CN105829297B - 具有抗疼痛的多重模式活性的哌啶化合物 - Google Patents

具有抗疼痛的多重模式活性的哌啶化合物 Download PDF

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Publication number
CN105829297B
CN105829297B CN201480070014.9A CN201480070014A CN105829297B CN 105829297 B CN105829297 B CN 105829297B CN 201480070014 A CN201480070014 A CN 201480070014A CN 105829297 B CN105829297 B CN 105829297B
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CN
China
Prior art keywords
substituted
methyl
phenyl
triazol
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201480070014.9A
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English (en)
Chinese (zh)
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CN105829297A (zh
Inventor
科多韦斯 费利克斯·奎瓦斯
卡门·阿尔曼萨-罗萨莱斯
加尔塞拉 埃娃·玛丽亚·阿耶特
卡瓦内斯 玛丽亚·特雷莎·塞拉菲尼
洛佩斯 莫妮卡·加西亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteven Pharmaceutical Co ltd
Esteve Pharmaceuticals SA
Original Assignee
Esteven Pharmaceutical Co ltd
Laboratorios del Dr Esteve SA
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Publication of CN105829297A publication Critical patent/CN105829297A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201480070014.9A 2013-12-20 2014-12-19 具有抗疼痛的多重模式活性的哌啶化合物 Expired - Fee Related CN105829297B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13384005 2013-12-20
EP13384005.8 2013-12-20
PCT/EP2014/078811 WO2015091988A1 (en) 2013-12-20 2014-12-19 Piperidine compounds having multimodal activity against pain

Publications (2)

Publication Number Publication Date
CN105829297A CN105829297A (zh) 2016-08-03
CN105829297B true CN105829297B (zh) 2019-08-09

Family

ID=49998041

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480070014.9A Expired - Fee Related CN105829297B (zh) 2013-12-20 2014-12-19 具有抗疼痛的多重模式活性的哌啶化合物

Country Status (8)

Country Link
US (1) US9902711B2 (https=)
EP (1) EP3083595B1 (https=)
JP (1) JP6498672B2 (https=)
CN (1) CN105829297B (https=)
CA (1) CA2931219A1 (https=)
ES (1) ES2806408T3 (https=)
MX (1) MX2016006603A (https=)
WO (1) WO2015091988A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2931051A1 (en) 2013-12-20 2015-06-25 Laboratorios Del Dr. Esteve, S.A. Piperidine derivatives having multimodal activity against pain
CA2967857A1 (en) * 2014-11-21 2016-05-26 Laboratorios Del Dr. Esteve, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
CA2991937A1 (en) * 2015-07-29 2017-02-02 Laboratorios Del Dr. Esteve, S.A. Substituted amide derivatives having multimodal activity against pain
CA2999940A1 (en) 2015-10-23 2017-04-27 Laboratorios Del Dr. Esteve, S.A. Substituted morpholine derivatives having activity against pain
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Citations (11)

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GB2083476A (en) * 1980-09-12 1982-03-24 Wyeth John & Brother Ltd Heterocyclic compounds
EP0241053A1 (en) * 1986-02-27 1987-10-14 Duphar International Research B.V Aryl-substituted (N-piperidinyl)-methyl- and (N-piperazinyl) methylazoles having antipsychotic properties
CN1102649A (zh) * 1993-06-26 1995-05-17 默克专利股份有限公司 哌啶和派嗪衍生物
CN1158608A (zh) * 1994-09-27 1997-09-03 纽罗根公司 一些氨甲基苯基咪唑的衍生物以及一类新的多巴胺受体亚型特异性配位体
WO2000059502A1 (en) * 1999-04-06 2000-10-12 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
EP1072592A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
CN1289333A (zh) * 1998-02-03 2001-03-28 美国家用产品公司 用作血清素－1a受体激动剂的噁唑衍生物
US20020094898A1 (en) * 2001-01-12 2002-07-18 Toyota Jidosha Kabushiki Kaisha Power transmission system
WO2005005411A1 (en) * 2003-07-04 2005-01-20 Glaxosmithkline S.P.A. Substituted indole ligands for the orl-1 receptor
WO2011072275A2 (en) * 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases
JP2013189395A (ja) * 2012-03-14 2013-09-26 Dainippon Sumitomo Pharma Co Ltd ジヒドロピロロピラジノン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
WO2008157844A1 (en) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
EP2375899B1 (en) 2009-01-12 2015-02-25 Array Biopharma Inc. Piperidine-containing compounds and use thereof in the treatment of diabetes
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
WO2011137331A2 (en) 2010-04-30 2011-11-03 Kinentia Biosciences Llc 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
JP2016028016A (ja) * 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2083476A (en) * 1980-09-12 1982-03-24 Wyeth John & Brother Ltd Heterocyclic compounds
EP0241053A1 (en) * 1986-02-27 1987-10-14 Duphar International Research B.V Aryl-substituted (N-piperidinyl)-methyl- and (N-piperazinyl) methylazoles having antipsychotic properties
CN1102649A (zh) * 1993-06-26 1995-05-17 默克专利股份有限公司 哌啶和派嗪衍生物
CN1158608A (zh) * 1994-09-27 1997-09-03 纽罗根公司 一些氨甲基苯基咪唑的衍生物以及一类新的多巴胺受体亚型特异性配位体
CN1289333A (zh) * 1998-02-03 2001-03-28 美国家用产品公司 用作血清素－1a受体激动剂的噁唑衍生物
WO2000059502A1 (en) * 1999-04-06 2000-10-12 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
EP1072592A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
US20020094898A1 (en) * 2001-01-12 2002-07-18 Toyota Jidosha Kabushiki Kaisha Power transmission system
WO2005005411A1 (en) * 2003-07-04 2005-01-20 Glaxosmithkline S.P.A. Substituted indole ligands for the orl-1 receptor
WO2011072275A2 (en) * 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases
JP2013189395A (ja) * 2012-03-14 2013-09-26 Dainippon Sumitomo Pharma Co Ltd ジヒドロピロロピラジノン誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
2-Phenylpyrroles as Conformationally Restricted Benzamide Analogues. A New Class of Potential Antipsychotics;Ineke van Wijngaarden等;《J. Med. Chem.》;19881231;第1988卷(第31期);第1934-1940页 *

Also Published As

Publication number Publication date
US20170001979A1 (en) 2017-01-05
CN105829297A (zh) 2016-08-03
WO2015091988A1 (en) 2015-06-25
JP2016540793A (ja) 2016-12-28
CA2931219A1 (en) 2015-06-25
MX2016006603A (es) 2016-09-06
EP3083595B1 (en) 2020-05-27
EP3083595A1 (en) 2016-10-26
ES2806408T3 (es) 2021-02-17
JP6498672B2 (ja) 2019-04-10
US9902711B2 (en) 2018-02-27

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Address after: Spain Barcelona

Applicant after: Steven pharmaceutical Limited by Share Ltd

Address before: Spain Barcelona

Applicant before: Enrique Manosas-Barrera/Attorney

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CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190809

Termination date: 20201219