CN104189594A - Traditional Chinese medicine composition for preventing and treating red skin disease of grass carp and preparation method - Google Patents
Traditional Chinese medicine composition for preventing and treating red skin disease of grass carp and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating a red skin disease of a grass carp and a preparation method. The traditional Chinese medicine composition comprises the following active ingredients: centipeda minima, lophatherum gracile, gardenia jasminoides, a coptis root, amoorcorn tree bark, ash bark, radix sophorae flavescentis, cortex dictamni, a honeysuckle flower, fructus forsythiae, herba andrographitis, folium isatidis, herba violae, a wild chrysanthemum flower, rhizoma paridis, dragonwort, cordate houttuynia, a sargentgloryvine stem, herba patriniae, potentilla discolor, indian iphigenia bulb, groundsel, ampelopsis japonica, Chinese holly, cortex moutan radicis, radix rehmanniae recen, lithospermum, herba cepbalanoplosis segeti, garden burnet, a sophora flower, rumex japonicus and lalang grass rhizome. The traditional Chinese medicine composition has the benefits that the traditional Chinese medicine composition has effects of clearing away heat and toxic materials and removing heat from blood to stop bleeding, has a high cure rate, takes effect quickly, has no medicine residue at the same time as detoxification, anti-inflammation and sterilization, and is low in cost price, the disease has low recurrent possibility, and the traditional Chinese medicine composition focuses on entirety, emphasizes adjustment of overall functions, improves disease resistance of an organism and is safe and reliable for long-term application.
Description
Technical field
The present invention relates to technical field of animal, particularly a kind of for preventing and treating Chinese medicine composition and the preparation method of Ctenopharyngodon idellus erythroderma.
Background technology
Red skin is again red skin pestilence, wipes skin pestilence.This disease is when drawing in the net to operate mostly or skin is injured in transit, and antibacterial is invaded mermaid body and causes.This disease is visible all the year round from early spring to severe winter, but taking 6-9 month as onset peak, and normal and gill rot, hemorrhagic disease are concurrent.Send out disease this with blue or green, grass, Cyprinus carpio more general.
Symptom: the hyperemia of the local or large portion of fish body surface, inflammation, scale comes off, especially obvious with fish body both sides and abdominal part, the hyperemia of serious sick fin base portion, fin ray tip rots, and the crocodile up and down of fish and the hyperemia of gill cover part, present block erythema.
Ctenopharyngodon idellus morbidity is often injured relevant with fish body, is conditioned pathogen.Cause of disease is pseudomonas fluorescens (Pseudomonas fluorescens), belongs to the Rhodopseudomonas of antibacterial territory, Proteobacteria, γ-distortion Gammaproteobacteria, Pseudomonadales, pseudomonadaceae on taxonomy.Cell is straight bacillus, and size is 0.7-0.8X2.3-2.8 micron, does not produce spore, Gram-negative.There are several polar flagellas, motion.Aerobic, carry out strict breathing pattern metabolism, taking oxygen as final electron acceptor.Can carry out anaerobic respiration taking nitrate as alternative electron acceptor.Chemotrophy heterotrophism, without the need for machine somatomedin.Oxidase positive, the catalase positive.Can utilize glucose and fructose, some bacterial strain can be from the synthetic levan of sucrose, gelatin liquefaction.Growth temperature range 4-37 DEG C, optimum growth temperature is 25-30 DEG C.In DNA, G+C content is 60-61%.Be distributed widely in nature, in soil, water, plant and animal activity environment.The biochemical ability of this bacterium is active, and the many artificial-synthetic compounds of degradable, are often used to environmental conservation.The multiple freshwater fishes such as this disease main harm Ctenopharyngodon idellus, Mylopharyngodon piceus, Cyprinus carpio, Megalobrama amblycephala, in China area of respectively breeding fish, have throughout the year popular, especially after fishing for, transporting.When the body surface of fish is intact, pathogen cannot be invaded the skin of fish.Only have and because of fishing for, transport, putting in a suitable place to breed, fish body is mechanically damaged when fish, or cold injury, or body surface is by parasite parasitism and when impaired, pathogen just can be taken advantage of a weak point, and causes morbidity.
Fish is slow in action, and bradykinesia is weak, peel off and solely swim in the water surface.Body surface part or large-area hemorrhage inflammation, scale comes off, and particularly fish body both sides and abdominal part are the most obvious.Fin hyperemia, afterbody rots, and forms " moth fin ".Hubei Province up and down of fish and the hyperemia of gill cover part, be block erythema.Sometimes the gill cover is rotten goes one, is porthole shape, occurs blank.Often there is fish molds parasitism in scale disengaging and fin ray rotten place, increase the weight of patient's condition.Falling ill will be dead after several days.
Doctor trained in Western medicine control Ctenopharyngodon idellus erythroderma is longer the course for the treatment of, and prevention effect is undesirable, rear easily recurrence, meanwhile, along with a large amount of uses of these medicines, residual drug toxicity in a large number in animal body, in the time of edible these grass carp meats of people, the mankind's life and health in serious threat.
Chinese medicine, not only has advantages of western modern medicine, also has the advantage that western modern medicine does not have, and not only cure rate is high, instant effect, in detoxicating, relieving inflammation, sterilization, and drug residue free, cost price is low, is difficult for more afterwards recurrence.The traditional Chinese medicine of China is conceived to entirety while application, emphasize to regulate allomeric function, improve the premunition of body, prolonged application is safe and reliable, therefore, having played more and more important effect aspect treatment Ctenopharyngodon idellus erythroderma, because have drawn from nature, and use to have hypertoxic medical herbs few, therefore Chinese herbal medicine can be more safer than Western medicine.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma.Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, and not only cure rate is high, instant effect, in detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, is difficult for more afterwards recurrence; The present invention is conceived to entirety, emphasizes to regulate allomeric function, improves the premunition of body, and prolonged application is safe and reliable.
In order to realize foregoing invention object, the invention provides a kind ofly for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, described Chinese medicine composition comprises following raw medicinal material: Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae, Radix Rumicis Japonici and Rhizoma Imperatae.
In described Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight portion, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Centipedae 14 weight portions, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions and Rhizoma Imperatae 25 weight portions.
Described Chinese medicine composition is Bao Kuo Rhizoma amorphophalli potato, Radix Apioris Fortunei, Limax, Asterias amurensis Lutken and Tinea Ranae also.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight portion, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion, Rhizoma Imperatae 15-40 weight portion, Rhizoma amorphophalli potato 15-26 weight portion, Radix Apioris Fortunei 10-22 weight portion, Limax 3-7 weight portion, Asterias amurensis Lutken 2-5 weight portion and Tinea Ranae 7-13 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Centipedae 14 weight portions, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions, Rhizoma Imperatae 25 weight portions, Rhizoma amorphophalli potato 15 weight portions, Radix Apioris Fortunei 11 weight portions, Limax 4 weight portions, Asterias amurensis Lutken 3 weight portions and Tinea Ranae 8 weight portions.
The dosage form of described Chinese medicine composition is granule, and its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 DEG C of the inlet temperature of spray dryer, 80～85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 DEG C dry, obtain granule.
The dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
In order better to realize foregoing invention object, the invention provides a kind ofly for preventing and treating the preparation method of Chinese medicine composition of Ctenopharyngodon idellus erythroderma, when the dosage form of Chinese medicine composition is granule, its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 DEG C of the inlet temperature of spray dryer, 80～85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 DEG C dry, obtain granule.
When the dosage form of Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
The invention has the beneficial effects as follows:
Chinese medicine composition of the present invention, has heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, and not only cure rate is high, instant effect, in detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, is difficult for more afterwards recurrence; The present invention has the entirety of being conceived to, and emphasizes to regulate allomeric function, improves the premunition of body, and prolonged application is safe and reliable.
Detailed description of the invention
The traditional Chinese medical science thinks that disease is body normal physiological function destruction to a certain extent, and the process of disease is exactly evil process of just struggling against.In the vital movement of body, healthy energy is being brought into play its effect that maintains body normal physiological function on the one hand, on the other hand, body be not also subject to the invasion and attack of pathogen all the time, the two is constantly struggled against, and also constantly averages out and unifies, and has ensured the health of body.Therefore, the generation of disease, is decided by the result that healthy energy and pathogen both sides struggle against.Traditional Chinese medical science pathogenesis had both been emphasized the decisive action of body healthy energy in morbidity, did not get rid of again the important function of pathogen, and thought that pathogen also can play conclusive effect under certain condition.
Therefore, treatment Ctenopharyngodon idellus erythroderma is mainly with heat-clearing and toxic substances removing, and cooling blood for hemostasis is primary treatment principle.Select based on this principle: Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae, Radix Rumicis Japonici and Rhizoma Imperatae; Preferably, all right Bao Kuo Rhizoma amorphophalli potato, Radix Apioris Fortunei, Limax, Asterias amurensis Lutken and Tinea Ranae.
Wherein, Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni clearing away heat-fire, dampness; Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Rhizoma amorphophalli potato, Radix Apioris Fortunei, Limax, Asterias amurensis Lutken and Tinea Ranae can heat-clearing and toxic substances removing, removing heat from blood sore; Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae, Radix Rumicis Japonici, Rhizoma Imperatae clearing away heat and cooling blood, hemostasis.Complete square in detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, is difficult for more afterwards recurrence, is conceived to entirety, emphasizes to regulate allomeric function, improves the premunition of body, and prolonged application is safe and reliable.
The pharmacology of each crude drug is as follows:
Herba Centipedae: pungent, temperature; Return lung, Liver Channel.Clearing the nasal passage, cough-relieving, for headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
Herba Lophatheri: nature and flavor, sweet, be slightly cold; GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.
Fructus Gardeniae: bitter, cold, nontoxic; GUIXIN warp, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swells and ache.
Rhizoma Coptidis: hardship, cold, nontoxic; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.
Cortex Phellodendri: hardship, cold; Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Cortex Fraxini: bitter in the mouth, cold; Return Liver Channel, gallbladder meridian, large intestine channel.Function heat clearing and damp drying, liver heat removing and eyesight improving, astringent therapy dysentery relieving, leukorrhagia stopping.For pyretic toxicity dysentery, leukorrhagia pudendal pruritus, liver-heat conjunctival congestion and swelling pain, the raw cataracta of order.
Radix Sophorae Flavescentis: bitter in the mouth; Cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel; Urinary bladder channel.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.
Cortex Dictamni: hardship, salty, cold; Return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel.Control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor Huang etc.
Flos Lonicerae: cold in nature, sweet in the mouth; Return lung, the heart, stomach warp.The effect with heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.
Fructus Forsythiae: bitter in the mouth, cold nature; GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.
Herba Andrographis: hardship, cold; GUIXIN, lung, large intestine, urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood, detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
Folium Isatidis: hardship, cold; Return liver, the heart, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Herba Violae: bitter in the mouth, pungent, cold in nature; GUIXIN, Liver Channel.There is the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, main influenza; Upper respiratory tract infection; Tonsillitis; Infectious hepatitis; Intestinal inflammation; Dysentery; Nephritis; Parotitis; Conjunctivitis; Acute appendicitis; Furuncle carbuncle; Scrofula.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent; Return liver, heart channel.Heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.
Rhizoma Paridis: slightly poisonous, bitter, cold; Return Liver Channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.For furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, convulsion with spasms.
Rhizoma Bistortae: hardship, cool; Return lung, liver, large intestine channel.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, tetanus, carbuncle scrofula, snake bite and insect sting.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula.
Herba Houttuyniae: cold nature, bitter in the mouth; Return lung meridian, bladder, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.
Caulis Sargentodoxae: bitter in the mouth, property is flat; Return liver, large intestine channel.There is the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Herba Patriniae: acrid in the mouth, hardship, be slightly cold; Return liver, stomach, large intestine channel.Function heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing, for acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, furuncle pain is swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea.
Herba Potentillae Discoloris: sweet, micro-hardship, flat, nontoxic.Thermal detoxification, cooling blood for hemostasis.For enteritis, bacillary dysentery, amebic dysentery, spits blood, and epistaxis, has blood in stool, leucorrhea; Wound is controlled in external, carbuncle furuncle and phyma poison.
Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool; Return liver, spleen channel.Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.For carbuncle furunculosis, scrofula sucutaneous nodule, tuberculous lymphadenitis, snake bite and insect sting.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth.Heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis; Gallbladder exudative dermatitis inflammation; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.
Radix Ampelopsis: hardship, is slightly cold; GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.For carbuncle carbuncle on the back, furuncle, scrofula, burn due to hot liquid or fire.
Ilex purpurea Hassk.[I.chinensis Sims: hardship, puckery, cool.Heat-clearing and toxic substances removing; Promoting tissue regeneration and ulcer healing; Promoting blood circulation and hemostasis.Main cough due to lung-heat; Laryngopharynx swelling and pain; Dysentery; Diarrhoea; Biliary tract infection; Urinary tract infection; Angina pectoris; Burn and scald; Pyretic toxicity carbuncle; Ulcer of the lower limb; Leprelcosis; Eczema; Chilblain; Chap; Thromboangiitis obliterans; Traumatic hemorrhage.
Cortex Moutan: bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel.Except pathogen, happy color, the natural fibre line of meat blood vessels of being open to the custom, evacuation of pus, logical menstruation, disappears and flutters damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, the tire lower eyelid that falls, puerperal all cold and hot vim and vigour.Nourishing YIN to lower pathogenic fire, separates speckle poison, throat, diuresis stasis.
Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Cure mainly folding and fall, muscle absolutely, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty; GUIXIN, Liver Channel.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Herba Cirsii: sweet, bitter, cold; GUIXIN, Liver Channel.Function cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, to spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Sanguisorbae: picric acid, cold, nontoxic; Return liver, lung, kidney, large intestine channel.Function cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.For spitting blood, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.
Flos Sophorae: bitter in the mouth, cold nature; Return liver, lung, the heart, large intestine channel.There is cooling blood for hemostasis, effect of purging liver-fire; Main discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.Be used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spits blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.
Radix Rumicis Japonici: hardship; Cold in nature; The heart, liver, large intestine channel.Effect clearing away heat and loosing the bowels, cooling blood for hemostasis, killing parasites for relieving itching.Cure mainly constipation, hematemesis and epistaxis, discharging fresh blood stool, hemorrhoidal bleeding, metrorrhagia, scabies, bald, carbuncle pyogenic infections from tumour or sore, traumatic injury in vain.
Rhizoma Imperatae: sweet in the mouth, cold in nature; Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Rhizoma amorphophalli potato: hardship; Cool; Slightly poisonous.Return stomach; Spleen; Liver Channel.Heat-clearing and toxic substances removing; Regulating QI to relieve pain.Main gastroenteritis; Gastric and duodenal ulcers; Dyspepsia; Dysentery; Hepatitis; Furuncle; Laryngopharynx swelling and pain; Burn and scald.
Radix Apioris Fortunei: sweet, micro-hardship, flat.Heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing.Pertussis, cold cough, laryngopharynx swelling and pain; Venom is controlled in external, sore swollen toxin.
Limax: salty, cold.Slightly poisonous.Heat-clearing and toxic substances removing, diuresis.For carbuncle furunculosis, anal fistula, dysuria.
Asterias amurensis Lutken: salty in the mouth; Property is put down.Return liver; Stomach warp.Checking hyperfunction of the liver for relieving convulsion; Anti-acid and regulating stomach; Heat-clearing and toxic substances removing.Main epilepsy; Stomachache acid regurgitation; Thyromegaly; Otitis media.
Tinea Ranae: sweet; Cold.Return spleen channel.Heat-clearing and toxic substances removing.Main hot carbuncle toxin; Mumps; Burn due to hot liquid or fire.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
It is a kind of for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma that the embodiment of the present invention provides, raw medicinal material by following ratio of weight and number is made: Herba Centipedae 14 weight portions, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions and Rhizoma Imperatae 25 weight portions.
Its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4 times, mixture be 85%, be heated to boiling reflux 4 hours, filter, adopt the speed slowly percolation of percolation with 2ml per minute, collect percolate, the mastic that while being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is 1.10, spraying is dry, 175 DEG C of the inlet temperature of spray dryer, 85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the dextrin of 0.1 times, granulation, in 50 DEG C dry, obtain granule.
Embodiment 2 pharmaceutical compositions 2
It is a kind of for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma that the embodiment of the present invention provides, and is made up: Herba Centipedae 14 weight portions of the raw medicinal material of following ratio of weight and number, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions, Rhizoma Imperatae 25 weight portions, Rhizoma amorphophalli potato 15 weight portions, Radix Apioris Fortunei 11 weight portions, Limax 4 weight portions, Asterias amurensis Lutken 3 weight portions and Tinea Ranae 8 weight portions.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
The toxicity test of Chinese medicine composition:
Get Herba Centipedae 23g, Herba Lophatheri 21g, Fructus Gardeniae 31g, Rhizoma Coptidis 29g, Cortex Phellodendri 18g, Cortex Fraxini 21g, Radix Sophorae Flavescentis 22g, Cortex Dictamni 18g, Flos Lonicerae 9g, Fructus Forsythiae 32g, Herba Andrographis 16g, Folium Isatidis 19g, Herba Violae 38g, Flos Chrysanthemi Indici 15g, Rhizoma Paridis 7g, Rhizoma Bistortae 28g, Herba Houttuyniae 13g, Caulis Sargentodoxae 28g, Herba Patriniae 13g, Herba Potentillae Discoloris 9g, Pseudobulbus Cremastrae Seu Pleiones 31g, Herba Senecionis Scandentis 31g, Radix Ampelopsis 28g, Ilex purpurea Hassk.[I.chinensis Sims 25g, Cortex Moutan 19g, Radix Rehmanniae 31g, Radix Arnebiae (Radix Lithospermi) 37g, Herba Cirsii 15g, Radix Sanguisorbae 26g, Flos Sophorae 32g, Radix Rumicis Japonici 14g and Rhizoma Imperatae 19g, after mix homogeneously, pulverize, to the cold water soak 10 hours that adds 1500g in the mixture after pulverizing, the boiled rear slow fire boiling of intense fire 2.5 hours, filters, obtain the first filtrate, in filtering residue, add the cold water of 1500g again to decoct 1.5 hours, filter, obtain the second filtrate, twice filtrate is mixed, be evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal, and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
The toxicity test of Chinese medicine composition:
Get Herba Centipedae 14g, Herba Lophatheri 22g, Fructus Gardeniae 25g, Rhizoma Coptidis 32g, Cortex Phellodendri 17g, Cortex Fraxini 25g, Radix Sophorae Flavescentis 32g, Cortex Dictamni 23g, Flos Lonicerae 7g, Fructus Forsythiae 31g, Herba Andrographis 20g, Folium Isatidis 21g, Herba Violae 29g, Flos Chrysanthemi Indici 19g, Rhizoma Paridis 5g, Rhizoma Bistortae 32g, Herba Houttuyniae 11g, Caulis Sargentodoxae 30g, Herba Patriniae 15g, Herba Potentillae Discoloris 10g, Pseudobulbus Cremastrae Seu Pleiones 26g, Herba Senecionis Scandentis 33g, Radix Ampelopsis 23g, Ilex purpurea Hassk.[I.chinensis Sims 27g, Cortex Moutan 30g, Radix Rehmanniae 24g, Radix Arnebiae (Radix Lithospermi) 39g, Herba Cirsii 18g, Radix Sanguisorbae 24g, Flos Sophorae 37g, Radix Rumicis Japonici 13g, Rhizoma Imperatae 25g, Rhizoma amorphophalli potato 15g, Radix Apioris Fortunei 11g, Limax 4g, Asterias amurensis Lutken 3g and Tinea Ranae 8g, after mix homogeneously, pulverize, to the cold water soak 10 hours that adds 1500g in the mixture after pulverizing, the boiled rear slow fire boiling of intense fire 2.5 hours, filters, obtain the first filtrate, in filtering residue, add the cold water of 1500g again to decoct 1.5 hours, filter, obtain the second filtrate, twice filtrate is mixed, be evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal, and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
(1) for examination animal
The sick fish of making a definite diagnosis from certain Ctenopharyngodon idellus plant of Yancheng of Jiangsu Province is chosen the sick fish of 600 tails at random as treatment contrast test object; Separately from this plant, choose at random the healthy fish of 600 tails as prevention contrast test object.
(2) bacterial strain extracts and cultivates:
The sick fish that infects Ctenopharyngodon idellus erythroderma in certain Ctenopharyngodon idellus plant of Yancheng of Jiangsu Province is cutd open to inspection, and the aseptic collection internal organs such as the liver, gallbladder, spleen of Ctenopharyngodon idellus of dying of illness are smeared and are inoculated in agar slant, cultivate 24h at 30 DEG C; Get the bacterium colony smear processed of growing on inclined-plane, gram's method dyeing, microscopy.Select colonies typical and be inoculated in meat soup, then after 30 DEG C of meat soups are cultivated 18h, bacterium liquid is diluted to 105-106 bacterium/ml for subsequent use.
(3) prevention contrast experiment:
600 tail healthy grass carp of random choose are divided into 3 groups (embodiment group 1, embodiment group 2 and matched groups) at random, wherein, embodiment group 1, embodiment group 2 are used respectively the granule of the embodiment of the present invention 1, the powder of embodiment 2, medicine is spilled in cultivation pool, making concentration in water is 0.5 mg/litre, be used in conjunction 5 days, matched group does not use any medicine.Then with culture for subsequent use, embodiment group 1, embodiment group 2 and matched group are carried out to artificial challenge, carry out intramuscular injection 0.2mL/ tail under dorsal fin, observed and recorded is respectively organized sickness rate and the mortality rate of Ctenopharyngodon idellus, and result is as shown in table 1.
Table 1 preventive effect synopsis
Data from table 1: Chinese medicine composition of the present invention has obvious preventive effect to Ctenopharyngodon idellus erythroderma.
(4) treatment contrast test:
Curative effect determinate standard
Recovery from illness: offer medicine in latter 7 days, Ctenopharyngodon idellus not death and transference cure is recovery from illness;
Take a turn for the better: offer medicine in latter 7 days, Ctenopharyngodon idellus not death and symptom alleviates as taking a turn for the better;
Invalid: the Ctenopharyngodon idellus of offeing medicine in latter 7 days is dead for invalid.
The erythroderma Ctenopharyngodon idellus that 600 tails of choosing are at random made a definite diagnosis is divided into 3 groups (treatment by Chinese herbs group, western medicine group, blank groups) at random, treat with different medicines, wherein, treatment by Chinese herbs group is selected the granule of embodiment 1, dose is every 100kg fish medication 20g, mixes with appropriate adhesive, admixes and in bait, makes bait feeding, dispensing 7 days continuously, every day 1 time; Western medicine group is selected sulfathiazole, dispensing 7 days continuously, every day 1 time, within l days, dosage is pressed 100kg fish medication 20g medication, mix with appropriate adhesive, admix in bait and make bait feeding, within the 2nd to the 7th day, dosage reduces by half, and external medication is full pond float bleaching powder (containing 30% effective chlorine) 1mg/kg; Blank group is not fed any medicine.Observed and recorded is respectively organized the cure rate of Ctenopharyngodon idellus, and result is as shown in table 2.
Table 2 therapeutic effect synopsis
Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to the therapeutic effect of Ctenopharyngodon idellus erythroderma, reduce mortality rate, improve cure rate.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. one kind for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae, Radix Rumicis Japonici and Rhizoma Imperatae.
2. according to claim 1ly it is characterized in that for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight portion, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
3. according to claim 1 and 2 for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Centipedae 14 weight portions, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions and Rhizoma Imperatae 25 weight portions.
4. arbitrary described for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma according to claim 1-3, it is characterized in that, described Chinese medicine composition is Bao Kuo Rhizoma amorphophalli potato, Radix Apioris Fortunei, Limax, Asterias amurensis Lutken and Tinea Ranae also.
According to described in claim 1-4 any one for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight portion, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion, Rhizoma Imperatae 15-40 weight portion, Rhizoma amorphophalli potato 15-26 weight portion, Radix Apioris Fortunei 10-22 weight portion, Limax 3-7 weight portion, Asterias amurensis Lutken 2-5 weight portion and Tinea Ranae 7-13 weight portion.
According to described in claim 1-5 any one for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Centipedae 14 weight portions, Herba Lophatheri 22 weight portions, Fructus Gardeniae 25 weight portions, Rhizoma Coptidis 32 weight portions, Cortex Phellodendri 17 weight portions, Cortex Fraxini 25 weight portions, Radix Sophorae Flavescentis 32 weight portions, Cortex Dictamni 23 weight portions, Flos Lonicerae 7 weight portions, Fructus Forsythiae 31 weight portions, Herba Andrographis 20 weight portions, Folium Isatidis 21 weight portions, Herba Violae 29 weight portions, Flos Chrysanthemi Indici 19 weight portions, Rhizoma Paridis 5 weight portions, Rhizoma Bistortae 32 weight portions, Herba Houttuyniae 11 weight portions, Caulis Sargentodoxae 30 weight portions, Herba Patriniae 15 weight portions, Herba Potentillae Discoloris 10 weight portions, Pseudobulbus Cremastrae Seu Pleiones 26 weight portions, Herba Senecionis Scandentis 33 weight portions, Radix Ampelopsis 23 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portions, Cortex Moutan 30 weight portions, Radix Rehmanniae 24 weight portions, Radix Arnebiae (Radix Lithospermi) 39 weight portions, Herba Cirsii 18 weight portions, Radix Sanguisorbae 24 weight portions, Flos Sophorae 37 weight portions, Radix Rumicis Japonici 13 weight portions, Rhizoma Imperatae 25 weight portions, Rhizoma amorphophalli potato 15 weight portions, Radix Apioris Fortunei 11 weight portions, Limax 4 weight portions, Asterias amurensis Lutken 3 weight portions and Tinea Ranae 8 weight portions.
7. arbitrary described for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma according to claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is granule, its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 DEG C of the inlet temperature of spray dryer, 80～85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 DEG C dry, obtain granule.
8. arbitrary described for preventing and treating the Chinese medicine composition of Ctenopharyngodon idellus erythroderma according to claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
As described in claim 1-6 any one for preventing and treating the preparation method of Chinese medicine composition for Ctenopharyngodon idellus erythroderma, it is characterized in that, the dosage form of described Chinese medicine composition is granule, its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed in described ratio, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 DEG C of the inlet temperature of spray dryer, 80～85 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 DEG C dry, obtain granule.
As described in claim 1-6 any one for preventing and treating the preparation method of Chinese medicine composition for Ctenopharyngodon idellus erythroderma, it is characterized in that, the dosage form of described Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, filters by second step the filtering residue obtaining and again adds in cold water, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of powder quality that second step obtains;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
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| CN105147904A (en) * | 2015-09-28 | 2015-12-16 | 全椒县花溪湖特种水产合作社 | Drug preventing and curing fish red skin disease |
| CN105519796A (en) * | 2015-12-29 | 2016-04-27 | 浏阳市辉章农牧科技有限公司 | Pelteobagrus fulvidraco breeding feed additive |
| CN105918703A (en) * | 2016-04-29 | 2016-09-07 | 青岛海之星生物科技有限公司 | Feed additive treating megalobrama amblycephala red skin diseases and preparation method thereof |
| CN107173280A (en) * | 2017-04-28 | 2017-09-19 | 靖西市秀美边城农业科技有限公司 | A kind of cultural method of anti-grass carp red skin disease |
| CN107812061A (en) * | 2017-11-27 | 2018-03-20 | 衡阳市日升娃娃鱼养殖基地 | A kind of natural bactericidal agent for giant salamander skin degerming and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105147904A (en) * | 2015-09-28 | 2015-12-16 | 全椒县花溪湖特种水产合作社 | Drug preventing and curing fish red skin disease |
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| CN107173280A (en) * | 2017-04-28 | 2017-09-19 | 靖西市秀美边城农业科技有限公司 | A kind of cultural method of anti-grass carp red skin disease |
| CN107812061A (en) * | 2017-11-27 | 2018-03-20 | 衡阳市日升娃娃鱼养殖基地 | A kind of natural bactericidal agent for giant salamander skin degerming and preparation method thereof |
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Application publication date: 20141210 |