "-" represents the longest bacterium.
It can be seen that extract A-C all has preferable Mlc in from the above, and extract A has optimal
Fungistatic effect.
Experimental example 2
The extract prepared by above-described embodiment is tested, and investigates its effect to pore.
One, experimental technique.
The Robo skin analyzer CS50 (Tokyo Inforward company limited) that application Japan produces measures 20 for examination
Number of pores seen from the skin of person (in terms of pore magnitude range 0.1 0.6mm), number of pores (the pore magnitude range increased
0.3 0.6mm meter).
For examination person using extract A as reagent, after morning and evening every day clean skin, smear with the extract solution of concentration 50mg/mL
Skin of face, after observing medication 30 days, the number of pores of increase accounts for the ratio change of all visible number of pores, to investigate Semen Castaneae
Extracting solution reduce pore effect.
And calculated by below equation and to reduce pore ratio:
Pore is increased before reducing pore ratio=(increasing number of pores after increasing number of pores-medication before medication)/medication
Quantity × 100%
Two, experimental result.
Table 2. extract exercising result to pore
It can be seen that male's average pore number is 2199 ± 804 in from the above, the pore of increase is 181 ± 90；Female
The average pore number of property is 1773 ± 746, and the pore of increase is 119 ± 63；Grand mean is 1965 ± 782, increase pore be 147 ±
80.After medication one month, the increase pore number of male and female all substantially reduces (p < 0.05), and male becomes 105 ± 44, women
Becoming 86 ± 31, total becomes 95 ± 37.Illustrate that the extract of the present invention has the effect reducing pore.
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, not to above-mentioned reality
The all possible combination of each technical characteristic executed in example is all described, but, as long as the combination of these technical characteristics is not deposited
In contradiction, all it is considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that, come for those of ordinary skill in the art
Saying, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. the preparation method of the extract improving skin condition, it is characterised in that comprise the following steps:
Take inner skin of Chinese chestnut as solvent, heating extraction at 60 DEG C-100 DEG C, to filter as raw material, addition water with Semen Castaneae sarcocarp
Filtrate, to obtain final product.
The preparation method of the extract improving skin condition the most according to claim 1, it is characterised in that in described raw material
The weight part ratio of inner skin of Chinese chestnut and Semen Castaneae sarcocarp is 0.5-1.5:1.5-2.5.
The preparation method of the extract improving skin condition the most according to claim 1, it is characterised in that described heating carries
It is taken as reflux, extract, 4hr-6hr.
The preparation method of the extract improving skin condition the most according to claim 1, it is characterised in that described solvent
Addition is 3-10 times of raw materials quality.
The preparation method of the extract improving skin condition the most according to claim 1, it is characterised in that described filtrate is also
Through concentrating, it is dried, obtains solids extraction thing.
6. the extract that the preparation method of the extract improving skin condition described in any one of claim 1-5 prepares.
7. the extract described in claim 6 is for preparing the application in propionibacterium inhibitor.
8. the extract described in claim 6 is used for the application improving in the skin care item of skin condition in preparation.
Application the most according to claim 7, it is characterised in that the described skin condition that improves for treatment acne and/or reduces
Pore.
10. the skin care item being used for improving skin condition, it is characterised in that include claim 6 institute as active component
The extract stated, and acceptable adjuvant on Dermatology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610517651.7A CN106074635B (en) | 2016-07-04 | 2016-07-04 | Extract for improving skin condition, and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610517651.7A CN106074635B (en) | 2016-07-04 | 2016-07-04 | Extract for improving skin condition, and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106074635A true CN106074635A (en) | 2016-11-09 |
| CN106074635B CN106074635B (en) | 2020-04-07 |
Family
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150049082A (en) * | 2013-10-29 | 2015-05-08 | 더마텍코리아(주) | Skin composition comprising the extract of fermented chestnut bur for anti-wrinkle or anti-bacterial activity |
| CN105168089A (en) * | 2015-09-11 | 2015-12-23 | 何红梅 | Whitening mask with five cereals and preparation method thereof |
-
2016
- 2016-07-04 CN CN201610517651.7A patent/CN106074635B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150049082A (en) * | 2013-10-29 | 2015-05-08 | 더마텍코리아(주) | Skin composition comprising the extract of fermented chestnut bur for anti-wrinkle or anti-bacterial activity |
| CN105168089A (en) * | 2015-09-11 | 2015-12-23 | 何红梅 | Whitening mask with five cereals and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 曾超珍等: "板栗壳抑菌物质提取工艺的优化", 《广东农业科学》 * |
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