CN105878103A - Dendrobium officinale small molecular peptide breast mask based on nanogold rod composite material - Google Patents
Dendrobium officinale small molecular peptide breast mask based on nanogold rod composite material Download PDFInfo
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- CN105878103A CN105878103A CN201610207757.7A CN201610207757A CN105878103A CN 105878103 A CN105878103 A CN 105878103A CN 201610207757 A CN201610207757 A CN 201610207757A CN 105878103 A CN105878103 A CN 105878103A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a dendrobium officinale small molecular peptide breast mask based on a nanogold rod composite material. The dendrobium officinale small molecular peptide breast mask based on the nanogold rod composite material comprises breast mask cloth and essence, and is characterized in that the essence is prepared from the following components in percentage by weight: 0.1% of carbomer, 1.0% of dendrobium officinale small molecular peptide, 1.0% of humulus lupulus spike extracting solution, 1.0% of fructus cassiae fistulae extracting solution, 1.0% of nanogold rod, 1.0% of leonurus sibiricus extracting solution, 2.0% of commiphora resin, 1.0% of polyethylene glycol-32, 0.03% of xanthan gum, 0.02% of EDTA-2Na, 4.0% of hyaluronic acid, 1.0% of beta-dextran, 1.0% of chondrus crispus, 0.1% of triethanolamine, 0.3% of PEG-40 hydrogenated castor oil, 0.1% of essence, 0.18% of 3-iodopropynyl butylcarbamate, 0.12% of bis(hydroxymethyl)dimethyl hydantoin, and the balance of water. The dendrobium officinale small molecular peptide and the nanogold rod composite material are added, so that the damaged skin can be repaired, the bacteria breeding can be inhibited, the skin whitening and moisturizing effects and the oxidation resistance can be effectively realized, and the breast skin is enabled to be soft, elastic, plump and tight.
Description
Technical field
The present invention relates to the formulation art of cosmetics, specifically disclose a kind of dendrobium candidum small-molecular peptides pleura.
Background technology
Breast is that women realizes curvaceous important indicator, is also one of the symbolic characteristic of pubarche or even adult female.
Breast is collectively constituted by skin, mammary gland, fat, connective tissue, nipple, and any one aspect of breast is defective all can be caused
Udder health and the perfection of profile.The faulty reason of female breast is caused to have a lot, main nutritious material want or nutrients
Matter proportional imbalance, too early band brassiere, wear that brassiere is unreasonable, do not get enough athletic exercise, after quick weight-lossing under cutis laxa, ovarian function
Fall, thus cause skin of breast to relax, the minimizing of fat mass, connective tissue tension force is unbalance, mammary gland stops growth or atrophy etc..
Chest enlarge currently, with respect to the cosmetics of breast enlarging and beautifying has little effect, and the chest enlarge effect of some chest enlarge product future visual, add
The harmful substances such as heavy dose of hormone.At present, dendrobium candidum mainly extracts polysaccharide for preparing medicine for oral administration, for small-molecular peptides
Extraction and application the most fewer.Dendrobium candidum small-molecular peptides can make wound location obtain mechanical protection, strengthens skin repair ability,
Make wound faster heal, the most also there is the effects such as skin whitening, moisturizing is anti-oxidant.And the most in the market, dendrobium candidum small-molecular peptides
His occupation rate of film is the least, so dendrobium candidum small-molecular peptides facial mask has the biggest development prospect.Scientific investigations showed that,
Nm of gold can make skin become consolidation soft, flexible, full, it is achieved the cosmetic results such as delay skin aging.Goldleaf at present,
Nm of gold etc., frequently as food additives or as dietary supplements, are applied to the considerably less of pleura of improving looks.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of dendrobium candidum small-molecular peptides and the dendrobium candidum utilizing it to make
Small-molecular peptides pleura.
The technical solution adopted in the present invention is:
A kind of dendrobium candidum small-molecular peptides pleura, including pleura cloth and Essence, described Essence by the one-tenth of following mass fraction
Be grouped into: water 84.05, carbomer 0.1, glycerine 6.0, dendrobium candidum small-molecular peptides 1, polyethylene glycol-32 1.0, xanthan gum 0.03,
EDTA-2Na 0.02, glycine betaine 1.0,1,3 butylene glycol 4.0, beta glucan 1.0, Chondrus crispus 1.0, triethanolamine 0.1,
In Cremophor RH40 0.3, essence 0.1, IPBC (IPBC) and dihydroxymethyl dimethyl second
Uride (3:2) 0.3.
The dendrobium candidum pleura of the present invention adds dendrobium candidum small-molecular peptides, can repair damaged skin, suppresses bacterial reproduction, energy
Whitening effect moisturizing is anti-oxidant.
Further, described pleura cloth is stealthy silk pleura paper.
Further, described nanometer gold bar is prepared with in-situ method, is steady with modified algal polysaccharides group block copolymer (SA-PVP)
Determine agent.
Further, the consumption of described modified algal polysaccharides group block copolymer is 11%.
Further, the average diameter of described nanometer gold bar about 10nm, average length about 60nm.
Further, the preparation method of described dendrobium candidum small-molecular peptides is: (1) uses normal temperature high voltage pretreatment dendrobium candidum,
To high degree of dispersion dendrobium candidum pretreatment fluid；(2) small-molecular peptides enzymolysis liquid is obtained with complex enzyme process；(3) to the dendrobium candidum obtained
Small-molecular peptides lysate is purified.
Further, described step (1), particularly as follows: dendrobium candidum is dried, is pulverized, and crosses 60 mesh sieves, is added by gained powder
Water, stirs, and soaks 10min and softens；Regulation low-temperature circulating pump bound temperature is-10 DEG C～-4 DEG C, is fallen by mixed material
Entering high pressure homogenizer, first material is poured under 5～10MPa pressure conditions, and then control valve is to required pressure, treats that pressure is stable
After, homogeneous is for several times；Under the conditions of gained homogenizing fluid 4000r/min, centrifugal 20min, collects supernatant.
Further, described step (2) is particularly as follows: alkali protease Alcalase 2.4L, and enzymatic hydrolysis condition is: enzyme-to-substrate concentration
Ratio is 6%, temperature 50 C, pH=8.5, and the reaction time is 8h；Or tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is
6%, temperature 42 DEG C, pH=8.0, the reaction time is 8h；Or alkali protease 37017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration
Ratio is 3%, temperature 50 C, pH=8.5, and the reaction time is 8h.
Further, the molecular weight of described dendrobium candidum small-molecular peptides is 1000～2000Da.
The present invention utilizes Meizhou distinguishing products dendrobium candidum small-molecular peptides to be core, captures the commanding elevation of international modern agricultural development,
The normal temperature high voltage utilizing integrated advanced person pre-processes, complex enzyme hydrolysis, micro-filtration, ultrafiltration and integrated technology thereof, build strong adaptability efficient
Separate dendrobium candidum small-molecular peptides preparation technology, it is achieved preparation quick, efficient and the scale application to dendrobium candidum small-molecular peptides,
Optimize pleura technical recipe, research and develop dendrobium candidum pleura product, and realize industrialization.
Additionally, the present invention prepares a kind of dendrobium candidum small-molecular peptides pleura based on nanogold composite material.Nm of gold penetrates effect
Rate is high, stability high, activity is high, can effectively carry nutrition speciality and go directly skin bottom, even pass through skin and enter human circulation
System, effectively discharges active component, offsets rapidly the basic reason causing skin ageing, directly solves wrinkle, lax, dark
Secretly, color spot, the key problem of this 5 big skin ageing of lack of water, make skin keep younger state, it is achieved corresponding cosmetic purpose.
And dendrobium candidum small-molecular peptides can make wound location obtain mechanical protection, strengthen skin repair ability, make wound faster heal, with
Time also there is the oxidation resistant function of skin whitening, moisturizing.
In order to be more fully understood that and implement, the following detailed description of the present invention.
Detailed description of the invention
[embodiment 1]
1, normal temperature high voltage pretreatment and complex enzyme hydrolysis technology of preparing
According to the design feature of dendrobium candidum protein, use normal temperature high voltage preconditioning technique to obtain high degree of dispersion dendrobium candidum and locate in advance
Reason liquid, according to the design feature of dendrobium candidum protein, uses normal temperature high voltage preconditioning technique to obtain high degree of dispersion dendrobium candidum and locates in advance
Reason liquid concrete operations: dendrobium candidum dries (40 DEG C), pulverize, and cross 60 mesh sieves, and gained powder is added a certain proportion of water,
Stir, soak 10min and soften.Regulation low-temperature circulating pump bound temperature is-10 DEG C one-4 DEG C, it is ensured that inside homogenizer
Temperature is normal temperature.Mixed material is poured into high pressure homogenizer, material first (5-10MPa), then control valve under the conditions of low pressure
To 40～50MPa, after pressure is stable, homogeneous is for several times；Centrifugal 20min under the conditions of gained homogenizing fluid 4000r/min.In collection
Clear liquid, residue is dried and is preserved.
Complex enzyme treatment technology is used to obtain small-molecular peptides enzymolysis liquid:
Actual conditions: the enzymatic hydrolysis condition of alkali protease Alcalase 2.4L is: enzyme-to-substrate concentration ratio (E/S) is 6%, temperature
50 DEG C, pH=8.5, the reaction time is 8h.Tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio (E/S) is 6%, temperature 42
DEG C, pH=8.0, the reaction time is 8h.The enzymatic hydrolysis condition of alkali protease 37017 is: enzyme-to-substrate concentration ratio (E/S) is
3%, temperature 50 C, pH=8.5, the reaction time is 8h.
2, dendrobium candidum small-molecular peptides separating and purifying technology
According to the design feature of the little molecule of dendrobium candidum, use the technology systems such as micro-filtration, ultrafiltration and Sephadex G desalting and purifying thereof
Standby dendrobium candidum small-molecular peptides, the final molecular weight obtaining the dendrobium candidum small-molecular peptides that molecular weight is is 1000～2000Da.
[embodiment 2] preparation pleura Essence and pleura packaging
The composition of the pleura of the present invention is as follows:
The nanometer gold bar used in the present invention is prepared by in-situ method, with modification of polysaccharides group block copolymer SA-PVP as stabilizer, its
The consumption of middle SA-PVP is 11%, and the algal polysaccharides unit in copolymer SA-PVP has the strongest complexing power, can be with multivalence
Metal ion forms complex compound, effectively snatches away the heavy metal ion in skin.The average diameter about 10nm of the nanometer gold bar of preparation,
Average length about 60nm, has obvious photo-thermal effect.
The preparation method of the pleura of the present invention is as follows: above-mentioned dispensing be sufficiently mixed, and stirring homogeneous is to transparent or semitransparent emulsion form
Obtain pleura Essence；By pleura Essence censorship, it is filled in advance according to 15 milliliters of amounts often pasted after every physical and chemical index is qualified
In packaging bag equipped with silk stealth pleura paper, encapsulation.
[embodiment 3] product quality detects
Microbiological Test: inspection project has total plate count, excrement colibacillus group, Pseudomonas aeruginosa, staphylococcus aureus, mould
And saccharomycete.Evaluation criterion: total plate count≤1 000cfu/ml (g)；Yeast and mold sum≤100cfu/ml (g)；
Excrement colibacillus group, Pseudomonas aeruginosa, staphylococcus aureus must not detect.All appearance >=1 index is non-compliant to be judged to
Failed test sample.
[embodiment 4] clinical practice
Respectively to 30 example 18 45 years old, there is the inaesthetic experimenter of breast and carry out 1 month trying out, observing effect, observe pair
Effect and bad reaction.
Efficacy assessment standard:
Effective: with after pleura 15～20 days, chest skin substantially highlighted, and skin water is tender glossy, the full consolidation of chest.
Effective: with after pleura 21～29 days, the chest colour of skin highlighted, and skin water is tender glossy, the full consolidation of chest is flexible.
Invalid: using pleura 30 days, chest does not has any change.
Calculate efficient with effective and effective case.
Result for the treatment of
| Group | Effective | Effectively | Invalid | Total effective rate |
| Pleura of the present invention | 18 | 12 | 0 | 100% |
| Common pleura group | 10 | 12 | 8 | 73.3% |
Have no adverse reaction temporarily
It can be seen that this pleura has certain moisturizing, whitening and antibacterial functions through preliminary trying out from data above, can be used for daily
Skin nursing.
The invention is not limited in above-mentioned embodiment, if to the various changes of the present invention or deformation without departing from the spirit of the present invention
And scope, if within the scope of these are changed and deform claim and the equivalent technologies belonging to the present invention, then the present invention is also intended to
Comprise these to change and deformation.
Claims (10)
1. a dendrobium candidum small-molecular peptides pleura based on nanometer gold bar composite, including pleura cloth and Essence, it is characterised in that
The one-tenth by following mass fraction of described Essence is grouped into: carbomer 0.1%, dendrobium candidum small-molecular peptides 1.0%, hops
Extract 1.0%, sausage fruit extract 1.0%, nanometer gold bar 1.0%, spire motherwort extract 1.0, India myrrh
Fat 2.0%, polyethylene glycol-32 1.0%, xanthan gum 0.03%, EDTA-2Na 0.02%, hyaluronic acid 4.0%, β-Portugal gather
Sugar 1.0%, Chondrus crispus 1.0%, triethanolamine 0.1%, Cremophor RH40 0.3%, essence 0.1%, iodo
Propynyl butylcarbamate 0.18%, dimethyloldimethylhydantoin 0.12%, water surplus.
Dendrobium candidum small-molecular peptides pleura the most according to claim 1, it is characterised in that described pleura cloth is stealthy silk pleura
Paper.
Dendrobium candidum small-molecular peptides pleura the most according to claim 1, it is characterised in that described nanometer gold bar is prepared with in-situ method,
With modified algal polysaccharides group block copolymer (SA-PVP) as stabilizer.
Dendrobium candidum small-molecular peptides pleura the most according to claim 3, it is characterised in that described modified algal polysaccharides base block is altogether
The consumption of polymers is 11%.
Dendrobium candidum small-molecular peptides pleura the most according to claim 3, it is characterised in that the average diameter of described nanometer gold bar is about
10nm, average length about 60nm.
Dendrobium candidum small-molecular peptides pleura the most according to claim 1, it is characterised in that the system of described dendrobium candidum small-molecular peptides
Preparation Method is: (1) uses normal temperature high voltage pretreatment dendrobium candidum, obtains high degree of dispersion dendrobium candidum pretreatment fluid；(2) with multiple
Synthase processes and obtains small-molecular peptides enzymolysis liquid；(3) the dendrobium candidum small-molecular peptides lysate obtained is purified.
Dendrobium candidum small-molecular peptides pleura the most according to claim 6, it is characterised in that described step (1) is particularly as follows: iron sheet
The stem of noble dendrobium is dried, and pulverizes, and crosses 60 mesh sieves, gained powder is added water, stirs, and soaks 1Omin and softens；Regulation low temperature
Circulating pump bound temperature is-10 DEG C～-4 DEG C, and mixed material is poured into high pressure homogenizer, and material is first at 5～l0MPa pressure bars
Pouring under part, then control valve is to required pressure, and after pressure is stable, homogeneous is for several times；Gained homogenizing fluid 4000r/min
Under the conditions of centrifugal 20min, collect supernatant.
Dendrobium candidum small-molecular peptides pleura the most according to claim 6, it is characterised in that described step (2) is particularly as follows: alkalescence
Protease A lcalase 2.4L, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 50 C, pH=8.5, the reaction time
For 8h；Or tryptic enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 42 DEG C, pH=8.0, the reaction time
For 8h；Or alkali protease 37017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 3%, temperature 50 C, pH=8.5, instead
It is 8h between Ying Shi.
Dendrobium candidum small-molecular peptides pleura the most according to claim 6, it is characterised in that the purification process in described step (3)
Purify including micro-filtration, ultrafiltration and glucose gel.
10. the dendrobium candidum small-molecular peptides pleura that any one of claim 1-9 is described, it is characterised in that the little molecule of described dendrobium candidum
The molecular weight of peptide is 1000～2000Da.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610207757.7A CN105878103A (en) | 2016-04-01 | 2016-04-01 | Dendrobium officinale small molecular peptide breast mask based on nanogold rod composite material |
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| CN201610207757.7A CN105878103A (en) | 2016-04-01 | 2016-04-01 | Dendrobium officinale small molecular peptide breast mask based on nanogold rod composite material |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281082A (en) * | 2017-06-29 | 2017-10-24 | 广州大澳化妆品有限公司 | A kind of nutrient solution containing small-molecular peptides and the facial mask and preparation method including it |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281082A (en) * | 2017-06-29 | 2017-10-24 | 广州大澳化妆品有限公司 | A kind of nutrient solution containing small-molecular peptides and the facial mask and preparation method including it |
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