CN105920377A - Feed additive for control of soft-shelled turtle putred-skin disease and preparation method thereof - Google Patents
Feed additive for control of soft-shelled turtle putred-skin disease and preparation method thereof Download PDFInfo
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- CN105920377A CN105920377A CN201510667905.9A CN201510667905A CN105920377A CN 105920377 A CN105920377 A CN 105920377A CN 201510667905 A CN201510667905 A CN 201510667905A CN 105920377 A CN105920377 A CN 105920377A
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Abstract
The invention discloses a feed additive for control of the soft-shelled turtle putred-skin disease and a preparation method thereof. The feed additive is mainly made from the following raw materials by weight: 5-8 parts of lophatherum gracile, 1-2 parts of ephedra, 3-5 parts of semen litchi, 10-20 parts of Bupleurum, 3-5 parts of Momordica grosvenori, 10-15 parts of honeysuckle, 3-7 parts of rose, 1-2 parts of calcium carbonate, 1-2 parts of wild hawthorn, 3-7 parts of diallyl disulfide and diallyl trisulfide, 1-3 parts of azithromycin, and 1-2 parts of acetaminophen. The feed additive for control of the soft-shelled turtle putred-skin disease can improve the immune and antiviral ability of the soft-shelled turtle, reduce the infection rate of the bacterial virus of the putred-skin disease and improve the prevention and control effect of the putred-skin disease. The feed additive has the advantages of convenient medication, high absorption rate, no drug residue, and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of rotten-skin diseases of trionyx sinensis feed additive and preparation method thereof, belong to veterinary medicament compositions and preparation method thereof field.
Background technology
Rotten-skin diseases of trionyx sinensis is infected by pseudomonas bacillus and causes.Because stocking density is relatively big, Testudinis baits mutually, after pathogenic bacteria invades, causes injury skin histology downright bad.Rotten-skin diseases of trionyx sinensis is owing to breeding environment deteriorates, the phenomenon such as chafing that Trionyx sinensis Wiegmann bacterial infection causes, edema, skin hemorrhage, red, bark rot, is referred to as beancurd sheet, is the frequently-occurring disease of Trionyx sinensis Wiegmann.Often mix generation with enteritis disease, cause more death, carry out the biggest loss to breeding soft-shell turtle industrial belt.Ill rear Trionyx sinensis Wiegmann food ration reduces, becomes thin, and death then occurs.Summer is this sick multiple season, and its pathogen is gram negative bacteria.Water quality deterioration, ammonia nitrogen amount is high, and dissolved oxygen is not enough；Water temperature is high, and the temperature difference is big；The reasons such as stocking density is high, mismanagement, wound cause soft-shelled turtle nourishing bad, immunity degradation, bacterial infection and fall ill.
The existing chemicals treating rotten-skin diseases of trionyx sinensis on the market is difficult to reach long-term treatment and preventive effect, it is an object of the invention to provide a kind of immunity of organisms of Trionyx sinensis Wiegmann, anti-virus ability of improving, reduce the infection probability of skin fester disease bacterial virus and the feed additive improving skin fester disease prevention effect and preparation method thereof.
Summary of the invention
It is an object of the invention to provide a kind of immunity of organisms of Trionyx sinensis Wiegmann, anti-virus ability of improving, reduce the infection probability of skin fester disease bacterial virus and the feed additive improving skin fester disease prevention effect and preparation method thereof.
Skin fester disease feed additive of the present invention is mainly prepared by the raw materials in: Herba Lophatheri 5-8 part, Herba Ephedrae 1-2 part, Semen Litchi 3-5 part, Radix Bupleuri 10-20 part, Fructus Momordicae 3-5 part, Flos Lonicerae 10-15 part, Flos Rosae Rugosae 3-7 part, calcium carbonate 1-2 part, Crataegi cuneatae 1-2 part, thioether sand star 3-7 part, azithromycin 1-3 part, acetaminophen 1-2 part.
It is preferably: Herba Lophatheri 6 parts, 1.5 parts of Herba Ephedrae, Semen Litchi 4 parts, Radix Bupleuri 15 parts, Fructus Momordicae 4 parts, Flos Lonicerae 12 parts, Flos Rosae Rugosae 5 parts, calcium carbonate 1.5 parts, Crataegi cuneatae 1.5 parts, 5 parts of thioether sand star, azithromycin 2 parts, acetaminophen 1.5 parts.
The preparation method of skin fester disease feed additive of the present invention, comprises the following steps:
Each raw material is weighed by described weight portion；
By sulphur removal ether sand star, add water 100 degree of boiling water of the raw material outside azithromycin and acetaminophen decoct twice, and each amount of water flooded raw material face, merges twice decocting liquid, filters to get filtrate, and was spray-dried to obtain powder；
Add the thioether sand star crossing 200 mesh sieves, azithromycin and acetaminophen powder, after mixing thoroughly, i.e. obtain rotten-skin diseases of trionyx sinensis feed additive.
The present invention selects above-mentioned raw materials combination to make each component and effect produce synergism such that it is able to improve the immunity of organisms of Trionyx sinensis Wiegmann, resistance against diseases, reduces the infection probability of skin fester disease bacterial virus and improves skin fester disease prevention effect.
The primary raw material wherein selected and major function thereof
| Herba Lophatheri | Herba Lophatheri has effect of clearing heat and relieving fidgetness, diuresis, kills small worm, heat extraction delays the functions such as spleen. |
| Herba Ephedrae | Diaphoresis is dispeled cold, inducing diuresis to remove edema, improves immunity of organisms. |
| Semen Litchi | Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving. |
| Radix Bupleuri | Radix Bupleuri is conventional diaphoretic medicine.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating. |
| Fructus Momordicae | Its primary efficacy is bactericidal antiphlogistic, promotes immunity of organisms, containing abundant vitamin C and glucoside, fructose, glucose, protein, lipid etc.. |
| Flos Lonicerae | Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil. |
| Flos Rosae Rugosae | Flos Rosae Rugosae sweet and slightly bitter taste, slightly warm in nature, return liver, spleen, stomach warp. |
| Calcium carbonate | Nano-calcium carbonate can increase feedstuff calcium content as calsium supplement in feedstuff industry. |
| Crataegi cuneatae | Invigorating Qi, strengthening the spleen and nourishing the stomach, clearing away heart-fire for tranquillization. |
| Thioether sand star | Thioether sand star has original killing action to fungus, Aeromonas hydrophila, Vibrio anguillarum, tarda and Cytophaga Columnaris is had good killing action simultaneously. |
| Azithromycin | There is good antibacterial and anti-inflammation functions, micrococcus scarlatinae, blood bacillus, mycoplasma can be killed. |
| Acetaminophen | Having antipyretic effect, can diminish inflammation disoperation. |
Skin fester disease feed additive of the present invention has heat-clearing and toxic substances removing, works in coordination with counteracting toxic substances, anti-inflammation, presses down effects such as killing the virus.Multiple skin fester disease virus, fungus, mycete, antibacterial can be killed, the growth breeding of suppression and eliminating pathogen, improve body immune system, promote physical recovery, can substantially mitigation symptoms, symptom management deteriorate the most at the initial stage of a disease, make Trionyx sinensis Wiegmann produce immunity, prevent the generation of rotten-skin diseases of trionyx sinensis, the skin fester disease etc. sent out also is had the strongest therapeutical effect.And convenient drug administration, absorbance is high, and drug residue free has no side effect.
Skin fester disease feed additive of the present invention can be thrown something and fed by 0.5% (i.e. 50g feed additive of the present invention is mixed in the 10 kg diet) feedstuff that stirs.Even feeding 7-14 days, serious symptom can suitably strengthen consumption.
Detailed description of the invention
Embodiment one: prepared by skin fester disease feed additive 1 of the present invention
Weigh Herba Lophatheri 5 grams, 1 gram of Herba Ephedrae, Semen Litchi 3 grams, Radix Bupleuri 10 grams, Fructus Momordicae 3 grams, Flos Lonicerae 10 grams, Flos Rosae Rugosae 3 grams, calcium carbonate 1 gram, Crataegi cuneatae 1 gram, 3 grams of thioether sand star, azithromycin 1 gram, acetaminophen 1 gram.
By sulphur removal ether sand star, the raw material boiling outside azithromycin and acetaminophen twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain 3.0 grams of powder；
Add the thioether sand star weighed, azithromycin and acetaminophen powder, after mixing thoroughly, i.e. obtain skin fester disease feed additive 1.
Embodiment two: prepared by skin fester disease feed additive 2 of the present invention
Weigh Herba Lophatheri 6 grams, 1.5 grams of Herba Ephedrae, Semen Litchi 4 grams, Radix Bupleuri 15 grams, Fructus Momordicae 4 grams, Flos Lonicerae 12 grams, Flos Rosae Rugosae 5 grams, calcium carbonate 1.5 grams, Crataegi cuneatae 1.5 grams, 5 grams of thioether sand star, azithromycin 2 grams, acetaminophen 1.5 grams.
By sulphur removal ether sand star, the raw material boiling outside azithromycin and acetaminophen twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain 4.0 grams of powder；
Add the thioether sand star weighed, azithromycin and acetaminophen powder, after mixing thoroughly, i.e. obtain skin fester disease feed additive 2.
Embodiment three: prepared by skin fester disease feed additive 3 of the present invention
Weigh Herba Lophatheri 8 grams, 2 grams of Herba Ephedrae, Semen Litchi 5 grams, Radix Bupleuri 20 grams, Fructus Momordicae 5 grams, Flos Lonicerae 15 grams, Flos Rosae Rugosae 7 grams, calcium carbonate 2 grams, Crataegi cuneatae 2 grams, 7 grams of thioether sand star, azithromycin 3 grams, acetaminophen 2 grams.
By sulphur removal ether sand star, the raw material boiling outside azithromycin and acetaminophen twice, add water 5 times amount for the first time, decocts 2 hours, and add water 5 times amount for the second time, decocts 1 hour, merges twice decocting liquid, filter to get filtrate, is spray-dried to obtain 5.0 grams of powder；
Add the thioether sand star weighed, azithromycin and acetaminophen powder, after mixing thoroughly, i.e. obtain skin fester disease feed additive 3.
Embodiment four: the feed additive of the present invention preventive effect to rotten-skin diseases of trionyx sinensis
Take healthy children Trionyx sinensis Wiegmann 250, it is divided into 5 groups at random, often group 50, suffering from skin fester disease Trionyx sinensis Wiegmann often organizing addition 5 in fish, after feeding 7 days, 1 group is continued normal nursing in every day, 2 groups add the medicine thioether sand star that feedstuff weighs the commercially available treatment skin fester disease of 0.5%, 3 groups add feedstuff weigh 0.5% feed additive Isosorbide-5-Nitrae group of the present invention add feedstuff weigh 0.5% feed additive of the present invention 2,5 groups add feedstuff weigh 0.5% feed additive of the present invention 3.Feeding process is observed the growth of Trionyx sinensis Wiegmann and dead, infection conditions, observes 4 weeks.
The results are shown in Table 1.Result shows, in Trionyx sinensis Wiegmann feeding process, skin fester disease mortality rate is up to 30% under normal circumstances, infection rate 70%；And existing the most commercially available drug deaths rate is up to 12%, infection rate 36%, skin fester disease is had certain anti-preact；And feed additive of the present invention can make skin fester disease mortality rate drop to 2-4%, infection rate 12-16%, can significantly prevent death and the infection effect of rotten-skin diseases of trionyx sinensis.
The table 1 feed additive of the present invention skin fester disease preventive effect to Trionyx sinensis Wiegmann
| Group number | 1 group | 2 groups | 3 groups | 4 groups | 5 groups |
| Death toll | 15 | 6 | 2 | 2 | 1 |
| Infect number | 20 | 12 | 5 | 6 | 5 |
| Healthy number | 15 | 32 | 43 | 42 | 44 |
| Mortality rate | 30% | 12% | 4% | 4% | 2% |
| Infection rate | 70% | 36% | 14% | 16% | 12% |
Claims (3)
1. one kind is used for preventing and treating rotten-skin diseases of trionyx sinensis feed additive, it is characterised in that it is made up of the crude drug of following weight portion: Herba Lophatheri 5-8 part, Herba Ephedrae 1-2 part, Semen Litchi 3-5 part, Radix Bupleuri 10-20 part, Fructus Momordicae 3-5 part, Flos Lonicerae
10-15 part, Flos Rosae Rugosae 3-7 part, calcium carbonate 1-2 part, Crataegi cuneatae 1-2 part, thioether sand star 3-7 part, azithromycin 1-3 part, acetaminophen 1-2 part.
2. skin fester disease feed additive as claimed in claim 1, the consumption that it is characterized in that crude drug is: Herba Lophatheri 6 parts, 1.5 parts of Herba Ephedrae, Semen Litchi 4 parts, Radix Bupleuri 15 parts, Fructus Momordicae 4 parts, Flos Lonicerae 12 parts, Flos Rosae Rugosae 5 parts, calcium carbonate 1.5 parts, Crataegi cuneatae 1.5 parts, 5 parts of thioether sand star, azithromycin 2 parts, acetaminophen 1.5 parts.
3. the preparation method of skin fester disease feed additive as claimed in claim 1 or 2, comprises the following steps:
(1) each raw material is weighed by described weight portion；
(2) by sulphur removal ether sand star, add water 100 degree of boiling water of the raw material outside azithromycin and acetaminophen decoct twice, and each amount of water flooded raw material face, merges twice decocting liquid, filters to get filtrate, and was spray-dried to obtain powder；
(3) add the thioether sand star of 200 mesh sieves, azithromycin and acetaminophen powder, after mixing thoroughly, i.e. obtain rotten-skin diseases of trionyx sinensis feed additive.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510667905.9A CN105920377A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of soft-shelled turtle putred-skin disease and preparation method thereof |
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| CN201510667905.9A CN105920377A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of soft-shelled turtle putred-skin disease and preparation method thereof |
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| CN105920377A true CN105920377A (en) | 2016-09-07 |
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| CN201510667905.9A Pending CN105920377A (en) | 2015-10-16 | 2015-10-16 | Feed additive for control of soft-shelled turtle putred-skin disease and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581632A (en) * | 2017-03-06 | 2017-04-26 | 长沙瑞多康生物科技有限公司 | Composition for control of putrid skin disease of soft-shelled turtle |
| CN112841227A (en) * | 2021-01-07 | 2021-05-28 | 清远海贝生物技术有限公司 | Composite plant extract for inhibiting aeromonas schubertii in water environment and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711766A (en) * | 2009-12-02 | 2010-05-26 | 肖建君 | Medicine for treating white spots and rotten skin of turtle |
| CN102973847A (en) * | 2011-09-07 | 2013-03-20 | 赵林斌 | Formula for prevention and treatment of the skin fester disease of soft-shelled turtles |
| CN104398617A (en) * | 2014-12-10 | 2015-03-11 | 安徽省旌德县国友龟鳖良种繁育场 | Medicament for treating ulcerate disease of soft-shelled turtles |
| CN104474233A (en) * | 2014-11-04 | 2015-04-01 | 占水秀 | Formula and preparation method of trionyx sinensis skin fester disease treating traditional Chinese medicine |
-
2015
- 2015-10-16 CN CN201510667905.9A patent/CN105920377A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711766A (en) * | 2009-12-02 | 2010-05-26 | 肖建君 | Medicine for treating white spots and rotten skin of turtle |
| CN102973847A (en) * | 2011-09-07 | 2013-03-20 | 赵林斌 | Formula for prevention and treatment of the skin fester disease of soft-shelled turtles |
| CN104474233A (en) * | 2014-11-04 | 2015-04-01 | 占水秀 | Formula and preparation method of trionyx sinensis skin fester disease treating traditional Chinese medicine |
| CN104398617A (en) * | 2014-12-10 | 2015-03-11 | 安徽省旌德县国友龟鳖良种繁育场 | Medicament for treating ulcerate disease of soft-shelled turtles |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581632A (en) * | 2017-03-06 | 2017-04-26 | 长沙瑞多康生物科技有限公司 | Composition for control of putrid skin disease of soft-shelled turtle |
| CN112841227A (en) * | 2021-01-07 | 2021-05-28 | 清远海贝生物技术有限公司 | Composite plant extract for inhibiting aeromonas schubertii in water environment and preparation method and application thereof |
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