CN105918644A - Feed additive for control of goldfish fin rot disease and preparation method thereof - Google Patents
Feed additive for control of goldfish fin rot disease and preparation method thereof Download PDFInfo
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- CN105918644A CN105918644A CN201510667887.4A CN201510667887A CN105918644A CN 105918644 A CN105918644 A CN 105918644A CN 201510667887 A CN201510667887 A CN 201510667887A CN 105918644 A CN105918644 A CN 105918644A
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- feed additive
- amoxicillin
- erythromycin
- gill rot
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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Abstract
The invention discloses a feed additive for control of the goldfish fin rot disease and a preparation method thereof. The feed additive is mainly made from the following raw materials by weight: 5-10 parts of plantain, 1-2 parts of roxburgh anoectochilus terminal bud, 3-5 parts of Houttuynia, 15-25 parts of Bupleurum, 3-5 parts of Bezoar, 7-15 parts of honeysuckle, 3-7 parts of lily, 3-7 parts of rhubarb, 3-7 parts of ofloxacin, 1-3 parts of erythromycin and 4-6 parts of amoxicillin. The feed additive for control of the goldfish fin rot disease can improve the immune and antiviral ability of the goldfish, reduce the infection rate of the bacterial virus of the fin rot disease and improve the prevention and control effect of the fin rot disease. The feed additive has the advantages of convenient medication, high absorption rate, no drug residue, and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Carassius auratus gill rot feed additive and preparation method thereof, belong to veterinary medicament compositions and preparation method thereof field.
Background technology
The gill is the respiratory apparatus of Carassius auratus, is in more sensitive position in Carassius auratus body, participates in functional metabolism, has function of carrying oxygen, serves the important function such as coordination, support in the whole vital movement of Carassius auratus.So once the gill portion of Carassius auratus occurs pathological changes, each histoorgan of whole body will be affected normal physiological function by its effect, even results in the death of Carassius auratus time serious.Gill rot is that a kind of propagated the course of disease is long by force, and relatively common Carassius auratus disease controls it once morbidity dyschezia and spreads, and this sick infection velocity is fast, and mortality rate is high.
The chemicals of the existing Carassius auratus gill rot for the treatment of on the market is difficult to reach long-term treatment and preventive effect, for this, treat Carassius auratus gill rot to need main attention to be placed in prevention, in addition to actively improving breeding environment and inoculating various vaccines, also will in breeding process the immunity of conscious raising animal body, anti-virus ability, thus reduce the infection probability of gill rot bacterial virus.
Summary of the invention
It is an object of the invention to provide a kind of immunity of organisms of Carassius auratus, anti-virus ability of improving, reduce the infection probability of gill rot bacterial virus and the feed additive improving gill rot prevention effect and preparation method thereof.
Gill rot feed additive of the present invention is mainly prepared by the raw materials in: Herba Plantaginis 5-10 part; Herba Anoectochili roxburghii 1-2 part; Herba Houttuyniae 3-5 part; Radix Bupleuri 15-25 part, Calculus Bovis 3-5 part, Flos Lonicerae 7-15 part, Bulbus Lilii 3-7 part, Radix Et Rhizoma Rhei 3-7 part, ofloxacin 3-7 part; erythromycin 1-3 part, amoxicillin 4-6 part.
It is preferably: Herba Plantaginis 8 parts, Herba Anoectochili roxburghii 1.5 parts, Herba Houttuyniae 4 parts, Radix Bupleuri 18 parts, Calculus Bovis 4 parts, Flos Lonicerae 10 parts, Bulbus Lilii 5 parts, Radix Et Rhizoma Rhei 5 parts, ofloxacin 5 parts, 2 parts of erythromycin, 5 parts, amoxicillin.
The preparation method of gill rot feed additive of the present invention, comprises the following steps:
Each raw material is weighed by described weight portion；
The 100 degree of boiling water that added water by raw material outside deoxygenation Flucloxacillin, erythromycin and amoxicillin decoct twice, and each amount of water flooded raw material face, merges twice decocting liquid, filters to get filtrate, and was spray-dried to obtain powder；
Add the ofloxacin crossing 200 mesh sieves, erythromycin and amoxicillin powder, after mixing thoroughly, i.e. obtain Carassius auratus gill rot feed additive.
The present invention selects above-mentioned raw materials combination to make each component and effect produce synergism such that it is able to improve the immunity of organisms of Carassius auratus, resistance against diseases, reduces the infection probability of gill rot bacterial virus and improves gill rot prevention effect.
The primary raw material wherein selected and major function thereof
| Composition | Composition function and characteristic |
| Herba Plantaginis | Pathogenic wind toxic, the liver affected by pathogenic wind heat can be gone, remove irritable feverish sensation of chest and heart. |
| Herba Anoectochili roxburghii | Contained by it, taurine, polysaccharide composition have nutrition, nourishing and protecting liver, the effect of regulation immunity of organism. |
| Herba Houttuyniae | Herba Houttuyniae acrid in the mouth, cold, this product has the effects such as antibacterial, antiviral, raising immunity of organisms. |
| Radix Bupleuri | Radix Bupleuri nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating. |
| Calculus Bovis | Calculus Bovis gas delicate fragrance, mildly bitter flavor is the sweetest, cool in nature.Can be used for antipyretic, removing toxic substances. |
| Flos Lonicerae | Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison. |
| Bulbus Lilii | Clearing away heart-fire for tranquillization.After calentura, waste heat comes clear. |
| Radix Et Rhizoma Rhei | Belonging to purgatives medicine, discharge function is relatively slow and is longer than eliminating fire and detoxication, eliminating damp-heat. |
| Ofloxacin | Ofloxacin is antibacterial, by acting on the A subunit of DNA of bacteria helicase, the suppression synthesis of DNA and duplication and cause bacterial death. |
| Erythromycin | Antimicrobial spectrum approximation penicillin, Yang Shi bacterium such as S. aureus L-forms (include penicillin resistant bacterial strain) blue to leather, streptococcus pneumoniae, streptococcus, anthrax bacillus, erysipelothrix porci, listeria spp, corrupt rib bacterium, clostridium chauvei etc. all have stronger antibacterial action. |
| Amoxicillin | Amoxicillin, has another name called amoxicillin or Amoxicillin, is a kind of the most frequently used semi-synthetic penicillins wide spectrum beta-lactam antibiotic, and amoxicillin bactericidal action is strong, and the ability of permeates cell membranes is the strongest. |
Gill rot feed additive of the present invention has heat-clearing and toxic substances removing, collaborative counteracting toxic substances, anti-inflammation, blood stasis dispersing and deswelling, presses down and kills the virus, prevents accompanying infection.Multiple gill rot virus, fungus, mycete, antibacterial can be killed, the growth breeding of suppression and eliminating pathogen, improve body immune system, promote physical recovery, can substantially mitigation symptoms, symptom management deteriorate the most at the initial stage of a disease, make Carassius auratus produce immunity, prevent the generation of Carassius auratus gill rot, the gill rot etc. sent out also is had the strongest therapeutical effect.And convenient drug administration, absorbance is high, and drug residue free has no side effect.
Gill rot feed additive of the present invention can be thrown something and fed by 1.0% (i.e. 100g feed additive of the present invention is mixed in the 10 kg diet) feedstuff that stirs.Even feeding 5-7 days, serious symptom can suitably strengthen consumption.
Detailed description of the invention
Embodiment one: prepared by gill rot feed additive 1 of the present invention
Weigh Herba Plantaginis 5 grams, Herba Anoectochili roxburghii 1 gram, Herba Houttuyniae 3 grams, Radix Bupleuri 15 grams, Calculus Bovis 3 grams, Flos Lonicerae 7 grams, Bulbus Lilii 3 grams, Radix Et Rhizoma Rhei 3 grams, ofloxacin 3 grams, 1 gram of erythromycin, 4 grams, amoxicillin.
By the raw material boiling outside deoxygenation Flucloxacillin, erythromycin and amoxicillin twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain 6.0 grams of powder；
Add the ofloxacin weighed, erythromycin and amoxicillin powder, after mixing thoroughly, i.e. obtain gill rot feed additive 1.
Embodiment two: prepared by gill rot feed additive 2 of the present invention
Weigh Herba Plantaginis 8 grams, Herba Anoectochili roxburghii 1.5 grams, Herba Houttuyniae 4 grams, Radix Bupleuri 18 grams, Calculus Bovis 4 grams, Flos Lonicerae 10 grams, Bulbus Lilii 5 grams, Radix Et Rhizoma Rhei 5 grams, ofloxacin 5 grams, 2 grams of erythromycin, 5 grams, amoxicillin.
By the raw material boiling outside deoxygenation Flucloxacillin, erythromycin and amoxicillin twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain 9.0 grams of powder；
Add the ofloxacin weighed, erythromycin and amoxicillin powder, after mixing thoroughly, i.e. obtain gill rot feed additive 2.
Embodiment three: prepared by gill rot feed additive 3 of the present invention
Weigh Herba Plantaginis 10 grams, Herba Anoectochili roxburghii 2 grams, Herba Houttuyniae 5 grams, Radix Bupleuri 25 grams, Calculus Bovis 5 grams, Flos Lonicerae 15 grams, Bulbus Lilii 7 grams, Radix Et Rhizoma Rhei 7 grams, ofloxacin 7 grams, 3 grams of erythromycin, 6 grams, amoxicillin.
By the raw material boiling outside deoxygenation Flucloxacillin, erythromycin and amoxicillin twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain powder 12g；
Add the ofloxacin weighed, erythromycin and amoxicillin powder, after mixing thoroughly, i.e. obtain gill rot feed additive 3.
Embodiment four: the feed additive of the present invention preventive effect to Carassius auratus gill rot
Take healthy children Carassius auratus 250, it is divided into 5 groups at random, often group 50, suffering from gill rot Carassius auratus often organizing addition 5 in fish, after feeding three days, 1 group is continued normal nursing in every day, 2 groups add the medicine amoxicillin that feedstuff weighs the commercially available treatment gill rot of 1%, 3 groups add feedstuff weigh 1% feed additive Isosorbide-5-Nitrae group of the present invention add feedstuff weigh 1% feed additive of the present invention 2,5 groups add feedstuff weigh 1% feed additive of the present invention 3.Feeding process is observed the growth of Carassius auratus and dead, infection conditions, observes two weeks.
The results are shown in Table 1.Result shows, in Carassius auratus feeding process, gill rot mortality rate is up to 40% under normal circumstances, infection rate 90%；And existing the most commercially available drug deaths rate is up to 16%, infection rate 46%, gill rot is had certain anti-preact；And feed additive of the present invention can make gill rot mortality rate drop to 6-8%, infection rate 20-26%, can significantly prevent death and the infection effect of Carassius auratus gill rot.
The table 1 feed additive of the present invention gill rot preventive effect to Carassius auratus
| Group number | 1 group | 2 groups | 3 groups | 4 groups | 5 groups |
| Death toll | 20 | 8 | 4 | 3 | 3 |
| Infect number | 25 | 15 | 8 | 7 | 10 |
| Healthy number | 5 | 27 | 38 | 40 | 37 |
| Mortality rate | 40% | 16% | 8% | 6% | 6% |
| Infection rate | 90% | 46% | 24% | 20% | 26% |
Claims (3)
1. one kind is used for preventing and treating Carassius auratus gill rot feed additive, it is characterised in that it is made up of the crude drug of following weight portion: Herba Plantaginis 5-10 part, Herba Anoectochili roxburghii 1-2 part, Herba Houttuyniae 3-5 part, Radix Bupleuri 15-25 part, Calculus Bovis 3-5 part, Flos Lonicerae
7-15 part, Bulbus Lilii 3-7 part, Radix Et Rhizoma Rhei 3-7 part, ofloxacin 3-7 part, erythromycin 1-3 part, amoxicillin 4-6 part.
2. gill rot feed additive as claimed in claim 1, it is characterised in that the consumption of crude drug is: Herba Plantaginis 8 parts, Herba Anoectochili roxburghii 1.5 parts; Herba Houttuyniae 4 parts; Radix Bupleuri 18 parts, Calculus Bovis 4 parts, Flos Lonicerae 10 parts, Bulbus Lilii 5 parts, Radix Et Rhizoma Rhei 5 parts, ofloxacin 5 parts, 2 parts of erythromycin, 5 parts, amoxicillin.
3. the preparation method of gill rot feed additive as claimed in claim 1 or 2, comprises the following steps:
(1) each raw material is weighed by described weight portion；
(2) the 100 degree of boiling water that added water by the raw material outside deoxygenation Flucloxacillin, erythromycin and amoxicillin decoct twice, and each amount of water flooded raw material face, merges twice decocting liquid, filters to get filtrate, and was spray-dried to obtain powder；
(3) add the ofloxacin of 200 mesh sieves, erythromycin and amoxicillin powder, after mixing thoroughly, i.e. obtain Carassius auratus gill rot feed additive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510667887.4A CN105918644A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of goldfish fin rot disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510667887.4A CN105918644A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of goldfish fin rot disease and preparation method thereof |
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| CN105918644A true CN105918644A (en) | 2016-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510667887.4A Pending CN105918644A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of goldfish fin rot disease and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578667A (en) * | 2016-11-25 | 2017-04-26 | 全椒县花溪湖特种水产专业合作社 | Feed capable of preventing and treating gill rot disease of mandarin fish |
| CN106729116A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating grass carp fin rot |
| CN106728670A (en) * | 2016-12-08 | 2017-05-31 | 浙江百寿堂药业有限公司 | A kind of goldfish loses the preventing and treating medicine of fish glue disease |
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| CN101670015A (en) * | 2009-09-17 | 2010-03-17 | 天津生机集团股份有限公司 | Composite for treating shrimp bacterial disease and preparation method thereof |
| CN102716247A (en) * | 2012-06-28 | 2012-10-10 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for preventing and treating bacterial gill rotting disease and preparation method thereof |
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2015
- 2015-10-16 CN CN201510667887.4A patent/CN105918644A/en active Pending
Patent Citations (5)
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| CN101670015A (en) * | 2009-09-17 | 2010-03-17 | 天津生机集团股份有限公司 | Composite for treating shrimp bacterial disease and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578667A (en) * | 2016-11-25 | 2017-04-26 | 全椒县花溪湖特种水产专业合作社 | Feed capable of preventing and treating gill rot disease of mandarin fish |
| CN106728670A (en) * | 2016-12-08 | 2017-05-31 | 浙江百寿堂药业有限公司 | A kind of goldfish loses the preventing and treating medicine of fish glue disease |
| CN106729116A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating grass carp fin rot |
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Application publication date: 20160907 |