CN105918703A - Feed additive treating megalobrama amblycephala red skin diseases and preparation method thereof - Google Patents
Feed additive treating megalobrama amblycephala red skin diseases and preparation method thereof Download PDFInfo
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- CN105918703A CN105918703A CN201610279851.3A CN201610279851A CN105918703A CN 105918703 A CN105918703 A CN 105918703A CN 201610279851 A CN201610279851 A CN 201610279851A CN 105918703 A CN105918703 A CN 105918703A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
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Abstract
The present invention belongs to the technical field of aquaculture, relates to a feed additive treating megalobrama amblycephala red skin diseases, and also relates to a preparation method of the feed additive treating the megalobrama amblycephala red skin diseases. The feed additive treating megalobrama amblycephala the red skin diseases consists of the following components in parts by mass: 36-45 parts of honeysuckles, 28-36 parts of cactus juice, 28-36 parts of single roxburgh roseroots, 27-33 parts of Chinese honeylocust fruits, 26-34 parts of hydrocotyle sibthorpioides, 26-33 parts of fresh gingers, 21-28 parts of folium isatidis, 20-27 parts of fructus cnidii, 20-27 parts of common cephalanoplos herbs, 18-25 parts of bitter gourds, 18-24 parts of dandelions, 16-24 parts of radix gentianae, 16-24 parts of radix rubiae, 16-24 parts of fructus gardeniae, 15-24 parts of fennel, 12-20 parts of earthworm powder, 10-16 parts of aquatic earthworm powder, etc. The feed additive is natural and environmentally protective, and can effectively treat megalobrama amblycephala red skin diseases.
Description
Technical field
The invention belongs to technical field of aquaculture, particularly relate to a kind of Megalobrama amblycephala Haemorrhagic Septicaemia for the treatment of
Feed additive；The invention still further relates to the feed additive of a kind of above-mentioned treatment Megalobrama amblycephala Haemorrhagic Septicaemia
Preparation method.
Background technology
Megalobrama amblycephala is named again blunt snout bream, belongs to Cypriniformes, Cyprinidae, subfamily, and triangular bream belongs to.The fifties in last century is by easily
Aquatic institute of Bai Lu etc. 30 multidigit Chinese Academy of Sciences research worker finds that having a kind of bream in Liangzi Lake is not have in previous literature
Having, he, by its named Megalobrama amblycephala, is commonly called as blunt snout bream.Megalobrama amblycephala body length 165～456 millimeters, side is flat
And high, assume diamond in shape, mouth end position, schistostoma is wider, curved, and body is cinerous, be distributed mainly in the Changjiang river,
The medium-sized lake in downstream, is relatively more suitable for hydrostatic sexual life.Blunt snout bream is nutritious, common people's all edibles,
All-ages.
Haemorrhagic Septicaemia, also known as erythroderma, red skin pestilence, wipes skin pestilence etc., respectively breeds fish area in China, 1 year
The four seasons have popular, but with during water temperature 25-30 DEG C as the time of popularity.The pathogen of Haemorrhagic Septicaemia is gas
Zymomonas mobilis, disease symptom is: sick fish is slow in action, bradykinesia, weak, peel off and solely swim in the water surface；Body
Table local or large-area hemorrhage inflammation, scale comes off, and particularly fish body both sides and abdominal part is the most obvious；Fin fills
Blood, afterbody rots, and is formed " moth fin ", and Hubei Province up and down of fish and gill cover part are congested, in block erythema；Have
Time the gill cover is rotten goes one piece, in roundlet window-like, blank occurs；Depart from past with fin ray rotten place at scale
Toward occurring that fish molds is parasitic, increasing the weight of patient's condition, morbidity after a few days will be dead.Treat Haemorrhagic Septicaemia at present
Main method is for using norfloxacin, and using method is: every 1kg fish body weight is thrown something and fed 30mg every time, mixes and raises throwing
Hello, 1 day 1 time, it is used in conjunction use 3-6 days.Or using bactrim treatment, using method is: every 1kg
Body weight is thrown something and fed 50mg every time, mixes to raise and throws something and feeds, 1 day 1 time, is used in conjunction use 5 days, and consumption doubles first.So
And existing Therapeutic Method and medicine not only therapeutic effect are limited, and frequently use antibiotic and easily make Fish
Develop immunity to drugs, be unfavorable for the sustainable health development of culture fishery.
Summary of the invention
An object of the present invention is to provide a kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, its
Raw material natural environmental-protective, and can effectively treat Megalobrama amblycephala Haemorrhagic Septicaemia.
In order to solve above-mentioned technical problem, the present invention by the following technical solutions: it is hemorrhage that one treats Megalobrama amblycephala
The feed additive of property rot, is made up of each component of following masses number: Flos Lonicerae 36-45 part, celestial being
People slaps juice 28-36 part, Radix Rosae Normalis 28-36 part, Fructus Gleditsia 27-33 part, Herba Hydrocotyles 26-34 part, Rhizoma Zingiberis Recens
26-33 part, Folium Isatidis 21-28 part, Fructus Cnidii 20-27 part, Herba Cirsii 20-27 part, Fructus Momordicae charantiae 18-25 part,
Herba Taraxaci 18-24 part, Radix Gentianae 16-24 part, Radix Rubiae 16-24 part, Fructus Gardeniae 16-24 part, Fructus Foeniculi 15-24
Part, Semen Pini 15-22 part, xanthorrhiza 14-22 part, Cortex Phellodendri 14-22 part, Herba Lophatheri 12-21 part, Herba Houttuyniae
14-21 part, Pericarpium Zanthoxyli 1-3 part, 16-24 part Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae 10-18 part, Lumbricus powder 12-20 part, red line
Worm powder 10-16 part, xanthan gum 2-3 part, fish oil 3-5 part.
Preferably, the feed additive of described treatment Megalobrama amblycephala Haemorrhagic Septicaemia, by following masses number
Each component forms: Flos Lonicerae 40 parts, Radix et Caulis Opuntiae Dillenii juice 33 parts, Radix Rosae Normalis 33 parts, Fructus Gleditsia 30 part, day
Herba Coriandri 30 parts, 30 parts of Rhizoma Zingiberis Recens, Folium Isatidis 25 parts, Fructus Cnidii 24 parts, Herba Cirsii 24 parts, 21 parts of Fructus Momordicae charantiae,
Herba Taraxaci 21 parts, Radix Gentianae 20 parts, 20 parts of Radix Rubiae, Fructus Gardeniae 20 parts, 20 parts of Fructus Foeniculi, 18 parts of Semen Pini,
Xanthorrhiza 18 parts, Cortex Phellodendri 18 parts, Herba Lophatheri 16 parts, Herba Houttuyniae 16 parts, 2 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 20 parts,
The Rhizoma Atractylodis Macrocephalae 14 parts, Lumbricus powder 16 parts, 13 parts of red line worm powder, xanthan gum 2 parts, 4 parts of fish oil.
Each component effect of the present invention resolves as follows:
Flos Lonicerae has another name called Radix Ophiopogonis, its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can dispel
Heresy, Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various febrile diseases, as fever of the body, dermexanthesis,
Sending out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal effect is notable, may be used to carbuncle furunculosis, congestion and swelling pain,
Also have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, stomach function regulating preventing or arresting vomiting effect, may be used to pathogenic heat and stops up resistance, disorder of stomach-QI, sends out
Heat is irritated, and chest and diaphragm painful abdominal mass is vexed, thirsty retch, and red tongue tongue is dry, effect of the sliding number of pulse condition.Radix et Caulis Opuntiae Dillenii sweet in the mouth is put down,
Can bactericidal antiphlogistic, can spleen reinforcing stomach invigorating, benefit strength of one's legs, except chronic diarrhea, it is also possible to heat-clearing and toxic substances removing, scattered silt is subsided a swelling, strong
Stomach and alleviating pain, antitussive, interior with controlling taste-blindness rate, acute dysentery, cough；The popular cheek is controlled in external
Adenitis, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.Radix Rosae Normalis is the root of Fructus Rosae Normalis plant, for rose
The root of common vetch section plant Fructus Rosae Normalis, nontoxic, energy stomach invigorating, help digestion, antidiarrheal, arresting seminal emission, cure mainly stomachache, have loose bowels, dysentery
Disease, seminal emission, metrorrhagia, leukorrhagia, chronic cough.Saponin element contained in Fructus Gleditsia is triterpene alkenes and oligosaccharide,
There are antiinflammatory, antiulcer, a disease-resistant change effect, the most anticancer and improve the effects such as acquired immune deficiency syndrome (AIDS) immunity.Herba Hydrocotyles
Energy heat clearing away, diuresis, detumescence, removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, dysentery, gonorrhea, dysuria, corneal nebula,
Larynx swells, carbuncle furuncle, and traumatic injury congestive edema can be used for acute icterohepatitis, acute nephritis, pertussis, urine
Road calculus, tinea pedis, herpes zoster, conjunctivitis, erysipelas.Rhizoma Zingiberis Recens energy disinfecting detoxifying, reducing swelling and alleviating pain, appetizing
Spleen invigorating, promotes appetite, increases gastrointestinal peristalsis.Folium Isatidis energy heat clearing away, removing toxic substances, removing heat from blood, hemostasis, control epidemic febrile disease
Intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, red
Poison, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Fructus Cnidii can antifungal, kill
Worm.Herba Cirsii has inhibitory action to Hemolytic streptococcus, streptococcus pneumoniae and diphtheria corynebacterium etc..Fructus Momordicae charantiae Fructus Momordicae charantiae has strong
Spleen appetizing, heat clearing away, improving eyesight, dysentery relieving, the effect of removing pathogenic heat from blood and toxic substance from the body.Dyspepsia, constipation are had by Herba Taraxaci
The effect improved, also improves eczema, dermatitis of releiving, clean blood effect of joint discomfort.Radix Gentianae has clearly
Heat, detumescence, hemostasis, removing toxic substances, the effect of yellow fluid of dispelling.Radix Rubiae has inhibitory action to various pathogens, regulation
Metabolism.Fructus Gardeniae have antibacterial, hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, stop blooding, the effect such as detumescence.Fennel
Fragrant stimulating appetite, cold expelling of regulating the flow of vital energy, there is supporing yang road, cure mainly cold in middle-JIAO, loss of appetite, nausea and vomiting, abdomen
Portion's cold type of pain；Hernia pain, painful and swollen testis；Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.Semen Pini can improve immunity,
Supplement QI and blood.Xanthorrhiza can cooling blood for hemostasis；Dampness removing jaundice eliminating；The strong muscle of dissipating blood stasis, cures mainly gingival hemorrhage；Anemia；Liver
Scorching；Rheumatic arthritis；Traumatic injury；Urinary tract infection.Cortex Phellodendri nature and flavor bitter cold, cures mainly hematodiarrhoea, has loose bowels,
Quench one's thirst, jaundice, flaccidity, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion swells
Bitterly, aphtha of the mouth and tongue, sore swollen toxin.Herba Lophatheri has effect of clearing heat and relieving fidgetness, diuresis, is mainly used in treating breast
Middle disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness,
Apoplectic aphasia is in silence, wind syndrome of head, spasmolytic are throbbed with fear bitterly, pestilence fan is vexed, kill small worm, heat extraction delays the symptoms such as spleen.Fish raw meat
Grass has the functions such as heat-clearing and toxic substances removing, bactericidal, eliminating carbuncle evacuation of pus.Pericarpium Zanthoxyli can promote salivation, increases appetite；
Distend the blood vessels, also can improve the mouthfeel of feedstuff and Chinese herbal medicine.Radix Ophiopogonis, feeble QI was fragrant, and sweet in the mouth, micro-hardship can be used
In dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, and dryness of the intestine is just
Secret, also can improve cellular immunity.The Rhizoma Atractylodis Macrocephalae can be used for weakness of the spleen and stomach, lack of appetite distension, fatigue and weakness, has loose bowels.
Lumbricus powder and red line worm powder delicious flavour, have food calling effect, be one of Megalobrama amblycephala natural feed Megalobrama amblycephala.
Add xanthan gum and can improve the feed additive of present invention stability in water, reduce the feedstuff of the present invention
The additive pollution to water body environment.Fish oil has food calling effect to Megalobrama amblycephala.
It is a further object of the present invention to provide the feed additive of a kind of above-mentioned treatment Megalobrama amblycephala Haemorrhagic Septicaemia
Preparation method, it comprises the following steps:
(1) Radix et Caulis Opuntiae Dillenii juice is weighed according to proportioning；
(2) Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, cnidium monnieri are weighed according to proportioning
Son, Herba Cirsii and Fructus Momordicae charantiae, gross weight is designated as 1 part, adds 12 parts of purified water, and 20-30 DEG C is soaked 6-9h；
(3) boil 2h after the Chinese herbal medicine of step (2) and the mixture of water being heated to boiling, separate and take out
Fried liquid, continues to add the purified water of 6 parts in medical material, continues to boil 1h, merge two after being heated to boiling
Secondary fried liquid is extracting solution；
(4) weigh respectively according to proportioning Herba Taraxaci, Radix Gentianae, Radix Rubiae, Fructus Gardeniae, Fructus Foeniculi, Semen Pini, xanthorrhiza,
Cortex Phellodendri, Herba Lophatheri, Herba Houttuyniae, Pericarpium Zanthoxyli, Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae, load ball mill grinding 2h, crosses 80 mesh sieves,
Obtain grounds travel；
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned over supercritical extraction
Taking in the extraction kettle in instrument, utilize carbon dioxide as medium and extract, extraction kettle pressure is 40Mpa,
Extraction temperature is 45 DEG C, separator pressure 12Mpa, and separator temperature is 70 DEG C, extracts 2 hours, obtains
Extract；
(6) weigh Lumbricus powder, red line worm powder, xanthan gum and fish oil according to proportioning, and with step (5) institute
Extract, load weighted Radix et Caulis Opuntiae Dillenii juice mix homogeneously in step (1), obtain mixing liquid, will mixing
Liquid at pressure for-0.06～-0.08Mpa, temperature be concentrated into thick viscous solution under the conditions of being 40～45 DEG C,
When the relative density of viscous solution is 45 DEG C 1.16～1.19；
(7) drying to moisture the viscous solution of step (6) gained less than 5%, micropowder is broken to mean diameter
Below 50 μm, obtain object.
The preparation method of described Radix et Caulis Opuntiae Dillenii juice is: is smashed to pieces by Radix et Caulis Opuntiae Dillenii, takes gained juice, for Radix et Caulis Opuntiae Dillenii juice
Liquid.
The preparation method of described Lumbricus powder is: cleaned by Lumbricus, and vacuum lyophilization is ground to the most dried
Powdering, crosses 80 mesh sieves.The advantage of vacuum lyophilization is to be dried thoroughly, will not make earthworm during being dried
Active substance inactivation in vermis.
The preparation method of described red line worm powder is: cleaned by red line worm fresh water, then with distilled water flushing three times,
Vacuum lyophilization, to thoroughly grinding to form powdery after drying, crosses 80 mesh sieves.The advantage of vacuum lyophilization is dry
Dry thoroughly, the active substance inactivation in red line polypide will not be made during being dried.
Usage and dosage: every 1kg fish body weight adds the feed additive of the 20-30mg present invention every time, mixes and raises throwing
Hello, 1 day 1 time, it is used in conjunction use 3-5 days.
In preparation method, by Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, Fructus Cnidii,
Herba Cirsii and Fructus Momordicae charantiae the 20-30 DEG C of purpose soaking 6-9h be advantageous for Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles,
Effective ingredient in Rhizoma Zingiberis Recens, Folium Isatidis, Fructus Cnidii, Herba Cirsii and Fructus Momordicae charantiae is the most fried in down-stream；
Will soak after Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, Fructus Cnidii, Herba Cirsii and
The effect that Fructus Momordicae charantiae decocts is the irritation effect that can change medicine, the relatively mild Megalobrama amblycephala that acts on, and promotes
The Megalobrama amblycephala absorption to medicine；By Herba Taraxaci, Radix Gentianae, Radix Rubiae, Fructus Gardeniae, Fructus Foeniculi, Semen Pini, xanthorrhiza,
Cortex Phellodendri, Herba Lophatheri, Herba Houttuyniae, Pericarpium Zanthoxyli, Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae grind and the effective ingredient in medical material can be made rear
Continuous step separates out more fully；Supercritical extraction, concentration step can retain in the present invention each to greatest extent
The effective ingredient of component；The advantage of the juice directly taking Radix et Caulis Opuntiae Dillenii is that preparation method is simple, saves medicinal raw material,
Improve the utilization rate to Radix et Caulis Opuntiae Dillenii, and take full advantage of the effective ingredient in Radix et Caulis Opuntiae Dillenii, the effect of bactericidal
Fruit is more preferably.
The feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention, according to Haemorrhagic Septicaemia
Etiopathogenesis, the suitable component of selection, prepare according to specific ratio and preparation method, can fully send out
Wave the synergistic function between each component, play the function of each component to greatest extent.The feedstuff of the present invention
In additive, Pericarpium Zanthoxyli can be in harmonious proportion feedstuff entirety mouthfeel, Lumbricus powder and red line worm powder delicious flavour, Lumbricus powder,
Red line worm and fish oil have collaborative food calling effect to Megalobrama amblycephala, and therefore the feed additive of the present invention can improve base
The mouthfeel of plinth feedstuff, stimulates the taste bud of Megalobrama amblycephala, induction Megalobrama amblycephala to ingest and with the addition of the feedstuff interpolation of the present invention
The normal feedstuff of agent, can strengthen Megalobrama amblycephala immunity and resistance, right in feed additive the most of the present invention
The pathogen of Haemorrhagic Septicaemia has the composition of notable bactericidal and bacteriostatic effect and can enter in Megalobrama amblycephala body, concurrently
Wave it to act on accordingly.
Additionally, the component of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention is green ring
Protect raw material, nontoxic to environment, do not contain chemical drugs or antibiotic, the Megalobrama amblycephala after edible recovery from illness is not
Human body can be brought injury, be also beneficial to the sustainable health development of culture fishery；And the raising of the present invention
Feed additives is good to the curative effect of Megalobrama amblycephala Haemorrhagic Septicaemia, and cure rate is high, makes ill Megalobrama amblycephala
Survival rate is to more than 90%, and after medication 2-4 days, Megalobrama amblycephala " moth fin " phenomenon disappears, fin congested and
Hubei Province, gill cover part hyperemia phenomenon disappear up and down, and scale stops dropping, and the state of an illness is controlled.The present invention uses
Get up safer, little to Megalobrama amblycephala damage, use the present invention's to treat raising of Megalobrama amblycephala Haemorrhagic Septicaemia
After feed additives, Megalobrama amblycephala Health restoration is fast, throws something and feeds 3-5 days, and Megalobrama amblycephala can recover normal activity, trip
Providing strong and vigorous, wound progressively heals, and ingests and progressively recovers normal.
Compared with prior art, the invention has the beneficial effects as follows:
(1) feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention, is corrupt according to hemorrhagic
Sick etiopathogenesis, the suitable component of selection, prepare according to specific ratio and preparation method, Ke Yichong
The synergistic function between each component is waved in distribution, plays the function of each component to greatest extent.The present invention's
In feed additive, Pericarpium Zanthoxyli can be in harmonious proportion feedstuff entirety mouthfeel, Lumbricus powder and red line worm powder delicious flavour, Lumbricus
Powder, red line worm and fish oil have collaborative food calling effect to Megalobrama amblycephala, and therefore the feed additive of the present invention can change
The mouthfeel of kind normal feedstuff, stimulates the taste bud of Megalobrama amblycephala, induction Megalobrama amblycephala to ingest and adds the feedstuff of the present invention and add
Add the normal feedstuff of agent, therefore in the feed additive of the present invention can strengthen Megalobrama amblycephala immunity and resistance,
The composition to the pathogen of Haemorrhagic Septicaemia with notable bactericidal and bacteriostatic effect can enter in Megalobrama amblycephala body, and
Play it to act on accordingly.
(2) component of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention is environmental protection
Raw material, nontoxic to environment, do not contain chemical drugs or antibiotic, the Megalobrama amblycephala after edible recovery from illness will not
Human body is brought injury, is also beneficial to the sustainable health development of culture fishery；And the feedstuff of the present invention
Additive is good to the curative effect of Megalobrama amblycephala Haemorrhagic Septicaemia, and cure rate is high, makes the one-tenth of ill Megalobrama amblycephala
Motility rate reaches more than 90%, and after medication 2-4 days, Megalobrama amblycephala " moth fin " phenomenon disappears, fin congested and on
Lower Hubei Province, gill cover part hyperemia phenomenon disappear, and scale stops dropping, and the state of an illness is controlled.The present invention uses
Come safer, little to Megalobrama amblycephala damage, use the feedstuff of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention
After additive, Megalobrama amblycephala Health restoration is fast, throws something and feeds 3-5 days, and Megalobrama amblycephala can recover normal activity, idle fund
Strong and vigorous, wound progressively heals, and ingests and progressively recovers normal.
(3) in preparation method, by Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, Serpentis
Machine tool, Herba Cirsii and Fructus Momordicae charantiae 20-30 DEG C soak 6-9h purpose be advantageous for Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia,
Effective ingredient in Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, Fructus Cnidii, Herba Cirsii and Fructus Momordicae charantiae is abundant in down-stream
Fried；Will soak after Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, Fructus Cnidii,
The effect that Herba Cirsii and Fructus Momordicae charantiae decoct is the irritation effect that can change medicine, relatively mild acts on Megalobrama amblycephala,
Promote the Megalobrama amblycephala absorption to medicine；By Herba Taraxaci, Radix Gentianae, Radix Rubiae, Fructus Gardeniae, Fructus Foeniculi, Semen Pini, Huang
Root, Cortex Phellodendri, Herba Lophatheri, Herba Houttuyniae, Pericarpium Zanthoxyli, Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae grind the effective ingredient that can make in medical material
Separate out more fully at subsequent step；Supercritical extraction, concentration step can retain the present invention to greatest extent
In the effective ingredient of each component；The advantage of the juice directly taking Radix et Caulis Opuntiae Dillenii is that preparation method is simple, saves medical material
Raw material, improves the utilization rate to Radix et Caulis Opuntiae Dillenii, and takes full advantage of the effective ingredient in Radix et Caulis Opuntiae Dillenii, and sterilization presses down
The effect of bacterium is more preferable.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.In following embodiment
Experimental technique, if no special instructions, be conventional method.
Embodiment 1
A kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, by each component group of following masses number
Become: Flos Lonicerae 45 parts, Radix et Caulis Opuntiae Dillenii juice 35 parts, Radix Rosae Normalis 35 parts, 33 parts of Fructus Gleditsia, Herba Hydrocotyles 33 parts,
33 parts of Rhizoma Zingiberis Recens, Folium Isatidis 28 parts, Fructus Cnidii 27 parts, Herba Cirsii 27 parts, 25 parts of Fructus Momordicae charantiae, Herba Taraxaci 24
Part, Radix Gentianae 24 parts, 22 parts of Radix Rubiae, Fructus Gardeniae 24 parts, 24 parts of Fructus Foeniculi, 22 parts of Semen Pini, xanthorrhiza 22
Part, Cortex Phellodendri 22 parts, Herba Lophatheri 21 parts, Herba Houttuyniae 21 parts, 3 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 22 parts, the Rhizoma Atractylodis Macrocephalae 18
Part, Lumbricus powder 20 parts, 15 parts of red line worm powder, xanthan gum 3 parts, 4 parts of fish oil.
The preparation method of the feed additive of above-mentioned treatment Megalobrama amblycephala Haemorrhagic Septicaemia comprises the following steps:
(1) Radix et Caulis Opuntiae Dillenii juice is weighed according to proportioning；
(2) Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, cnidium monnieri are weighed according to proportioning
Son, Herba Cirsii and Fructus Momordicae charantiae, gross weight is designated as 1 part, adds 12 parts of purified water, and 20-30 DEG C is soaked 6-9h；
(3) boil 2h after the Chinese herbal medicine of step (2) and the mixture of water being heated to boiling, separate and take out
Fried liquid, continues to add the purified water of 6 parts in medical material, continues to boil 1h, merge two after being heated to boiling
Secondary fried liquid is extracting solution；
(4) weigh respectively according to proportioning Herba Taraxaci, Radix Gentianae, Radix Rubiae, Fructus Gardeniae, Fructus Foeniculi, Semen Pini, xanthorrhiza,
Cortex Phellodendri, Herba Lophatheri, Herba Houttuyniae, Pericarpium Zanthoxyli, Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae, load ball mill grinding 2h, crosses 80 mesh sieves,
Obtain grounds travel；
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned over supercritical extraction
Taking in the extraction kettle in instrument, utilize carbon dioxide as medium and extract, extraction kettle pressure is 40Mpa,
Extraction temperature is 45 DEG C, separator pressure 12Mpa, and separator temperature is 70 DEG C, extracts 2 hours, obtains
Extract；
(6) weigh Lumbricus powder, red line worm powder, xanthan gum and fish oil according to proportioning, and with step (5) institute
Extract, load weighted Radix et Caulis Opuntiae Dillenii juice mix homogeneously in step (1), obtain mixing liquid, will mixing
Liquid at pressure for-0.06～-0.08Mpa, temperature be concentrated into thick viscous solution under the conditions of being 40～45 DEG C,
When the relative density of viscous solution is 45 DEG C 1.16～1.19；
(7) drying to moisture the viscous solution of step (6) gained less than 5%, micropowder is broken to mean diameter
Below 50 μm, obtain object.
The preparation method of described Radix et Caulis Opuntiae Dillenii juice is: is smashed to pieces by Radix et Caulis Opuntiae Dillenii, takes gained juice, for Radix et Caulis Opuntiae Dillenii juice
Liquid.
The preparation method of described Lumbricus powder is: cleaned by Lumbricus, and vacuum lyophilization is ground to the most dried
Powdering, crosses 80 mesh sieves.The advantage of vacuum lyophilization is to be dried thoroughly, will not make earthworm during being dried
Active substance inactivation in vermis.
The preparation method of described red line worm powder is: cleaned by red line worm fresh water, then with distilled water flushing three times,
Vacuum lyophilization, to thoroughly grinding to form powdery after drying, crosses 80 mesh sieves.The advantage of vacuum lyophilization is dry
Dry thoroughly, the active substance inactivation in red line polypide will not be made during being dried.
Embodiment 2
A kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, by each component group of following masses number
Become: Flos Lonicerae 42 parts, Radix et Caulis Opuntiae Dillenii juice 36 parts, Radix Rosae Normalis 36 parts, 32 parts of Fructus Gleditsia, Herba Hydrocotyles 34 parts,
33 parts of Rhizoma Zingiberis Recens, Folium Isatidis 27 parts, Fructus Cnidii 27 parts, Herba Cirsii 26 parts, 24 parts of Fructus Momordicae charantiae, Herba Taraxaci 24
Part, Radix Gentianae 23 parts, 24 parts of Radix Rubiae, Fructus Gardeniae 23 parts, 22 parts of Fructus Foeniculi, 21 parts of Semen Pini, xanthorrhiza 21
Part, Cortex Phellodendri 20 parts, Herba Lophatheri 20 parts, Herba Houttuyniae 20 parts, 3 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 24 parts, the Rhizoma Atractylodis Macrocephalae 16
Part, Lumbricus powder 18 parts, 16 parts of red line worm powder, xanthan gum 2 parts, 5 parts of fish oil.
The preparation method of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present embodiment is with embodiment 1.
Embodiment 3
A kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, by each component group of following masses number
Become: Flos Lonicerae 36 parts, Radix et Caulis Opuntiae Dillenii juice 30 parts, Radix Rosae Normalis 30 parts, 27 parts of Fructus Gleditsia, Herba Hydrocotyles 26 parts,
26 parts of Rhizoma Zingiberis Recens, Folium Isatidis 22 parts, Fructus Cnidii 20 parts, Herba Cirsii 20 parts, 18 parts of Fructus Momordicae charantiae, Herba Taraxaci 18
Part, Radix Gentianae 18 parts, 16 parts of Radix Rubiae, Fructus Gardeniae 16 parts, 15 parts of Fructus Foeniculi, 15 parts of Semen Pini, xanthorrhiza 15
Part, Cortex Phellodendri 15 parts, Herba Lophatheri 14 parts, Herba Houttuyniae 14 parts, 2 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 16 parts, the Rhizoma Atractylodis Macrocephalae 10
Part, Lumbricus powder 12 parts, 12 parts of red line worm powder, xanthan gum 3 parts, 3 parts of fish oil.
The preparation method of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present embodiment is with embodiment 1.
Embodiment 4
In the 4th detailed description of the invention of the present invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, by each component group of following masses number
Become: Flos Lonicerae 39 parts, Radix et Caulis Opuntiae Dillenii juice 28 parts, Radix Rosae Normalis 28 parts, 28 parts of Fructus Gleditsia, Herba Hydrocotyles 28 parts,
26 parts of Rhizoma Zingiberis Recens, Folium Isatidis 21 parts, Fructus Cnidii 21 parts, Herba Cirsii 21 parts, 20 parts of Fructus Momordicae charantiae, Herba Taraxaci 20
Part, Radix Gentianae 16 parts, 16 parts of Radix Rubiae, Fructus Gardeniae 18 parts, 16 parts of Fructus Foeniculi, 15 parts of Semen Pini, xanthorrhiza 14
Part, Cortex Phellodendri 14 parts, Herba Lophatheri 12 parts, Herba Houttuyniae 14 parts, 1 part of Pericarpium Zanthoxyli, Radix Ophiopogonis 16 parts, the Rhizoma Atractylodis Macrocephalae 10
Part, Lumbricus powder 15 parts, 10 parts of red line worm powder, xanthan gum 2 parts, 4 parts of fish oil.
The preparation method of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present embodiment is with embodiment 1.
Embodiment 5
In the 5th detailed description of the invention of the present invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive treating Megalobrama amblycephala Haemorrhagic Septicaemia, by each component group of following masses number
Become: Flos Lonicerae 40 parts, Radix et Caulis Opuntiae Dillenii juice 33 parts, Radix Rosae Normalis 33 parts, 30 parts of Fructus Gleditsia, Herba Hydrocotyles 30 parts,
30 parts of Rhizoma Zingiberis Recens, Folium Isatidis 25 parts, Fructus Cnidii 24 parts, Herba Cirsii 24 parts, 21 parts of Fructus Momordicae charantiae, Herba Taraxaci 21
Part, Radix Gentianae 20 parts, 20 parts of Radix Rubiae, Fructus Gardeniae 20 parts, 20 parts of Fructus Foeniculi, 18 parts of Semen Pini, xanthorrhiza 18
Part, Cortex Phellodendri 18 parts, Herba Lophatheri 16 parts, Herba Houttuyniae 16 parts, 2 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 20 parts, the Rhizoma Atractylodis Macrocephalae 14
Part, Lumbricus powder 16 parts, 13 parts of red line worm powder, xanthan gum 2 parts, 4 parts of fish oil.
The preparation method of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present embodiment is with embodiment 1.
Experimental result
In order to verify the therapeutic effect of the present invention, the Megalobrama amblycephala suffering from Haemorrhagic Septicaemia is being carried out treatment effect
The inspection of fruit, each experimental group and matched group be respectively provided with two repetition, and the standard that sick fish is fully recovered is Megalobrama amblycephala
" moth fin " phenomenon disappears, and the congested and upper and lower Hubei Province of fin, gill cover part hyperemia phenomenon disappear, and scale stops
Dropping, the state of an illness is controlled, and the process of experimental group and matched group is as follows:
The process of matched group is as follows: every 1kg fish body weight is thrown something and fed 50mg bactrim every time, mixes to raise and throws something and feeds, and 1
It 1 time, consumption doubles first, is used in conjunction use until sick fish is fully recovered.
The process of experiment A group is as follows: every 1kg fish body weight is added the feedstuff of the 25mg embodiment of the present invention 1 every time and added
Agent, mixes to raise and throws something and feeds, 1 day 1 time, until sick fish recovery from illness.
The process of experiment B group is as follows: every 1kg fish body weight is added the feedstuff of the 25mg embodiment of the present invention 2 every time and added
Agent, mixes to raise and throws something and feeds, 1 day 1 time, until sick fish recovery from illness.
The process of experiment C group is as follows: every 1kg fish body weight is added the feedstuff of the 25mg embodiment of the present invention 3 every time and added
Agent, mixes to raise and throws something and feeds, 1 day 1 time, until sick fish recovery from illness.
The process of experiment D group is as follows: every 1kg fish body weight is added the feedstuff of the 25mg embodiment of the present invention 4 every time and added
Agent, mixes to raise and throws something and feeds, 1 day 1 time, until sick fish recovery from illness.
The process of experiment E group is as follows: every 1kg fish body weight is added the feedstuff of the 25mg embodiment of the present invention 5 every time and added
Agent, mixes to raise and throws something and feeds, 1 day 1 time, until sick fish recovery from illness.
Experimental result is shown in Table 1:
The feed additive therapeutic effect of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of table 1 present invention
In the feed additive of the present invention, Pericarpium Zanthoxyli can be in harmonious proportion feedstuff entirety mouthfeel, Lumbricus powder and red line worm powder taste
Road is delicious, and Lumbricus powder, red line worm and fish oil have a collaborative food calling effect to Megalobrama amblycephala, therefore the raising of the present invention
Feed additives can improve the mouthfeel of normal feedstuff, stimulates the taste bud of Megalobrama amblycephala, induction Megalobrama amblycephala to ingest interpolation originally
The normal feedstuff of the feed additive of invention, therefore the Megalobrama amblycephala that can strengthen in the feed additive of the present invention is exempted from
Epidemic disease power and resistance, pathogen to Haemorrhagic Septicaemia have the composition of notable bactericidal and bacteriostatic effect and can enter
In Megalobrama amblycephala body, and play it and act on accordingly.The feedstuff of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention
The component of additive is environmental protection raw material, nontoxic to environment, does not contains chemical drugs or antibiotic,
Human body will not be brought injury by the Megalobrama amblycephala after edible recovery from illness, and the health being also beneficial to culture fishery is sustainable
Development；And the feed additive of the present invention is good to the curative effect of Megalobrama amblycephala Haemorrhagic Septicaemia, cure rate
Height, makes the survival rate of ill Megalobrama amblycephala to more than 90%, and after medication 2-4 days, Megalobrama amblycephala " moth fin " is existing
As disappearing, the congested and upper and lower Hubei Province of fin, gill cover part hyperemia phenomenon disappear, and scale stops dropping, the state of an illness
Controlled.The present invention uses safer, little to Megalobrama amblycephala damage, uses the treatment group of the present invention
After the feed additive of head triangular bream Haemorrhagic Septicaemia, Megalobrama amblycephala Health restoration is fast, throws something and feeds 3-5 days, Megalobrama amblycephala
Can recover normal activity, idle fund is strong and vigorous, and wound progressively heals, and ingests and progressively recovers normal.
Bacteriostatic test checks
With bactrim as matched group, the treatment Megalobrama amblycephala hemorrhagic of embodiment of the present invention 1-embodiment 5 is rotten
The feed additive losing disease is that experimental group carries out antibacterial inspection contrast.
Culture medium: LB culture medium.
Strain is: Aeromonas.
Matched group antibacterial liquid is prepared: is dissolved in sterile deionized water by bactrim, makes the new promise of compound recipe
Bright content is 0.02mg/ml.
Experimental group antibacterial liquid is prepared: by the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of embodiment of the present invention 1-embodiment 5
Feed additive be dissolved in respectively in sterile deionized water, being diluted to concentration respectively is 0.02mg/ml.
Observe and record experimental result:
Represent with "-" without inhibition zone；
Antibacterial circle diameter ＜ 10mm is the most antibacterial, with "+" represent；
Antibacterial circle diameter 10～14mm is that moderate is antibacterial, represents with " ++ "；
Antibacterial circle diameter ＞ 14mm is that height is antibacterial, represents with " +++ "；The fungistatic effect of Aeromonas is shown in
Table 2:
The bactericidal and bacteriostatic effect of the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of table 2 present invention
From table 2, the feed additive of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia of the present invention is corrupt to hemorrhagic
Sick pathogen Aeromonas, has good bactericidal and bacteriostatic effect.
The above is only the preferred embodiment of the present invention, it should be pointed out that: common for the art
For technical staff, under the premise without departing from the principles of the invention, it is also possible to make some improvement, these change
Enter to should be regarded as protection scope of the present invention.
Claims (6)
1. a treatment Megalobrama amblycephala Haemorrhagic Septicaemia feed additive, it is characterised in that: by following masses part
Number each component composition: Flos Lonicerae 36-45 part, Radix et Caulis Opuntiae Dillenii juice 28-36 part, Radix Rosae Normalis 28-36 part,
Fructus Gleditsia 27-33 part, Herba Hydrocotyles 26-34 part, Rhizoma Zingiberis Recens 26-33 part, Folium Isatidis 21-28 part, Fructus Cnidii 20-27
Part, Herba Cirsii 20-27 part, Fructus Momordicae charantiae 18-25 part, Herba Taraxaci 18-24 part, Radix Gentianae 16-24 part, Radix Rubiae
16-24 part, Fructus Gardeniae 16-24 part, Fructus Foeniculi 15-24 part, Semen Pini 15-22 part, xanthorrhiza 14-22 part, Cortex Phellodendri
14-22 part, Herba Lophatheri 12-21 part, Herba Houttuyniae 14-21 part, Pericarpium Zanthoxyli 1-3 part, 16-24 part Radix Ophiopogonis, white
Art 10-18 part, Lumbricus powder 12-20 part, red line worm powder 10-16 part, xanthan gum 2-3 part, fish oil 3-5
Part.
Treatment Megalobrama amblycephala Haemorrhagic Septicaemia feed additive the most according to claim 1, its feature exists
In: described treatment Megalobrama amblycephala Haemorrhagic Septicaemia feed additive, it is made up of each component of following masses number:
Flos Lonicerae 40 parts, Radix et Caulis Opuntiae Dillenii juice 33 parts, Radix Rosae Normalis 33 parts, 30 parts of Fructus Gleditsia, Herba Hydrocotyles 30 parts, life
Rhizoma Zingiberis Recens 30 parts, Folium Isatidis 25 parts, Fructus Cnidii 24 parts, Herba Cirsii 24 parts, 21 parts of Fructus Momordicae charantiae, Herba Taraxaci 21 parts,
Radix Gentianae 20 parts, 20 parts of Radix Rubiae, Fructus Gardeniae 20 parts, 20 parts of Fructus Foeniculi, 18 parts of Semen Pini, xanthorrhiza 18 parts,
Cortex Phellodendri 18 parts, Herba Lophatheri 16 parts, Herba Houttuyniae 16 parts, 2 parts of Pericarpium Zanthoxyli, Radix Ophiopogonis 20 parts, the Rhizoma Atractylodis Macrocephalae 14 parts,
Lumbricus powder 16 parts, 13 parts of red line worm powder, xanthan gum 2 parts, 4 parts of fish oil.
3. the preparation of the treatment Megalobrama amblycephala Haemorrhagic Septicaemia feed additive described in a claim 1 or 2
Method, it is characterised in that: comprise the following steps:
(1) Radix et Caulis Opuntiae Dillenii juice is weighed according to proportioning；
(2) Flos Lonicerae, Radix Rosae Normalis, Fructus Gleditsia, Herba Hydrocotyles, Rhizoma Zingiberis Recens, Folium Isatidis, cnidium monnieri are weighed according to proportioning
Son, Herba Cirsii and Fructus Momordicae charantiae, gross weight is designated as 1 part, adds 12 parts of purified water, and 20-30 DEG C is soaked 6-9h；
(3) boil 2h after the Chinese herbal medicine of step (2) and the mixture of water being heated to boiling, separate and take out
Fried liquid, continues to add the purified water of 6 parts in medical material, continues to boil 1h, merge two after being heated to boiling
Secondary fried liquid is extracting solution；
(4) weigh respectively according to proportioning Herba Taraxaci, Radix Gentianae, Radix Rubiae, Fructus Gardeniae, Fructus Foeniculi, Semen Pini, xanthorrhiza,
Cortex Phellodendri, Herba Lophatheri, Herba Houttuyniae, Pericarpium Zanthoxyli, Radix Ophiopogonis and the Rhizoma Atractylodis Macrocephalae, load ball mill grinding 2h, crosses 80 mesh sieves,
Obtain grounds travel；
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned over supercritical extraction
Taking in the extraction kettle in instrument, utilize carbon dioxide as medium and extract, extraction kettle pressure is 40Mpa,
Extraction temperature is 45 DEG C, separator pressure 12Mpa, and separator temperature is 70 DEG C, extracts 2 hours, obtains
Extract；
(6) weigh Lumbricus powder, red line worm powder, xanthan gum and fish oil according to proportioning, and with step (5) institute
Extract, load weighted Radix et Caulis Opuntiae Dillenii juice mix homogeneously in step (1), obtain mixing liquid, will mixing
Liquid at pressure for-0.06～-0.08Mpa, temperature be concentrated into thick viscous solution under the conditions of being 40～45 DEG C,
When the relative density of viscous solution is 45 DEG C 1.16～1.19；
(7) drying to moisture the viscous solution of step (6) gained less than 5%, micropowder is broken to mean diameter
Below 50 μm, obtain object.
The preparation method for the treatment of Megalobrama amblycephala Haemorrhagic Septicaemia feed additive the most according to claim 3,
It is characterized in that: the preparation method of described Radix et Caulis Opuntiae Dillenii juice is: is smashed to pieces by Radix et Caulis Opuntiae Dillenii, takes gained juice, for
Radix et Caulis Opuntiae Dillenii juice.
The preparation method for the treatment of Megalobrama amblycephala Haemorrhagic Septicaemia feed additive the most according to claim 3,
It is characterized in that: the preparation method of described Lumbricus powder is: cleaned by Lumbricus, vacuum lyophilization is to the most dry
Grind to form powdery after dry, cross 80 mesh sieves.
The preparation method for the treatment of Megalobrama amblycephala Haemorrhagic Septicaemia feed additive the most according to claim 3,
It is characterized in that: the preparation method of described red line worm powder is: is cleaned by red line worm fresh water, then uses distilled water
Rinsing three times, vacuum lyophilization, to thoroughly grinding to form powdery after drying, crosses 80 mesh sieves.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106490402A (en) * | 2016-10-28 | 2017-03-15 | 青岛海之星生物科技有限公司 | A kind of feed addictive for treating colored perch red skin disease and preparation method thereof |
| CN106562117A (en) * | 2016-10-26 | 2017-04-19 | 宁波大学 | Catfish feed additive composition and application thereof |
| CN107788276A (en) * | 2017-12-11 | 2018-03-13 | 佛山市高明区生产力促进中心 | A kind of megalobrama amblycephala feeding feed of pre- disease prevention |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189594A (en) * | 2014-09-15 | 2014-12-10 | 山东新希望六和集团有限公司 | Traditional Chinese medicine composition for preventing and treating red skin disease of grass carp and preparation method |
| CN105147904A (en) * | 2015-09-28 | 2015-12-16 | 全椒县花溪湖特种水产合作社 | Drug preventing and curing fish red skin disease |
| CN105285523A (en) * | 2015-11-27 | 2016-02-03 | 青岛海之源智能技术有限公司 | Feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus and preparation method of feed additive |
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2016
- 2016-04-29 CN CN201610279851.3A patent/CN105918703A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189594A (en) * | 2014-09-15 | 2014-12-10 | 山东新希望六和集团有限公司 | Traditional Chinese medicine composition for preventing and treating red skin disease of grass carp and preparation method |
| CN105147904A (en) * | 2015-09-28 | 2015-12-16 | 全椒县花溪湖特种水产合作社 | Drug preventing and curing fish red skin disease |
| CN105285523A (en) * | 2015-11-27 | 2016-02-03 | 青岛海之源智能技术有限公司 | Feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus and preparation method of feed additive |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106562117A (en) * | 2016-10-26 | 2017-04-19 | 宁波大学 | Catfish feed additive composition and application thereof |
| CN106490402A (en) * | 2016-10-28 | 2017-03-15 | 青岛海之星生物科技有限公司 | A kind of feed addictive for treating colored perch red skin disease and preparation method thereof |
| CN107788276A (en) * | 2017-12-11 | 2018-03-13 | 佛山市高明区生产力促进中心 | A kind of megalobrama amblycephala feeding feed of pre- disease prevention |
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