CN112190769A - Hyaluronic acid lubricating liquid and preparation method thereof - Google Patents
Hyaluronic acid lubricating liquid and preparation method thereof Download PDFInfo
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The invention discloses hyaluronic acid lubricating liquid which is characterized by comprising the following components in parts by weight: 1-3 parts of hyaluronic acid, 1-3 parts of modified hyperbranched polyamino acid, 0.5-1 part of chitosan quaternary ammonium salt, 0.3-0.5 part of water-soluble silicone oil, 0.1-0.3 part of ursolic acid, 0.1-0.2 part of water-soluble vitamin, 0.1-0.3 part of almond oil, 1-2 parts of honey extract, 0.5-1.5 parts of lygodium japonicum extract, 2-4 parts of Chinese herbal medicine extract, 5-10 parts of hyperbranched polyglycerol, 20-30 parts of deionized water and 1-3 parts of emulsifier. The invention also discloses a preparation method of the hyaluronic acid lubricating liquid. The hyaluronic acid lubricating liquid disclosed by the invention is good in lubricating property, capable of effectively improving sexual excitation effect, good in antibacterial and mildew-proof properties, easy to clean, excellent in biocompatibility with human skin, free of uncomfortable effects such as allergy and stimulation, good in effects of repairing cells and protecting mucosa, and good in economic benefit, social benefit and ecological benefit.
Description
Technical Field
The invention relates to the technical field of washing and caring articles, in particular to hyaluronic acid lubricating liquid and a preparation method thereof.
Background
With the improvement of living standard, the sales volume of condoms is increased year by year, and the safety and the effectiveness of the condoms attract the wide attention of people. The condom is a daily life-planning article commonly used by people in daily life, and is mainly used for separating the combination of sperms and ova in the sexual life of human beings and preventing pregnancy. In modern life, with the spread of various venereal diseases such as AIDS, in sexual life, the male wearing condom is the simplest and effective means for preventing venereal diseases.
The contraception and interplanting in the market are various, the colors are various, the smells are different, lubricating liquid is usually added into the contraception and interplanting, and the added human body lubricating liquid not only can increase the lubricating effect, improve the sexual pleasure, enable the sexual life to be more harmonious and improve the feelings among couples; meanwhile, the skin injury is reduced, and the corrosion chance of harmful microorganisms such as bacteria, viruses and the like to the human body is reduced; effectively reducing the damage of the condom and reducing the probability of accidental pregnancy. Therefore, it is very important to develop a human body lubricant with excellent comprehensive performance.
The application of human body lubricating fluid in human sexual life has also a long history, but people in early days adopt vegetable oil such as olive oil and the like. But because the limited effect of the components is not ideal, the clothes are easy to be polluted and absorbed by the body; later, petroleum-based mineral oily substances such as vaseline, baby oil, bath lotion, massage oil, etc. were tried to be used as lubrication; these materials tend to be too viscous to clean easily. The condom is easy to remain after being used, even the condom can block the urethral orifices of both men and women after being used, the difficult and painful sensation of urination is generated, the stability of the condom is damaged, and the accidental pregnancy is caused, which can cause damage to the human body.
The Chinese invention patent with the application number of 201711047938.9 relates to hyaluronic acid lubricating liquid and a preparation method thereof, and the hyaluronic acid lubricating liquid is prepared from the following raw materials in parts by weight: 10-15 parts of oat beta-glucan, 0.5-1.5 parts of hyaluronic acid, 2-5 parts of water-soluble camellia seed oil, 0.5-1.5 parts of hexanediol, 20-30 parts of black tea fungus fermentation liquor, 0.25-1 part of cananga odorata essential oil, 0.5-2.5 parts of black tea fungus fermentation membrane modifier and 50-70 parts of deionized water. The hyaluronic acid lubricating liquid is prepared from natural plants, is convenient to carry and use, can effectively clean and improve sexual excitation effect, and is a lubricating liquid product capable of being used for a long time. However, the lubricating effect of the black tea fungus fermentation membrane is still to be further improved, and the preparation process of the black tea fungus fermentation membrane modifier added in the black tea fungus fermentation membrane modifier is complex and high in cost.
Therefore, the hyaluronic acid lubricating liquid which has good lubricating property, can effectively improve sexual excitation effect, has good antibacterial and mildew-proof properties, is easy to clean, has excellent biocompatibility with human skin, does not have uncomfortable effects such as allergy and stimulation, has the effects of repairing cells and protecting mucosa, has simple preparation process, low preparation cost, meets the market demand, has wide market value and application prospect, and has very important significance for promoting the development of the human lubricating oil industry.
Disclosure of Invention
In view of the above, the invention aims to provide a hyaluronic acid lubricating liquid and a preparation method thereof, wherein the preparation method is simple, convenient to operate and control, rich in raw material source, low in cost, high in preparation efficiency and yield, and suitable for large-scale production; the hyaluronic acid lubricating liquid prepared by the preparation method has good lubricating property, can effectively improve sexual excitation effect, has good antibacterial and mildew-proof properties, is easy to clean, has excellent biocompatibility with human skin, does not have uncomfortable effects such as allergy, stimulation and the like, has the effects of repairing cells and protecting mucosa, and has good economic, social and ecological benefits.
In order to achieve the purpose, the invention adopts the technical scheme that:
the hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 1-3 parts of hyaluronic acid, 1-3 parts of modified hyperbranched polyamino acid, 0.5-1 part of chitosan quaternary ammonium salt, 0.3-0.5 part of water-soluble silicone oil, 0.1-0.3 part of ursolic acid, 0.1-0.2 part of water-soluble vitamin, 0.1-0.3 part of almond oil, 1-2 parts of honey extract, 0.5-1.5 parts of lygodium japonicum extract, 2-4 parts of Chinese herbal medicine extract, 5-10 parts of hyperbranched polyglycerol, 20-30 parts of deionized water and 1-3 parts of emulsifier.
Preferably, the emulsifier is one or more of tween-80, tween-20 and polyoxyethylene vegetable oil.
Preferably, the preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 4-6 hours at 70-80 ℃, and then performing rotary evaporation to remove the solvent to obtain the modified hyperbranched polyamino acid.
Preferably, the mass ratio of the hyperbranched polyamino acid to the high-boiling-point solvent to the silane coupling agent KH560 is 1 (3-5) to 0.1-0.3.
Preferably, the high boiling point solvent is at least one of dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone.
Preferably, the preparation method of the hyperbranched polyamino acid is prior art, and is referred to Chinese patent application No. 200910062702.1, namely embodiment 8.
Preferably, the weight average molecular weight of the chitosan quaternary ammonium salt is 1 ten thousand, and the substitution degree is 80%.
Preferably, the water-soluble silicone oil is purchased from Qingdao Baotou silicon materials science and technology limited, and the model is ZBH-205.
Preferably, the water-soluble vitamin is at least one of vitamin B1 and vitamin C.
Preferably, the preparation method of the hyperbranched polyglycerol is referred to as specific examples of Chinese patent application No. 201480013222.5, is already prior art, and is a fourth generation product.
Preferably, the Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 3-5 parts of arnica, 2-4 parts of eyebright, 1-4 parts of phellodendron, 2-5 parts of moutan bark, 2-4 parts of pseudo-ginseng, 2-4 parts of prepared rhizome of rehmannia and 3-5 parts of radix bupleuri.
Preferably, the preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting to obtain mixed raw materials, adding purified water 4-8 times the mass of the mixed raw materials, decocting at 90-100 deg.C for 2-4 hr, filtering to obtain filtrate, and removing purified water by rotary evaporation to obtain Chinese herbal medicine extract.
Another object of the present invention is to provide a method for preparing the hyaluronic acid lubricating fluid, which comprises the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying at the temperature of 70-80 ℃ and the rotating speed of 1500-2500 rpm for 20-30 minutes, and then stirring at the temperature of 25-35 ℃ and the rotating speed of 35-45 rpm for 10-15 minutes.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
(1) the preparation method of the hyaluronic acid lubricating liquid provided by the invention has the advantages that the hyaluronic acid lubricating liquid is prepared by directly and uniformly mixing the components in parts by weight, special equipment is not required, the preparation cost is low, the preparation method is reliable in process, convenient to operate and high in production efficiency, and industrial production is facilitated.
(2) The hyaluronic acid lubricating liquid provided by the invention overcomes the defects that the traditional lubricating liquid is not ideal in effect, is easy to pollute clothes and is not easy to be absorbed by a body; too high viscosity and difficult cleaning. The hyaluronic acid lubricating liquid has the advantages that residues are easy to cause after use, even the urethral orifices of both men and women are likely to be blocked after use, the difficult and painful urination is generated, the stability of the condom can be damaged, the accidental pregnancy is caused, and the harm to the human body is caused.
(3) The hyaluronic acid lubricating liquid provided by the invention is added with ursolic acid, water-soluble vitamins, almond oil, honey extract, lygodium japonicum extract and Chinese herbal medicine extract components, and due to the synergistic effect of the natural components and toxic and side effects, the effects of beautifying, resisting relaxation and increasing the elasticity of the vagina of a female on the vagina skin can be effectively increased.
(4) The hyaluronic acid lubricating liquid provided by the invention has the synergistic effect of hyaluronic acid, modified hyperbranched polyamino acid and water-soluble silicone oil, so that the lubricating effect of the lubricating liquid is more obvious, the sexual excitation effect can be effectively cleaned and improved, the problem of vaginal dryness caused by reasons such as menopause can be solved, the hyaluronic acid lubricating liquid can be effectively lubricated, and the effects of relieving itching and diminishing inflammation can be realized. The used silicone oil is water-soluble silicone oil, so that the condom is easy to clean, does not have greasy feeling, and does not cause the problem of urethral blockage, the organic silicon structure of the condom is similar to the components of the condom and is easy to bond with the condom, the modified hyperbranched polyamino acid introduces the alkoxy silicon structure through modification, the bonding with the condom is further improved, and more hydrophilic groups are introduced, so that the surface of the condom is smooth, and the female vagina can not be damaged when the condom is used; the addition of the chitosan quaternary ammonium salt can play a role in lubricating and also has an antibacterial effect.
(5) The hyaluronic acid lubricating liquid provided by the invention adopts hyperbranched polyglycerol, so that the stimulation can be reduced, the skin-friendly property of the lubricating liquid can be improved, the compatibility among all components can be improved, the storage stability of the lubricating liquid can be improved, and the quality guarantee period of the lubricating liquid can be prolonged. Through the addition of the Chinese herbal medicine extract, the lubricating liquid has the effects of health care, antibiosis, inflammation diminishing, wound healing promotion and sexual excitation improvement through fragrance on the premise of improving the lubricating performance.
Detailed Description
In order to make the technical solutions of the present invention better understood and make the above features, objects, and advantages of the present invention more comprehensible, the present invention is further described with reference to the following examples. The examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
In the embodiment of the invention, the raw materials are all purchased commercially; the preparation method of the hyperbranched polyglycerol refers to specific examples of Chinese invention patent with application number 201480013222.5, which is already the prior art and is a fourth generation product; the preparation method of the hyperbranched polyamino acid is the prior art, and is shown in the Chinese invention patent example 8 with the application number of 200910062702.1; the weight average molecular weight of the chitosan quaternary ammonium salt is 1 ten thousand, and the substitution degree is 80%; the water-soluble silicone oil is purchased from Qingdao Zhongbao silicon material science and technology limited company, and the model is ZBH-205.
Example 1
The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 1 part of hyaluronic acid, 1 part of modified hyperbranched polyamino acid, 0.5 part of chitosan quaternary ammonium salt, 0.3 part of water-soluble silicone oil, 0.1 part of ursolic acid, 0.1 part of water-soluble vitamin, 0.1 part of almond oil, 1 part of honey extract, 0.5 part of spora lygodii extract, 2 parts of Chinese herbal medicine extract, 5 parts of hyperbranched polyglycerol, 20 parts of deionized water and 1 part of emulsifier.
The emulsifier is tween-80.
The preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 4 hours at 70 ℃, and then performing rotary evaporation to remove the solvent to obtain modified hyperbranched polyamino acid; the mass ratio of the hyperbranched polyamino acid to the high-boiling point solvent to the silane coupling agent KH560 is 1:3: 0.1; the high boiling point solvent is dimethyl sulfoxide.
The water-soluble vitamin is vitamin B1.
The Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 3 parts of arnica, 2 parts of eyebright, 1 part of phellodendron, 2 parts of moutan bark, 2 parts of pseudo-ginseng, 2 parts of prepared rehmannia root and 3 parts of bupleurum.
The preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting to obtain a mixed raw material medicine, adding purified water with the mass 4 times of that of the mixed raw material medicine, decocting at 90 ℃ for 2 hours, filtering in sequence to obtain filtrate, and removing the purified water by rotary evaporation to obtain the Chinese herbal medicine extract.
The preparation method of the hyaluronic acid lubricating liquid is characterized by comprising the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying at the temperature of 70 ℃ and the rotating speed of 1500 rpm for 20 minutes, and then stirring at the temperature of 25 ℃ and the rotating speed of 35 rpm for 10 minutes.
Example 2
The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 1.5 parts of hyaluronic acid, 1.5 parts of modified hyperbranched polyamino acid, 0.6 part of chitosan quaternary ammonium salt, 0.35 part of water-soluble silicone oil, 0.15 part of ursolic acid, 0.12 part of water-soluble vitamin, 0.15 part of almond oil, 1.2 parts of honey extract, 0.7 part of spora lygodii extract, 2.5 parts of Chinese herbal medicine extract, 6 parts of hyperbranched polyglycerol, 23 parts of deionized water and 1.5 parts of emulsifier; the emulsifier is tween-20.
The preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 4.5 hours at 73 ℃, and then performing rotary evaporation to remove the solvent to obtain modified hyperbranched polyamino acid; the mass ratio of the hyperbranched polyamino acid to the high-boiling point solvent to the silane coupling agent KH560 is 1:3.5: 0.15; the high boiling point solvent is N, N-dimethylformamide.
The water-soluble vitamin is vitamin C.
The Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 3.5 parts of arnica, 2.5 parts of eyebright, 2 parts of phellodendron, 2.5 parts of moutan bark, 2.5 parts of pseudo-ginseng, 2.5 parts of prepared rhizome of rehmannia and 3.5 parts of radix bupleuri.
The preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting to obtain mixed raw materials, adding purified water with the mass 5 times of the mass of the mixed raw materials, decocting at 93 ℃ for 2.5 hours, filtering to obtain filtrate, and removing purified water by rotary evaporation to obtain the Chinese herbal medicine extract.
The preparation method of the hyaluronic acid lubricating liquid is characterized by comprising the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying at 73 ℃ and 1800 rpm for 23 minutes, and then stirring at 28 ℃ and 38 rpm for 12 minutes.
Example 3
The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 2 parts of hyaluronic acid, 2 parts of modified hyperbranched polyamino acid, 0.8 part of chitosan quaternary ammonium salt, 0.4 part of water-soluble silicone oil, 0.2 part of ursolic acid, 0.15 part of water-soluble vitamin, 0.2 part of almond oil, 1.5 parts of honey extract, 1 part of spora lygodii extract, 3 parts of Chinese herbal medicine extract, 8 parts of hyperbranched polyglycerol, 25 parts of deionized water and 2 parts of emulsifier; the emulsifier is polyoxyethylene vegetable oil.
The preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 5 hours at 75 ℃, and then performing rotary evaporation to remove the solvent to obtain modified hyperbranched polyamino acid; the mass ratio of the hyperbranched polyamino acid to the high-boiling point solvent to the silane coupling agent KH560 is 1:4: 0.2; the high boiling point solvent is N, N-dimethylacetamide.
The water-soluble vitamin is vitamin B1.
The Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 4 parts of arnica, 3 parts of eyebright, 2.5 parts of phellodendron, 3.5 parts of tree peony bark, 3 parts of pseudo-ginseng, 3 parts of prepared rehmannia root and 4 parts of bupleurum.
The preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting to obtain a mixed raw material medicine, adding purified water with the mass 6 times of that of the mixed raw material medicine, decocting at 95 ℃ for 3 hours, filtering in sequence to obtain filtrate, and removing the purified water by rotary evaporation to obtain the Chinese herbal medicine extract.
The preparation method of the hyaluronic acid lubricating liquid is characterized by comprising the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying the mixture for 25 minutes at the temperature of 75 ℃ and the rotating speed of 2000 r/min, and then stirring the mixture for 13 minutes at the temperature of 30 ℃ and the rotating speed of 40 r/min.
Example 4
The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 2.5 parts of hyaluronic acid, 2.5 parts of modified hyperbranched polyamino acid, 0.9 part of chitosan quaternary ammonium salt, 0.45 part of water-soluble silicone oil, 0.25 part of ursolic acid, 0.19 part of water-soluble vitamin, 0.28 part of almond oil, 1.9 parts of honey extract, 1.4 parts of lygodium japonicum extract, 3.5 parts of Chinese herbal medicine extract, 9 parts of hyperbranched polyglycerol, 28 parts of deionized water and 2.6 parts of emulsifier; the emulsifier is formed by mixing tween-80, tween-20 and polyoxyethylene vegetable oil according to the mass ratio of 1:3: 5.
The preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 5.8 hours at 78 ℃, and then performing rotary evaporation to remove the solvent to obtain modified hyperbranched polyamino acid; the mass ratio of the hyperbranched polyamino acid to the high-boiling point solvent to the silane coupling agent KH560 is 1:4.5: 0.28; the high boiling point solvent is formed by mixing dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone according to a mass ratio of 1:2:3: 2.
The water-soluble vitamin is formed by mixing vitamin B1 and vitamin C according to the mass ratio of 3: 5.
The Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 4.8 parts of arnica, 3.7 parts of eyebright, 3.5 parts of phellodendron, 4.5 parts of moutan bark, 3.5 parts of pseudo-ginseng, 3.5 parts of prepared rehmannia root and 4.5 parts of bupleurum.
The preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting into pieces to obtain mixed raw materials, adding purified water 7 times the mass of the mixed raw materials, decocting at 98 deg.C for 3.5 hr, filtering to obtain filtrate, and removing purified water by rotary evaporation to obtain Chinese herbal medicine extract.
The preparation method of the hyaluronic acid lubricating liquid is characterized by comprising the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying the mixture at 78 ℃ and 2400 rpm for 28 minutes, and then stirring the mixture at 34 ℃ and 43 rpm for 14 minutes.
Example 5
The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 3 parts of hyaluronic acid, 3 parts of modified hyperbranched polyamino acid, 1 part of chitosan quaternary ammonium salt, 0.5 part of water-soluble silicone oil, 0.3 part of ursolic acid, 0.2 part of water-soluble vitamin, 0.3 part of almond oil, 2 parts of honey extract, 1.5 parts of lygodium japonicum extract, 4 parts of Chinese herbal medicine extract, 10 parts of hyperbranched polyglycerol, 30 parts of deionized water and 3 parts of emulsifier; the emulsifier is tween-80.
The preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 6 hours at 80 ℃, and then performing rotary evaporation to remove the solvent to obtain modified hyperbranched polyamino acid; the mass ratio of the hyperbranched polyamino acid to the high-boiling point solvent to the silane coupling agent KH560 is 1:5: 0.3; the high boiling point solvent is N-methyl pyrrolidone.
The water-soluble vitamin is vitamin C.
The Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 5 parts of arnica, 4 parts of eyebright, 4 parts of phellodendron, 5 parts of moutan bark, 4 parts of pseudo-ginseng, 4 parts of prepared rehmannia root and 5 parts of bupleurum.
The preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting into pieces to obtain mixed raw materials, adding purified water with mass 8 times of the mixed raw materials, decocting at 100 deg.C for 4 hr, filtering to obtain filtrate, and removing purified water by rotary evaporation to obtain Chinese herbal medicine extract.
The preparation method of the hyaluronic acid lubricating liquid is characterized by comprising the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying the mixture for 30 minutes at 80 ℃ and at the rotating speed of 2500 rpm, and then stirring the mixture for 15 minutes at 35 ℃ and at the rotating speed of 45 rpm.
Comparative example 1
The present example provides a hyaluronic acid lubricant, the formulation and preparation method of which are substantially the same as those of example 1, except that modified hyperbranched polyamino acid is not added.
Comparative example 2
This example provides a hyaluronic acid lubricant, which has a formulation and a preparation method substantially the same as those of example 1, except that no chitosan quaternary ammonium salt is added.
Comparative example 3
This example provides a hyaluronic acid lubricating fluid, which is substantially the same as example 1 in formulation and preparation method, except that no water-soluble silicone oil is added.
Comparative example 4
This example provides a hyaluronic acid lubricating fluid, which is substantially the same as that of example 1 in formulation and preparation, except that no honey extract is added.
Comparative example 5
This example provides a hyaluronic acid lubricant, which is substantially the same as example 1 in formulation and preparation method, except that no herbal extract is added.
Comparative example 6
This example provides a hyaluronic acid lubricant, which is substantially the same as example 1 in formulation and preparation method, except that glycerin is used instead of hyperbranched polyglycerol.
To further illustrate the beneficial technical effects of the hyaluronic acid lubricating fluid according to the embodiments of the present invention, the healthy 28-45 year old couples volunteers were selected and divided into 11 groups, wherein 20 pairs of each group were provided with 3 condom containing lubricating fluid (condom material and quality of the lubricating fluid are the same) for each couple, and 9 condom containing lubricating fluid were provided. The questionnaire was filled out after use within two months. The questionnaire is evaluated from three items of lubrication degree, lubrication duration and easy cleaning degree, each full score is 5 points, the average score of the couple scores of each group is taken as the group score, and the specific experimental result is shown in table 1.
TABLE 1
| Item | Degree of lubrication | Length of lubrication | Degree of easy cleaning | Total score |
| Example 1 | 4.8 | 4.6 | 4.8 | 14.2 |
| Example 2 | 4.8 | 4.8 | 4.9 | 14.5 |
| Example 3 | 4.9 | 4.9 | 5.0 | 14.8 |
| Example 4 | 5.0 | 4.9 | 5.0 | 14.9 |
| Example 5 | 5.0 | 5.0 | 5.0 | 15.0 |
| Comparative example 1 | 4.0 | 4.3 | 4.5 | 12.8 |
| Comparative example 2 | 3.5 | 4.1 | 4.6 | 12.2 |
| Comparative example 3 | 3.8 | 3.9 | 4.4 | 12.1 |
| Comparative example 4 | 3.9 | 4.0 | 4.3 | 12.2 |
| Comparative example 5 | 3.7 | 3.8 | 4.6 | 12.1 |
| Comparative example 6 | 4.2 | 4.0 | 4.2 | 12.4 |
As can be seen from table 1, the hyaluronic acid lubricating fluids disclosed in the examples of the present invention have more excellent lubricating properties and are easier to clean than the comparative examples, which is a result of the synergistic effect of the components.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. The hyaluronic acid lubricating liquid is characterized by comprising the following components in parts by weight: 1-3 parts of hyaluronic acid, 1-3 parts of modified hyperbranched polyamino acid, 0.5-1 part of chitosan quaternary ammonium salt, 0.3-0.5 part of water-soluble silicone oil, 0.1-0.3 part of ursolic acid, 0.1-0.2 part of water-soluble vitamin, 0.1-0.3 part of almond oil, 1-2 parts of honey extract, 0.5-1.5 parts of lygodium japonicum extract, 2-4 parts of Chinese herbal medicine extract, 5-10 parts of hyperbranched polyglycerol, 20-30 parts of deionized water and 1-3 parts of emulsifier.
2. The hyaluronic acid lubricating fluid according to claim 1, wherein the emulsifier is one or more of tween-80, tween-20 and polyoxyethylene vegetable oil.
3. The hyaluronic acid lubricating fluid according to claim 1, wherein the preparation method of the modified hyperbranched polyamino acid comprises the following steps: adding the hyperbranched polyamino acid into a high-boiling point solvent, then adding a silane coupling agent KH560, stirring and reacting for 4-6 hours at 70-80 ℃, and then performing rotary evaporation to remove the solvent to obtain the modified hyperbranched polyamino acid.
4. The hyaluronic acid lubricating fluid as defined in claim 3, wherein the mass ratio of the hyperbranched polyamino acid, the high-boiling-point solvent and the silane coupling agent KH560 is 1 (3-5) to (0.1-0.3).
5. The hyaluronic acid lubricating fluid according to claim 1, wherein the high boiling point solvent is at least one of dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone.
6. The hyaluronic acid lubricating fluid according to claim 1, wherein the weight average molecular weight of the chitosan quaternary ammonium salt is 1 ten thousand, and the substitution degree is 80%; the water-soluble vitamin is at least one of vitamin B1 and vitamin C.
7. The hyaluronic acid lubricating fluid as defined in claim 1, wherein the Chinese herbal medicine extract is prepared from the following raw material medicines in parts by weight: 3-5 parts of arnica, 2-4 parts of eyebright, 1-4 parts of phellodendron, 2-5 parts of moutan bark, 2-4 parts of pseudo-ginseng, 2-4 parts of prepared rhizome of rehmannia and 3-5 parts of radix bupleuri.
8. The hyaluronic acid lubricating fluid as defined in claim 7, wherein the preparation method of the Chinese herbal medicine extract comprises the following steps: mixing the raw materials, cleaning, cutting to obtain mixed raw materials, adding purified water 4-8 times the mass of the mixed raw materials, decocting at 90-100 deg.C for 2-4 hr, filtering to obtain filtrate, and removing purified water by rotary evaporation to obtain Chinese herbal medicine extract.
9. The hyaluronic acid lubricating fluid according to any of claims 1-8, wherein the preparation method of hyaluronic acid lubricating fluid comprises the following steps: the hyaluronic acid lubricating liquid is prepared by uniformly mixing the components in parts by weight, adding the mixture into an emulsifying pot, stirring and emulsifying at the temperature of 70-80 ℃ and the rotating speed of 1500-2500 rpm for 20-30 minutes, and then stirring at the temperature of 25-35 ℃ and the rotating speed of 35-45 rpm for 10-15 minutes.
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Citations (4)
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|---|---|---|---|---|
| CN103446630A (en) * | 2013-08-23 | 2013-12-18 | 蔡智浙 | Safe and easy-to-clean lubricating oil composition for condoms and preparation method thereof |
| CN105999426A (en) * | 2016-07-26 | 2016-10-12 | 广东诺丝科技股份有限公司 | Hyaluronan water-soluble human body lubricating liquid |
| CN107789437A (en) * | 2017-10-31 | 2018-03-13 | 福建师范大学 | A kind of fermentation of seaweed lubricating fluid and preparation method thereof |
| CN107811958A (en) * | 2017-10-31 | 2018-03-20 | 福建师范大学 | A kind of fermented tea fermentation lubricating fluid and preparation method thereof |
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2020
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|---|---|---|---|---|
| CN103446630A (en) * | 2013-08-23 | 2013-12-18 | 蔡智浙 | Safe and easy-to-clean lubricating oil composition for condoms and preparation method thereof |
| CN105999426A (en) * | 2016-07-26 | 2016-10-12 | 广东诺丝科技股份有限公司 | Hyaluronan water-soluble human body lubricating liquid |
| CN107789437A (en) * | 2017-10-31 | 2018-03-13 | 福建师范大学 | A kind of fermentation of seaweed lubricating fluid and preparation method thereof |
| CN107811958A (en) * | 2017-10-31 | 2018-03-20 | 福建师范大学 | A kind of fermented tea fermentation lubricating fluid and preparation method thereof |
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