CN105873937A - 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 - Google Patents

用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 Download PDF

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Publication number
CN105873937A
CN105873937A CN201480071722.4A CN201480071722A CN105873937A CN 105873937 A CN105873937 A CN 105873937A CN 201480071722 A CN201480071722 A CN 201480071722A CN 105873937 A CN105873937 A CN 105873937A
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Prior art keywords
salt
nicotinamide riboside
skin
weight
compound
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Pending
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CN201480071722.4A
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English (en)
Chinese (zh)
Inventor
安·德仁-路易斯
特洛伊·鲁尼穆斯
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Chromadex Inc
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Chromadex Inc
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Priority to CN201910027571.7A priority Critical patent/CN109985056A/zh
Publication of CN105873937A publication Critical patent/CN105873937A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Birds (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Cosmetics (AREA)
CN201480071722.4A 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 Pending CN105873937A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910027571.7A CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361897713P 2013-10-30 2013-10-30
US61/897,713 2013-10-30
PCT/US2014/063260 WO2015066382A1 (en) 2013-10-30 2014-10-30 Nicotinamide riboside compositions for topical use in treating skin conditions

Related Child Applications (1)

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CN201910027571.7A Division CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

Publications (1)

Publication Number Publication Date
CN105873937A true CN105873937A (zh) 2016-08-17

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Family Applications (2)

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CN201480071722.4A Pending CN105873937A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物
CN201910027571.7A Pending CN109985056A (zh) 2013-10-30 2014-10-30 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物

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Country Status (12)

Country Link
US (2) US10688118B2 (https=)
EP (1) EP3063163B1 (https=)
JP (1) JP6509844B2 (https=)
KR (3) KR20220098049A (https=)
CN (2) CN105873937A (https=)
AU (1) AU2014342185B2 (https=)
CA (1) CA2928656C (https=)
ES (1) ES2925879T3 (https=)
MX (2) MX394291B (https=)
NZ (1) NZ719328A (https=)
WO (1) WO2015066382A1 (https=)
ZA (1) ZA201603314B (https=)

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CN110913864A (zh) * 2018-08-17 2020-03-24 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
CN111166760A (zh) * 2019-12-17 2020-05-19 浙江安赛新材料科技有限公司 β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用
CN111246838A (zh) * 2017-10-06 2020-06-05 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN111454311A (zh) * 2020-04-03 2020-07-28 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
WO2021073426A1 (zh) * 2019-10-17 2021-04-22 泓博元生命科技（深圳）有限公司 Nadh 及其盐在制备皮肤色素抑制剂中的应用
CN114423771A (zh) * 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途

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JP2017518306A (ja) * 2014-06-02 2017-07-06 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用
AU2015270090A1 (en) 2014-06-06 2016-12-22 Glaxosmithkline Intellectual Property (No.2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
US10323058B2 (en) 2014-07-24 2019-06-18 W. R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
EP3268379B1 (en) 2015-03-09 2023-11-01 W.R. Grace & CO. - CONN. Crystalline form of nicotinamide riboside
WO2016149395A1 (en) * 2015-03-16 2016-09-22 ChromaDex Inc. Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof
WO2016178944A1 (en) 2015-05-01 2016-11-10 The Procter & Gamble Company Method of improving the appearance of skin and compositions therefor using nicotinamide riboside
JP2018515485A (ja) 2015-05-01 2018-06-14 ザ プロクター アンド ギャンブル カンパニー 皮膚の外観を改善する方法及びニコチンアミドリボシドを使用したそのための組成物
JP6611099B2 (ja) * 2015-05-01 2019-11-27 ザ プロクター アンド ギャンブル カンパニー 皮膚の健康を改善する方法及びそのための組成物
JP2018517774A (ja) 2015-06-10 2018-07-05 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法
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WO2017004102A1 (en) 2015-06-29 2017-01-05 The Procter & Gamble Company Multi-component skin care product comprising nicoinamide riboside in a multi-chambered container
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MX393076B (es) * 2016-04-20 2025-03-24 Chromadex Inc Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+
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EP3558255B1 (en) 2016-12-21 2021-10-13 Unilever IP Holdings B.V. Topical skin lightening additive and composition with amino acids and nicotinamide compounds
JP7084924B2 (ja) 2016-12-21 2022-06-15 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ 難溶性化合物を含むパーソナルケア組成物
US11260005B2 (en) 2016-12-21 2022-03-01 Conopco, Inc. Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
RU2651047C1 (ru) * 2017-05-04 2018-04-18 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Лекарственная композиция цитопротекторного действия и способ ее получения
WO2018213715A1 (en) * 2017-05-18 2018-11-22 Elysium Health, Inc. Methods and compositions for improving sleep
SG11201912267SA (en) 2017-06-19 2020-01-30 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
CN110785161B (zh) 2017-06-23 2023-06-20 宝洁公司 用于改善皮肤外观的组合物和方法
WO2019023471A1 (en) * 2017-07-28 2019-01-31 Centers For Age Control, Inc. COMPOSITIONS AND METHODS FOR PREVENTING AND INVERTING THE ASPECTS OF AGING
KR102852384B1 (ko) * 2017-09-14 2025-09-01 메구미 타나카 노화 방지제 및 노화 방지 방법
CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
CN112437657A (zh) 2018-07-03 2021-03-02 宝洁公司 处理皮肤状况的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
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CN111184732B (zh) * 2020-03-04 2023-09-08 武汉华纳联合药业有限公司 一种复合组合物制剂及其制备方法和皮肤炎症中的应用
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JP7761652B2 (ja) * 2021-01-19 2025-10-28 バイオシント アクチェンゲゼルシャフト 塩メタセシスによるニコチンアミドリボフラノシド塩の製造方法、そのトシレート塩の結晶形態及びそのクロリド：ヨージド塩の共結晶化した形態
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CN114129509B (zh) * 2021-12-03 2023-12-01 药酚享科技(北京)有限公司 一种保湿性nmn亲水凝胶剂及其制备方法
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CN111246838A (zh) * 2017-10-06 2020-06-05 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN111246838B (zh) * 2017-10-06 2024-01-26 艾克斯奥巴德蒙公司 用于将活性成分递送至皮肤的套件
CN110913864A (zh) * 2018-08-17 2020-03-24 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
CN110913864B (zh) * 2018-08-17 2022-12-13 邦泰生物工程(深圳)有限公司 一种稳定型烟酰胺核糖组合物及其制备方法
US12344629B2 (en) 2019-07-19 2025-07-01 Biosynth Ag Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
CN114423771A (zh) * 2019-07-19 2022-04-29 生物合成股份公司 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途
WO2021073426A1 (zh) * 2019-10-17 2021-04-22 泓博元生命科技（深圳）有限公司 Nadh 及其盐在制备皮肤色素抑制剂中的应用
CN111166760A (zh) * 2019-12-17 2020-05-19 浙江安赛新材料科技有限公司 β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
US11505570B2 (en) 2020-04-03 2022-11-22 Shenzhen Dieckmann Tech Co., Ltd Organic acid salt of nicotinamide riboside, composition including organic acid salt, and preparation methods of organic acid salt and composition
KR20220156642A (ko) * 2020-04-03 2022-11-25 썬전 디에크만 테크 컴퍼니 리미티드 니코틴아미드 리보사이드의 유기산염 및 이의 조성물 및 제조방법
AU2020440743B2 (en) * 2020-04-03 2024-02-15 Shenzhen Dieckmann Tech Co. Ltd Organic acid salt of nicotinamide riboside, composition thereof and preparation method therefor
WO2021196349A1 (zh) * 2020-04-03 2021-10-07 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
KR102591687B1 (ko) 2020-04-03 2023-10-20 썬전 디에크만 테크 컴퍼니 리미티드 니코틴아미드 리보사이드의 유기산염 및 이의 조성물 및 제조방법
CN111454311A (zh) * 2020-04-03 2020-07-28 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途
CN116621898A (zh) * 2022-04-13 2023-08-22 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途

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Application publication date: 20160817