CN105769957A - Pseudo-ginseng powder prepared from snow pears and rice water, preparation of pseudo-ginseng powder and preparation method - Google Patents
Pseudo-ginseng powder prepared from snow pears and rice water, preparation of pseudo-ginseng powder and preparation method Download PDFInfo
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Abstract
The invention provides pseudo-ginseng powder prepared from snow pears and rice water, a preparation of the pseudo-ginseng powder and a preparation method.The pseudo-ginseng powder prepared from the snow pears and the rice water is prepared from, by weight, 5-100 parts of pseudo-ginseng, 5-60 parts of snow pears and 5-100 parts of rice water.The pseudo-ginseng powder prepared from the snow pears and the rice water can relieve side effects of thirst, astriction, weakness of limbs, dysphoria with smothery sensation and the like generated after pseudo-ginseng is taken, the effects of strengthening the middle warmer, strengthening the spleen and stomach, promoting secretion of saliva or body fluid and lubricating the intestines are added, pseudo-ginseng relieves losses of body fluid while dispersing stasis and stopping bleeding, no fever or dryness heat is generated, the bitter taste of pseudo-ginseng is relieved, and people can more easily take the pseudo-ginseng powder.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pear rice-washed water Radix Notoginseng powder and preparation thereof and preparation method.
Background technology
Radix Notoginseng has another name called Radix Notoginseng, the dry root of panax araliaceae plant Panaxnotoginseng (Burk.) F.H.Chen and rhizome, and main product is in Yunnan Wenshan Prefecture, therefore named mountain of papers Radix Notoginseng.Chinese crude drug Radix Notoginseng is using its root as medicinal effects, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.
Sweet in the mouth, micro-hardship, temperature.Effect, dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
A large amount of medical researches prove, Radix Notoginseng can be used for treating the various inside and outside hemorrhages such as traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria；Expansion blood vessel, thrombus, improves microcirculation, the cardiovascular and cerebrovascular disease such as prevention and treatment hyperlipidemia, cholesterol increase, coronary heart diseases and angina pectoris, apoplexy sequela；The hepatopathy such as fatty liver, hepatic fibrosis and lose blood, body deficiency syndrome that puerperal, the reason such as prolonged illness cause.Radix Notoginseng, to cardiovascular system, to body material's metabolism, nervous system, auxiliary are suppressed anticancer, the antioxidation whitening colour of skin, slow down aging and tonification many-sided pharmacological action such as strong, makes it prevent and treat multiple disease, health care aspect extensive use.
But owing to Radix Notoginseng is warm in nature, easily consumption impairment of body fluid liquid, causes the disease of the deficiency of YIN.Show as and after taking Radix Notoginseng, occur that thirsty, constipation, myasthenia of limbs, dysphoria with smothery sensation, evening take the side effect such as insomnia.
Summary of the invention
In order to overcome scarce limit of the prior art, the invention provides a kind of pear rice-washed water Radix Notoginseng powder, its can improve take produce after Radix Notoginseng thirsty, constipation, myasthenia of limbs, the aspect side effect such as dysphoria with smothery sensation, increase invigorating middle warmer invigorating the spleen and regulating the stomach, promote the production of body fluid effect of intestine moistening, make Radix Notoginseng alleviate the not raw hot dryness-fire of consumption wound of body fluid while dissipating blood stasis stops blooding, improve Radix Notoginseng bitterness mouthfeel simultaneously, make people be easier to take.The present invention is realized by following technical scheme.
On the one hand, the invention provides a kind of pear rice-washed water Radix Notoginseng powder, it is made up by ratio of weight and the number of copies of following component: Radix Notoginseng 5～100 parts, pear 5～60 parts, rice-washed water 5～100 parts；Preferred Radix Notoginseng 20～100 parts, pear 5～40 parts, rice-washed water 5～80 parts；More preferably Radix Notoginseng 30～70 parts, pear 5～20 parts, rice-washed water 40～80 parts；Most preferably Radix Notoginseng 40～70 parts, pear 10～20 parts, rice-washed water 50～70 parts.
The pear rice-washed water Radix Notoginseng powder of the present invention is to be prepared by the method comprised the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choose the squeezing of fresh pear, filter, add 2～4 times of clear water and obtain snow pear juice；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain pear rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in pear rice-washed water prepared by step 4) and control 10～20 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
On the other hand, the invention provides a kind of Chinese medicine preparation, it comprises above-mentioned pear rice-washed water Radix Notoginseng powder.
Further, the preparation method that present invention also offers described pear rice-washed water Radix Notoginseng powder, it comprises the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choose the squeezing of fresh pear, filter, add 2～4 times of clear water and obtain snow pear juice；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain pear rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in pear rice-washed water prepared by step 4) and control 10～20 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
The pharmacological effect side of pear rice-washed water Radix Notoginseng powder of the present invention solves as follows:
Pear: nature and flavor acid sweet, micro-, cold；Attach to the lung and stomach meridians.Have and moisturize, promote the production of body fluid, heat clearing away effect, it is usually used in hyperactivity of fire caused by deficiency of YIN, dryness-heat impairing the lung, the auxiliary treatment that Tianjin wound is thirsty.Recording according to Compendium of Material Medica, " pears person, also, its property is descending fluently for profit." there is the effect of lung moistening clearing away dryness, promoting the production of body fluid to quench thirst, nourishing blood and promoting granulation.The traditional Chinese medical science thinks the lung and the large intestine being interior-exteriorly related, therefore has effect of moistening dryness for relaxing bowels while moisturizing lung heat clearing, and the throat therefore deficiency of YIN occurred is dry, thirsty, dryness of the intestine dry stool all has good effect.
Radix Notoginseng: nature and flavor hardship sweet, micro-, temperature, return through returning liver, stomach warp.There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling down swells and ache.Just it is acknowledged as since ancient times and there is significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Rice-washed water: nature and flavor are sweet, cool, nontoxic.Can be used for concocting medicine, can go dry property and and in and laxation effect, function of spleen and stomach regulating, heat clearing away stops excessive thirst and stops the effects such as excessive thirst, diuresis, removing heat from blood, removing toxic substances.
The positive effect of the present invention is in that: the present invention is based on theory of Chinese medical science basis, utilize said medicine compatibility, Radix Notoginseng and pear rice-washed water mutual restraint between two drugs is made to prove effective, pear rice-washed water has effect of promoting the production of body fluid to quench thirst, moistening dryness for relaxing bowels relieving restlessness, the dry property of warm of Radix Notoginseng can be reduced, improve the side effect such as thirsty, constipation, heating, insomnia, make Radix Notoginseng not consume impairment of body fluid liquid while dissipating blood stasis stops blooding, raw hot dryness-fire；Improve again Radix Notoginseng bitterness mouthfeel makes people be easier to take simultaneously.
Detailed description of the invention
Embodiments below and case application, be only for clearly demonstrating example of the present invention, and be not limitation of the invention.For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description.And the apparent change thus amplified out or variation are still among protection scope of the present invention.
Embodiment 1:
The preparation method of pear rice-washed water Radix Notoginseng powder:
1, take 50g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%；
2, taking the squeezing of 10g pear, filter, it is standby that addition 20g clear water obtains snow pear juice；
3, choose 30g rice addition 300g clear water repeatedly to wash by rubbing with the hands, filter and obtain rice-washed water；
4, step 2 and 3 mix homogeneously are obtained pear rice-washed water standby；
5, being placed in pear rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 20 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb pear rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 3 hours through low temperature 30 DEG C, be dried to water content 15%；
7, smash as impalpable powder and get final product.
Embodiment 2:
The preparation method of pear rice-washed water Radix Notoginseng powder:
1, take 300g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%；
2, taking the squeezing of 100g pear, filter, it is standby that addition 200g clear water obtains snow pear juice；
3, choose 150g rice to add 1000g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water；
4, step 2 and 3 mix homogeneously are obtained pear rice-washed water standby；
5, being placed in pear rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 12 hours constant temperature 15 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb pear rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 5 hours through low temperature 23 DEG C, be dried to water content 13%；
7, smash as impalpable powder and get final product.
Embodiment 3:
The preparation method of pear rice-washed water Radix Notoginseng powder:
1, take 100g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 28 DEG C, be dried to water content 20%；
2, taking the squeezing of 80g pear, filter, it is standby that addition 200g clear water obtains snow pear juice；
3, choose 60g rice to add 700g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water；
4, step 2 and 3 mix homogeneously are obtained pear rice-washed water standby；
5, being placed in pear rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 18 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb pear rice-washed water；
6, step 5 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 2 hours through low temperature 25 DEG C, be dried to water content 14%；
7, smash as impalpable powder and get final product.
Test example 1: Pharmacodynamic Data
Effectiveness for proving this invention has carried out pharmacological evaluation from pharmacodynamics aspect, is reported as follows:
1, test material
1-1 medicine: primary Radix Notoginseng powder and pear rice-washed water Radix Notoginseng powder, territory, north, Jilin Province Radix Panacis Quinquefolii studying company limited provides, lot number 20151119.Dosage setting is by people and animal body surface area equivalent dosage conversions, and people's daily maximum dose level (9g/60kg) is equivalent to mice 1.2g/kg.Therefore this test set the primary Radix Notoginseng powder of mice and pear rice-washed water Radix Notoginseng powder dosage be 0.6,1.2,2.4g/kg group, be all configured to desired concn with 0.5% sodium carboxymethyl cellulose during test.
1-2 animal: ICR mice, body weight 18～22g, the quality certification number: SCXK(is lucky) 2015-0003, Jilin University Bethune medical college animal experimental center supply.Raise ground: Jilin University Bethune medical college animal experimental center.
2, test method
ICR mice 140,18～22g, male and female half and half.It is randomly divided into 7 groups, it may be assumed that matched group, primary Radix Notoginseng powder basic, normal, high dosage group and the basic, normal, high dosage group of pear rice-washed water Radix Notoginseng powder, often each 10 of male and female of group by sex, body weight.Gavage capacity is 20ml/kg, every day 1 time, continuous 30 days.In administration 30 days, respectively organize the equal lumbar injection pentobarbital sodium 50mg/kg of mice, the incubation period slept in recording 30 minutes and the length of one's sleep.
3, observation index
Each group all observes lower index for 10,20,30 days respectively in administration:
(1) 10 minutes interior autonomic activities situations of mice；
(2) mice symptom and sign: the expression of animal, activity (grabbing nose, pruritus etc.) situation；
(3) the mice amount of drinking water of 24 hours, urine volume and color, feces shape etc. change.
4, result of the test
Within 10,20,30 days, mice autonomic activities is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice autonomic activities number of times (p<0.05), and the basic, normal, high dosage group of pear rice-washed water Radix Notoginseng powder has no notable difference (p>0.05), in Table 1.
Within 10,20,30 days, mice amount of drinking water and urine volume situation of change is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice amount of drinking water and urine volume (p<0.05) for 20,30 days in administration, the basic, normal, high dosage group of pear rice-washed water Radix Notoginseng powder has no notable difference (p>0.05), in Table 2.
Within 10,20,30 days, mice urine volume color, feces shape, the expression of animal, activity (grabbing nose, pruritus etc.) situation is observed respectively in administration, compare with matched group, the visible mice expression of primary Radix Notoginseng powder middle and high dosage group is irritated, movable increase, hydrouria, darken, feces gets rid of minimizing, shape is hard, and the basic, normal, high dosage group of pear rice-washed water Radix Notoginseng powder has no notable difference, in Table 3.
In administration 30 days, observe the synergism to the sleep of threshold dose pentobarbital sodium, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can be obviously prolonged Sleep latency, and curtail sleep (p<0.05), the basic, normal, high dosage group of pear rice-washed water Radix Notoginseng powder has no notable difference (p>0.05 or p<0.01), in Table 4.
The primary Radix Notoginseng powder of table 1 and the present invention impact (± S, n=10) on mice autonomic activities
Compare with matched group, * p < 0.05
The primary Radix Notoginseng powder of table 2 and the present invention are on 24 hours water uptakes impact (± S, n=10) of mice
Compare with matched group, * p < 0.05
Mice twenty-four-hour urine amount is affected (± S, n=10) by the primary Radix Notoginseng powder of table 3 and the present invention
The primary Radix Notoginseng powder of table 4 and the present invention impact (± S, n=10) on mice pentobarbital sodium hypnosis
Compare with matched group, * p < 0.05, * * p < 0.01
5, conclusion (of pressure testing)
Primary Radix Notoginseng powder can substantially increase mice autonomic activities number of times, hence it is evident that increases mice amount of drinking water and urine volume, and mice expression can be made irritated, movable increase, hydrouria, darkens, and feces gets rid of minimizing, shape is hard, the sleep of threshold dose pentobarbital sodium is had synergism, Sleep latency can be obviously prolonged, and curtail sleep, point out primary Radix Notoginseng powder continuous oral 1 month, can make animal that the side effect such as thirsty, constipation, insomnia occur.The continuous oral present invention 1 month, has no obvious animal and the side effect such as thirsty, dysphoria with smothery sensation, constipation, insomnia occurs.
Test example 2: typical case
1, certain man, 37 years old, diagnosis: esophagitis, upper gastrointestinal hemorrhage, hematemesis, black of defecating.
Treatment: every day 3 times, a 3g took the hemorrhage minimizing after 1 week of primary Radix Notoginseng powder, hematemesis stops, but causes blood deficiency owing to losing blood, and dysphoria with smothery sensation, thirsty, constipation symptom occurs.Secondary.
Effect: the rear Radix Notoginseng powder using the embodiment of the present invention 1 preparation, often takes 3 grams, improves the symptom of dysphoria with smothery sensation, thirsty, constipation, do not occur any side effect yet, and disease is fully recovered after taking 21 days continuously after using pear rice-washed water Radix Notoginseng powder of the present invention every day 3 instead.
2, certain man, 48 years old, diagnosis: the spitting of blood that pulmonary tuberculosis causes.
Treatment: while conventional antituberculosis therapy, take Radix Notoginseng powder 3g every day 3 times, symptom of spitting blood after taking 1 week alleviates.But occur in that the side effect that Radix Notoginseng causes: thirsty, constipation, slightly have a sleepless night.
Effect: subsequently primary Radix Notoginseng powder is used instead in the embodiment of the present invention pear rice-washed water Radix Notoginseng powder of 2 preparations, thirsty after taking, constipation, the disappearance of mild insomnia shape.After taking 1 month continuously, spitting of blood symptom is wholly absent, and continues antituberculosis therapy and fully recovers after 3 months.
3, certain man, 50 years old tcm diagnosis: tcm syndrome differentiation and treatment type of hyperactivity of fire caused by deficiency of YIN hematuria.
Treatment: compatibility Radix Rehmanniae Preparata, Fructus Corni, Rhizoma dioscoreae, Poria, Rhizoma Alismatis, Cortex Moutan, the Rhizoma Anemarrhenae, Cortex Phellodendri.Radix Notoginseng powder is taken after mixing it with water, every day 3 times, each 3g, after taking 5 days continuously, substantially stops hematuria, but serious constipation occurs, simultaneously with thirsty, and the side reaction such as dysphoria with smothery sensation, myasthenia of limbs.
Effect: after by primary Radix Notoginseng powder this with the pear rice-washed water Radix Notoginseng powder in embodiment of the present invention 3, constipation, dysphoria with smothery sensation, thirsty side reaction disappear, and do not occur any side effect after taking 15 days continuously yet, and disease is fully recovered.
Claims (4)
1. a pear rice-washed water Radix Notoginseng powder, it is characterised in that be made up by ratio of weight and the number of copies of following component:
Radix Notoginseng 5～100 parts, pear 5～60 parts, rice-washed water 5～100 parts；Preferred Radix Notoginseng 20～100 parts, pear 5～40 parts, rice-washed water 5～80 parts；More preferably Radix Notoginseng 30～70 parts, pear 5～20 parts, rice-washed water 40～80 parts；Most preferably Radix Notoginseng 40～70 parts, pear 10～20 parts, rice-washed water 50～70 parts.
2. pear rice-washed water Radix Notoginseng powder as claimed in claim 1, it is characterised in that prepared by the method comprised the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choose the squeezing of fresh pear, filter, add 2～4 times of clear water and obtain snow pear juice；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain pear rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in pear rice-washed water prepared by step 4) and control 10～20 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
3. a Chinese medicine preparation, it is characterised in that comprise pear rice-washed water Radix Notoginseng powder as claimed in claim 1 or 2.
4. the preparation method of pear rice-washed water Radix Notoginseng powder as claimed in claim 1, it is characterised in that comprise the steps:
1) Radix Notoginseng is cleaned smashing for coarse powder；
2) choose the squeezing of fresh pear, filter, add 2～4 times of clear water and obtain snow pear juice；
3) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby；
4) by step 2) and 3) to obtain pear rice-washed water standby for mix homogeneously；
5) the Radix Notoginseng coarse powder after smashing being put into temperature in pear rice-washed water prepared by step 4) and control 10～20 DEG C of leaching systems 2～48 hours, period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb refined honey rice-washed water；
6) by the notoginseng drying after leaching system to water content less than 15%；
7) Radix Notoginseng step 6) dried is pulverized as impalpable powder and get final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951911A (en) * | 2018-01-12 | 2018-04-24 | 天马（安徽）国药科技股份有限公司 | A kind of pseudo-ginseng micro mist and its processing method |
| CN108208644A (en) * | 2017-12-01 | 2018-06-29 | 天马（安徽）国药科技股份有限公司 | A kind of Radix Notoginseng micro mist of delicate mouthfeel and preparation method thereof |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108208644A (en) * | 2017-12-01 | 2018-06-29 | 天马（安徽）国药科技股份有限公司 | A kind of Radix Notoginseng micro mist of delicate mouthfeel and preparation method thereof |
| CN107951911A (en) * | 2018-01-12 | 2018-04-24 | 天马（安徽）国药科技股份有限公司 | A kind of pseudo-ginseng micro mist and its processing method |
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| Publication number | Publication date |
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| CN105769957B (en) | 2017-05-03 |
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