CN104189175A - Traditional Chinese medicine preparation for treating poultry air sacculitis - Google Patents
Traditional Chinese medicine preparation for treating poultry air sacculitis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating the poultry air sacculitis. The traditional Chinese medicine preparation is characterized by comprising the following raw materials in parts by weight: 20 to 60 parts of faenum graecum, 10 to 40 parts of pericarpium citri reticulatae, 10 to 30 parts of waxgourd peel and 10 to 30 parts of peach blossom. In the pharmaceutical active ingredients adopted by the traditional Chinese medicine preparation, the faenum graecum has high fiber content and has the effect of treating inflammation and infection; the pericarpium citri reticulatae has a relaxing effect on the trachea, has the obvious effect of relieving asthma and meanwhile, can promote secretion of digestive juice and improve the feed intake; the waxgourd peel can treat swelling and remove heat toxin; the peach blossom has the effects of eliminating the edema, activating blood and dissolving stasis. Experiment results prove that the traditional Chinese medicine preparation disclosed by the invention has a synergetic effect on pathology of treating the poultry air sacculitis, can effectively replace antibiotic or antiviral medicaments and does not generate drug resistance or drug residues.
Description
Technical field
The invention belongs to the technical field of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of birds airsacculitis.
Background technology
Airsacculitis is commonly encountered diseases popular in birds feeding process, Chang Bingfa, and infect soon, mortality rate is high, has caused very large economic loss to raiser.Its symptom is as follows: birds lethargy, and the necking down of bowing, feather pine is disorderly, tarnish, the wing that hangs down, swollen eye, shed tears, ataxia, minority mouth breathing, there is rale, row's white or yellow green loose stool, course of disease elder is preced with wattle purple darkly, shout strangely, send " snore " sound, cough, sneeze, fervescence, piles up or a slow-witted vertical side.Dissect visible air bag muddiness, thicken, inside have yellow cheesy thing, thoracic respiration becomes ventral breathing, in the visible mesentery having, is mixed with a large amount of bubbles.
Under current poultry large-scale cultivation condition, clinical normal and be difficult to prevention and control of bacterial air sacculitis in livestock.Develop fast and caused very large obstacle to the health of Chinese poultry resource aquaculture.Colibacillosis, mycoplasma, aspergillosis are the principal elements of bringing out chicken airsacculitis, for these diseases, the main treatment that adopts antibiotic medicine administration, adopt the chemotherapys such as antiviral and antibiotic, easily produce drug resistance, and because the half-life of this type of medicine is longer, make to produce high amount of drug in Fowl meat, egg product residual, jeopardize food safety.
Summary of the invention
The present invention is the defect that overcomes prior art, a kind of Chinese medicine preparation for the treatment of birds airsacculitis is provided, can effectively treat birds airsacculitis through long-term research and a large amount of evidences, and all nontoxic no drug residues of raw material that use, life-time service can not produce drug resistance, can make up the deficiency of antibody therapy and antibiotherapy.
The present invention is that the technical scheme that realizes its object employing is:
Treat a Chinese medicine preparation for birds airsacculitis, in described Chinese medicine preparation, the part by weight umber of each raw material is: Semen Trigonellae 20-60 part, Pericarpium Citri Reticulatae 10-40 part, Exocarpium Benincasae 10-30 part, Flos persicae 10-30 part.
In described Chinese medicine preparation, the part by weight umber of each raw material is: 60 parts of Semen Trigonellaes, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 10 parts, Flos persicae.
In described Chinese medicine preparation, the part by weight umber of each raw material is: 20 parts of Semen Trigonellaes, 40 parts of Pericarpium Citri Reticulataes, 30 parts of Exocarpium Benincasaes, 10 parts, Flos persicae.
In described Chinese medicine preparation, the part by weight umber of each raw material is: 30 parts of Semen Trigonellaes, 30 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 20 parts, Flos persicae.
In described Chinese medicine preparation, the part by weight umber of each raw material is: 50 parts of Semen Trigonellaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Exocarpium Benincasaes, 30 parts, Flos persicae.
In described Chinese medicine preparation, the part by weight umber of each raw material is: 40 parts of Semen Trigonellaes, 20 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 30 parts, Flos persicae.
Described Chinese medicine preparation can be made tablet, powder, oral liquid, granule, extractum.
The invention has the beneficial effects as follows: the effective ingredient Semen Trigonellae fiber content that the present invention adopts is very high, have effect for the treatment of inflammation, infection, Pericarpium Citri Reticulatae has relexation to trachea, has the effect of significantly relievining asthma, and secretion that simultaneously can facilitating digestion liquid, improves feed intake.Exocarpium Benincasae can be controlled swelling, pyretic toxicity disappears, Flos persicae has elimination edema, effect of blood circulation promoting and blood stasis dispelling, prove by experiment, Chinese medicine preparation of the present invention has and complements each other on the pathology for the treatment of birds airsacculitis, the effect of Synergistic, the high fiber in Semen Trigonellae can increase the effect of relievining asthma of Pericarpium Citri Reticulatae, can improve effect of Pericarpium Citri Reticulatae facilitating digestion liquid secretion.Pericarpium Citri Reticulatae volatile oil has faint dilating effect to bronchus, and with nutrient mass-energy blood vessel dilating in Flos persicae, promotion of blood circulation effect is consistent, and Pericarpium Citri Reticulatae can also be eliminated the side effect of Semen Trigonellae gastrointestinal upset.Exocarpium Benincasae can be controlled swelling, and the pyretic toxicity that disappears can strengthen the antiinflammation of Pericarpium Citri Reticulatae, promotes the excretion of toxin, strengthens effect of Semen Trigonellae treatment inflammation and infection.This Chinese medicine preparation is the use of substitute antibiotics or antiviral class medicine effectively, does not produce drug resistance and drug residue.
Semen Trigonellae: bitter in the mouth, warm in nature.Kidney-replenishing, dispelling cold and dampness.Control colic of cold type, abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.
Pericarpium Citri Reticulatae: acrid in the mouth, hardship, warm in nature.There is regulating the flow of Qi and the middle Jiao, drying dampness to eliminate phlegm, effect of diuretic relieving constipation.Cure mainly incoordination between the spleen and stomach, abdominal distention, anorexia, vomiting hiccup; Accumulation of phlegm-damp in the lung, cough with copious phlegm, chest and diaphragm is full vexed, the vertigo; Edema, dysuria, constipation; Acute mastitis scabies, middle fish Eriocheir sinensis poison, alcoholism.
Exocarpium Benincasae: property is sweet and be slightly cold.From the character of food, Benincasa cold nature, has effect of promoting diuresis to clear away damp pathogen.Can control swelling, the pyretic toxicity that disappears, diuresis, Exocarpium Benincasae is rich in saccharide, protein, vitamin C.
Flos persicae: bitter in the mouth; Property is put down, and Flos persicae is deciduous tree. elliptic leaf shape lanceolar, and leaf margin has rough sawn tooth, without hair, effect having: diuretic; Blood circulation promoting and blood stasis dispelling.Main edema; Foot gas; Phlegm retention; Diuretic relieving constipation; Stranguria dne to urolithiasis; Constipation; Amenorrhea; Demented; Skin ulcer rash.For edema, ascites, constipation.
By long-term research and strict experimental results show that, adopt ratio umber of the present invention: Semen Trigonellae 20-60 part, Pericarpium Citri Reticulatae 10-40 part, Exocarpium Benincasae 10-30 part, Flos persicae 10-30 part, successful on treatment birds airsacculitis, finds under study for action, in the time that the weight portion proportioning of Exocarpium Benincasae and Flos persicae is greater than 30 parts, curative effect increase is not remarkable and birds excretion is increased.This Chinese medicine preparation is especially 50 parts of Semen Trigonellaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Exocarpium Benincasaes, best results in 30 parts of these ratios of Flos persicae, the symptom that not only can alleviate rapidly disease chicken, reduces the mortality rate of disease chicken, and, no matter chicken after healing is the equal drug residue free of broiler or laying hen, and nutritive value also obviously promotes.
Detailed description of the invention
The present invention is the defect that overcomes prior art, a kind of Chinese medicine preparation for the treatment of birds airsacculitis is provided, can effectively treat birds airsacculitis through long-term research and a large amount of evidences, and all nontoxic no drug residues of raw material that use, life-time service can not produce drug resistance, can make up the deficiency of antibody therapy and antibiotherapy.Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
Preparation 1000g Chinese medicine preparation is example, gets Semen Trigonellae 600g, Pericarpium Citri Reticulatae 100g, Exocarpium Benincasae 100g, Flos persicae 100g.
Embodiment 2
Preparation 1000g Chinese medicine preparation is example, gets Semen Trigonellae 200g, Pericarpium Citri Reticulatae 400g, Exocarpium Benincasae 300g, Flos persicae 100g.
Embodiment 3
Preparation 1000g Chinese medicine preparation is example, gets Semen Trigonellae 300g, Pericarpium Citri Reticulatae 300g, Exocarpium Benincasae 100g, Flos persicae 200g.
Embodiment 4
Preparation 1000g Chinese medicine preparation is example, gets Semen Trigonellae 500g, Pericarpium Citri Reticulatae 200g, Exocarpium Benincasae 200g, Flos persicae 300g.
Embodiment 5
Preparation 1000g Chinese medicine preparation is example, gets Semen Trigonellae 400g, Pericarpium Citri Reticulatae 200g, Exocarpium Benincasae 100g, Flos persicae 300g.
It is example that the Chinese medicine preparation of above-mentioned five kinds of embodiment is made to oral liquid,
Adopt traditional decoction method to extract, each component is mixed to the water that adds 10-12 times of weight, 100 DEG C are refluxed 2 hours, get after filtrate, filtering residue is continued to add to the water of 8-10 times of weight, 100 DEG C are refluxed 1 hour, filter, merge reflux, extract, gained filtrate twice, 75% ethanol precipitation, Chinese medicine preparation weight: ethanol volume=10:1, precipitate 12 hours, get supernatant, at 60-65 DEG C of concentration and recovery ethanol to without alcohol taste, keep temperature 60-65 DEG C, continue to be concentrated into the extractum that relative density (this relative density is the density with respect to water) is 1.1-1.2, by 10% sucrose adjustment for extractum, making the solution concentration after adjusting is containing crude drug 1g/ml, stir evenly, fill, oral liquid is made in sterilizing.
The liquid that takes that the Chinese medicine preparation of above-mentioned five kinds of embodiment is made has carried out following clinical trial:
Clinical trial 1
3000 of the white plumage broiler of AA are raised in Tian Qin cultivation base, Hebei, when 25 age in days, fall ill, and the respiratory symptom of sick chicken is obvious, mouth breathing, dyspnea, snore, sheds tears, lethargy, feed intake declines, and dead 10-30 of every day, cuts open the visible air bag muddiness of inspection and thickens, bronchus has cheesy secretions, and clinical diagnosis is airsacculitis.
Control drug: bar card peaceful (polygynax soluble powder, amikacin)
Choose at random 1500 of disease fowl, be divided at random three groups, 500 every group, three groups from aspect no significant differences (P>0.05) such as clinical symptoms performance, fuselage state, diet water ways.First group of medicine drinking-water treatment (every 50ml is watered 100kg, every day 2 times) that adopts embodiment 1 to prepare, second group adopts the treatment of bar card peaceful (every 100g is watered 200kg, every day 2 times) drinking-water.The 3rd group of program diet drinking-water routinely.After first group of sick chicken administration 25min, the state of an illness is alleviated, and breathing, snore, the situation of shedding tears alleviate, administration after 3 days symptom obviously alleviate, mental restoration is normal, the situation of searching for food is normal; Second group of sick chicken administration after 5 days symptom alleviate, search for food and recover gradually normal; The 3rd group of sick chicken is without significant change, and after 7 days, comparative test result is as shown in table 1:
Table 1 clinical trial comparative test result
Note: cure rate=(total number of cases-do not cure number of elements-dead number of elements)/total number of cases × 100%; Mortality rate=dead number of elements/total number of cases × 100%; Effective percentage=(total number of cases-dead number of elements)/total number of cases × 100%.
Table 2 clinical trial detects Fowl meat product drug residue situation
Result of the test shows, uses the Chinese medicine preparation of the present invention can be controlled rapidly, and medication can all be cured after 7 days, and therapeutic effect is better than matched group.
Clinical trial 2
6000 yellow-feather broilers that introduce in one broiler breeding base, Pujiang County, Sichuan, when 33 age in days, fall ill, sick chicken dyspnea, cough ataxia, indivedual chicken cockscomb wattle purples darkly, shout strangely, send snore, arrange white just or yellow green loose stool, feed intake declines, larynx and trachea hyperemia, there is mucus, cut open inspection symptom torso bag muddiness, have yellow cheesy thing to adhere to; Saccus abdominalis also becomes turbid, thickens.Clinical diagnosis is airsacculitis.
Control drug: cefotaxime sodium
Choose at random 1800 sick chickens, chicken group is divided into three groups at random, 600 every group, three groups at feed intake, the environment of feeding, the aspect no significant differences (P>0.05) such as mode of feeding.First group of medicine that adopts embodiment 2 to prepare drunk water, and (every 50ml is watered 100kg in treatment, every day 2 times), second group adopts cefotaxime sodium (every 1g is watered 20kg, the every day 2 times) treatment of drink water, the 3rd group routinely program diet drink water.After first group of sick chicken administration 30min, the state of an illness is alleviated, and breathing, snore, cough ataxia situation alleviate, administration after 3 days symptom obviously alleviate, mental restoration is normal, the situation of searching for food is normal; Second group of sick chicken administration after 5 days symptom alleviate, search for food and recover gradually normal; The 3rd group of sick chicken be without significant change, comparing result after 7 days, as shown in table 3, table 4:
Table 3 clinical trial comparative test result
Note: cure rate=(total number of cases-do not cure number of elements-dead number of elements)/total number of cases × 100%; Mortality rate=dead number of elements/total number of cases × 100%; Effective percentage=(total number of cases-dead number of elements)/total number of cases × 100%.
Table 4 clinical trial detects Fowl meat product drug residue situation
Clinical effectiveness shows, adopts Chinese medicine preparation of the present invention, can effectively control the mortality rate of disease chicken, can only control its infection rate, its mortality rate and blank group no significant difference and adopt antibiotic to treat sick chicken.Adopt therapeutic effect of the present invention to be obviously better than antibiotic group.
Clinical trial 3
Broiler breeding field, Guanling of Guizhou county, introduces 15000 of Lingnan Yellow chickens, starts morbidity, broiler their early stage in the time of 35 age in days, chicken group directly just starts to have a small amount of cough, and feather pine disorderly, and has station and spirit not, dyspnea, cough, and there is fragmentary death, feedstuff starts to decline.Cut open the visible nasal mucosa hyperemia of inspection, the hyperemia of larynx trachea, torso bag muddiness, has yellow-white piece-like cheese sample thing to adhere to, digestive tract edema, kidney enlargement, intestinal mucosa swelling.Extract disease Sanguis Gallus domesticus and do the experiment of mycoplasma whole blood agglutination antigen, without significantly condensing piece, get rid of mycoplasma infection.More gram negative bacilli in antibacterial culturing, according to clinical symptoms, laboratory diagnosis, is defined as the airsacculitis that escherichia coli cause.
Random choose goes out 3000 of disease chickens, is equally divided at random three groups, 1000 every group.Three groups at feed intake, clinical symptoms, the aspect no significant differences (P>0.05) such as environment of feeding.First group of invention product drinking-water treatment (every 50ml is watered 100kg, every day 2 times, is used in conjunction 7 days) that adopts embodiment 3 to prepare, second group adopts every intramuscular injection gentamycin (80,000～100,000 units, every day 2 times, be used in conjunction 3 days), the 3rd group of program diet drinking-water routinely.After first group of sick chicken administration 30min, the state of an illness is alleviated, breathe, cough situation alleviates, administration after 3 days symptom obviously alleviate, mental restoration is normal, the situation of searching for food is normal; Second group of sick chicken administration after 5 days symptom alleviate, search for food and recover gradually normal; The 3rd group of sick chicken is without significant change, and after 7 days, contrast and experiment is as shown in table 5, table 6.
Table 5 clinical trial comparative test result
Note: cure rate=(total number of cases-do not cure number of elements-dead number of elements)/total number of cases × 100%; Mortality rate=dead number of elements/total number of cases × 100%; Effective percentage=(total number of cases-dead number of elements)/total number of cases × 100%.
Table 6 clinical trial detects Fowl meat product drug residue situation
Experimental result demonstration, the broiler state of an illness has obtained effective control, and mortality rate no longer increases.Adopt the successful of Chinese medicine preparation of the present invention to be better than the method for intramuscular injection.
Clinical trial 4
Distributions in Liaocheng of Shandong Province city raises 10000 of laying hens in one breeding layer chicken field, and laying hen fell ill in the time of 28 week age, and laying hen feed intake reduces suddenly, sick chicken dehisces to stretch neck and breathes, and instigates with abdominal part, and egg production die-offs, loose and watery stool Huang, eyelid and lower jaw swelling, total body fat has petechia more.Cut open inspection result, diseased region has muddiness at torso bag, occurs cheesy thing, yellow in the majority, causes and suffocates.
Control drug: U.S. good fortune is (10% florfenicol powder) first
Choose at random 4000 of disease chickens, be divided at random four groups, 1000 every group, two groups at clinical symptoms, feed intake, the mode of searching for food, the aspect no significant differences (P>0.05) such as environment of searching for food.First group adopts invention product drinking-water treatment prepared by the embodiment of the present invention 4 (every 50ml is watered 100kg, every day 2 times, be used in conjunction 7 days), second group adopts invention product drinking-water treatment prepared by the embodiment of the present invention 5 (every 50ml is watered 100kg, be used in conjunction 7 day 2 every day), the 3rd group adopts first (10% florfenicol powder) the drinking-water treatment (70g is watered 150L) of the U.S. good fortune of control drug, the 4th group adopts blank group, without medicine, after first group of sick chicken administration 15min, the state of an illness is alleviated, breathe, snore, the situation of shedding tears alleviates, administration after 3 days symptom obviously alleviate, mental restoration is normal, the situation of searching for food is normal, after second group of sick chicken administration 20min, the state of an illness is alleviated, and breathing, snore, the situation of shedding tears alleviate, administration after 3 days symptom obviously alleviate, mental restoration is normal, the situation of searching for food is normal, the 3rd group of sick chicken administration after 5 days symptom alleviate, search for food and recover gradually normal, the 4th group of sick chicken is without significant change.After 7 days, comparative test result is as shown in table 7, table 8, table 9:
Table 7 clinical trial comparative test result
Note: cure rate=(total number of cases-do not cure number of elements-dead number of elements)/total number of cases × 100%; Mortality rate=dead number of elements/total number of cases × 100%; Effective percentage=(total number of cases-dead number of elements)/total number of cases × 100%.
The result of table 8 clinical trial egg number and laying rate
Note: always lay eggs piece number/sevens' day livestock on hand laying hen of laying rate=seven day is counted summation × 100%
Table 9 clinical trial detects Fowl meat and egg product drug residue situation
After medication 7 days, to the testing result of normal Fowl meat nutrient composition content
Claims (7)
1. a Chinese medicine preparation for the treatment of birds airsacculitis, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: Semen Trigonellae 20-60 part, Pericarpium Citri Reticulatae 10-40 part, Exocarpium Benincasae 10-30 part, Flos persicae 10-30 part.
2. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: 60 parts of Semen Trigonellaes, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 10 parts, Flos persicae.
3. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: 20 parts of Semen Trigonellaes, 40 parts of Pericarpium Citri Reticulataes, 30 parts of Exocarpium Benincasaes, 10 parts, Flos persicae.
4. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: 30 parts of Semen Trigonellaes, 30 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 20 parts, Flos persicae.
5. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: 50 parts of Semen Trigonellaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Exocarpium Benincasaes, 30 parts, Flos persicae.
6. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: in described Chinese medicine preparation, the part by weight umber of each raw material is: 40 parts of Semen Trigonellaes, 20 parts of Pericarpium Citri Reticulataes, 10 parts of Exocarpium Benincasaes, 30 parts, Flos persicae.
7. a kind of Chinese medicine preparation for the treatment of birds airsacculitis according to claim 1, is characterized in that: described Chinese medicine preparation can be made tablet, powder, oral liquid, granule, extractum.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104938830A (en) * | 2015-06-09 | 2015-09-30 | 柳州市明达鸽业养殖专业合作社 | Air sacculitis preventing and treating health sand for pigeon feeding |
| CN105833161A (en) * | 2016-04-30 | 2016-08-10 | 何佑兵 | Pharmaceutical composition for preventing and treating poultry air sac inflammation and preparation method thereof |
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| CN102988874A (en) * | 2012-12-29 | 2013-03-27 | 潍坊富邦药业有限公司 | Novel prescription for treating bird air sacculitis by traditional Chinese medicine and preparation process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104938830A (en) * | 2015-06-09 | 2015-09-30 | 柳州市明达鸽业养殖专业合作社 | Air sacculitis preventing and treating health sand for pigeon feeding |
| CN105833161A (en) * | 2016-04-30 | 2016-08-10 | 何佑兵 | Pharmaceutical composition for preventing and treating poultry air sac inflammation and preparation method thereof |
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