CN105943796A - Traditional Chinese medicine for treating facioplegia caused by exopathogenic cold-wind - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating facioplegia caused by exopathogenic cold-wind, which is prepared from the following raw material medicines: yellowflower toadlily herb, gomphrena globosa L., rhaphidophora decursiva, downy rosemyrtle root, spearmint, atalantia buxifolia, litsea coreana, vicia unijuga, forsythia viridissima lindl, dindygulen peperomia herb, endive, nephrolepis auriculata, common melastoma herb, murdannia bracteata, yellowhairy strawberry herb, rorippa indica, and Chinese wedelia herb or root. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine is combined with common western medicines for treating the facioplegia caused by exopathogenic cold-wind, the pertinence is strong, the treatment effect of the western medicines is improved effectively, the curing rate is higher, toxic or side effects are avoided, and the untoward effects of the western medicines are reduced or eliminated.

Description

A kind of Chinese medicine treating affection by exopathogenic cold-wind profile paralysis and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of treat affection by exopathogenic cold-wind profile paralysis Chinese medicine and Its preparation method.

Background technology

Face paralysis is equivalent to the facial paralysis of western medicine, it is common that refer to caused by a variety of causes non-enter The abnormal kentrokiness obstacle caused of row nervus facialis is based on facial expression muscle group dyskinesia Want a kind of commonly encountered diseases of feature.General symptom is facial hemiparalysis, is a kind of commonly encountered diseases, not by age limit.

Modern medicine is thought, it is sick that facial paralysis belongs to acute nonsuppurative, is the nervus facialis impression sent in stylomastoid foramen Virus infect or adjacent tissue inflammatory lesion damage so that local nutrient vessel spasm and cause neural ischemia Or edema；Its pathologic basis is that face nerve pipe can not increase thick need with the nervus facialis hyperemia of inflammation, edema Want and expand accordingly, cause relative narrowness, nervus facialis pressurized occurs, show as facial expression myoparalysis.

The traditional Chinese medical science thinks that its cause of disease is many because of positive QI-insufficiency, and venation is hollow, affection of exogenous wind-cold, and the heresy of wind heat invades Sun is bright, the arteries and veins of few sun, so that lose foster through gas obstruction of meridian, muscle amyotonia is not received and fallen ill, facial paralysis be by Hindering in head meridians, the arteries and veins jaws ring lip that foot sun is bright in wind-phlegm, the arteries and veins of the foot sun arises from inner canthus, and sun is bright Interior storage expectorant is turbid, and in wind during the sun is outer, wind-phlegm hinders in head meridians, then through the most unfavorable, muscles loses supports, no With and delay, in place of naivete, QI and blood still can be run, relatively anxious, and slow person be that urgency person draws, therefore facial hemiparalysis.

Summary of the invention

The technical problem to be solved is, it is provided that a kind of therapeutic effect is good, have no side effect Chinese medicine for the treatment of affection by exopathogenic cold-wind profile paralysis and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating affection by exopathogenic cold-wind profile paralysis, Described Chinese medicine includes following raw medicinal material: Herba Tricyrtis Pilosae, Flos Gomphrenae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rhodomyrti, Herba Menthae Rotundifoliae, East wind Fructus Citri tangerinae, Litsea coreana, Vicia unijuga, Forsyihia viridissima Lindl, Herba Peperomiae Dindygulensis, Herba Lactucae versicoloris, Herba pteridis vittatae, Herba Melastomatis Candii, phlegm-fire Grass, Herba Fragariae nilerrensis, dish and Herbia Wedeliae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Tricyrtis Pilosae 15～25 parts, Flos Gomphrenae 20～30 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～20 parts, Radix Rhodomyrti 20～30 parts, Herba Menthae Rotundifoliae 15～25 parts, east Wind Fructus Citri tangerinae 10～20 parts, Litsea coreana 20～30 parts, Vicia unijuga 15～25 parts, Forsyihia viridissima Lindl 10～20 parts, stone Cicadae Grass 12～22 parts, Herba Lactucae versicoloris 20～30 parts, Herba pteridis vittatae 10～20 parts, Herba Melastomatis Candii 15～25 parts, phlegm-fire grass 10～ 20 parts, Herba Fragariae nilerrensis 10～20 parts, dish 5～15 parts and Herbia Wedeliae 20～30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 17～22 parts, Flos Gomphrenae 20～25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～15 parts, Radix Rhodomyrti 20～25 parts, Herba Menthae Rotundifoliae 18～ 23 parts, east wind Fructus Citri tangerinae 12～17 parts, Litsea coreana 20～25 parts, Vicia unijuga 17～22 parts, Forsyihia viridissima Lindl 10～15 Part, Herba Peperomiae Dindygulensis 15～20 parts, Herba Lactucae versicoloris 20～25 parts, Herba pteridis vittatae 15～20 parts, Herba Melastomatis Candii 18～23 parts, Phlegm-fire grass 12～17 parts, Herba Fragariae nilerrensis 13～18 parts, dish 8～13 parts and Herbia Wedeliae 22～27 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 21 parts, Flos Gomphrenae 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 14 parts, Radix Rhodomyrti 22 parts, Herba Menthae Rotundifoliae 23 parts, east wind Fructus Citri tangerinae 12 parts, Litsea coreana 24 parts, Vicia unijuga 18 parts, Forsyihia viridissima Lindl 14 parts, Herba Peperomiae Dindygulensis 16 parts, Herba Lactucae versicoloris 24 parts, Herba pteridis vittatae 16 Part, Herba Melastomatis Candii 22 parts, phlegm-fire grass 14 parts, Herba Fragariae nilerrensis 17 parts, dish 9 parts and Herbia Wedeliae 26 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 18 parts, Flos Gomphrenae 24 parts, Radix Seu Caulis Rhaphidophorae Decursivae 12 parts, Radix Rhodomyrti 24 parts, Herba Menthae Rotundifoliae 20 parts, east wind Fructus Citri tangerinae 16 parts, Litsea coreana 20 parts, Vicia unijuga 21 parts, Forsyihia viridissima Lindl 11 parts, Herba Peperomiae Dindygulensis 18 parts, Herba Lactucae versicoloris 21 parts, Herba pteridis vittatae 20 Part, Herba Melastomatis Candii 20 parts, phlegm-fire grass 16 parts, Herba Fragariae nilerrensis 14 parts, dish 12 parts and Herbia Wedeliae 24 parts.

When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder；

Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, with slow fire boiling, Decocting time is 3 hours～5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, the matter of the water added Amount is 2～4 times of the powder quality that the first step obtains；

3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～ 4 hours, filter obtain the second filtrate, the quality of the water added be second step obtain powder quality 2～ 4 times；

The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, decompression Concentrating and remove water, dry, pulverize into powder, granularity is 80～120 mesh；

5th step, in the powder that described 4th step obtains, adds starch, and described starch is at described powder In percentage by weight be 15%～30%, will mixing after material pouch or packing box subpackage, every 5～10 Gram it is one bag or a box subpackage.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is The mastic of 1.04～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

Beneficial effects of the present invention: the Chinese medicine associating conventional western medicine treatment affection by exopathogenic cold-wind profile that the present invention provides Paralysis, with strong points, it is effectively improved the therapeutic effect of Western medicine, cure rate is higher, has no side effect, simultaneously The untoward reaction of Western medicine can be reduced or eliminated.

Detailed description of the invention

The invention provides a kind of Chinese medicine treating affection by exopathogenic cold-wind profile paralysis, its raw medicinal material includes: stain Grass, Flos Gomphrenae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rhodomyrti, Herba Menthae Rotundifoliae, east wind Fructus Citri tangerinae, Litsea coreana, Vicia unijuga, Forsyihia viridissima Lindl, Herba Peperomiae Dindygulensis, Herba Lactucae versicoloris, Herba pteridis vittatae, Herba Melastomatis Candii, phlegm-fire grass, Herba Fragariae nilerrensis, dish and Herbia Wedeliae, Rhizoma Chuanxiong, Fructus Piperis, become mildewed Eurya plant leaf, Fructus Jujubae, Herba Menthae, Caulis Piperis Kadsurae, Flos Carthami and Nidus Vespae.

The pharmacology of various raw medicinal materials is as follows:

Herba Tricyrtis Pilosae: [another name] founds bamboo root (" Traditional Chinese Medicine in Sichuan will "), Fructus Cucumidis sativi dish, dredge hair Herba Tricyrtidis macropodae, Cucumber is fragrant, melon rice dish (" Shaanxi Chinese herbal medicine ").[source] is liliaceous plant pubescence Herba Tricyrtidis macropodae Herb.[nature and flavor] " Traditional Chinese Medicine in Sichuan will ": " puckery, property is put down, nontoxic ".[function cures mainly] " four River Chinese medicinal herbal ": " controlling the whole body to swell, sun stroke pain due to disorder of QI, heat attacking the pericardium and rubella pruritus ".[extracts] " in Medicine voluminous dictionary "

Flos Gomphrenae: [another name] Lagerstroemia indica L., a thousand pieces of gold is red, one hundred days are white, thousand white, Coriaria nepalensis, Luzon chrysanthemum, Boiling water flower, boiling water chrysanthemum, long-living flower, Aeschna melanictera Flos Celosiae Cristatae red, spherical, thousand days spoil.[source] medical material base Source: for inflorescence or the herb of amaranthaceous plant Flos Gomphrenae.[nature and flavor] are sweet；Micro-salty；Property flat.[return through] Lung；Liver Channel.[function cures mainly] relieving cough and asthma；Liver heat removing and eyesight improving；Removing toxic substances.Main cough；Asthma；One hundred days Cough；The nocturnal fretfulness in infants；Conjunctival congestion and swelling pain；Liver-heat is dizzy；Headache；Dysentery；Furuncle.[extracts] " China Book on Chinese herbal medicine "

Radix Seu Caulis Rhaphidophorae Decursivae: [another name] Cayratia trifolia (L.) Domin, Acer buergerianum Miq．, Malong head lobe, fly Scolopendra, Red Triangle region maple, big Leaf green grapes, little Radix Seu Caulis Rhaphidophorae Decursivae.[source] medical material Ji Yuan: climb rattan and Zhi Nan for vitaceae Folium Trapae precipice Root or the rattan of rattan is climbed on precipice.[nature and flavor] are pungent；Temperature.[function cures mainly] wind-damp dispelling；Dissipating blood stasis swells；Continuous muscle Bone.Main rheumatic arthritis；Traumatic injury congestive edema；Fracture；Burn；Ulcerative carbuncle is red and swollen.[extracts] " China is originally Grass "

Radix Rhodomyrti: [another name] downy rosemyrtle root, when Radix pyri, cutter lotus head, for many years sheet, root of trembling, many days, Tremble beer daughter root, tremble sound of sighing head.[source] medical material Ji Yuan: for myrtaceous of myrtle.[property Taste] acrid in the mouth；Sweet；Property flat.[function cures mainly] regulating QI to relieve pain；Dampness removing antidiarrheal；Passive stasis of blood hemostasis；Benefit Kidney nourishes blood.Main epigastric pain；Dyspepsia；Vomiting and diarrhoea dysentery；Hypochondriac pain；Abdominal mass；Mass in the abdomen；Metrorrhagia；Labor Hinder hemorrhage；Traumatic pain；Rheumatic arthralgia；Blood deficiency is weak；Lumbago due to renal deficiency；Knee joint is soft；Frequent micturition；Nebulousurine； Edema；Hernia；Carbuncle scrofula；Hemorrhoid；Burn.[extracts] " China's book on Chinese herbal medicine "

Herba Menthae Rotundifoliae: [another name] south Herba Menthae, yang invigorating dish, Mentha spicata L., Mentha viridis L, tomentosecalyx elsholtzia leaf, blood Herba Coriandri, Carnis Canitis Herba Menthae fragrant, false, wrinkle leaf Herba Menthae, savoury.[source] medical material Ji Yuan: stay for labiate The herb of Lan Xiang.[nature and flavor] acrid in the mouth；Slightly warm in nature.[function cures mainly] induces sweat；In with；Regulate the flow of vital energy.[pluck Record] " China's book on Chinese herbal medicine "

East wind Fructus Citri tangerinae: [another name] pin son, cow dung Fructus Citri tangerinae, Canis familiaris L. Fructus Citri tangerinae thorn.[source] is Rutaceae wine cake Platymiscium wine cake, is used as medicine with root and leaf.The whole year can adopt.Root is cleaned and is dried；Leaf dries in the shade standby or using fresh herb. [nature and flavor] are pungent, bitter, tepor.[function cures mainly] expelling pathogenic wind from the body surface, preventing phlegm from forming and stopping coughing, regulating QI to relieve pain.With In flu, headache, cough, bronchitis, malaria, stomachache, rheumatic arthritis, lumbago and skelalgia.[pluck Record] " whole nation Chinese herbal medicine compilation "

Litsea coreana: [another name] raises sub-Fructus Litseae pungentis, peeling maple, flower shell bavin.[source] medical material Ji Yuan: Root and peel of stem for canella Litsea coreana.[nature and flavor] are pungent；Bitter；Temperature.[return through] stomach；Spleen channel. [function cures mainly] warming middle-JIAO to relieve pain；Regulate the flow of vital energy row water.Main epigastric distending pain；Edema.[extracts] " China is originally Grass "

Vicia unijuga: [another name] two YEDOU Seedling, Radix seu Folium Viciae Unijugae, grass bean, vetch.[source] pulse family is wild Pisum plant Vicia unijuga, with all herbal medicine.Xia Qiu gathers, and dries.[nature and flavor] are sweet, flat.[merit Can cure mainly] qi-restoratives tune liver, regulating QI to relieve pain, clearing away heat and promoting diuresis.For dizziness, body is impractical swollen, stomachache；Outward With controlling furuncle furuncle.[extracts] " whole nation Chinese herbal medicine compilation "

Forsyihia viridissima Lindl: [another name] Fructus Hyperici belli.[source] medical material Ji Yuan: for Oleaceae plants Forsyihia viridissima Lindl Shell, root or leaf.[nature and flavor] are bitter；Cool in nature.[function cures mainly] heat clearing away；Removing toxic substances；Eliminating stagnation.Main sense Emit heating；Conjunctival congestion swells.[extracts] " China's book on Chinese herbal medicine "

Herba Peperomiae Dindygulensis: [another name] burn leaf, peppergrass, stone Semen Benincasae, SANYE are harvested, Radix Ardisiae Punctatae, Shi Macai, Herba Seu Radix Peperomiae Tetraphyllae, scattered blood gallbladder, Semen Phaseoli lobe, Semen Sojae Preparatum seven.[source] medical material Ji Yuan: for Piperaceae phytobezoar Cicadae The herb of grass.[nature and flavor] are pungent；Cool.[return through] lung；Spleen；Liver；Kidney channel.[function cures mainly] is clear Thermal detoxification；Blood stasis-eliminating and stagnation-dissipating；Inducing diuresis to remove edema.Main lung-heat cough with asthma；Measles；Sore；Cancerous protuberance；Burn and scald； Traumatic injury；Oedema due to nephritis.[extracts] " China's book on Chinese herbal medicine "

Herba Lactucae versicoloris: [another name] corn salad, narrow lettuce, northeast Herba Sonchi Oleracei, rabbit son's dish.[source] medical material Ji Yuan: Herb or root for feverfew Herba Lactucae versicoloris.[nature and flavor] bitter in the mouth；Cold in nature.[function cures mainly] heat-clearing and toxic substances removing. Main jaundice；Gastritis；Dysentery；Cough due to lung-heat；Intestinal produces swollen；Orchitis；Parent's skin ulcer；Carbuncle；Impetigo. [extracts] " China's book on Chinese herbal medicine "

Herba pteridis vittatae: [another name] Pteris vittata L, little cyrtomium fortunei, BAIYE point, Pteris vittata L, Rhizoma Osmundae, dalberga obtusifolia, Double-edged fine-toothed comb Herba pteridis vittatae careless, little, Rhizoma Cibotii, the licorice fern that comes into leaves, false aloe, little dalberga obtusifolia, Scolopendra connect, cut grass Sword, comb Lycopodium casuarinoides Spring careless, black.[source] medical material Ji Yuan: for the herb of Pteridaceae plant Herba pteridis vittatae Or rhizome.[nature and flavor] are light；Bitter；Cool.[return through] liver；Large intestine；Bladder warp.[function cures mainly] Expelling wind and removing dampness；Relaxing muscles and tendons and activating QI and blood in the collateral；Removing toxic substances parasite killing.The wet bones and muscles pain of main air；Lumbago；Limb fiber crops joint stuffiness； Hemiplegia；Traumatic injury；Flu；Dysentery；Acute mastitis；Sore；Scabies；Ascariasis；Serpentis is early bitten. [extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Herba Melastomatis Candii: [another name] pig Herba Linderniae Crustaceae, Catunaregam spinosa (Thunb.) Tirveng., Herba Melastomatis Candii, leopard tooth Lang Mu, HUOXUEDAN, high foot mountain Fall Soviet Union, gulp down a mouthful bar, felt bar, hair foot bar, balaustine, gold pomegranate, golden pheasant lower limb, pig are harvested, cattle Harvest, red quick-fried tooth wolf, tank switching foot careless, high are harvested, Pu pen young, nine spiral shell sons spend, do not stay row, great Du bridge, water Outer year, high foot Pu pears, large size sky kind stove.[source] medical material Ji Yuan: for Melastomateae plants Herba Melastomatis Candii Herb.[nature and flavor] sour in the mouth；Puckery；Cool in nature.[return through] returns spleen；Stomach；Lung；Liver Channel.[function Cure mainly] removing food stagnancy dampness removing, promoting blood circulation and hemostasis；Heat-clearing and toxic substances removing.Staple food amasss；Let out dysentery；Hepatitis；Outside treating swelling and pain by traumatic injury Hinder hemorrhage；Epistaxis；Hemoptysis；Spit blood；Have blood in stool；Menorrhagia；Metrorrhagia；Puerperal abdonimal pain；Leucorrhea；Breast Under main loop；Thromboangiitis；Acute appendicitis；Skin ulcer swells；Venom.[extracts] " China's book on Chinese herbal medicine "

Phlegm-fire grass: [another name] encloses JIACAO, cancer grass, QINGZHU mussel, blue or green Herba Commelinae.[source] medical material Ji Yuan: for the herb of Commelianaceae plant Murdannia bracteata (C. B. Clarke) O. UhtzeexJ. K. Mortoh.[nature and flavor] are sweet；Light；Cool.[function master Control] dissipating phlegm and resolving masses；Clearing heat and freeing strangury.Main scrofula sucutaneous nodule；Pyretic stranguria.[extracts] " China's book on Chinese herbal medicine "

Herba Fragariae nilerrensis: [another name] three wind, the wild poplar certain kind of berries, Fructus Fragariae Ananssae, BAIPAO youngster, the stem or leaf of cattail white, white, white The ground certain kind of berries.[source] medical material Ji Yuan: for the herb of rosaceous plant proso millet prolamin.[nature and flavor] are sweet, bitter； Cool.[return through] lung；Liver；Kidney channel.[function cures mainly] clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling.Main lung-heat is coughed Cough；Pertussis；Aphtha of the mouth and tongue；Furuncle；Venom, burn and scald [extracts] " China's book on Chinese herbal medicine "

Dish: [another name] peppery rice dish, sarson, pool Pueraria lobota dish, Herba Rorippae, Radix Loxostigmatis griffithii, Carnis Gallus domesticus dish, Field Pueraria lobota dish, Herba Rorippae, wild potherb mustard, wild mustard grass, wild herbs, barbarea, Du Gencai, chervil, Spun gold pod.[source] medical material Ji Yuan: for crucifer dish with without the herb of lobe.[nature and flavor] Acrid in the mouth；Bitter；Slightly warm in nature.[return through] lung；Liver Channel.[function cures mainly] expelling phlegm for arresting cough；Relieving exterior syndrome and dispelling cold； Promoting blood circulation and detoxication；Dampness removing jaundice eliminating.Main cough phlegm dyspnea；Cold, fever；Measles without adequate eruption；Rheumatic arthralgia； Laryngopharynx swelling and pain；Furuncle carbuncle；Dermatitis rhus；Amenorrhea；Traumatic injury；Jaundice；Edema.[extracts] " in China's book on Chinese herbal medicine "

Herbia Wedeliae: [another name] Flos Chrysanthemi Indici, Herba Kalimeridis grass, Sesarmae dehaani flower, water orchid, Herba Wedeliae Prostratae, Hemerocallis citrina Baroni dragon tongue Grass, Hemerocallis citrina Baroni Anacamptis pyromaidalis, liatris, Hemerocallis citrina Baroni ink dish, Herba Otteliae Alismoidis.[source] comes from " book on Chinese herbal medicine asks former ". [source] medical material Ji Yuan: for the herb of feverfew Herbia Wedeliae.[nature and flavor] mildly bitter flavor；Sweet；Cool in nature. [function cures mainly] heat-clearing and toxic substances removing；Cool the blood dissipate blood stasis.Main cold, fever；Pharyngolaryngitis；Tonsillitis；Rib gland Scorching；Diphtheria；Pertussis；Tracheitis；Pneumonia；Hemoptysis of pulmonary tuberculosis；Epistaxis；Hematuria；Infectious hepatitis； Dysentery；Hemorrhoid；Furuncle insane asylum toxic swelling.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Herba Tricyrtis Pilosae 15～25 parts, Flos Gomphrenae 20～30 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～20 parts, Radix Rhodomyrti 20～30 parts, Herba Menthae Rotundifoliae 15～25 parts, east Wind Fructus Citri tangerinae 10～20 parts, Litsea coreana 20～30 parts, Vicia unijuga 15～25 parts, Forsyihia viridissima Lindl 10～20 parts, stone Cicadae Grass 12～22 parts, Herba Lactucae versicoloris 20～30 parts, Herba pteridis vittatae 10～20 parts, Herba Melastomatis Candii 15～25 parts, phlegm-fire grass 10～ 20 parts, Herba Fragariae nilerrensis 10～20 parts, dish 5～15 parts and Herbia Wedeliae 20～30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 17～22 parts, Flos Gomphrenae 20～25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～15 parts, Radix Rhodomyrti 20～25 parts, Herba Menthae Rotundifoliae 18～ 23 parts, east wind Fructus Citri tangerinae 12～17 parts, Litsea coreana 20～25 parts, Vicia unijuga 17～22 parts, Forsyihia viridissima Lindl 10～15 Part, Herba Peperomiae Dindygulensis 15～20 parts, Herba Lactucae versicoloris 20～25 parts, Herba pteridis vittatae 15～20 parts, Herba Melastomatis Candii 18～23 parts, Phlegm-fire grass 12～17 parts, Herba Fragariae nilerrensis 13～18 parts, dish 8～13 parts and Herbia Wedeliae 22～27 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 21 parts, Flos Gomphrenae 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 14 parts, Radix Rhodomyrti 22 parts, Herba Menthae Rotundifoliae 23 parts, east wind Fructus Citri tangerinae 12 parts, Litsea coreana 24 parts, Vicia unijuga 18 parts, Forsyihia viridissima Lindl 14 parts, Herba Peperomiae Dindygulensis 16 parts, Herba Lactucae versicoloris 24 parts, Herba pteridis vittatae 16 Part, Herba Melastomatis Candii 22 parts, phlegm-fire grass 14 parts, Herba Fragariae nilerrensis 17 parts, dish 9 parts and Herbia Wedeliae 26 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Herba Tricyrtis Pilosae 18 parts, Flos Gomphrenae 24 parts, Radix Seu Caulis Rhaphidophorae Decursivae 12 parts, Radix Rhodomyrti 24 parts, Herba Menthae Rotundifoliae 20 parts, east wind Fructus Citri tangerinae 16 parts, Litsea coreana 20 parts, Vicia unijuga 21 parts, Forsyihia viridissima Lindl 11 parts, Herba Peperomiae Dindygulensis 18 parts, Herba Lactucae versicoloris 21 parts, Herba pteridis vittatae 20 Part, Herba Melastomatis Candii 20 parts, phlegm-fire grass 16 parts, Herba Fragariae nilerrensis 14 parts, dish 12 parts and Herbia Wedeliae 24 parts.

When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder；

Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, with slow fire boiling, Decocting time is 3 hours～5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, the matter of the water added Amount is 2～4 times of the powder quality that the first step obtains；

3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～ 4 hours, filter obtain the second filtrate, the quality of the water added be second step obtain powder quality 2～ 4 times；

The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, decompression Concentrating and remove water, dry, pulverize into powder, granularity is 80～120 mesh；

5th step, in the powder that described 4th step obtains, adds starch, and described starch is at described powder In percentage by weight be 15%～30%, will mixing after material pouch or packing box subpackage, every 5～10 Gram it is one bag or a box subpackage.

When the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, is molten with backflow Agent, with filtering residue as solute, uses percolation with the speed slowly percolation of per minute 1～2ml, collects percolation Liquid, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is The mastic of 1.04～1.10, is spray-dried, and the inlet temperature 160 of spray dryer～175 DEG C, goes out pathogenic wind-warm Spend 80～85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this Execute.

Embodiment 1: powder

Take Herba Tricyrtis Pilosae 210g, Flos Gomphrenae 200g, Radix Seu Caulis Rhaphidophorae Decursivae 140g, Radix Rhodomyrti 220g, Herba Menthae Rotundifoliae 230g, East wind Fructus Citri tangerinae 120g, Litsea coreana 240g, Vicia unijuga 180g, Forsyihia viridissima Lindl 140g, Herba Peperomiae Dindygulensis 160g, Herba Lactucae versicoloris 240g, Herba pteridis vittatae 160g, Herba Melastomatis Candii 220g, phlegm-fire grass 140g, Herba Fragariae nilerrensis 170g, dish 90g and Herbia Wedeliae 260g；

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder；

Second step, obtains the first step powder and adds immersion 10 hours in cold water, with slow fire boiling, decoct Time is 3 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, the quality of the water added is that the first step obtains 4 times of the powder quality obtained；

3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 4 hours, Filtering and obtain the second filtrate, the quality of the water added is 2 times of the powder quality that second step obtains；

The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, decompression Concentrating and remove water, dry, pulverize into powder, granularity is 100 mesh；

5th step, in the powder that described 4th step obtains, adds starch, and described starch is described Percentage by weight in powder is 20%, and by the material pouch subpackage after mixing, every 10 grams are one bag point Dress.

Embodiment 2: granule

Take Herba Tricyrtis Pilosae 180g, Flos Gomphrenae 240g, Radix Seu Caulis Rhaphidophorae Decursivae 120g, Radix Rhodomyrti 240g, Herba Menthae Rotundifoliae 200g, East wind Fructus Citri tangerinae 160g, Litsea coreana 200g, Vicia unijuga 210g, Forsyihia viridissima Lindl 110g, Herba Peperomiae Dindygulensis 180g, Herba Lactucae versicoloris 210g, Herba pteridis vittatae 200g, Herba Melastomatis Candii 200g, phlegm-fire grass 160g, Herba Fragariae nilerrensis 140g, dish 120g and Herbia Wedeliae 240g；

Its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, add relative to 6 times of mixture is pure and strong Degree is the ethanol of 95%, is heated to boiling reflux 4 hours, filters, with backflow as solvent, with filtering residue For solute, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, subsequently very Being evaporated to relative density when 55 DEG C under reciprocal of duty cycle 0.07Mpa is the mastic of 1.08, is spray-dried, spray The inlet temperature of mist drying machine 170 DEG C, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add the cane sugar powder and 0.1 relative to dried cream powder quality 0.2 times in the dried cream powder obtained Dextrin again, makes granule, is dried in 40 DEG C, it is thus achieved that granule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 22～30g, carries out acute poison Property test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, incite somebody to action this The Chinese powder medicine of inventive embodiment 1 preparation is dissolved in water, and (concentration is 7.28g crude drug/ml, the highest Concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 36.4 crude drugs/kg), comparison Group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, sees continuously after administration Examine 14 days, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, After administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, Body weight increases the most normal.Powder LD50 > 36.4 crude drugs/the kg of the Mouse oral gavage present invention, every day is maximum Dosage is 72.8 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is 6.4g crude drug/day/people, Adult's body weight is in terms of 60KG, and average dosage is 0.107g crude drug/kg/ day.By weighing machine: mice As quantity 680 times of the dosis tolerata of the Chinese medicine of (average weight is in terms of 26g) oral administration gavage present invention. Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: three groups of mices (often group 20) are pressed 12.18,21.32 by Chinese powder medicine of the present invention With 38.26g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks After, result shows: Chinese medicine of the present invention to the hair of rat, behavior, defecation, body weight, organ weights, The indexs such as hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not find difference Change and histological indications show, after medication 15 weeks and drug withdrawal 4 weeks, each internal organs of rat are all without obvious Change.Illustrate that Chinese medicine of the present invention is little to toxicity after rat long-term prescription, after drug withdrawal, also there is no difference reaction, Application safety.

Clinical data:

Case selection: whole 120 example cases are my institute patient, male 68 people, women 52 people, year Age 22～65 years old；Fall ill 1～10 day.All patients are randomly divided into two groups, wherein, and treatment group 60 example, Man 35 examples, female 25 example, age 22-63 year；Fall ill 1～10 day.Matched group 60 example, male 33 examples, Female 27 example, age 23-65 year；Fall ill 1～10 day.Treatment group and matched group at sex, age, send out The sick each side such as time and clinical symptoms performance compares no significant difference, has comparability.

Diagnostic criteria: meet following Western medicine diagnose standard and Syndrome Types of TCM standard.

Western medicine diagnose standard: " clinical disease diagnosis and the Outcome measure write with reference to hospital associate of Hunan Province Standard " prosopoplegic diagnostic criteria in (Wang Weiwen chief editor).

Syndrome Types of TCM standard: affection by exopathogenic cold-wind: suddenly facial hemiparalysis, the tight contracture in face, wooden do not relax, or wink Mesh is shed tears, and anemophobia is lossless, has blowing process of suffering from cold, light red tongue, white and thin fur, floating and tense pulse or floating slow more.

Therapeutic Method:

Matched group: give cefalexin capsule, each 1 (0.25g) three times a day；Prednisolone acetate Sheet, each 2 (10mg), three times a day；Vitamin B₁Sheet, each 2 (20mg), every day 3 times；Bendazol Tablets, each 1 (10mg), three times a day；Within 2 weeks, it is 1 course for the treatment of, treats 2 The individual course for the treatment of.

Treatment group: take the powder of the embodiment of the present invention 1,2 bags/time (every bag on the basis of matched group 10g), 3 times/day；Within 2 weeks, it is 1 course for the treatment of, treats 2 courses for the treatment of.

Curative effect judging standard: use H-B grade scale.Recovery from illness: reach H-B I grade, bilateral volume stricture of vagina, nose Labial groove recovers symmetry, closes one's eyes normal, and during the drum cheek, bicker is air tight, show tooth without crooked, facial expression is normal； Effective: to reach H-B II grade, i.e. bilateral volume stricture of vagina and nasolabial fold almost symmetry, eye Guan Bi is owed real, is seen when showing tooth Bicker is the most asymmetric, and during the drum cheek, bicker is air tight；Take a turn for the better: be improved as after treatment by H-B IV～VI grade More than III grade；Invalid: to remain in H-B after treatment more than IV grade.

Therapeutic outcome: after two groups are treated two courses for the treatment of respectively, curative effect see table.

Group	Number of cases	Recovery from illness	Effective	Take a turn for the better	Invalid	Total effective rate
							Treatment group	60	55	3	2	0	55 (100%)
Matched group	60	41	7	5	7	53 (88.3%)

By upper table, treatment group curative effect is higher than matched group, Chinese Medicine and Clavicular doctor trained in Western medicine routine medicine the most of the present invention Thing can be effectively improved the therapeutic effect of Western medicine.

Untoward reaction: matched group 60 example patient, in therapeutic process, there is Nausea and vomiting, appetite in 4 examples Depressed waiting gastrointestinal upset, there is mild headache in 1 example, hepatic and renal function injure does not all occur or other are bad Reaction., in therapeutic process, all there is not gastrointestinal upset, hepatic and renal function injure in treatment group 60 example patient Or other untoward reaction.

Concrete case: permitted certain, male, 49 years old, went out before 2 days, because dry monsoon is big, mouth occurs suddenly Eye is crooked, does not alleviates, see a doctor to hospital after 2 days.Disease sees unexpected facial hemiparalysis, the tight contracture in face, wooden Not relaxing, anemophobia is lossless, light red tongue, white and thin fur, floating and tense pulse, makes a definite diagnosis and typing is wind and cold through clinical examination Attack outward profile paralysis.Give cefalexin capsule, prednisone acetate tablets, vitamin B₁Sheet, Bendazol Tablets with And the embodiment of the present invention 1 powder, treat healing in 3 weeks, follow up a case by regular visits to 3 months not recur.

The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention, Still fall within the protection domain of technical solution of the present invention.

Claims (9)

1. the Chinese medicine treating affection by exopathogenic cold-wind profile paralysis, it is characterized in that, described Chinese medicine includes following raw medicinal material: Herba Tricyrtis Pilosae, Flos Gomphrenae, Radix Seu Caulis Rhaphidophorae Decursivae, Radix Rhodomyrti, Herba Menthae Rotundifoliae, east wind Fructus Citri tangerinae, Litsea coreana, Vicia unijuga, Forsyihia viridissima Lindl, Herba Peperomiae Dindygulensis, Herba Lactucae versicoloris, Herba pteridis vittatae, Herba Melastomatis Candii, phlegm-fire grass, Herba Fragariae nilerrensis, dish and Herbia Wedeliae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Tricyrtis Pilosae 15～25 parts, Flos Gomphrenae 20～30 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～20 parts, Radix Rhodomyrti 20～30 parts, Herba Menthae Rotundifoliae 15～25 parts, east wind Fructus Citri tangerinae 10～20 parts, Litsea coreana 20～30 parts, Vicia unijuga 15～25 parts, Forsyihia viridissima Lindl 10～20 parts, Herba Peperomiae Dindygulensis 12～22 parts, Herba Lactucae versicoloris 20～30 parts, Herba pteridis vittatae 10～20 parts, Herba Melastomatis Candii 15～25 parts, phlegm-fire grass 10～20 parts, Herba Fragariae nilerrensis 10～20 parts, dish 5～15 parts and Herbia Wedeliae 20～30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Tricyrtis Pilosae 17～22 parts, Flos Gomphrenae 20～25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 10～15 parts, Radix Rhodomyrti 20～25 parts, Herba Menthae Rotundifoliae 18～23 parts, east wind Fructus Citri tangerinae 12～17 parts, Litsea coreana 20～25 parts, Vicia unijuga 17～22 parts, Forsyihia viridissima Lindl 10～15 parts, Herba Peperomiae Dindygulensis 15～20 parts, Herba Lactucae versicoloris 20～25 parts, Herba pteridis vittatae 15～20 parts, Herba Melastomatis Candii 18～23 parts, phlegm-fire grass 12～17 parts, Herba Fragariae nilerrensis 13～18 parts, dish 8～13 parts and Herbia Wedeliae 22～27 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Tricyrtis Pilosae 21 parts, Flos Gomphrenae 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 14 parts, Radix Rhodomyrti 22 parts, Herba Menthae Rotundifoliae 23 parts, east wind Fructus Citri tangerinae 12 parts, Litsea coreana 24 parts, Vicia unijuga 18 parts, Forsyihia viridissima Lindl 14 parts, Herba Peperomiae Dindygulensis 16 parts, Herba Lactucae versicoloris 24 parts, Herba pteridis vittatae 16 parts, Herba Melastomatis Candii 22 parts, phlegm-fire grass 14 parts, Herba Fragariae nilerrensis 17 parts, dish 9 parts and Herbia Wedeliae 26 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Tricyrtis Pilosae 18 parts, Flos Gomphrenae 24 parts, Radix Seu Caulis Rhaphidophorae Decursivae 12 parts, Radix Rhodomyrti 24 parts, Herba Menthae Rotundifoliae 20 parts, east wind Fructus Citri tangerinae 16 parts, Litsea coreana 20 parts, Vicia unijuga 21 parts, Forsyihia viridissima Lindl 11 parts, Herba Peperomiae Dindygulensis 18 parts, Herba Lactucae versicoloris 21 parts, Herba pteridis vittatae 20 parts, Herba Melastomatis Candii 20 parts, phlegm-fire grass 16 parts, Herba Fragariae nilerrensis 14 parts, dish 12 parts and Herbia Wedeliae 24 parts.

6. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder；

Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, and with slow fire boiling, decocting time is 3 hours～5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, and the quality of the water added is 2～4 times of the powder quality that the first step obtains；

3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water added is 2～4 times of the powder quality that second step obtains；

The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry, pulverize into powder, and granularity is 80～120 mesh；

5th step, in the powder that described 4th step obtains, adds starch, and described starch percentage by weight in described powder is 15%～30%, and by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.

7. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is granule, it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～8 times, it is heated to boiling reflux 3～5 hours, filter, with backflow as solvent, with filtering residue as solute, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is the mastic of 1.04～1.10, it is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, make granule, is dried in 40～50 DEG C, it is thus achieved that granule.

8. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder；

Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, and with slow fire boiling, decocting time is 3 hours～5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, and the quality of the water added is 2～4 times of the powder quality that the first step obtains；3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water added is 2～4 times of the powder quality that second step obtains；

The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry, pulverize into powder, and granularity is 80～120 mesh；

5th step, in the powder that described 4th step obtains, adds starch, and described starch percentage by weight in described powder is 15%～30%, and by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.

9. the Chinese medicine described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is granule, it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85%～95% relative to mixture 4～8 times, it is heated to boiling reflux 3～5 hours, filter, with backflow as solvent, with filtering residue as solute, use percolation with per minute 1～2ml speed slowly percolation, collect percolate, when being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is the mastic of 1.04～1.10, it is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times and the dextrin of 0.1～0.2 times in the dried cream powder obtained, make granule, is dried in 40～50 DEG C, it is thus achieved that granule.