MX394291B - Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. - Google Patents
Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel.Info
- Publication number
- MX394291B MX394291B MX2021009652A MX2021009652A MX394291B MX 394291 B MX394291 B MX 394291B MX 2021009652 A MX2021009652 A MX 2021009652A MX 2021009652 A MX2021009652 A MX 2021009652A MX 394291 B MX394291 B MX 394291B
- Authority
- MX
- Mexico
- Prior art keywords
- nicotinamide riboside
- treatment
- compositions
- skin conditions
- skin
- Prior art date
Links
- 235000020956 nicotinamide riboside Nutrition 0.000 title abstract 6
- 239000011618 nicotinamide riboside Substances 0.000 title abstract 6
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000000699 topical effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000037041 intracellular level Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Birds (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361897713P | 2013-10-30 | 2013-10-30 | |
| PCT/US2014/063260 WO2015066382A1 (en) | 2013-10-30 | 2014-10-30 | Nicotinamide riboside compositions for topical use in treating skin conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2021009652A MX2021009652A (es) | 2022-07-26 |
| MX394291B true MX394291B (es) | 2025-03-24 |
Family
ID=53005146
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021009652A MX394291B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. |
| MX2016005574A MX385305B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016005574A MX385305B (es) | 2013-10-30 | 2014-10-30 | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10688118B2 (https=) |
| EP (1) | EP3063163B1 (https=) |
| JP (1) | JP6509844B2 (https=) |
| KR (3) | KR20220098049A (https=) |
| CN (2) | CN105873937A (https=) |
| AU (1) | AU2014342185B2 (https=) |
| CA (1) | CA2928656C (https=) |
| ES (1) | ES2925879T3 (https=) |
| MX (2) | MX394291B (https=) |
| NZ (1) | NZ719328A (https=) |
| WO (1) | WO2015066382A1 (https=) |
| ZA (1) | ZA201603314B (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017518306A (ja) * | 2014-06-02 | 2017-07-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 |
| AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| US10323058B2 (en) | 2014-07-24 | 2019-06-18 | W. R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| EP3268379B1 (en) | 2015-03-09 | 2023-11-01 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
| WO2016149395A1 (en) * | 2015-03-16 | 2016-09-22 | ChromaDex Inc. | Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof |
| WO2016178944A1 (en) | 2015-05-01 | 2016-11-10 | The Procter & Gamble Company | Method of improving the appearance of skin and compositions therefor using nicotinamide riboside |
| JP2018515485A (ja) | 2015-05-01 | 2018-06-14 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の外観を改善する方法及びニコチンアミドリボシドを使用したそのための組成物 |
| JP6611099B2 (ja) * | 2015-05-01 | 2019-11-27 | ザ プロクター アンド ギャンブル カンパニー | 皮膚の健康を改善する方法及びそのための組成物 |
| JP2018517774A (ja) | 2015-06-10 | 2018-07-05 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法 |
| WO2016210232A1 (en) * | 2015-06-25 | 2016-12-29 | N.V. Perricone Llc | Niacinamide mononucleotide formulations for skin aging |
| WO2017004101A1 (en) | 2015-06-29 | 2017-01-05 | The Procter & Gamble Company | Skin care compositions comprising particles with nicotinamide riboside and methods of using the same |
| WO2017004100A1 (en) | 2015-06-29 | 2017-01-05 | The Procter & Gamble Company | Encapsulated particles comprising nicotinamide riboside |
| WO2017004102A1 (en) | 2015-06-29 | 2017-01-05 | The Procter & Gamble Company | Multi-component skin care product comprising nicoinamide riboside in a multi-chambered container |
| EP3236928B1 (en) | 2016-01-11 | 2020-12-09 | The Procter and Gamble Company | Method of treating a skin condition and compositions therefor |
| WO2017161165A1 (en) | 2016-03-16 | 2017-09-21 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| MX393076B (es) * | 2016-04-20 | 2025-03-24 | Chromadex Inc | Uso de derivados de ribósido de ácido nicotínico o ribósido de nicotinamida, y derivados reducidos de estos, como precursores que incrementan nad+ |
| EP3500267A4 (en) | 2016-08-22 | 2020-03-18 | Elysium Health, Inc. | NICOTINAMIDRIBOSIDE AND PTEROSTILLE COMPOSITIONS AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES |
| EP3538099B1 (en) | 2016-11-11 | 2026-04-22 | The Queen's University of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および／または子の健康を向上させるためのｎａｄ前駆体の使用 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US11337908B2 (en) | 2016-12-21 | 2022-05-24 | Conopco, Inc. | Personal care compositions with cystine |
| EP3558255B1 (en) | 2016-12-21 | 2021-10-13 | Unilever IP Holdings B.V. | Topical skin lightening additive and composition with amino acids and nicotinamide compounds |
| JP7084924B2 (ja) | 2016-12-21 | 2022-06-15 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 難溶性化合物を含むパーソナルケア組成物 |
| US11260005B2 (en) | 2016-12-21 | 2022-03-01 | Conopco, Inc. | Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids |
| RU2651047C1 (ru) * | 2017-05-04 | 2018-04-18 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Лекарственная композиция цитопротекторного действия и способ ее получения |
| WO2018213715A1 (en) * | 2017-05-18 | 2018-11-22 | Elysium Health, Inc. | Methods and compositions for improving sleep |
| SG11201912267SA (en) | 2017-06-19 | 2020-01-30 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| CN110785161B (zh) | 2017-06-23 | 2023-06-20 | 宝洁公司 | 用于改善皮肤外观的组合物和方法 |
| WO2019023471A1 (en) * | 2017-07-28 | 2019-01-31 | Centers For Age Control, Inc. | COMPOSITIONS AND METHODS FOR PREVENTING AND INVERTING THE ASPECTS OF AGING |
| KR102852384B1 (ko) * | 2017-09-14 | 2025-09-01 | 메구미 타나카 | 노화 방지제 및 노화 방지 방법 |
| GB201716391D0 (en) * | 2017-10-06 | 2017-11-22 | Xobaderm Ltd | Kit for delivery of an active compound into a biological barrier |
| CN112020363A (zh) | 2017-12-22 | 2020-12-01 | 益力舒健康公司 | 烟酰胺核苷氯化物的结晶形式 |
| CN112437657A (zh) | 2018-07-03 | 2021-03-02 | 宝洁公司 | 处理皮肤状况的方法 |
| WO2019210607A1 (zh) * | 2018-08-17 | 2019-11-07 | 邦泰生物工程(深圳)有限公司 | 一种稳定型烟酰胺核糖组合物及其制备方法 |
| KR102060374B1 (ko) * | 2018-12-14 | 2019-12-30 | 주식회사 휴메딕스 | 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| WO2020131578A2 (en) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| BR112022000963A2 (pt) | 2019-07-19 | 2022-04-05 | Biosynth Ag | Método de fabricação de sais de nicotinamida ribofuranosídeo, sais de nicotinamida ribofuranosídeo como tal e usos dos mesmos |
| CN110638827A (zh) * | 2019-10-17 | 2020-01-03 | 泓博元生命科技（深圳）有限公司 | Nadh及其盐在制备皮肤色素抑制剂中的应用 |
| KR102315139B1 (ko) | 2019-12-17 | 2021-10-20 | 주식회사 휴메딕스 | 지방아민 컨쥬게이션된 니코틴아미드 리보사이드 유도체 |
| CN111166760A (zh) * | 2019-12-17 | 2020-05-19 | 浙江安赛新材料科技有限公司 | β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用 |
| CN111184732B (zh) * | 2020-03-04 | 2023-09-08 | 武汉华纳联合药业有限公司 | 一种复合组合物制剂及其制备方法和皮肤炎症中的应用 |
| CN111454311B (zh) * | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| WO2021234009A1 (fr) * | 2020-05-20 | 2021-11-25 | Nuvamid Sa | Compositions cosmetiques anti-age comprenant du nmn |
| FR3110410A1 (fr) * | 2020-05-20 | 2021-11-26 | Nuvamid Sa | Compositions cosmétiques anti-âge comprenant de la NMN |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| JP7590462B2 (ja) | 2020-06-01 | 2024-11-26 | ザ プロクター アンド ギャンブル カンパニー | ビタミンｂ３化合物の皮膚への浸透を改善する方法 |
| CN111632049A (zh) * | 2020-06-09 | 2020-09-08 | 西北农林科技大学 | 一种通过综合矫正细胞活性氧簇代谢紊乱以缓解睾丸衰老损伤的复合配方 |
| WO2022047182A1 (en) * | 2020-08-28 | 2022-03-03 | University Of Washington | High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation |
| EP4029496A1 (en) * | 2021-01-18 | 2022-07-20 | Universitat de València | Pterostilbene and silibinin for preventing, ameliorating or reducing radiation-induced diseases |
| JP7761652B2 (ja) * | 2021-01-19 | 2025-10-28 | バイオシント アクチェンゲゼルシャフト | 塩メタセシスによるニコチンアミドリボフラノシド塩の製造方法、そのトシレート塩の結晶形態及びそのクロリド：ヨージド塩の共結晶化した形態 |
| JP2024517463A (ja) * | 2021-05-04 | 2024-04-22 | ソヴィダ ソリューションズ リミテッド | ニコチンアミドアデニンジヌクレオチド（ｎａｄ）組成物、それらの製造方法、及びそれらの使用方法 |
| CN114129509B (zh) * | 2021-12-03 | 2023-12-01 | 药酚享科技(北京)有限公司 | 一种保湿性nmn亲水凝胶剂及其制备方法 |
| CN116621898A (zh) * | 2022-04-13 | 2023-08-22 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途 |
| KR102784901B1 (ko) * | 2022-06-23 | 2025-03-21 | 제너럴바이오(주) | Nr, nmn 및 nad를 함유한 피부 주름 개선용 화장료 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200305174B (en) * | 2001-02-22 | 2004-09-23 | Unilever Plc | Skin composition for reducing skin oils and grease. |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| JP2007521835A (ja) | 2004-02-10 | 2007-08-09 | トラスティーズ・オブ・ダートマウス・カレッジ | ニコチンアミドリボシドキナーゼ組成物およびそれらの使用方法 |
| JP2008501343A (ja) | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| CN101257897A (zh) * | 2005-07-07 | 2008-09-03 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| WO2007008548A2 (en) * | 2005-07-07 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| EP3369738B1 (en) * | 2005-11-18 | 2020-05-20 | Cornell Research Foundation, Inc. | Method for making nicotinoyl ribosides and nicotinamide beta-riboside |
| ES2439582T3 (es) * | 2007-03-12 | 2014-01-23 | Dsm Ip Assets B.V. | Composiciones cosméticas |
| US20090069444A1 (en) | 2007-09-07 | 2009-03-12 | The United States Of America, As Represented By Th E Secretary Of Agriculture | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
| EP2522355B1 (en) * | 2010-01-06 | 2018-02-21 | Kabushiki Kaisha Yakult Honsha | Dna damage repair promoter for oral application, and elastase activity inhibitor for oral application |
-
2014
- 2014-10-30 KR KR1020227022241A patent/KR20220098049A/ko not_active Ceased
- 2014-10-30 CN CN201480071722.4A patent/CN105873937A/zh active Pending
- 2014-10-30 CN CN201910027571.7A patent/CN109985056A/zh active Pending
- 2014-10-30 MX MX2021009652A patent/MX394291B/es unknown
- 2014-10-30 KR KR1020167014302A patent/KR20160067195A/ko not_active Ceased
- 2014-10-30 AU AU2014342185A patent/AU2014342185B2/en active Active
- 2014-10-30 MX MX2016005574A patent/MX385305B/es unknown
- 2014-10-30 JP JP2016526337A patent/JP6509844B2/ja active Active
- 2014-10-30 EP EP14857903.0A patent/EP3063163B1/en active Active
- 2014-10-30 KR KR1020217026414A patent/KR20210107895A/ko not_active Ceased
- 2014-10-30 ES ES14857903T patent/ES2925879T3/es active Active
- 2014-10-30 NZ NZ719328A patent/NZ719328A/en unknown
- 2014-10-30 US US15/033,285 patent/US10688118B2/en active Active
- 2014-10-30 CA CA2928656A patent/CA2928656C/en active Active
- 2014-10-30 WO PCT/US2014/063260 patent/WO2015066382A1/en not_active Ceased
-
2016
- 2016-05-16 ZA ZA2016/03314A patent/ZA201603314B/en unknown
-
2020
- 2020-06-03 US US16/891,824 patent/US11033568B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105873937A (zh) | 2016-08-17 |
| EP3063163A1 (en) | 2016-09-07 |
| NZ719328A (en) | 2022-04-29 |
| CA2928656A1 (en) | 2015-05-07 |
| JP2016538271A (ja) | 2016-12-08 |
| CA2928656C (en) | 2020-07-28 |
| EP3063163A4 (en) | 2017-05-10 |
| CN109985056A (zh) | 2019-07-09 |
| US20160250241A1 (en) | 2016-09-01 |
| KR20220098049A (ko) | 2022-07-08 |
| EP3063163B1 (en) | 2022-08-10 |
| MX385305B (es) | 2025-03-18 |
| ZA201603314B (en) | 2017-09-27 |
| WO2015066382A1 (en) | 2015-05-07 |
| ES2925879T3 (es) | 2022-10-20 |
| KR20210107895A (ko) | 2021-09-01 |
| US20200289536A1 (en) | 2020-09-17 |
| US10688118B2 (en) | 2020-06-23 |
| AU2014342185B2 (en) | 2019-01-03 |
| MX2016005574A (es) | 2016-12-09 |
| MX2021009652A (es) | 2022-07-26 |
| KR20160067195A (ko) | 2016-06-13 |
| US11033568B2 (en) | 2021-06-15 |
| JP6509844B2 (ja) | 2019-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX385305B (es) | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. | |
| BR112017019696A2 (pt) | composto e usos de um composto | |
| BR112014006455A2 (pt) | alquilamidotiazóis, preparações cosméticas ou dermatológicas com um teor de um ou vários alquilamidotiazóis e uso de um ou vários alquilamidotiazóis | |
| EA201890435A1 (ru) | Производные никотинамидмононуклеотида и их применение | |
| PE20150223A1 (es) | Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos | |
| MX394252B (es) | Tratamiento del cancer usando combinaciones de inhibidores de erk y raf | |
| CL2016000544A1 (es) | Composición cosmética que comprende 0,0001 a 10% en peso de extracto de guacatonga (casearia sylvestris) y 0,00005 a 10% en peso de extracto de aroeira (schinus terebinthifolius raddi) ambos respecto al peso total de la composición; uso de la composición en la prevención y/o tratamiento de los signos de envejicimiento de la piel; metodo para prevenir y/o tratar los signos de envejecimiento de la piel. | |
| ES2572211T3 (es) | Regeneración de músculo esquelético utilizando células madre mesenquimales | |
| BR112015007878A2 (pt) | composto compreendendo oligonucleotídeo modificado, composição, combinação e uso dos mesmos | |
| BR112016000335A8 (pt) | método de tratamento da rosácea papulopustular, de tratamento de lesões inflamatórias da rosácea papulopustular e uso de uma composição farmacêutica | |
| BRPI0919020B8 (pt) | uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris | |
| BR112014003071A2 (pt) | tratamento de doença vascular periférica com o uso de células derivadas do tecido do cordão umbilical | |
| RU2014150505A (ru) | Способ идентификации лигандов рецептора ahr, которые обладают терапевтической себосупрессивной активностью, и указанные лиганды | |
| WO2012116990A3 (en) | Novel use | |
| AR083651A1 (es) | Composiciones de brimonidina en gel y metodos de uso | |
| BR112012015984A2 (pt) | composição para melhorar a função cerebral, e, polipeptídeo | |
| CO6660486A2 (es) | Composición tópica famacéutica o cosmética útil para el tratamiento de enfermedades o condiciones que cursan con un déficit de la maduración de la envoltura córnea | |
| MX385999B (es) | Composiciones y métodos para tratamiento de la piel. | |
| MX349854B (es) | Composiciones antitranspirantes y metodo para reducir la transpiracion. | |
| BR112012023747A2 (pt) | compostos de adenosina e seu uso | |
| MX378190B (es) | Composiciones para el uso en el tratamiento de trastornos oculares que usan dipiridamol. | |
| BR112015002041A2 (pt) | formulação transdérmica contendo inibidores de cox | |
| AR097216A1 (es) | Composición para el tratamiento contra el envejecimiento de la piel | |
| CO6602160A2 (es) | Terapia de b12 oral | |
| CR20130488A (es) | Derivados de tieno [2,3-d]pirimidina y su uso para tratar arritmia |