CN105873922B - 9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用 - Google Patents

9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用 Download PDF

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Publication number
CN105873922B
CN105873922B CN201480071487.0A CN201480071487A CN105873922B CN 105873922 B CN105873922 B CN 105873922B CN 201480071487 A CN201480071487 A CN 201480071487A CN 105873922 B CN105873922 B CN 105873922B
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alkyl
compound
diyl
tetrafluoro
imidazol
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CN201480071487.0A
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Chinese (zh)
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CN105873922A (zh
Inventor
王勇
赵立文
王德忠
周海平
张先
陈宏雁
张迪
张仓
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Nanjing Sanhome Pharmaceutical Co Ltd
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Nanjing Sanhome Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480071487.0A 2013-12-31 2014-12-26 9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用 Active CN105873922B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2013107543184 2013-12-31
CN201310754318 2013-12-31
PCT/CN2014/095043 WO2015101215A1 (zh) 2013-12-31 2014-12-26 9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用

Publications (2)

Publication Number Publication Date
CN105873922A CN105873922A (zh) 2016-08-17
CN105873922B true CN105873922B (zh) 2018-08-14

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CN201480071487.0A Active CN105873922B (zh) 2013-12-31 2014-12-26 9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用
CN201410835606.7A Active CN104744444B (zh) 2013-12-31 2014-12-29 9,9,10,10-四氟-9,10二氢菲类丙型肝炎病毒抑制剂及其应用

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Country Status (9)

Country Link
US (1) US9512108B2 (enExample)
EP (1) EP3091010A4 (enExample)
JP (1) JP2017536329A (enExample)
KR (1) KR101857689B1 (enExample)
CN (2) CN105873922B (enExample)
AU (1) AU2014375584B2 (enExample)
CA (1) CA2935089C (enExample)
TW (1) TWI532735B (enExample)
WO (1) WO2015101215A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107266424A (zh) * 2016-04-07 2017-10-20 南京圣和药业股份有限公司 二氢菲类化合物及其制备方法
CN108623569A (zh) * 2017-03-21 2018-10-09 南京圣和药业股份有限公司 9,10-二氢菲类化合物的制备方法
CN108623570A (zh) * 2017-03-21 2018-10-09 南京圣和药业股份有限公司 9,10-二氢菲类化合物、其制备方法及用途
CN108619102A (zh) * 2017-03-21 2018-10-09 南京圣和药业股份有限公司 一种包含丙型肝炎病毒抑制剂的药物组合物及其制备方法
CN108623568B (zh) * 2017-03-21 2022-04-19 南京汇诚制药有限公司 9,10二氢菲类丙型肝炎病毒抑制剂的盐型及其制备
CN109419806B (zh) * 2017-08-23 2023-06-20 南京圣和药业股份有限公司 抗病毒组合物及其应用
CN114890916A (zh) * 2022-04-25 2022-08-12 常州吉恩药业有限公司 一种n-甲氧羰基-l-叔亮氨酸的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068234A2 (en) * 2010-11-17 2012-05-24 Gilead Sciences, Inc. Antiviral compounds
CN102596936A (zh) * 2009-05-13 2012-07-18 吉里德科学公司 抗病毒化合物
WO2013028953A1 (en) * 2011-08-24 2013-02-28 Glaxosmithkline Llc Combination treatments for hepatitis c

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19524230A1 (de) * 1995-07-04 1997-01-09 Hoechst Ag Fluorierte Phenanthren-Derivate und ihre Verwendung in flüssigkristallinen Mischungen
US6455744B1 (en) * 2001-01-23 2002-09-24 Air Products And Chemicals, Inc. Synthesis of vicinal difluoro aromatics and intermediates thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596936A (zh) * 2009-05-13 2012-07-18 吉里德科学公司 抗病毒化合物
WO2012068234A2 (en) * 2010-11-17 2012-05-24 Gilead Sciences, Inc. Antiviral compounds
WO2013028953A1 (en) * 2011-08-24 2013-02-28 Glaxosmithkline Llc Combination treatments for hepatitis c

Also Published As

Publication number Publication date
CN105873922A (zh) 2016-08-17
KR20160058187A (ko) 2016-05-24
JP2017536329A (ja) 2017-12-07
CA2935089A1 (en) 2015-07-09
TW201524973A (zh) 2015-07-01
CN104744444B (zh) 2019-02-26
KR101857689B1 (ko) 2018-05-14
CA2935089C (en) 2018-11-27
AU2014375584B2 (en) 2017-11-09
US9512108B2 (en) 2016-12-06
TWI532735B (zh) 2016-05-11
EP3091010A1 (en) 2016-11-09
CN104744444A (zh) 2015-07-01
EP3091010A4 (en) 2017-10-04
US20160297804A1 (en) 2016-10-13
WO2015101215A1 (zh) 2015-07-09
AU2014375584A1 (en) 2016-07-07
HK1222845A1 (zh) 2017-07-14

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