CN105902513B - 一种肠溶型金霉素微丸预混剂及其制备方法 - Google Patents
一种肠溶型金霉素微丸预混剂及其制备方法 Download PDFInfo
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- CN105902513B CN105902513B CN201610313360.6A CN201610313360A CN105902513B CN 105902513 B CN105902513 B CN 105902513B CN 201610313360 A CN201610313360 A CN 201610313360A CN 105902513 B CN105902513 B CN 105902513B
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- aureomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Abstract
Description
组别 | 平均平面临界角(Φ) | 水分含量(%) | 载药量(%) | 收率(%) |
实施例1 | 10.8° | 3.25 | 41.32 | 92.47 |
实施例2 | 11.4° | 3.37 | 39.74 | 92.24 |
实施例3 | 11.0° | 3.32 | 42.12 | 92.35 |
实施例4 | 10.4° | 3.25 | 37.58 | 92.52 |
实施例5 | 11.5° | 3.46 | 42.20 | 92.46 |
对比例1 | 13.3° | 3.87 | 41.27 | 92.22 |
对比例2 | 11.0° | 5.12 | 41.20 | 92.15 |
Claims (9)
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CN201610313360.6A CN105902513B (zh) | 2016-05-11 | 2016-05-11 | 一种肠溶型金霉素微丸预混剂及其制备方法 |
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CN201610313360.6A CN105902513B (zh) | 2016-05-11 | 2016-05-11 | 一种肠溶型金霉素微丸预混剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105902513A CN105902513A (zh) | 2016-08-31 |
CN105902513B true CN105902513B (zh) | 2018-10-16 |
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CN201610313360.6A Active CN105902513B (zh) | 2016-05-11 | 2016-05-11 | 一种肠溶型金霉素微丸预混剂及其制备方法 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108143720A (zh) * | 2016-12-02 | 2018-06-12 | 中国科学院大连化学物理研究所 | 可生物降解型止血抗感染的缓释药物组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101242811A (zh) * | 2005-08-15 | 2008-08-13 | 索尔瓦药物有限公司 | 酸不稳定性药物的控释药物组合物 |
CN103271876A (zh) * | 2013-01-16 | 2013-09-04 | 内蒙古金河动物药业有限公司 | 一种肠溶包衣金霉素预混剂及其制备方法 |
CN103284956A (zh) * | 2013-01-16 | 2013-09-11 | 内蒙古金河动物药业有限公司 | 一种金霉素预混剂及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6958161B2 (en) * | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
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2016
- 2016-05-11 CN CN201610313360.6A patent/CN105902513B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101242811A (zh) * | 2005-08-15 | 2008-08-13 | 索尔瓦药物有限公司 | 酸不稳定性药物的控释药物组合物 |
CN103271876A (zh) * | 2013-01-16 | 2013-09-04 | 内蒙古金河动物药业有限公司 | 一种肠溶包衣金霉素预混剂及其制备方法 |
CN103284956A (zh) * | 2013-01-16 | 2013-09-11 | 内蒙古金河动物药业有限公司 | 一种金霉素预混剂及其制备方法 |
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Address after: 510000 No. 6 Huafeng Road, Yonghe District, Guangzhou Economic and Technological Development Zone, Guangdong Province Patentee after: Guangdong Jiadele Technology Co.,Ltd. Address before: 510000 No. 6 Huafeng Road, Yonghe District, Guangzhou Economic and Technological Development Zone, Guangdong Province Patentee before: GUANGZHOU CARDLO BIOCHEMICAL TECHNOLOGY Co.,Ltd. |