CN105999426A - Hyaluronan water-soluble human body lubricating liquid - Google Patents

Abstract

The invention discloses hyaluronan water-soluble human body lubricating liquid, and belongs to the technical field of materials for medical science or hygiene. The hyaluronan water-soluble human body lubricating liquid is prepared from the following components in percentage by mass: 0.3 to 0.9 percent of hydroxyethyl cellulose, 0.10 to 0.3 percent of sodium hyaluronate, 0.05 to 0.2 percent of rose extract, 0.01 to 0.1 percent of polylysine, 13 to 18 percent of glycerin and the balance of purified water. According to the hyaluronan water-solubility human body lubricating liquid disclosed by the invention, the rose extract added in a formula of the hyaluronan water-solubility human body lubricating liquid is more environmentally-friendly and has higher safety, the retention rate of effective components is high, the fragrance of rose is lasting, the using effect is better, more water and moisture can be given to skin, and lasting lubrication is realized; meanwhile, the hyaluronan water-soluble human body lubricating liquid has a perfect maintaining function on the skin of the pudenda, a tender, compact, elastic and young state of the skin can be recovered, and dryness and tightness can be prevented; the pH (Potential of Hydrogen) value of the hyaluronan water-solubility human body lubricating liquid is approximate to the pH degree of secretion of a female, and the hyaluronan water-solubility human body lubricating liquid is gentle in nature, has no addition of other chemical components, is safe and non-irritant, and is suitable for sensitive skin.

Description

A kind of hyaluronic acid water-soluble human body lubricating fluid

Technical field

The present invention relates to a kind of body lotion, specifically a kind of hyaluronic acid water-soluble human body lubricating fluid, belong to medical science or hygiology field of material technology.

Background technology

Lubricating fluid (oily) is applied the earliest in the clinical medicine inspection to human body: a lot of medical apparatus and instruments all can when going deep in human body in various degree cause mechanical injuries, lubricating fluid can at utmost reduce bodily tissue, the infringement of mucosa.Except Ying Yu is in medical treatment, also has and be mainly used in complementary life specially, play the body lotion of lubrication.

The Vegetable oil lipoprotein such as olive oil of people's many employings in early days etc. are as the lubrication of complementary life, but owing to the limited effect of composition is unsatisfactory, easily pollute clothes, are also not easy to be absorbed by the body；People also attempted using the petroleum-based mineral oily matters such as vaseline, baby oil, body lotion, massage oil as lubrication later；These materials often viscosity is excessive, not easy cleaning, easily causes residual after using, it is likely to block the urethral orifice of men and women after even with, produces dysuric pain, and it can destroy the stable type of condom, causing unplanned pregnancy, human body all can be caused damage by these.Body lotion product is main composition from raw material with glycerol and hydrophilic substance, improved by compositions such as addition hyaluronic acid sodium, ethyl cellulose, carbomers afterwards, reduce sliminess after improvement, Balancing degree, make it try one's best similar to human body fluid, decrease the Probability of allergic symptom.

The most common body lotion mainly has silicone lubricating oil, petroleum oil, soluble oil etc..Silicone lubricating oil be mainly composed of silicones, its water resistance is good, and action time is than water-soluble lubricating degree of oil modification, but this class lubricating oil can damage the goods of material of the same race, therefore can not be used in conjunction with the temperament and interest toy of silicones；Petroleum oil is mainly made up of mineral oil or oil, owing to it can dissolve latex, so definitely can not be used together with latex prophylactic etc.；The lubricating oil of oiliness also can dissolve latex prophylactic, and is not easily decomposed in intravaginal, may induce women vaginitis.Soluble oil main component is by pure water and fiber, and glycerol, propyleneglycoles, spice, sucralose etc.；Owing to main component is water, therefore it is felt the most natural, uses most convenient, and it can be used together with latex prophylactic etc., is difficult to cause allergy.But due to water soluble ingredient easily by air evaporation and being absorbed by the skin, therefore action time is shorter.

Along with the change of people's attitude towards sex, the various impromptu style of sexual life kind increases in addition, and body lotion, in constantly development, market is developed the lubricant product being applied under different scene.Due to special use environment, if the special construction of oral cavity, rectal tract etc. and mucosal epithelial cells are more susceptible to damage, therefore, it is also required to the lubricant agent special developed exclusively for this, as increased the properties such as sterilizing, bacteriostasis antibiosis, increase lubricity, with the infection avoided damage to or thus cause；Simultaneously personalized in order to meet people demand, lubricating fluid product too increases different taste (odor type), color and luster or addition of spermicidal, helps vigorous time delay, moistens specific functions such as repairing, edible.

The lubricant of the plants essential oil classes such as existing interpolation Flos Rosae Rugosae quintessence oil, the solvent that the extraction of its quintessence oil constituents is used mostly is the chemical compositions such as petroleum ether, the extract obtained cannot be removed completely, therefore, for the crowd of some sensitivity skin, the product being added with this type of quintessence oil can cause allergic phenomena after directly contact skin on the contrary.Use carbon dioxide supercritical fluid extraction, the most of component in raw material all can be extracted, but the most unnecessary composition can be separated out the most in the lump while extracting, such as chemical fertilizer or the farm chemical ingredients of residual.Simultaneously, in preparing this type of product adding plant extract component, in the preparation extract is directly added and mix with other components, cause during transport, storing, the partial loss of effective ingredient in extract, do not reach the expection using effect of product, such as fragrance not persistently, moistness poor etc..

Summary of the invention

It is an object of the invention to provide a kind of hyaluronic acid water-soluble human body lubricating fluid that with the addition of hyaluronic acid and Flos Rosae Rugosae extract, the more environmental protection of Flos Rosae Rugosae extract in this lubricating fluid, safety are higher, effective ingredient retention rate is high, and Flos Rosae Rugosae fragrance is lasting, using effect more preferably hyaluronic acid water-soluble human body lubricating fluid.

Another object of the present invention is to provide the preparation method of above-mentioned a kind of hyaluronic acid water-soluble human body lubricating fluid.

Technical scheme is as follows: a kind of hyaluronic acid water-soluble human body lubricating fluid, containing the component of following quality proportioning: hydroxyethyl cellulose 0.3-0.9%, hyaluronate sodium 0.10-0.3%, Flos Rosae Rugosae extract 0.05-0.2%, polylysine 0.01-0.1%, glycerol 13-18%, pure water surplus.

The preferably quality proportioning of component is as follows: pure water 84.1%, glycerol 15%, hydroxyethyl cellulose 0.6%, hyaluronate sodium 0.15%, Flos Rosae Rugosae extract 0.1%, polylysine 0.05%.

Further, the hyaluronic acid water-soluble human body lubricating fluid component species of the present invention can also be containing the soybean isoflavone 0.05-0.15% and/or red wine polyphenols 0.05-0.2% of following mass fraction.

The preparation method of the hyaluronic acid water-soluble human body lubricating fluid of the present invention is as follows: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium being added in agitator, be heated to 70-78 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35-45 DEG C, add Flos Rosae Rugosae extract, be uniformly mixed, be cooled to 30-35 DEG C, add polylysine, being cooled to 28-32 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then be filled with, pack.

The preparation method of described Flos Rosae Rugosae extract is as follows:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 2 ~ 6:1, pulverizes, obtains particle；The pure water of particle and particle quality 3 ~ 8 times is mixed, at 28-32 DEG C of airtight soaking fermentation 24-48h, takes filtrate, be heated to boiling, keep boiling 3-5min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 10-20min at 30 ~ 38 DEG C in the fermentation water of roseleaf quality 2 ~ 5 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 10-25min of 50-70kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby.

Further, in described Flos Rosae Rugosae extract preparation process, step (2) described ultrasonication also can add enzyme and carry out enzymolysis, the effective ingredient in assisted extraction roseleaf in ultrasonic procedure, and described enzyme is preferably by pectase and cellulase.

Pectase and cellulase carry out the method for complex enzyme hydrolysis and may is that the rose pulp first step (2) obtained is at 25-35 DEG C, through supersound process 5-10min of 50-70kHz, it is subsequently adding the pectase accounting for rose pulp quality 0.05-0.07%, at 51-55 DEG C, pH=4-4.5 enzymolysis 10-20min, add the cellulase accounting for rose pulp quality 0.03-0.05%, at 42-45 DEG C, pH=4-4.5 enzymolysis 10-30min, enzyme denaturing, again at 25-35 DEG C, through supersound process 5-15min of 50-70kHz, obtain sonification fluid.Then sonification fluid is homogenized further by step (2) described method and obtains Flos Rosae Rugosae extract afterwards.

The hyaluronic acid water-soluble human body lubricating fluid of the present invention, it is also possible to use following preparation method to prepare:

(1) raw material of following quality proportioning is prepared: hydroxyethyl cellulose 0.3-0.9%, hyaluronate sodium 0.10-0.3%, Flos Rosae Rugosae extract 0.05-0.2%, polylysine 0.01-0.1%, glycerol 13-18%, pure water surplus；Use aforesaid Flos Rosae Rugosae extract preparation method, prepare Flos Rosae Rugosae extract；

(2) Flos Rosae Rugosae extract is risen again, spray-dried, make the extract fine powder of particle diameter 80-200 mesh, glycerol, hydroxyethyl cellulose are added in dispersing stirrer, disperses stirring 3 ~ 5min, reduction rotating speed to 800 ~ 1500r/min with rotating speed 2000 ~ 4000r/min, through lance ejection, extract fine powder is entered agitator along the tangential direction of material movement in agitator mix with the material in agitator, stirring 3 ~ 5min, stops stirring, obtains mixed material；

(3) by pure water, hyaluronate sodium mixing, being heated to 70-78 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35-45 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 30-35 DEG C, add polylysine, be cooled to 28-32 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, to obtain final product.

The present invention having the beneficial effect that relative to prior art:

(1) lubricating fluid formula of the present invention adds hyaluronic acid, Flos Rosae Rugosae extract composition, skin more juicy can be given and moisten, pcrmanent lubrication, pudendum skin can be played the effect of perfect maintenance maintenance simultaneously, recover that skin is delicate, compact, elastic younger state, prevent from being dried and tight；When checking for intervention medically, the anxiety of the those who are investigated that are conducive to releiving and sense of discomfort, contribute to checking is smoothed out；

(2) pH value 5.5 of lubricating fluid of the present invention, close to the acid-base value of female secretion liquid, character is gentle, without adding other chemical compositions, safe, non-stimulated, is also applied for sensitive skin；

(3) Flos Rosae Rugosae extract in lubricating fluid formula of the present invention is not to be added in the way of Flos Rosae Rugosae quintessence oil, reduces zest risk that may be present；Flos Rosae Rugosae raw material processes through being prepared, by rice, Oryza glutinosa and water, the fermentation water obtained, and can remove pesticide that may be present or chemical composition residual in raw material further, reduce zest, improves Product Safety；Preparation process auxiliary ultrasonic processing or ultrasound wave combine enzymolysis processing, can sufficiently be extracted by the effective ingredient in raw material；

(4) lubricating fluid of the present invention is in the preparation, Flos Rosae Rugosae extract is mixed with glycerol and the hydroxyethyl cellulose of high speed dispersion in advance with the form of fine particle, hydroxy ethyl fiber have good film property, in mixed system, in the oil film that Flos Rosae Rugosae extract is wrapped in glycerol, hydroxyethyl cellulose is formed, extend the time of Flos Rosae Rugosae fragrance release, avoid the loss of effective ingredient, play slow releasing function in use, make product fragrance lasting, temperament and interest can be increased for complementary life, wake up libido up, give user perfect experience light, romantic；When checking for intervention medically, the fragrance of Flos Rosae Rugosae be also beneficial to the mood of those who are investigated loosen, relieving mood；

(5) the lubricating fluid composition of the present invention can also add soybean isoflavone and/or red wine polyphenols；Add soybean isoflavone, particularly preferably add the soybean isoflavone of natural extract, life quality can be improved, particularly with climacteric women, soybean isoflavone adds jointly with red wine polyphenols, plays the beneficial effects such as improvement discomfort, regulation temperament and interest, reduction inflammation generation, anti-oxidation.

Detailed description of the invention

Being described in further details the present invention below by embodiment, these embodiments are only used for the present invention is described, do not limit the scope of the invention.

Embodiment 1 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 3:1, pulverizes, obtains particle；The pure water of particle and particle quality 5 times is mixed, at 28-32 DEG C of airtight soaking fermentation 48h, takes filtrate, be heated to boiling, keep boiling 4min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 15min at 30 ~ 32 DEG C in the fermentation water of roseleaf quality 3 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 10min of 65kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: glycerol 15%, hydroxyethyl cellulose 0.6%, hyaluronate sodium 0.15%, Flos Rosae Rugosae extract 0.1%, polylysine 0.05%, pure water 84.1%；

3, prepared by lubricating fluid: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium being added in agitator, be heated to 75 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 40 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 35 DEG C, add polylysine, be cooled to 30 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Embodiment 2 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 2:1, pulverizes, obtains particle；The pure water of particle and particle quality 6 times is mixed, at 28-32 DEG C of airtight soaking fermentation 24h, takes filtrate, be heated to boiling, keep boiling 3min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 18min at 32 ~ 34 DEG C in the fermentation water of roseleaf quality 4 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 20min of 55kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: hydroxyethyl cellulose 0.7%, hyaluronate sodium 0.10%, Flos Rosae Rugosae extract 0.2%, polylysine 0.01%, glycerol 13%, pure water surplus；

3, prepared by lubricating fluid: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium being added in agitator, be heated to 75 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 40 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 35 DEG C, add polylysine, be cooled to 30 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Embodiment 3 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 4:1, pulverizes, obtains particle；The pure water of particle and particle quality 3 times is mixed, at 28-32 DEG C of airtight soaking fermentation 36h, takes filtrate, be heated to boiling, keep boiling 5min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 10min at 35 ~ 38 DEG C in the fermentation water of roseleaf quality 2 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 15min of 60kHz, take out, obtain sonification fluid；It is subsequently adding the pectase accounting for rose pulp quality 0.05%, at 51-55 DEG C, pH=4-4.5 enzymolysis 15min, add the cellulase accounting for rose pulp quality 0.05%, at 42-45 DEG C, pH=4-4.5 enzymolysis 30min, enzyme denaturing, again at 25-35 DEG C, through supersound process 15min of 50kHz, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: hydroxyethyl cellulose 0.8%, hyaluronate sodium 0.2%, Flos Rosae Rugosae extract 0.05%, polylysine 0.03%, glycerol 16%, pure water surplus；

3, prepared by lubricating fluid: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium being added in agitator, be heated to 70 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 32 DEG C, add polylysine, be cooled to 30 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Embodiment 4 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 6:1, pulverizes, obtains particle；The pure water of particle and particle quality 4 times is mixed, at 28-32 DEG C of airtight soaking fermentation 40h, takes filtrate, be heated to boiling, keep boiling 3min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 20min at 33 ~ 36 DEG C in the fermentation water of roseleaf quality 5 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 10min of 65kHz, take out, obtain sonification fluid；It is subsequently adding the pectase accounting for rose pulp quality 0.07%, at 51-55 DEG C, pH=4-4.5 enzymolysis 10min, add the cellulase accounting for rose pulp quality 0.03%, at 42-45 DEG C, pH=4-4.5 enzymolysis 20min, enzyme denaturing, again at 25-35 DEG C, through supersound process 10min of 70kHz, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: hydroxyethyl cellulose 0.3-0.10%, hyaluronate sodium 0.3%, Flos Rosae Rugosae extract 0.15%, polylysine 0.1%, glycerol 14%, pure water surplus；

3, prepared by lubricating fluid: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium being added in agitator, be heated to 72 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 38 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 30 DEG C, add polylysine, be cooled to 28 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Embodiment 5 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 4.5:1, pulverizes, obtains particle；The pure water of particle and particle quality 7 times is mixed, at 28-32 DEG C of airtight soaking fermentation 48h, takes filtrate, be heated to boiling, keep boiling 4min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 15min at 35 ~ 38 DEG C in the fermentation water of roseleaf quality 2 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 25min of 50kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: hydroxyethyl cellulose 0.9%, hyaluronate sodium 0.15%, Flos Rosae Rugosae extract 0.1%, polylysine 0.06%, glycerol 18%, soybean isoflavone 0.01%, pure water surplus；

3, prepared by lubricating fluid:

(1) Flos Rosae Rugosae extract is risen again, spray-dried, make the extract fine powder of particle diameter 200 mesh, glycerol, hydroxyethyl cellulose are added in dispersing stirrer, disperses stirring 3 ~ 5min, reduction rotating speed to 800r/min with rotating speed 2000r/min, through lance ejection, extract fine powder is entered agitator along the tangential direction of material movement in agitator mix with the material in agitator, stirring 3 ~ 5min, stops stirring, obtains mixed material；

(2) by pure water, hyaluronate sodium mixing, being heated to 73 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35 DEG C, adds the mixed material of step (1), be uniformly mixed, it is cooled to 35 DEG C, add soybean isoflavone, polylysine, be cooled to 30 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Embodiment 6 uses following steps to realize the present invention:

1, the preparation of Flos Rosae Rugosae extract:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 5:1, pulverizes, obtains particle；The pure water of particle and particle quality 8 times is mixed, at 28-32 DEG C of airtight soaking fermentation 24h, takes filtrate, be heated to boiling, keep boiling 5min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 12min at 30 ~ 34 DEG C in the fermentation water of roseleaf quality 3.5 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 23min of 70kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby；

2, by the following quality proportioning each component of preparation: hydroxyethyl cellulose 0.3%, hyaluronate sodium 0.25%, Flos Rosae Rugosae extract 0.15%, polylysine 0.08%, glycerol 17%, soybean isoflavone 0.01%, red wine polyphenols 0.1%, pure water surplus；

3, prepared by lubricating fluid:

(1) Flos Rosae Rugosae extract is risen again, spray-dried, make the extract fine powder of particle diameter 80 mesh, glycerol, hydroxyethyl cellulose are added in dispersing stirrer, disperses stirring 3 ~ 5min, reduction rotating speed to 1500r/min with rotating speed 4000r/min, through lance ejection, extract fine powder is entered agitator along the tangential direction of material movement in agitator mix with the material in agitator, stirring 3 ~ 5min, stops stirring, obtains mixed material；

(2) by pure water, hyaluronate sodium mixing, being heated to 78 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 45 DEG C, adds the mixed material of step (1), be uniformly mixed, it is cooled to 35 DEG C, add polylysine, soybean isoflavone, red wine polyphenols, be cooled to 32 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, obtain hyaluronic acid water-soluble human body lubricating fluid finished product.

Claims (8)

1. a hyaluronic acid water-soluble human body lubricating fluid, it is characterised in that: it contains component and each constituent mass proportioning is as follows: hydroxyethyl cellulose 0. 3-0.9%, hyaluronate sodium 0.10-0.3%, Flos Rosae Rugosae extract 0.05-0.2%, polylysine 0.01-0.1%, glycerol 13-18%, pure water surplus.

Hyaluronic acid water-soluble human body lubricating fluid the most according to claim 1, it is characterised in that: possibly together with the soybean isoflavone 0.05-0.15% and/or red wine polyphenols 0.05-0.2% of following mass fraction.

Hyaluronic acid water-soluble human body lubricating fluid the most according to claim 1, it is characterized in that: its preparation method is as follows: pure water, glycerol, hydroxyethyl cellulose, hyaluronate sodium are added in agitator, it is heated to 70-78 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35-45 DEG C, add Flos Rosae Rugosae extract, it is uniformly mixed, it is cooled to 30-35 DEG C, adds polylysine, be cooled to 28-32 DEG C, the sampling inspection of semifinished product, regulation pH value, 5.5, after the assay was approved, then is filled with, packs.

Hyaluronic acid water-soluble human body lubricating fluid the most according to claim 1, it is characterised in that: made by the component of following quality proportioning is compounding: pure water 84.1%, glycerol 15%, hydroxyethyl cellulose 0.6%, hyaluronate sodium 0.15%, Flos Rosae Rugosae extract 0.1%, polylysine 0.05%.

5. according to the hyaluronic acid water-soluble human body lubricating fluid described in claim 1 or 3 or 4, it is characterised in that: the preparation method of described Flos Rosae Rugosae extract is as follows:

(1) take rice, Oryza glutinosa mixes according to the ratio of mass ratio 2 ~ 6:1, pulverizes, obtains particle；The pure water of particle and particle quality 3 ~ 8 times is mixed, at 28-32 DEG C of airtight soaking fermentation 24-48h, takes filtrate, be heated to boiling, keep boiling 3-5min, be cooled to room temperature, obtain fermentation water；

(2) take fresh, clean Flos Rosae Rugosae petal, pulverize, immerse the insulation 10-20min at 30 ~ 38 DEG C in the fermentation water of roseleaf quality 2 ~ 5 times, colloid mill, obtains rose pulp, then by rose pulp at 25-35 DEG C, through supersound process 10-25min of 50-70kHz, take out, obtain sonification fluid；Ultrasonic Treatment liquid is homogenized further ,-20 ~-10 DEG C of lyophilizations, it is thus achieved that Flos Rosae Rugosae extract, preserves at being placed in-4 DEG C, standby.

Hyaluronic acid water-soluble human body lubricating fluid the most according to claim 5, it is characterised in that: in described Flos Rosae Rugosae extract preparation process, step (2) described ultrasonication adds pectase and cellulase carries out complex enzyme hydrolysis.

nullHyaluronic acid water-soluble human body lubricating fluid the most according to claim 6，It is characterized in that: described ultrasonication addition pectase and cellulase carry out the concrete grammar of complex enzyme hydrolysis and be: the rose pulp first step (2) obtained is at 25-35 DEG C、Supersound process 5-10min through 50-70kHz，It is subsequently adding the pectase accounting for rose pulp quality 0.05-0.07%，At 51-55 DEG C、PH=4-4.5 enzymolysis 10-20min，Add the cellulase accounting for rose pulp quality 0.03-0.05%，At 42-45 DEG C、PH=4-4.5 enzymolysis 10-30min，Enzyme denaturing，Again at 25-35 DEG C、Supersound process 5-15min through 50-70kHz，Obtain sonification fluid，Homogenate further，-20 ~-10 DEG C of lyophilizations，Obtain Flos Rosae Rugosae extract，Preserve at being placed in-4 DEG C，Standby，Obtain Flos Rosae Rugosae extract.

8. the hyaluronic acid water-soluble human body lubricating fluid described in claim 1, it is characterised in that: use following preparation method to prepare:

(1) raw material of following quality proportioning is prepared: hydroxyethyl cellulose 0.3-0.9%, hyaluronate sodium 0.10-0.3%, Flos Rosae Rugosae extract 0.05-0.2%, polylysine 0.01-0.1%, glycerol 13-18%, pure water surplus；Use the Flos Rosae Rugosae extract preparation method described in claim 3, prepare Flos Rosae Rugosae extract；

(2) Flos Rosae Rugosae extract is risen again, spray-dried, make the extract fine powder of particle diameter 80-200 mesh, glycerol, hydroxyethyl cellulose are added in dispersing stirrer, disperses stirring 3 ~ 5min, reduction rotating speed to 800 ~ 1500r/min with rotating speed 2000 ~ 4000r/min, through lance ejection, extract fine powder is entered agitator along the tangential direction of material movement in agitator mix with the material in agitator, stirring 3 ~ 5min, stops stirring, obtains mixed material；

(3) by pure water, hyaluronate sodium mixing, being heated to 70-78 DEG C while stirring, stirring is to being completely dissolved, it is cooled to 35-45 DEG C, adds Flos Rosae Rugosae extract, be uniformly mixed, it is cooled to 30-35 DEG C, add polylysine, be cooled to 28-32 DEG C, sample the inspection of semifinished product, regulation pH value is 5.5, after the assay was approved, then it is filled with, packs, to obtain final product.