CN105828785B - 具有减少的表面污染的口腔护理组合物 - Google Patents
具有减少的表面污染的口腔护理组合物 Download PDFInfo
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- CN105828785B CN105828785B CN201480068428.8A CN201480068428A CN105828785B CN 105828785 B CN105828785 B CN 105828785B CN 201480068428 A CN201480068428 A CN 201480068428A CN 105828785 B CN105828785 B CN 105828785B
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- oral care
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- 239000004474 valine Substances 0.000 description 1
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- 235000004416 zinc carbonate Nutrition 0.000 description 1
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- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
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- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 description 1
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Abstract
表面污染可通过提供包含以下各项的口腔护理组合物来最小化或消除：包含颜料的第一膜；以及任选地第二膜；其中所述第一膜在水性介质中具有与其厚度成反比的溶解速率，其中所述第一膜呈颗粒形式。
Description
发明背景
建议儿童应刷他们的牙齿至少45-60秒，并且成人应至少90至120秒。大部分人尤其是儿童并未刷他们的牙齿足以获得最大益处的时间段，并且另外难以准确估算刷牙所需要的时间。
在本领域中，最显著地在PCT/US2011/065308(Colgate-Palmolive Company)中已描述了包含膜的牙膏，这些牙膏在刷牙适当时间段后递送颜色改变信号并且任选地在刷牙时段期间递送活性成分。这些牙膏鼓励使用者刷牙更长的时间段。
然而，与使用此类牙膏相关的一个问题是牙膏处置(例如已咳出(吐出)到水槽中的牙膏)时的表面污染。污染是由处置时留在牙膏内的任何未溶解膜的溶解引起的。
因此，本领域仍需要在刷牙后递送颜色改变信号但最小化或消除牙膏处置时的表面污染的包含膜的牙膏。
发明概述
出人意料地，已发现表面污染可通过提供包含以下各项的口腔护理组合物来最小化或消除：包含颜料的第一膜；以及任选地第二膜；其中所述第一膜在水性介质中具有与其厚度成反比的溶解速率，其中所述第一膜呈颗粒形式。
本发明的其他适用范围将根据下文提供的详述而变得显而易知。应理解，详述和具体实施例虽然指示了本发明的优选实施方案，但是只希望用于说明目的而不欲限制本发明的范围。
附图简述
图1示出了使用具有(A)1.6mm方块膜和(B)30-50目膜的牙膏时的玻璃表面污染。
图2示出了月桂基硫酸钠(SLS)对膜沉降的影响。
发明详述
以下对于优选实施方案的描述本质上仅是示例性的，并且绝非意图限制本发明、其应用或用途。
本发明的一些实施方案提供一种可溶解膜(膜1)，其包含纤维素醚、增塑剂、非离子型表面活性剂以及颜料，其中所述膜呈颗粒形式。
出于本发明的目的，术语颗粒是指膜的较小尺寸或碎片，例如所述膜被切割或研磨成较小尺寸或碎片。
膜的各种实施方案包括但不限于：
1.1.膜1，其中所述膜包含纤维素醚，例如选自
(i)烷基纤维素，例如甲基纤维素；
(ii)羟烷基纤维素，例如选自羟丙基甲基纤维素、羟乙基丙基纤维素、羟丁基甲基纤维素、羟基丙基甲基纤维素、羧甲基纤维素及其混合物；
以及(iii)其混合物；
1.2.任何上述膜，其包含淀粉，例如预胶凝淀粉；
1.3.任何上述膜，其包含增塑剂，例如多元醇，例如山梨醇、丙二醇、甘油或低分子量聚乙二醇例如PEG 200；
1.4.任何上述膜，其包含例如有效地为所述膜提供可塑性的量的丙二醇，例如按膜干重计约20％-30％；
1.5.任何上述膜，其包含例如按膜干重计约1％-5％的量的非离子型表面活性剂或乳化剂，例如聚山梨醇酯，例如聚山梨醇酯80(也称为聚氧乙烯(20)去水山梨醇单油酸酯，例如可作为80商购获得)；
1.6.任何上述膜，其包含颜料，所述颜料可以包括但不限于颜料蓝15[147-14-8]、颜料蓝15：2、颜料绿7[1328-53-6]、颜料橙5[3468-63-1]、颜料红4[2814-77-9]、颜料红5[6410-41-9]、颜料红48：4[5280-66-0]、颜料红53：1[5160-02-1]、颜料红57[5858-81-1]、颜料红57：1[5281-04-9]；颜料红57：2钡色淀[17852-98-1]、颜料红63：1[6417-83-0]、颜料红64：1[6371-76-2]、颜料红68[5850-80-6]、颜料红83、颜料红90：1铝色淀[16508-80-8]、颜料红112[6535-46-2]、颜料红172铝色淀[12227-78-0]、颜料红173铝色淀、颜料紫19[1047-16-1]、颜料黄1[2512-29-0]、颜料黄3[6486-23-3]、颜料黄12[6358-85-6]、颜料黄13[5102-83-0]、颜料黄73[13515-40-7]或任何这些颜料的组合。
1.7.任何上述膜，其包含在水存在下在口腔内或皮肤上刷洗、擦洗或搅动大于30秒且小于180秒的时间段之后基本上溶解的物质；
1.8.任何上述膜，其中粒度处于选自由以下组成的组的范围内：10-100目(0.0059-0.0787英寸)、20-80目(0.0070-0.0331英寸)；25-60目(0.0098-0.0278英寸)以及30-50目(0.0117-0.0234英寸)-注意：1密耳＝0.001英寸；
1.9.任何上述膜，其中膜颗粒的颜料在膜颗粒溶解时释放，从而在儿童用牙膏刷牙30-180秒，例如约45-60秒或者在成人用牙膏刷牙约90-120秒的时段之后改变牙膏的颜色，由此释放颜料并向使用者提供充分刷牙的颜色信号；
1.10.任何上述膜，其包含按膜干重计20％-60％纤维素醚；10％-30％增塑剂；1％-5％非离子型表面活性剂；以及15％-55％颜料；
1.11.任何上述膜，其包含按膜干重计20％-60％的选自甲基纤维素、羟丙基甲基纤维素及其混合物的纤维素醚；10％-30％丙二醇；1％-5％聚山梨醇酯80；以及15％-55％颜料；
1.12.任何上述膜，其中膜还包含选自调味剂、芳香剂、抗菌剂、美化剂或其组合的活性剂；
1.13.任何上述膜，其为局部可接受的；
1.14.任何上述膜，其为口腔可接受的；
1.15.任何上述膜，其包含抗菌剂；在一个本发明的实施方案中，抗菌剂选自三氯生和来自植物提取物的挥发油例如甲醇。
本发明的膜能够实现颜料在口腔内的充分释放，但令人惊奇地在膜处置到表面区域上并冲洗掉时快速去除。
本发明还提供一种包含可溶性膜(膜1)的产品(产品1)，所述可溶性膜包含纤维素醚、增塑剂、非离子型表面活性剂以及颜料，其中所述膜呈上述颗粒形式。
1.16.产品1，其中所述产品为包含上述膜1的口腔护理产品，口腔护理产品为例如洁齿剂，例如牙膏，例如透明凝胶牙膏或不透明牙膏；
1.17.1.16的产品1，其中所述产品为透明凝胶牙膏或不透明牙膏并且膜颗粒的颜料在膜颗粒溶解时释放，从而在儿童用牙膏刷牙30-180秒，例如约45-60秒或者在成人用牙膏刷牙约90-120秒的时段之后改变牙膏的颜色，由此释放颜料并向使用者提供充分刷牙的颜色信号；
1.18.任何上述产品，其中所述产品还含有活性剂，所述活性剂包括但不限于调味剂、美化剂、抗菌剂、氨基酸、氟源、增白剂、锌化合物以及其混合物。
1.19.任何上述产品，其中所述产品为洗手皂或沐浴皂；
1.20.任何上述产品，其中所述产品为口香糖；
1.21.任何上述产品，其为口香糖，其中不同活性物为不同调味剂，以使得口香糖随着时间改变味感。
1.22.任何上述产品，其中所述产品还包含阴离子型表面活性剂，其包括但不限于C8-20烷基硫酸酯的水溶性盐、C8-20脂肪酸的磺化单甘油酯诸如氢化椰子油脂肪酸的单硫酸化单甘油酯的钠盐、肌氨酸盐、牛磺酸盐及其混合物。这些和其他表面活性剂的说明性实例为高级烷基硫酸盐，诸如月桂基硫酸钠、椰子单甘油硫酸钠、月桂基肌氨酸钠、月桂基羟乙基磺酸钠、月桂基羧酸钠；烷基芳基磺酸盐诸如十二烷基苯磺酸钠；高级烷基磺基乙酸盐，月桂基磺基乙酸钠；1，2-二羟基丙烷磺酸盐的高级脂肪酸酯；以及低级脂族氨基羧酸化合物的基本上饱和的高级脂族酰基酰胺，诸如脂肪酸、烷基或酰基中具有12至16个碳的那些(酰胺为N-月桂酰肌氨酸以及N-月桂酰、N-肉豆蔻酰或N-棕榈酰肌氨酸的钠盐、钾盐和乙醇胺盐等)；及其混合物。在本发明的一个实施方案中，阴离子型表面活性剂为月桂基硫酸钠(SLS)。
1.23.任何上述产品，其中阴离子型表面活性剂的量在选自由以下组成的组的量的范围内：1.5重量％至5.0重量％和1.5重量％至2.0重量％。
1.24.任何上述产品，其中所述产品还包含研磨材料，研磨材料诸如二氧化硅、煅烧氧化铝、碳酸氢钠、碳酸钙、磷酸二钙和焦磷酸钙可以包含在用于实践本发明的基本洁齿剂组合物中。其他研磨材料也可适用于本文所述的组合物。视觉上透明的洁齿剂组合物可通过使用研磨材料诸如胶态二氧化硅例如以商品名销售的可从HuberCorporation获得的那些胶态二氧化硅或折射率接近于洁齿剂组合物中所使用的胶凝剂-液体(包含水和/或湿润剂)系统的折射率的碱金属铝硅酸盐复合物(即组合在其基质中的含二氧化硅的氧化铝)来获得。
1.25.任何上述产品，其中抗菌剂包括但不限于，三氯生(5-氯-2-(2，4-二氯苯氧基)苯酚)；8-羟基喹啉及其盐，锌和亚锡离子源诸如柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸锌钠以及焦磷酸亚锡；铜(II)化合物，诸如氯化铜(II)、氟化铜(II)、硫酸铜(II)以及氢氧化铜(II)；邻苯二甲酸及其盐，诸如邻苯二甲酸氢钾镁；血根碱；季铵化合物，诸如烷基吡啶鎓氯化物(例如，十六烷基吡啶鎓氯化物(CPC)、CPC与锌和/或酶的组合、十四烷基吡啶鎓氯化物以及N-十四烷基-4-乙基吡啶鎓氯化物)；双胍类，诸如氯己定二葡糖酸盐、海克替啶、奥替尼啶、阿来西定；卤化双酚化合物，诸如2，2′亚甲基双-(4-氯-6-溴苯酚)；苯扎氯铵；水杨苯胺、溴化度米芬；碘；磺胺类；二聚双胍；酚醛树脂；哌啶基衍生物，诸如地莫匹醇和辛哌醇；木兰提取物；葡萄籽提取物；百里酚；丁香酚；薄荷醇；香叶醇；香芹酚；柠檬醛；桉树脑；儿茶酚；4-烯丙基儿茶酚；己基间苯二酚；水杨酸甲酯；抗生素，诸如沃格孟汀、阿莫西林、四环素、多西环素、米诺环素、甲硝唑、新霉素、卡那霉素以及克林霉素；以及其混合物。
1.26.任何上述产品，其中所述产品还包含氨基酸(除非另外指定，否则包括游离胺和盐形式)。在本发明的一个实施方案中，氨基酸选自由以下组成的组：精氨酸、半胱氨酸、亮氨酸、异亮氨酸、赖氨酸、丙氨酸、天冬酰胺、天冬氨酸、苯丙氨酸、谷氨酸盐、谷氨酸、苏氨酸、谷氨酰胺、色氨酸、甘氨酸、缬氨酸、脯氨酸、丝氨酸、酪氨酸以及组氨酸，以及其两种或更多种的组合。在本发明的另一个实施方案中，
1.27.任何上述产品，其中所述产品还包含氟源。在一个实施方案中，氟源选自氟化亚锡、氟化钠、氟化钾、单氟磷酸钠、氟硅酸钠、氟硅酸铵、氟化胺、氟化铵及其混合物。
1.28.任何上述产品，其中所述产品还包含增白剂。在一个实施方案中，增白剂为过氧化物(包括但不限于过氧化氢或过氧化脲)、过氧酸或非过氧化物化合物(包括但不限于高度清洁二氧化硅、二氧化氯、亚氯酸盐、次氯酸盐以及着色剂(诸如二氧化钛和羟基磷灰石))。
1.29.任何上述产品，其中所述产品还包含锌化合物。在一个实施方案中，锌化合物选自由以下组成的组：乙酸锌、硼酸锌、丁酸锌、碳酸锌、柠檬酸锌、甲酸锌、葡萄糖酸锌、甘油酸锌、乙醇酸根锌、乳酸锌、氧化锌、磷酸锌、吡啶甲酸锌、丙酸锌、水杨酸锌、硅酸锌、硬脂酸锌、酒石酸锌、十一烯酸锌及其混合物。
在另一个实施方案中，本发明提供一种改善口腔护理组合物的用后处置的方法，所述口腔护理组合物含有在使用期间释放的颜料，所述方法包括在制备所述口腔护理组合物过程期间添加如上所述的膜，其中所述口腔护理组合物的用后处置并不污染处置区域的表面。
在所述方法的另一个实施方案中，制备所述口腔护理组合物的方法还包括添加1.5重量％至5.0重量％和1.5重量％至2.0重量％的量的阴离子型表面活性剂。在本发明的此方面的另一个实施方案中，阴离子型表面活性剂为月桂基硫酸钠。
在一些实施方案中，基本上所有的颜料同时释放。如本文所用，术语“基本上所有”是指大于膜中所含有的颜料的总量的90％。在一些实施方案中，第一膜在一个特定时间点释放其中所含有的至少90％的总量的颜料。在一些实施方案中，第一膜在一个指定时间点释放其中所含有的大于90％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少91％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少95％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少96％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少97％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少98％的总量的颜料。在一些实施方案中，第一膜在指定时间点释放其中所含有的至少99％的总量的颜料。
口腔可接受或局部可接受：本发明的组合物旨在局部用于口腔内或皮肤上，因此用于本发明的组分应为口腔可接受的，即以所提供的量和浓度局部用于口腔是安全的。
通篇使用的范围用作描述范围内的每个值的简略表达方式。范围内的任何值可选为范围终点。另外，本文引用的所有参考文献的全部内容以引用方式并入本文。如果本公开中的定义和所引用参考文献的定义发生冲突，则以本公开为准。
除非另外规定，否则本文和在本说明书中其他处表达的所有百分比和量应理解为是指重量百分比。给定量是基于材料的有效重量计。
以下实施例中将进一步描述本发明的实施方案。所述实施例仅为说明性的并且不以任何方式限定为所述和所要求保护的发明范围。
实施例
实施例1-本发明的膜的实施方案
本发明的膜可如下述制备。称量约百分之五十的所需膜配方水，并根据聚合物类型按照需要加热。在混合条件下将聚合物(HPMC、MC等)缓慢添加到水中并且允许所述聚合物分散并水合10-15分钟。另外添加水至足量，直到浆液具有蜂蜜的稠度为止。然后应添加增塑剂和表面活性剂，同时混合，并且允许混合5分钟。然后应将其他颗粒诸如染料、颜料等添加到所述混合物中并且允许再混合10分钟。然后应将浆液脱气。接着可由所述浆液浇注并干燥成通常1-10密耳的所需厚度的膜。
这些程序产生包含以下各项的30-50目膜颗粒：
表1
实施例2-膜颗粒掺入到口腔护理组合物中
将来自实施例1的膜颗粒掺入到如下表2所述的液体牙膏中
表2
实施例3-用于评估膜折损和所产生的表面污染的程序
将来自实施例2的10-50g液体牙膏放置到闪烁小瓶内。将实施例1中所描述的足够量的膜颗粒添加到液体牙膏中并且目视评价(通常0.2％或更少)。将液体牙膏和膜手动剧烈振摇15秒并且将其放置在台面上。记下管底部上的初始分布和量，之后启动计时器。目视检查液体牙膏和膜并且记录膜随着时间折损的百分比。完成后，将闪烁小瓶的内容物注入到水槽中。将闪烁小瓶放置在水龙头下方并且容许水从水龙头流下10秒。将闪烁小瓶排空，并且然后倒置。记录留下的膜残余物的量的差异。
实施例4-比较膜沉降和残余污染
将研磨的膜颗粒为30-50目的本发明牙膏的膜沉降量与具有1.6mm(约12目)厚度方块的膜的比较牙膏(PCT/US2011/065308的牙膏)进行比较。由以下表3的数据可看出，10分钟后膜沉降量显著降低。
表3-在牙膏于水中的3∶1浆液中的膜沉降量
图1示出了在沉降20分钟并随后冲洗后的玻璃表面。表面(A)暴露于具有1.6mm方块膜的牙膏浆液，而表面(B)暴露于具有研磨的膜30-50目的牙膏浆液。由图中可看出，表面(A)与表面(B)相比显示大量污染。虽然不希望受理论约束，但认为具有较小尺寸的膜颗粒的残余膜具有增加的浮力并因此在观察残余污染之前，即颜料从丢弃的膜颗粒中释放到表面之前更容易用水冲洗掉。
实施例5-阴离子型表面活性剂对膜沉降的影响
将实施例1所述的膜颗粒掺入到具有以下表4所述配方的牙膏组合物中。
表4
实施例6-阴离子型表面活性剂对膜沉降的影响
本发明的实施方案之一为进一步将阴离子型表面活性剂添加到膜颗粒组合物中。图2示出将不同量的阴离子型表面活性剂例如月桂基硫酸钠(SLS)添加到实施例5所述的口腔护理组合物中的影响。将SLS的量增加到约1.75％，使得颜料的残余污染显著更少。
如本领域技术人员将了解，可在不背离本发明的精神的情况下对本文所述的实施方案做出许多变化和修改。意图所有此类变化均属于所附权利要求书的范围内。
Claims (12)
1.一种口腔护理组合物，其包含一种膜，所述膜包含按所述膜干重计20重量％-60重量％纤维素醚；10重量％-30重量％增塑剂；1重量％-5重量％非离子型表面活性剂；1.75重量％-2.0重量％阴离子型表面活性剂，以及15重量％-55重量％颜料；
其中所述膜是可溶解的；并且
其中所述膜呈具有0.18-0.84mm(20-80目)的尺寸的颗粒形式。
2.根据权利要求1所述的口腔护理组合物，其中所述阴离子型表面活性剂为月桂基硫酸钠。
3.根据权利要求1或2所述的口腔护理组合物，其中所述膜呈具有0.30-0.59mm(30-50目)的尺寸的颗粒形式；和/或其中所述膜在水存在下在口腔内或皮肤上刷洗、擦洗或搅动大于30秒且小于180秒的时间段之后基本上溶解。
4.根据权利要求3所述的口腔护理组合物，其中所述膜包含选自由以下组成的组的纤维素醚：烷基纤维素、羟烷基纤维素及其组合。
5.根据权利要求4所述的口腔护理组合物，其中所述烷基纤维素为甲基纤维素。
6.根据权利要求4所述的口腔护理组合物，其中所述羟烷基纤维素选自由以下组成的组：羟丙基甲基纤维素、羟乙基丙基纤维素、羟丁基甲基纤维素、羟基丙基甲基纤维素、羧甲基纤维素及其组合。
7.根据权利要求1所述的口腔护理组合物，其中所述膜还包含选自以下各项的增塑剂：山梨醇、丙二醇、甘油以及低分子量聚乙二醇。
8.根据权利要求1所述的口腔护理组合物，其中所述非离子型表面活性剂包括聚山梨醇酯。
9.根据权利要求1所述的口腔护理组合物，其中所述颜料包括颜料蓝15[147-14-8]、颜料蓝15∶2、颜料绿7[1328-53-6]、颜料橙5[3468-63-1]、颜料红4[2814-77-9]、颜料红5[6410-41-9]、颜料红48∶4[5280-66-0]、颜料红53∶1[5160-02-1]、颜料红57[5858-81-1]、颜料红57∶1[5281-04-9]；颜料红57∶2钡色淀[17852-98-1]、颜料红63∶1[6417-83-0]、颜料红64∶1[6371-76-2]、颜料红68[5850-80-6]、颜料红83、颜料红90∶1铝色淀[16508-80-8]、颜料红112[6535-46-2]、颜料红172铝色淀[12227-78-0]、颜料红173铝色淀、颜料紫19[1047-16-1]、颜料黄1[2512-29-0]、颜料黄3[6486-23-3]、颜料黄12[6358-85-6]、颜料黄13[5102-83-0]、颜料黄73[13515-40-7]、或任何这些颜料的组合。
10.根据权利要求1所述的口腔护理组合物，其包含按所述膜干重计20重量％-60重量％的选自甲基纤维素、羟丙基甲基纤维素及其组合的纤维素醚；10重量％-30重量％丙二醇；1重量％-5重量％聚山梨醇酯80；以及15重量％-55重量％颜料。
11.根据权利要求1所述的口腔护理组合物，其中所述组合物为牙膏。
12.根据权利要求1所述的口腔护理组合物，其中所述组合物还包含选自由以下组成的组的活性剂：调味剂、麻醉剂、抗菌剂、氨基酸、氟源、增白剂、锌化合物、及其混合物。
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201336517A (zh) * | 2011-12-16 | 2013-09-16 | Colgate Palmolive Co | 包含變色薄膜之口腔保健組成物 |
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|---|---|
| AR098920A1 (es) | 2016-06-22 |
| US20160324753A1 (en) | 2016-11-10 |
| IL246225A0 (en) | 2016-07-31 |
| CN105828785A (zh) | 2016-08-03 |
| PH12016501032A1 (en) | 2016-07-04 |
| IN2013DE03736A (zh) | 2015-06-26 |
| MX2016007842A (es) | 2016-09-29 |
| AU2014370250B2 (en) | 2017-03-02 |
| US10045927B2 (en) | 2018-08-14 |
| EP3086762A1 (en) | 2016-11-02 |
| WO2015100010A1 (en) | 2015-07-02 |
| BR112016013888B1 (pt) | 2020-11-17 |
| MX359752B (es) | 2018-10-01 |
| RU2016125142A (ru) | 2018-01-30 |
| AU2014370250A1 (en) | 2016-06-16 |
| EP3086762B1 (en) | 2019-08-28 |
| TW201609158A (zh) | 2016-03-16 |
| RU2016125142A3 (zh) | 2018-08-28 |
| RU2681220C2 (ru) | 2019-03-05 |
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