CN105878742A - 一种益胃中药组合物 - Google Patents
一种益胃中药组合物 Download PDFInfo
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Abstract
本发明公开的一种益胃中药组合物,其特征在于,所述中药组合物由重量份数组成:黄芪20份~25份、半夏3份~5份、麻黄1份~3份、白术4份~6份、陈皮1份~3份、葛根3份~5份、人参1份~3份、厚朴4份~6份、茯苓3份~5份、甘草3份~5份、木香2份~5份、甘松3份~5份、刀豆1份~3份、枳实4份~6份、枳壳1份~3份、扁豆3份~5份、山药1份~3份、百合4份~6份、党参3份~5份、孩儿参3份~5份、饴糖1份~3份、黄精4份~6份;本发明又公开了一种益胃中药组合物的制备方法;本发明所采取的处方精简,药力强见效快,既能迅速行气止痛,治疗胃寒症状,又能够从根本上调理胃功能,不易复发,而且服用方便。
Description
技术领域
本发明涉及药物技术领域,尤其涉及一种益胃中药组合物。
背景技术
胃是人体重要的消化器官,主受纳腐熟水谷,为水谷精微之仓、气血之海,胃以通降为顺,与脾相表里,脾胃常合称为后天之本。胃与脾同居中土,但胃为燥土属阳,脾为湿土属阴,胃最忌受寒。但是,现代人的生活节奏快,精神紧张,饮食不规律,饮食不节,嗜食生冷,或经常冷热食物一起吃,吃饭不按时或者饥饱不均,久而久之就会造成胃寒。中医认为胃寒的形成原因主要有:脾胃阳气虚衰;腹部受凉;脾胃阳气虚衰,过食生冷,或寒邪直中所致阴寒凝滞胃腑的证候。症见胃脘疼痛,得温痛减,呕吐清涎,口淡喜热饮,食不化,舌淡苔白滑,脉沉迟。中医中的“胃脘痛”为现代医学所说的胃溃疡、十二指肠溃疡、慢性胃炎、胃下垂、胃神经官能症及胃黏膜脱垂等疾患。
目前西药治疗此类疾病,主要以抑制胃酸分泌、中和胃酸及抗菌消炎为主,侧重于治疗胃部局部病变,治愈后容易复发,难以从根本上解决患者的痛苦。而传统中药对于此类疾病的方剂甚多,虽能够标本兼治,但是受到煎药、服用的限制,药物浓度稀,很少有短时间内立竿见影的效果,而且传统的服药方式与现代社会条件、人们生活习惯有很大差异,故限制了传统中药在此类疾病上的临床应用。
发明内容
本发明为了解决上述不足,提供一种益胃中药组合物。
本发明的解决方案是基于中医对胃寒及其症状的发病机理认识及其治疗原则,参照现代制药工艺,从传统医学宝库中,筛选出益气健脾,温中健胃的药物组合成而成,本发明药物是由下列重量分组分制成的:
黄芪20份~25份、半夏3份~5份、麻黄1份~3份、白术4份~6份、陈皮1份~3份、葛根3份~5份、人参1份~3份、厚朴4份~6份、茯苓3份~5份、甘草3份~5份、木香2份~5份、甘松3份~5份、刀豆1份~3份、枳实4份~6份、枳壳1份~3份、扁豆3份~5份、山药1份~3份、百合4份~6份、党参3份~5份、孩儿参3份~5份、饴糖1份~3份、黄精4份~6份。
进一步的,本发明的最佳重量份配比是:
黄芪23份、半夏4份、麻黄2份、白术5份、陈皮2份、葛根4份、人参2份、厚朴5份、茯苓4份、甘草4份、木香3份、甘松4份、刀豆2份、枳实5份、枳壳1份、扁豆5份、山药2份、百合6份、党参5份、孩儿参4份、饴糖3份、黄精4份。
根据本发明的又一发明目的,本发明提供了一种制作上述一种益胃中药组合物的制作方法,包括以下步骤:
第一步:取黄芪粉碎后,用乙醇溶液提取,过滤,滤液备用;
第二步:取步骤1的药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合,加纯净水提取2次,过滤,滤液备用;
第三步:将步骤1和步骤2的滤液混合,将混合溶液经过喷雾干燥器干燥,得到药物粉末备用;
第四步:将人参、陈皮、葛根粉碎,与步骤3的药物粉末混合,添加饴糖、辅料,制粒,得到所需要的制剂。
进一步的,在第一步中,所述一种益胃中药组合物的制作方法中黄芪的粉碎细度为20~40目,以便于提取和过滤。
进一步的,在第一步中,所述一种益胃中药组合物的制作方法中黄芪的提取方式为用10~15倍量的75~85%乙醇溶液在70~80℃条件下提取2次,每次3~4小时。
进一步的,在第二步中,所述一种益胃中药组合物的制作方法中的药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合后的提取方式为加10~12倍纯净水在70~80℃条件下提取2次,每次2~3小时。
进一步的,在第三步中,所述一种益胃中药组合物的制作方法中的喷雾干燥器干燥的工作条件为:进风温度140~150℃、出风温度80~90℃、雾化器频率50Hz。
进一步的,在第四步中,所述一种益胃中药组合物的制作方法中人参、陈皮、葛根的粉碎细度为120目以下。
更进一步的,一种益胃中药组合物,所制备的剂型为胶囊剂、片剂、颗粒剂。
本发明的优点是:
本发明公开的一种益胃中药组合物,其中人参、白术、甘草补气养胃,柴胡、麻黄升举清阳、祛风除湿,半夏、陈皮、茯苓、厚朴、黄芪除湿清热;适用于脾胃气虚、清阳不升、湿郁胃寒之证。木香、甘松、刀豆、枳实、枳壳为理气药,调理胃脘中气,扁豆、山药、百合、党参、孩儿参、饴糖、黄精为补益药,针对脾胃虚弱用药。本方中药组合物的药力强、见效快,既能迅速行气止痛,治疗胃寒症状,又能够从根本上调理胃功能,不易复发,而且同时用现代工艺制药,方便服用。
具体实施方式
以下给出本发明的具体实施例,用来对本发明作进一步详细说明。
下述实施例中的实验方法,如无特殊说明,均为常规方法。下述实施例中所用的药材原料、试剂材料等,如无特殊说明,均为市售购买产品。
实施例1
一种益胃中药组合物
其制作方法为:
(1)称取黄芪2.3kg、人参0.2kg、厚朴0.5kg、茯苓0.4kg、甘草0.4kg、半夏0.4kg、麻黄0.2kg、白术0.5kg、陈皮0.2kg、葛根0.4kg、木香0.35kg、甘松0.4kg、刀豆0.2kg、枳实0.5kg、枳壳0.2kg、扁豆0.4kg、山药0.2kg、百合0.5kg、党参0.4kg、孩儿参0.4kg、饴糖0.2kg、黄精0.5kg。
(2)取黄芪粉碎,过20目筛,用23kg 75%乙醇溶液在70℃条件下提取2次,每次3小时,过滤,滤液备用;
(3)取步骤(2)的药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合,加纯净水87.5kg在70℃条件下提取2次,每次2小时,过滤,滤液备用;
(4)将步骤(2)和步骤(3)的滤液混合,将混合溶液经过进风温度140℃、出风温度80℃、雾化器频率50Hz喷雾干燥器干燥,得到药物粉末1.32kg备用;
(5)将人参、陈皮、葛根粉碎至120目以下,与步骤(4)的药物粉末混合,添加饴糖0.2kg,淀粉、乙醇适量,制粒。
(6)将制粒后的药物粉末经过制粒机装胶囊处理,每粒装胶囊400mg,得到胶囊5000粒。
实施例2
一种益胃中药组合物
其制作方法为:
(1)称取黄芪2.5kg、人参0.3kg、厚朴0.6kg、茯苓0.5kg、甘草0.5kg、半夏0.5kg、麻黄0.3kg、白术0.6kg、陈皮0.3kg、葛根0.5kg、木香0.5kg、甘松0.5kg、刀豆0.3kg、枳实0.3kg、枳壳0.3kg、扁豆0.5kg、山药0.3kg、百合0.6kg、党参0.5kg、孩儿参0.5kg、饴糖0.3kg、黄精0.6kg。
(2)取黄芪粉碎,过40目筛,用37.5kg 85%乙醇溶液在80℃条件下提取2次,每次4小时,过滤,滤液备用;
(3)取步骤(2)的药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合,加纯净水156kg在80℃条件下提取2次,每次3小时,过滤,滤液备用;
(4)将步骤(2)和步骤(3)的滤液混合,将混合溶液经过进风温度150℃、出风温度90℃、雾化器频率50Hz喷雾干燥器干燥,得到药物粉末1.56kg备用;
(5)将人参、陈皮、葛根粉碎至120目以下,与步骤(4)的药物粉末混合,添加饴糖0.3kg。
(6)将第(5)步的药物混合物按照药物混合物:蔗糖:淀粉=3:1:1的比例添加蔗糖0.62kg、淀粉0.62kg,混合均匀,加入乙醇适量,制粒成颗粒剂,按每袋2.5g的重量装袋,得到颗粒剂1240袋。
实施例3
一种益胃中药组合物
其制作方法为:
(1)称取黄芪2.0kg、人参0.1kg、厚朴0.4kg、茯苓0.3kg、甘草0.3kg、半夏0.3kg、麻黄0.1kg、白术0.4kg、陈皮0.1kg、葛根0.3kg、木香0.5kg、甘松0.5kg、刀豆0.3kg、枳实0.3kg、枳壳0.3kg、扁豆0.5kg、山药0.3kg、百合0.6kg、党参0.5kg、孩儿参0.5kg、饴糖0.3kg、黄精0.6kg。
(2)取黄芪粉碎,过30目筛,用24kg 80%乙醇溶液在75℃条件下提取2次,每次3.5小时,过滤,滤液备用;
(3)取步骤(2)的药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合,加纯净水104.4kg在75℃条件下提取2次,每次2.5小时,过滤,滤液备用;
(4)将步骤(2)和步骤(3)的滤液混合,将混合溶液经过进风温度145℃、出风温度85℃、雾化器频率50Hz喷雾干燥器干燥,得到药物粉末1.56kg备用;
(5)将人参、陈皮、葛根粉碎至120目以下,与步骤(4)的药物粉末混合,添加饴糖0.5kg,淀粉、乙醇适量,制粒。
(6)将制粒,的药物粉末经过制粒机装胶囊处理,每粒装胶囊500mg,得到胶囊6000粒。
实验例1
本发明的中药组合物的动物急性毒性试验
本实施例通过小鼠口服给药药物半数致死量的测定,考察了实施例2制备的中药组合物对小鼠的急性毒性反应和死亡情况。
取小鼠30只,每组10只,分3组,即高、中、低3个剂量组(0.8、0.4、0.2ml/15g)灌胃给药3次/日,预测药物半数致死量的范围。结果显示,高剂量组测不出半数致死量,故将药物灌胃给药半数致死量的测定改做最大体积下之最大弄点—最大耐受量的测定。
取小鼠30只,空腹12小时后,以预测选定的0.8ml/15g计量逐只灌胃给药给受试动物3次/日,连续观察7天。
在灌胃给受试品24小时,小鼠自发性活动下降,摄食、摄水减少;第二天自发性活动逐渐趋于正常,大、小便未见异常,小鼠活动、摄食量、体重增长、粪便等均正常,观察期满后受试小鼠全部存活。
观察期满后处死全部受试小鼠肉眼尸检,发现各重要脏器,如心、肝、脾、肺、肾、卵巢、肠、胃等无明显病理形态改变。
药物灌胃给药的最大给药量试验结果表明:30只小鼠给药后均无明显的毒性反应,一周内亦无死亡。给小鼠灌胃给药药物后测得最大耐受量为50.9g/kg·d,如按临床成人口服剂量8.0g/60kg计算,则该药的小鼠一日灌胃最大耐受量为临床成人一日口服量的[(50.9g/kg)÷(8.0g/60kg)≈382]倍。说明本发明所述中药组合物的安全性好。
实验例2
本发明一种益胃中药组合物的人体试验
临床资料
一、一般性资料:本中药组合物应用于临床观察病例100例,男67例,女33例,年龄30~70岁。
二、用法用量:临床应用时,组合物中的组分根据患者的体重、年龄及症状酌情增减。本发明实施例1药物,一次三粒,一日三次。服药期间低盐、低脂饮食,禁烟酒。
三、疗效标准:
(1)痊愈:临床症状消失,生活完全自理,并能从事劳动;
(2)显效:临床症状和体征基本消失,生活可自理;
(3)有效:症状和体征一部分好转;
(4)无效;症状和体征均无明显改善,症状如前。
四、治疗效果:该临床观察病例中,服药1~6个月,治疗期间未发生毒副作用,具体情况见下表1。
表1本发明专利的产品在临床应用中的治愈情况
总之,本发明所述的一种益胃中药组合物,总之,本发明所述的一种益胃中药组合物,为纯中药制剂,药方精简,制备方法简单、加工成本低、疗效显著、无任何不良反应,药力强、见效快,能迅速消除胃寒症状,采用现代工艺制药,方便服用的特点。
以上仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.一种益胃中药组合物,其特征在于,所述中药组合物由重量份数组成:黄芪20份~25份、半夏3份~5份、麻黄1份~3份、白术4份~6份、陈皮1份~3份、葛根3份~5份、人参1份~3份、厚朴4份~6份、茯苓3份~5份、甘草3份~5份、木香2份~5份、甘松3份~5份、刀豆1份~3份、枳实4份~6份、枳壳1份~3份、扁豆3份~5份、山药1份~3份、百合4份~6份、党参3份~5份、孩儿参3份~5份、饴糖1份~3份、黄精4份~6份。
2.根据权利要求1所述的中药组合物,其特征在于,所述中药组合物最佳重量份配比是:黄芪23份、半夏4份、麻黄2份、白术5份、陈皮2份、葛根4份、人参2份、厚朴5份、茯苓4份、甘草4份、木香3份、甘松4份、刀豆2份、枳实5份、枳壳1份、扁豆5份、山药2份、百合6份、党参5份、孩儿参4份、饴糖3份、黄精4份。
3.根据权利要求1或2所述的制作方法,包括以下步骤:
步骤S01、取黄芪20份~25份粉碎后,用乙醇溶液提取,过滤,滤液备用;
步骤S02、取步骤S01的药渣与半夏3份~5份、麻黄1份~3份、白术4份~6份、厚朴4份~6份、茯苓3份~5份、甘草3份~5份、木香2份~5份、甘松3份~5份、刀豆1份~3份、枳实4份~6份、枳壳1份~3份、扁豆3份~5份、山药1份~3份、百合4份~6份、党参3份~5份、孩儿参3份~5份、黄精4份~6份混合,加纯净水提取2次,过滤,滤液备用;
步骤S03、将步骤S01和步骤S02的滤液混合,将混合溶液经过喷雾干燥器干燥,得到药物粉末备用;
步骤S04、将人参、陈皮、葛根粉碎,与步骤S03的药物粉末混合,添加饴糖1份~3份、辅料,制粒,得到所需要的制剂。
4.根据权利要求3所述的制作方法,其特征在于,步骤S01中,所述黄芪的粉碎细度为20目~40目,以便于提取和过滤。
5.根据权利要求3所述的制作方法,其特征在于,步骤S01中黄所述芪的提取方式为用10倍~15倍量的75%~85%乙醇溶液在70℃~80℃条件下提取2次,每次3小时~4小时。
6.根据权利要求3所述的制作方法,其特征在于,步骤S02中,所述药渣与半夏、麻黄、白术、厚朴、茯苓、甘草、木香、甘松、刀豆、枳实、枳壳、扁豆、山药、百合、党参、孩儿参、黄精混合后的提取方式为加10倍~12倍纯净水在70℃~80℃条件下提取2次,每次2小时~3小时。
7.根据权利要求3所述的制作方法,其特征在于,步骤S03中,所述喷雾干燥器干燥的工作条件为:进风温度140℃~150℃、出风温度80℃~90℃、雾化器频率50Hz。
8.根据权利要求3所述的制作方法,其特征在于,步骤S04中,所述人参、陈皮、葛根的粉碎细度为120目以下。
9.根据权利要求1~8中任意一种益胃中药组合物,所制备的剂型为胶囊剂、片剂、颗粒剂。
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