CN105833161A - Pharmaceutical composition for preventing and treating poultry air sac inflammation and preparation method thereof - Google Patents
Pharmaceutical composition for preventing and treating poultry air sac inflammation and preparation method thereof Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating a poultry air sac inflammation and a preparation method thereof .The pharmaceutical composition for preventing and treating the poultry air sac inflammation is prepared from nervate twayblade herb, fig fruit, cortex fraxini, platycodon roots, licorice roots, betel nuts, tsaoko amomum fruit, officinal magnolia bark, Chinese thorowax roots, baical skullcap roots, raw lotus leaves, herba houttuyniae, pine needles, opuntia dillenii Haw., radix sophorae flavescentis, fructus forsythiae, mulberry leaves, honeysuckle flowers, common fenugreek seeds, dried tangerine peel, Chinese wax gourd peel, peach flowers, Chinese lobelia herb, radix gentianae and radix ophiopogonis by weight .The traditional Chinese medicine preparation has the complementary and synergistic effects on treating pathology of the poultry air sac inflammation, is mild in drug property, free of irritation to respiratory mucosae, capable of rapidly relieving respiratory symptoms caused by air sac inflammation type respiratory diseases and repairing the respiratory mucosae, stable in drug efficacy and lasting in effect and can obviously cure or relieve poultry air sac inflammation symptoms, decrease poultry death rate and reduce losses.
Description
Technical field
The present invention relates to animal-use drug technical field, a kind of pharmaceutical composition for preventing and treating birds airsacculitis and system thereof
Preparation Method.
Background technology
Airsacculitis is commonly encountered diseases popular in birds feeding process, Chang Bingfa, and infects fast, and mortality rate is high, to raiser
Cause the biggest economic loss.Its symptom is as follows: birds lethargy, necking down of bowing, and feather pine is disorderly, matt, hangs down
Wing, swollen eye, shed tears, ataxia, minority mouth breathing, have sound, row's white or yellow green loose stool, course of disease elder is preced with wattle
Purple darkly, shouts strangely, and sends " snore " sound, cough, sneeze, and body temperature raises, and piles up or slow-witted vertical side.Dissection can
Seeing that air bag is muddy, thicken, inside have the cheesy thing of yellow, thoracic respiration becomes ventral breathing, is mixed with in the visible mesentery having
A large amount of bubbles.
Under the conditions of current poultry large-scale cultivation, bacterial air sacculitis in livestock is clinical often to be sent out and is difficult to prevention and control.Support to Chinese poultry resource
The healthy quickly development growing industry causes the biggest obstacle.Colibacillosis, mycoplasma, aspergillosis are induction chicken gas
The principal element of capsulitis, for these diseases, the main treatment using antibiotic medicine to be administered, uses antiviral and antibiotic
Deng chemotherapy, easily produce drug resistance, and owing to the half-life of this type of medicine is longer, make Fowl meat, egg product produce
Raw high amount of drug residual, jeopardizes food safety.
Summary of the invention
It is an object of the invention to provide a kind of instant effect, eutherapeutic pharmaceutical composition for preventing and treating birds airsacculitis and
Preparation method, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 10-20 part,
Fructus Fici 10-20 part, Cortex Fraxini 8-12 part, Radix Platycodonis 15-25 part, Radix Glycyrrhizae 20-30 part, Semen Arecae 10-20 part, Fructus Tsaoko 10-20
Part, Cortex Magnoliae Officinalis 8-10 part, Radix Bupleuri 20-30 part, Radix Scutellariae 5-7 part, raw Folium Nelumbinis 5-15 part, Herba Houttuyniae 4-8 part, Folium Pini 15-25
Part, Radix et Caulis Opuntiae Dillenii 5-15 part, Radix Sophorae Flavescentis 4-8 part, Fructus Forsythiae 8-10 part, Folium Mori 6-10 part, Flos Lonicerae 5-10 part, Semen Trigonellae 30-40
Part, Pericarpium Citri Reticulatae 15-25 part, Exocarpium Benincasae 4-6 part, Flos persicae 10-30 part, Herba Lobeliae Chinensis 10-20 part, Radix Gentianae 1-3 part, 6-8 Radix Ophiopogonis
Part.
As the further scheme of the present invention: the described pharmaceutical composition for preventing and treating birds airsacculitis, former according to weight portion
Material includes: Herba Liparidis nervosae 12-18 part, Fructus Fici 12-18 part, Cortex Fraxini 9-11 part, Radix Platycodonis 18-22 part, Radix Glycyrrhizae 22-28 part,
Semen Arecae 12-18 part, Fructus Tsaoko 12-18 part, Cortex Magnoliae Officinalis 8.5-9.5 part, Radix Bupleuri 22-28 part, Radix Scutellariae 5.5-6.5 part, raw Folium Nelumbinis 8-12
Part, Herba Houttuyniae 5-7 part, Folium Pini 18-22 part, Radix et Caulis Opuntiae Dillenii 8-12 part, Radix Sophorae Flavescentis 5-7 part, Fructus Forsythiae 8.5-9.5 part, Folium Mori 7-9
Part, Flos Lonicerae 7-9 part, Semen Trigonellae 32-38 part, Pericarpium Citri Reticulatae 18-22 part, Exocarpium Benincasae 4.5-5.5 part, Flos persicae 15-25 part,
Herba Lobeliae Chinensis 12-18 part, Radix Gentianae 1.5-2.5 part, 6.5-7.5 part Radix Ophiopogonis.
As the present invention further scheme: the described pharmaceutical composition for preventing and treating birds airsacculitis, according to weight portion
Raw material includes: Herba Liparidis nervosae 15 parts, Fructus Fici 15 parts, Cortex Fraxini 10 parts, Radix Platycodonis 20 parts, 25 parts of Radix Glycyrrhizae, Semen Arecae 15 parts,
Fructus Tsaoko 15 parts, Cortex Magnoliae Officinalis 9 parts, Radix Bupleuri 25 parts, Radix Scutellariae 6 parts, raw 10 parts of Folium Nelumbinis, Herba Houttuyniae 6 parts, 20 parts of Folium Pini,
Radix et Caulis Opuntiae Dillenii 10 parts, Radix Sophorae Flavescentis 6 parts, Fructus Forsythiae 9 parts, 8 parts of Folium Mori, Flos Lonicerae 8 parts, Semen Trigonellae 35 parts, Pericarpium Citri Reticulatae 20 parts,
Exocarpium Benincasae 5 parts, 20 parts of Flos persicae, Herba Lobeliae Chinensis 15 parts, Radix Gentianae 2 parts, Radix Ophiopogonis 7 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 50-70 mesh;
(4) medicated powder step (3) obtained mixes with the ethanol solution that concentration is 85-95% of 60-80 part, 25-30 DEG C
Lower extraction 2-4h, sucking filtration 2-3 time, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, system
Become the clear paste of relative density 1.2-1.25;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by the 6-10 times amount of raw medicinal material gross weight, soak 8-12h, then
Being heated up to 95-105 DEG C and extract 1-3h, filter, obtain the first extracting solution, medicinal residues are standby;Holding the Chinese medicine extracting tank of medicinal residues
In by raw medicinal material gross weight 3-5 times amount second time add water, be heated to 80-100 DEG C extract 1-3h, filter, obtain second
Extracting solution, merges the first extracting solution and the second extracting solution, stands 3-5h post-heating and is concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 100-200
The fine powder of mesh sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Compared with prior art, the invention has the beneficial effects as follows:
The Chinese medicine preparation of the present invention treatment birds airsacculitis pathology on have complement each other, the effect of Synergistic, the property of medicine
Gentle, to respiratory mucosa nonirritant, the respiratory symptom that rapid recovery causes because of airsacculitis type respiratory tract disease, repair
Respiratory mucosa, efficacy stability, persistent, it is possible to substantially cure or alleviate birds airsacculitis symptom, reduce birds dead
Rate, reduces loss.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 10 parts, nothing
Flowers and fruits 10 parts, Cortex Fraxini 8 parts, Radix Platycodonis 15 parts, 20 parts of Radix Glycyrrhizae, Semen Arecae 10 parts, Fructus Tsaoko 10 parts, Cortex Magnoliae Officinalis 8 parts, bavin
20 parts recklessly, Radix Scutellariae 5 parts, raw 5 parts of Folium Nelumbinis, Herba Houttuyniae 4 parts, 15 parts of Folium Pini, Radix et Caulis Opuntiae Dillenii 5 parts, Radix Sophorae Flavescentis 4 parts, even
Stick up 8 parts, 6 parts of Folium Mori, Flos Lonicerae 5 parts, Semen Trigonellae 30 parts, Pericarpium Citri Reticulatae 15 parts, Exocarpium Benincasae 4 parts, 10 parts of Flos persicae,
Herba Lobeliae Chinensis 10 parts, Radix Gentianae 1 part, Radix Ophiopogonis 6 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 50 mesh;
(4) medicated powder step (3) obtained and the ethanol solution that concentration is 85% mixing of 60 parts, extract 2h at 25 DEG C,
Sucking filtration 2 times, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, make relative density 1.2
Clear paste;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by 6 times amount of raw medicinal material gross weight, soak 8h, be then heated up to
95 DEG C are extracted 1h, filter, obtain the first extracting solution, and medicinal residues are standby;By raw medicinal material in the Chinese medicine extracting tank hold medicinal residues
3 times amount second time of gross weight add water, and are heated to 80 DEG C and extract 1-3h, filter, obtain the second extracting solution, extract first
Liquid and the second extracting solution merge, and stand 3h post-heating and are concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 100 mesh
The fine powder of sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Embodiment 2
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 12 parts, nothing
Flowers and fruits 12 parts, Cortex Fraxini 9 parts, Radix Platycodonis 18 parts, 22 parts of Radix Glycyrrhizae, Semen Arecae 12 parts, Fructus Tsaoko 12 parts, Cortex Magnoliae Officinalis 8.5 parts, bavin
22 parts recklessly, Radix Scutellariae 5.5 parts, raw 8 parts of Folium Nelumbinis, Herba Houttuyniae 5 parts, 18 parts of Folium Pini, Radix et Caulis Opuntiae Dillenii 8 parts, Radix Sophorae Flavescentis 5 parts,
Fructus Forsythiae 8.5 parts, 7 parts of Folium Mori, Flos Lonicerae 7 parts, Semen Trigonellae 32 parts, Pericarpium Citri Reticulatae 18 parts, Exocarpium Benincasae 4.5 parts, Flos persicae 15
Part, Herba Lobeliae Chinensis 12 parts, Radix Gentianae 1.5 parts, Radix Ophiopogonis 6.5 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 55 mesh;
(4) medicated powder step (3) obtained and the ethanol solution that concentration is 88% mixing of 65 parts, extract 2.5h at 26 DEG C,
Sucking filtration 3 times, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, make relative density 1.21
Clear paste;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by 7 times amount of raw medicinal material gross weight, soak 9h, be then heated up to
98 DEG C are extracted 1.5h, filter, obtain the first extracting solution, and medicinal residues are standby;By crude drug in the Chinese medicine extracting tank hold medicinal residues
3.5 times amount second time of material gross weight add water, and are heated to 85 DEG C and extract 1.5h, filter, obtain the second extracting solution, by first
Extracting solution and the second extracting solution merge, and stand 3.5h post-heating and are concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 120 mesh
The fine powder of sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Embodiment 3
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 15 parts, nothing
Flowers and fruits 15 parts, Cortex Fraxini 10 parts, Radix Platycodonis 20 parts, 25 parts of Radix Glycyrrhizae, Semen Arecae 15 parts, Fructus Tsaoko 15 parts, Cortex Magnoliae Officinalis 9 parts, bavin
25 parts recklessly, Radix Scutellariae 6 parts, raw 10 parts of Folium Nelumbinis, Herba Houttuyniae 6 parts, 20 parts of Folium Pini, Radix et Caulis Opuntiae Dillenii 10 parts, Radix Sophorae Flavescentis 6 parts,
Fructus Forsythiae 9 parts, 8 parts of Folium Mori, Flos Lonicerae 8 parts, Semen Trigonellae 35 parts, Pericarpium Citri Reticulatae 20 parts, Exocarpium Benincasae 5 parts, 20 parts of Flos persicae,
Herba Lobeliae Chinensis 15 parts, Radix Gentianae 2 parts, Radix Ophiopogonis 7 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 60 mesh;
(4) medicated powder step (3) obtained and the ethanol solution that concentration is 90% mixing of 70 parts, extract 3h at 28 DEG C,
Sucking filtration 2 times, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, make relative density 1.22
Clear paste;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by 8 times amount of raw medicinal material gross weight, soak 10h, then heat
Extracting 2h to 100 DEG C, filter, obtain the first extracting solution, medicinal residues are standby;By raw material in the Chinese medicine extracting tank hold medicinal residues
4 times amount second time of medical material gross weight add water, and are heated to 90 DEG C and extract 2h, filter, obtain the second extracting solution, by first
Extracting solution and the second extracting solution merge, and stand 4h post-heating and are concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 150 mesh
The fine powder of sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Embodiment 4
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 18 parts, nothing
Flowers and fruits 18 parts, Cortex Fraxini 11 parts, Radix Platycodonis 22 parts, 28 parts of Radix Glycyrrhizae, Semen Arecae 18 parts, Fructus Tsaoko 18 parts, Cortex Magnoliae Officinalis 9.5 parts,
Radix Bupleuri 28 parts, Radix Scutellariae 6.5 parts, raw 12 parts of Folium Nelumbinis, Herba Houttuyniae 7 parts, 22 parts of Folium Pini, Radix et Caulis Opuntiae Dillenii 12 parts, Radix Sophorae Flavescentis 7
Part, Fructus Forsythiae 9.5 parts, 9 parts of Folium Mori, Flos Lonicerae 9 parts, Semen Trigonellae 38 parts, Pericarpium Citri Reticulatae 22 parts, Exocarpium Benincasae 5.5 parts, Fructus Persicae
Spend 25 parts, Herba Lobeliae Chinensis 18 parts, Radix Gentianae 2.5 parts, Radix Ophiopogonis 7.5 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 65 mesh;
(4) medicated powder step (3) obtained and the ethanol solution that concentration is 92% mixing of 75 parts, extract 3.5h at 29 DEG C,
Sucking filtration 3 times, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, make relative density 1.24
Clear paste;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by 9 times amount of raw medicinal material gross weight, soak 11h, then heat
Extracting 2.5h to 102 DEG C, filter, obtain the first extracting solution, medicinal residues are standby;By former in the Chinese medicine extracting tank hold medicinal residues
4.5 times amount second time of material medical material gross weight add water, and are heated to 95 DEG C and extract 2.5h, filter, obtain the second extracting solution, will
First extracting solution and the second extracting solution merge, and stand 4.5h post-heating and are concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 180 mesh
The fine powder of sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Embodiment 5
A kind of pharmaceutical composition for preventing and treating birds airsacculitis, includes according to the raw material of weight portion: Herba Liparidis nervosae 20 parts, nothing
Flowers and fruits 20 parts, Cortex Fraxini 12 parts, Radix Platycodonis 25 parts, 30 parts of Radix Glycyrrhizae, Semen Arecae 20 parts, Fructus Tsaoko 20 parts, Cortex Magnoliae Officinalis 10 parts,
Radix Bupleuri 30 parts, Radix Scutellariae 7 parts, raw 15 parts of Folium Nelumbinis, Herba Houttuyniae 8 parts, 25 parts of Folium Pini, Radix et Caulis Opuntiae Dillenii 15 parts, Radix Sophorae Flavescentis 8 parts,
Fructus Forsythiae 10 parts, 10 parts of Folium Mori, Flos Lonicerae 10 parts, Semen Trigonellae 40 parts, Pericarpium Citri Reticulatae 25 parts, Exocarpium Benincasae 6 parts, Flos persicae 30
Part, Herba Lobeliae Chinensis 20 parts, Radix Gentianae 3 parts, Radix Ophiopogonis 8 parts.
The preparation method of the described pharmaceutical composition for preventing and treating birds airsacculitis, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 70 mesh;
(4) medicated powder step (3) obtained and the ethanol solution that concentration is 95% mixing of 80 parts, extract 4h at 30 DEG C,
Sucking filtration 3 times, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, make relative density 1.25
Clear paste;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by 10 times amount of raw medicinal material gross weight, soak 12h, then heat
Extracting 3h to 105 DEG C, filter, obtain the first extracting solution, medicinal residues are standby;By raw material in the Chinese medicine extracting tank hold medicinal residues
5 times amount second time of medical material gross weight add water, and are heated to 100 DEG C and extract 3h, filter, obtain the second extracting solution, by first
Extracting solution and the second extracting solution merge, and stand 5h post-heating and are concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 200 mesh
The fine powder of sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
Toxicity test:
Select SD rat, give the powder of the embodiment of the present invention 2 of variable concentrations (18.0,6.0,2.0g crude drug/kg), often
Once, continuous 90 days, last was administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), remaining 1/2 animal it gavage
Live after continuing to observe 2 weeks and kill.The outward appearance of animal, general behavior, food ration, body weight change is observed, after administration during test
Within 90 days, within 2 weeks, carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood life with drug withdrawal
Change (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, internal organs system
The index checkings such as number, histopathology.
Result of the test shows: the Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, outward appearance sign,
Behavioral activity, food-intake and body weight increase change the most without exception;Three dosage groups and matched group hematological examination, blood biochemical
Learn, urine biochemical analysis all between normal range, group without significant difference;Each group main organs histopathological examination has no bright
Aobvious abnormal.These parameters drug withdrawal also had no change after 2 weeks.This test dosage be respectively clinical medicine dose 180,
60,20 times, according to the Chinese medicine preparation of the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg)
Even within 90 days, being administered and have no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no and prolongs
Property toxic reaction late, the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
The Chinese medicine preparation of the present invention treatment birds airsacculitis pathology on have complement each other, the effect of Synergistic, the property of medicine
Gentle, to respiratory mucosa nonirritant, the respiratory symptom that rapid recovery causes because of airsacculitis type respiratory tract disease, repair
Respiratory mucosa, efficacy stability, persistent, it is possible to substantially cure or alleviate birds airsacculitis symptom, reduce birds dead
Rate, reduces loss.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment,
In the ken that those of ordinary skill in the art is possessed, it is also possible to make each on the premise of without departing from this patent objective
Plant change.
Claims (4)
1. the pharmaceutical composition being used for preventing and treating birds airsacculitis, it is characterised in that include according to the raw material of weight portion: see
Serum 10-20 part, Fructus Fici 10-20 part, Cortex Fraxini 8-12 part, Radix Platycodonis 15-25 part, Radix Glycyrrhizae 20-30 part, Semen Arecae 10-20
Part, Fructus Tsaoko 10-20 part, Cortex Magnoliae Officinalis 8-10 part, Radix Bupleuri 20-30 part, Radix Scutellariae 5-7 part, raw Folium Nelumbinis 5-15 part, Herba Houttuyniae 4-8
Part, Folium Pini 15-25 part, Radix et Caulis Opuntiae Dillenii 5-15 part, Radix Sophorae Flavescentis 4-8 part, Fructus Forsythiae 8-10 part, Folium Mori 6-10 part, Flos Lonicerae 5-10
Part, Semen Trigonellae 30-40 part, Pericarpium Citri Reticulatae 15-25 part, Exocarpium Benincasae 4-6 part, Flos persicae 10-30 part, Herba Lobeliae Chinensis 10-20 part, dragon
Gallbladder 1-3 part, 6-8 part Radix Ophiopogonis.
Pharmaceutical composition for preventing and treating birds airsacculitis the most according to claim 1, it is characterised in that according to weight
The raw material of part includes: Herba Liparidis nervosae 12-18 part, Fructus Fici 12-18 part, Cortex Fraxini 9-11 part, Radix Platycodonis 18-22 part, Radix Glycyrrhizae 22-28
Part, Semen Arecae 12-18 part, Fructus Tsaoko 12-18 part, Cortex Magnoliae Officinalis 8.5-9.5 part, Radix Bupleuri 22-28 part, Radix Scutellariae 5.5-6.5 part, raw lotus
Leaf 8-12 part, Herba Houttuyniae 5-7 part, Folium Pini 18-22 part, Radix et Caulis Opuntiae Dillenii 8-12 part, Radix Sophorae Flavescentis 5-7 part, Fructus Forsythiae 8.5-9.5 part,
Folium Mori 7-9 part, Flos Lonicerae 7-9 part, Semen Trigonellae 32-38 part, Pericarpium Citri Reticulatae 18-22 part, Exocarpium Benincasae 4.5-5.5 part, Flos persicae 15-25
Part, Herba Lobeliae Chinensis 12-18 part, Radix Gentianae 1.5-2.5 part, 6.5-7.5 part Radix Ophiopogonis.
Pharmaceutical composition for preventing and treating birds airsacculitis the most according to claim 1, it is characterised in that according to weight
The raw material of part includes: Herba Liparidis nervosae 15 parts, Fructus Fici 15 parts, Cortex Fraxini 10 parts, Radix Platycodonis 20 parts, 25 parts of Radix Glycyrrhizae, Semen Arecae
15 parts, Fructus Tsaoko 15 parts, Cortex Magnoliae Officinalis 9 parts, Radix Bupleuri 25 parts, Radix Scutellariae 6 parts, raw 10 parts of Folium Nelumbinis, Herba Houttuyniae 6 parts, Folium Pini
20 parts, Radix et Caulis Opuntiae Dillenii 10 parts, Radix Sophorae Flavescentis 6 parts, Fructus Forsythiae 9 parts, 8 parts of Folium Mori, Flos Lonicerae 8 parts, Semen Trigonellae 35 parts, Pericarpium Citri Reticulatae
20 parts, Exocarpium Benincasae 5 parts, 20 parts of Flos persicae, Herba Lobeliae Chinensis 15 parts, Radix Gentianae 2 parts, Radix Ophiopogonis 7 parts.
4. a preparation method for the pharmaceutical composition for preventing and treating birds airsacculitis as described in claim 1-3 is arbitrary, its
It is characterised by, specifically comprises the following steps that
(1) each raw material is weighed according to weight portion;
(2) Semen Arecae, Fructus Tsaoko, Cortex Magnoliae Officinalis, Radix Bupleuri, Radix Scutellariae, Radix Platycodonis, Radix Glycyrrhizae and Pericarpium Citri Reticulatae are individually pulverized, use super
Atomizer is pulverized, and by No. 9 medicinal sieves to micron order, then the fine powder after pulverizing is put at the beginning of carrying out in mixer
Mixed, obtain mixture;
(3) Herba Liparidis nervosae, Fructus Fici, Cortex Fraxini, raw Folium Nelumbinis, Herba Houttuyniae and Folium Pini are processed into the medicated powder of 50-70 mesh;
(4) medicated powder step (3) obtained mixes with the ethanol solution that concentration is 85-95% of 60-80 part, 25-30 DEG C
Lower extraction 2-4h, sucking filtration 2-3 time, merging filtrate, decompression distillation, fling to ethanol, and concentrate on vacuum rotary evaporator, system
Become the clear paste of relative density 1.2-1.25;
(5) by Radix et Caulis Opuntiae Dillenii, Radix Sophorae Flavescentis, Fructus Forsythiae, Folium Mori, Flos Lonicerae, Semen Trigonellae, Exocarpium Benincasae, Flos persicae, Herba Lobeliae Chinensis, dragon
Gallbladder and Radix Ophiopogonis are positioned in Chinese medicine extracting tank, add water by the 6-10 times amount of raw medicinal material gross weight, soak 8-12h, then
Being heated up to 95-105 DEG C and extract 1-3h, filter, obtain the first extracting solution, medicinal residues are standby;Holding the Chinese medicine extracting tank of medicinal residues
In by raw medicinal material gross weight 3-5 times amount second time add water, be heated to 80-100 DEG C extract 1-3h, filter, obtain second
Extracting solution, merges the first extracting solution and the second extracting solution, stands 3-5h post-heating and is concentrated into pasty state;
(6) product that step (4) and step (5) obtain is put into drying in oven, after cooling, grind to form 100-200
The fine powder of mesh sieve, adds the mixture that step (2) obtains, obtains powder finished product after mix homogeneously.
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CN115737491A (en) * | 2022-03-23 | 2023-03-07 | 北京东方淼森生物科技有限公司 | Plant composition and preparation method and application thereof |
CN115737491B (en) * | 2022-03-23 | 2023-12-26 | 北京东方淼森生物科技有限公司 | Plant composition and preparation method and application thereof |
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