CN102824503A - Concentrated pill for treating atrophic gastritis and strengthening stomach and preparation method thereof - Google Patents
Concentrated pill for treating atrophic gastritis and strengthening stomach and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition and a preparation thereof, and especially relates to a concentrated pill with effects of reinforcing spleen, harmonizing stomach, nourishing gas yin, helping digestion, removing dampness, activating collaterals, and relieving pain. The concentrated pill for treating atrophic gastritis and strengthening stomach is mainly characterized by comprising the following raw materials by weight: 2-4 parts by weight of licorice, 1.0-2.0 parts by weight of pseudo-ginseng, 4-6 parts by weight of radix pseudostellariae, 5-7 parts by weight of Chinese yam (stir-baked with bran), 4-6 parts by weight of rhizoma corydalis (stir-baked with vinegar), and 3-5 parts by weight of tangerine peel. Administration by majority of people proves that the concentrated pill has the functions of alleviating symptoms of chronic atrophic gastritis, chronic superficial gastritis, various dyspepsia, and anorexia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation thereof, be meant a kind of invigorating the spleen and regulating the stomach that has especially, nourishing gas is cloudy, the food stagnation removing dehumidifying, and the system of active analgesic therapy effect is withered and is held up the stomach concentrated pill.
Background technology
Along with expanding economy; People's rhythm of life is accelerated day by day; Have a strong impact on human health from the pressure of each side such as work, life and society and bad living habit as having a liking for tobacco and wine, eating and drinking without temperance etc., the sickness rate of chronic gastritis in the general population is up to more than 90%.Among the people have individual saying " ten people, nine stomaches ", and promptly ten people have nine people to suffer from gastropathy.At present, some food that improves disease of stomach or medicines are arranged also, but all exist side effect more in various degree, relapse rate is high, deficiencies such as function singleness, the medicine that fruit not yet in effect so far is good and side effect is little.
Summary of the invention
The objective of the invention is to avoid the deficiency of prior art to provide a kind of system to wither and hold up the stomach concentrated pill.Invigorating the spleen and regulating the stomach of the present invention, nourishing gas is cloudy, the food stagnation removing dehumidifying, active analgesic therapy effect can the relieve chronic atrophic gastritis, chronic superficial gastritis and various dyspepsia, symptoms such as loss of appetite, and have no side effect, the system of method for making science is withered and is held up the stomach concentrated pill.
Be to realize above-mentioned purpose, the technical scheme that the present invention takes is: a kind of system is withered, and to hold up stomach concentrated pill, its main feature be to include following raw materials in weight portion:
Radix Glycyrrhizae 2～4 weight portions, Radix Notoginseng 1.0～2.0 weight portions, Radix Pseudostellariae 4～6 weight portions, Rhizoma Dioscoreae (parched with bran) 5～7 weight portions, Rhizoma Corydalis (processed with vinegar) 4～6 weight portions, Pericarpium Citri Reticulatae 3～5 weight portions.
Described system is withered and is held up the stomach concentrated pill, also includes following raw materials in weight portion:
Fructus Mume 41～45 weight portions, Fructus Crataegi 61～65 weight portions, Radix Paeoniae Alba (stir-fry) 11～15 weight portions.
Described system is withered and is held up the stomach concentrated pill, also includes following raw materials in weight portion:
Fructus Hordei Germinatus (stir-fry) 41～45 weight portions, Radix Salviae Miltiorrhizae 10～12 weight portions, Massa Medicata Fermentata 3.5～4.5 weight portions.
Described system is withered and is held up the stomach concentrated pill, also includes following raw materials in weight portion:
Fructus Forsythiae 5～7 weight portions, Semen Raphani (stir-fry) 9～11 weight portions.
A kind of system is withered and is held up the method for preparing of stomach concentrated pill, and its main feature is may further comprise the steps:
(1) extract, be condensed into extractum: by the above weight portion proportioning Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae respectively being distinguished the flavor of adds 8～12 times of water gagings after medical material mixes or ethanol decocts 2～3 times; Each 1～2 hour; Merge extractive liquid, filters, and it is 1.25～1.30 that filtrating is concentrated into relative density; Temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: the weight portion proportioning by claim 1 to 4 is mixed Radix Paeoniae Alba, Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, pseudo-ginseng, pulverizes 60～80 mesh sieves, and is subsequent use;
(3) with moulding the method for making pill: Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae extract clear paste and Radix Paeoniae Alba, Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae, Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng are used the mixer mix homogeneously; Prepare 1000 ball concentrated pills with moulding method for making; The heavy 60mg of every ball, particle diameter 0.3mm;
(4) drying: will mould pill and put in the dish, thickness is no more than lcm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15m1, Pulvis Talci l0～15g; Activated carbon powder (120 order) 0.4～0.6%, the coating pan rotating speed is: 30～40 (r/min), to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
Advantage of the present invention is: according to Chinese traditional methods to keep in good health's theory of medicine, screening free of contamination crude drug is that raw material is processed, through port food mode; Regulate the human body physiological requirement, reach relieve chronic atrophic gastritis, chronic superficial gastritis and various dyspepsia, the effect of symptoms such as loss of appetite; Improve level of human health; Optimize the human life quality, remarkable, nontoxic, the good stability of its effect
System of the present invention wither hold up that stomach concentrated pill volume is little, dose is little, easy to carry, do not add any antiseptic, keep natural characteristic, meet that people in modern is recovered one's original simplicity, the demand of uphold nature.And disintegrative is good, be easy to absorb, and solid dosage forms, sealing is preserved, its good stability.Production equipment is simple, and production cost is low, is the bonded product of traditional Chinese medicine and modern technologies; Both embodied the advance of modern pharmaceutical technology; The advantage that has kept traditional decoction again not only meets middle medical drugs characteristics but also is suitable for mechanization production, is applicable to that also grass-roots unit produces; And be the black piller, good looking appearance.
Description of drawings:
Fig. 1 is a preparation process flow chart of the present invention.
The specific embodiment
Below principle of the present invention and characteristic are described, institute gives an actual example and only is used to explain the present invention, is not to be used to limit scope of the present invention.
Embodiment 1: a kind of system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 2 grams, Radix Notoginseng 1.0 grams, Radix Pseudostellariae 4 grams, Rhizoma Dioscoreae (parched with bran) 5 grams, Rhizoma Corydalis (processed with vinegar) 4 grams, Pericarpium Citri Reticulatae 3 grams.
Embodiment 2: a kind of system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 3 grams, Radix Notoginseng 1.5 grams, Radix Pseudostellariae 5 grams, Rhizoma Dioscoreae (parched with bran) 6 grams, Rhizoma Corydalis (processed with vinegar) 5 grams, Pericarpium Citri Reticulatae 4 grams.
Embodiment 3: a kind of system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 4 grams, Radix Notoginseng 2.0 grams, Radix Pseudostellariae 6 grams, Rhizoma Dioscoreae (parched with bran) 7 grams, Rhizoma Corydalis (processed with vinegar) 6 grams, Pericarpium Citri Reticulatae 5 grams.
Embodiment 4: a kind of system is withered and is held up the method for preparing of stomach concentrated pill, and its main feature is may further comprise the steps:
(1) extracts, is condensed into extractum: add 8～12 times of water gagings or ethanol decoction 2～3 times after by the weight portion proportioning of embodiment 1 to 3 Pericarpium Citri Reticulatae, Radix Glycyrrhizae being mixed; Each 1～2 hour; Merge extractive liquid, filters, and it is 1.25～1.30 that filtrating is concentrated into relative density; Temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: pulverize after by the weight portion proportioning of embodiment 1 to 3, pulverized 60～80 mesh sieves Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Radix Pseudostellariae, panax mixed, subsequent use;
(3) with moulding the method for making pill: Pericarpium Citri Reticulatae, Radix Glycyrrhizae extract clear paste and Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Radix Pseudostellariae, Radix Notoginseng are used the mixer mix homogeneously, prepare 1000 ball concentrated pills, the heavy 60mg of every ball, particle diameter 0.3mm with moulding method for making;
(4) drying: will mould pill and put in the dish, thickness is no more than lcm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15m1, Pulvis Talci l0～15g; Activated carbon powder (120 order) 0.4～0.6%, the coating pan rotating speed is: 30～40 (r/min), to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
Embodiment 5: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 2 grams, Radix Notoginseng 1.0 grams, Radix Pseudostellariae 4 grams, Rhizoma Dioscoreae (parched with bran) 5 grams, Rhizoma Corydalis (processed with vinegar) 4 grams, Pericarpium Citri Reticulatae 3 grams, Fructus Mume 41 grams, Fructus Crataegi 61 grams, Radix Paeoniae Alba (stir-fry) 11 grams.
Embodiment 6: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 3 grams, Radix Notoginseng 1.5 grams, Radix Pseudostellariae 5 grams, Rhizoma Dioscoreae (parched with bran) 6 grams, Rhizoma Corydalis (processed with vinegar) 5 grams, Pericarpium Citri Reticulatae 4 grams, Fructus Mume 43 grams, Fructus Crataegi 63 grams, Radix Paeoniae Alba (stir-fry) 13 grams.
Embodiment 7: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 4 grams, Radix Notoginseng 2.0 grams, Radix Pseudostellariae 6 grams, Rhizoma Dioscoreae (parched with bran) 7 grams, Rhizoma Corydalis (processed with vinegar) 6 grams, Pericarpium Citri Reticulatae 5 grams, Fructus Mume 45 grams, Fructus Crataegi 65 grams, Radix Paeoniae Alba (stir-fry) 15 grams.
Embodiment 8: a kind of system is withered and is held up the method for preparing of stomach concentrated pill, and its main feature is may further comprise the steps:
(1) extracts, is condensed into extractum: the weight portion proportioning of pressing embodiment 5 to 7; With adding 8～12 times of water gagings or ethanol decoction 2～3 times, each 1～2 hour, merge extractive liquid, after Fructus Mume, Fructus Crataegi, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae mixing; Filter; It is 1.25～1.30 that filtrating is concentrated into relative density, and temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: the weight portion proportioning of pressing embodiment 5 to 7 was pulverized 60～80 mesh sieves with Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Radix Pseudostellariae, Radix Notoginseng medicament mixed, and was subsequent use;
(3) with moulding the method for making pill: Fructus Mume, Fructus Crataegi, Pericarpium Citri Reticulatae, Radix Glycyrrhizae extract clear paste and Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Radix Pseudostellariae, Radix Notoginseng are used the mixer mix homogeneously; Prepare 1000 ball concentrated pills with moulding method for making; The heavy 60mg of every ball, particle diameter 0.3mm;
(4) drying: will mould pill and put in the dish, thickness is no more than lcm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15m1, Pulvis Talci l0～15g; Activated carbon powder (120 order) 0.4～0.6%, the coating pan rotating speed is: 30～40 (r/min), to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
Embodiment 9: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 2 grams, Radix Notoginseng 1.0 grams, Radix Pseudostellariae 4 grams, Rhizoma Dioscoreae (parched with bran) 5 grams, Rhizoma Corydalis (processed with vinegar) 4 grams, Pericarpium Citri Reticulatae 3 grams, Fructus Mume 41 grams, Fructus Crataegi 61 grams, Radix Paeoniae Alba (stir-fry) 11 grams, Fructus Hordei Germinatus (stir-fry) 41 grams, Radix Salviae Miltiorrhizae 10 grams, Massa Medicata Fermentata 3.5 grams.
Embodiment 10: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 3 grams, Radix Notoginseng 1.5 grams, Radix Pseudostellariae 5 grams, Rhizoma Dioscoreae (parched with bran) 6 grams, Rhizoma Corydalis (processed with vinegar) 5 grams, Pericarpium Citri Reticulatae 4 grams, Fructus Mume 42 grams, Fructus Crataegi 63 grams, Radix Paeoniae Alba (stir-fry) 12 grams, Fructus Hordei Germinatus (stir-fry) 43 grams, Radix Salviae Miltiorrhizae 11 grams, Massa Medicata Fermentata 4.0 grams.
Embodiment 11: described system is withered and is held up the stomach concentrated pill, includes following raw materials in weight portion:
Radix Glycyrrhizae 4 grams, Radix Notoginseng 2.0 grams, Radix Pseudostellariae 6 grams, Rhizoma Dioscoreae (parched with bran) 7 grams, Rhizoma Corydalis (processed with vinegar) 6 grams, Pericarpium Citri Reticulatae 5 grams, Fructus Mume 45 grams, Fructus Crataegi 65 grams, Radix Paeoniae Alba (stir-fry) 15 grams, Fructus Hordei Germinatus (stir-fry) 45 grams, Radix Salviae Miltiorrhizae 12 grams, Massa Medicata Fermentata 4.5 grams.
Embodiment 12, and a kind of system is withered and held up the method for preparing of stomach concentrated pill, and its main feature is may further comprise the steps:
(1) extracts, is condensed into extractum: the weight portion proportioning of pressing embodiment 9-11; With adding 8～12 times of water gagings or ethanol decoction 2～3 times, each 1～2 hour, merge extractive liquid, after Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, the Radix Glycyrrhizae mixing; Filter; It is 1.25～1.30 that filtrating is concentrated into relative density, and temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: the weight portion proportioning of pressing embodiment 9 to 11 was pulverized 60～80 mesh sieves with Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng medicament mixed, and was subsequent use;
(3) with moulding the method for making pill: press embodiment 9 to 11 Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, Radix Glycyrrhizae extract clear paste and Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng are used the mixer mix homogeneously; Prepare 1000 ball concentrated pills with moulding method for making; The heavy 60mg of every ball, particle diameter 0.3mm;
(4) drying: will mould pill and put in the dish, thickness is no more than lcm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15m1, Pulvis Talci l0～15g; Activated carbon powder (120 order) 0.4～0.6%, the coating pan rotating speed is: 30～40 (r/min), to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
Embodiment 13～17: a kind of system is withered and is held up the stomach concentrated pill, comprises by the activated feedstock of the weight portion proportioning in the table 1 and forming:
Table 1
Embodiment 18, and a kind of system is withered and held up the method for preparing of stomach concentrated pill, and its main feature is may further comprise the steps:
(1) extracts, is condensed into extractum: add 8～12 times of water gagings or ethanol decoction 2～3 times after by the weight portion proportioning of embodiment 13 to 17 Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae being mixed; Each 1～2 hour; Merge extractive liquid, filters, and it is 1.25～1.30 that filtrating is concentrated into relative density; Temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: the weight portion proportioning of pressing embodiment 13 to 17 was pulverized 60～80 mesh sieves with Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng medicament mixed, and was subsequent use;
(3) with moulding the method for making pill: press embodiment 13 to 17 Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae extract clear paste and Radix Paeoniae Alba, Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng are used the mixer mix homogeneously; Prepare 1000 ball concentrated pills with moulding method for making; The heavy 60mg of every ball, particle diameter 0.3mm;
(4) drying: will mould pill and put in the dish, thickness is no more than lcm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15m1, Pulvis Talci l0～15g; Activated carbon powder (120 order) 0.4～0.6%, the coating pan rotating speed is: 30～40 (r/min), to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
Compound basis of the present invention is following:
Chronic atrophic gastritis belongs to motherland's medical science " gastric abscess " category, and the pathogenesis key is that insufficiency of the spleen heresy stagnates and stomach-QI being unable to descend normally, so see simulataneous insufficiency and excessive more.Theory of Chinese medical science is thought its pathogenesis nothing more than cold-evil visitor stomach, and diet injures one's stomach, hyperactive liver-QI attacking the stomach and weakness of the spleen and stomach etc.Stomach is a sun soil, and happiness profit and dislike dryly is the big source of the vital organs of the human body, is the internal organs of the many blood of many gas, the main digesting food of being received, its gas with reduce to suitable.So, being invaded by exogenous pathogen, the internal injury diet, disorder of emotion, overstrain all can injure taste, causes stomach-QI being unable to descend normally, depression and stagnation of QI, gastral cavilty is had a pain.Prolonged illness then consumes the moon that injures one's stomach, and deficiency of stomach-Yin is the indistinct causalgia of gastral cavilty portion then, like hunger but having no desire to eat, and dryness of the mouth and throat, dysphoria with feverish sensation in the chest palms and soles shows as deficiency of stomach-Yin, dyspeptic symptom, the traditional Chinese medical science so-called " the spleen transporting the nutrients for the stomach " is just explained the importance of stomach-Yin.So in treatment, will note turning round and look at protecting stomach-Yin everywhere.The prescription compatibility that making withers holds up the stomach concentrated pill has embodied the principle of " strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease " in the theory of Chinese medical science.Basic to this morbidity of deficiency of stomach-Yin on the one hand, the yin nourishing stomach reinforcing is to set upright.On the other hand, mistake is moistened and is supported and pain to deficiency of YIN stomach, then regulating QI to relieve pain and eliminating evil.Take into account nourishing YIN and clearing away heat, promoting flow of QI and blood to important pathology links such as the deficiency-heat that occurs in the course of disease, blood stasis simultaneously.To set upright be main for Radix Pseudostellariae, Rhizoma Dioscoreae, spleen invigorating in the side; Assistant Radix Notoginseng, Rhizoma Corydalis, Radix Salviae Miltiorrhizae promoting blood circulation to remove obstruction in the collateral, dissipating blood stasis analgesic therapy and improve the atrophy pathological changes; With Fructus Forsythiae, Radix Salviae Miltiorrhizae heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, Fructus Mume, Fructus Crataegi, Radix Paeoniae Alba sour and sweet drugs can transforme into YIN, the stomach function regulating that promotes the production of body fluid, with Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Raphani, Pericarpium Citri Reticulatae help digestion and in, the stagnant dissipating depression of QI of row to be to rouse oneself middle-jiao yang, function of the spleen and stomach; Radix Glycyrrhizae QI invigorating stomach function regulating, and coordinating the actions of various ingredients in a prescription.Full side's compatibility is mended the combination that disappears, and attacks heresy and does not just hinder, and tonify deficiency and do not hold back heresy is played the yin nourishing stomach reinforcing, the effect of regulating QI to relieve pain altogether.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, and spleen, stomach, Liver Channel are gone in Fructus Crataegi sweet in the mouth, slightly warm in nature acid; Has promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling, the function of convergence dysentery relieving; Cure mainly meat stagnation, the stagnation of children's's breast food, gastral cavilty stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia etc." book on Chinese herbal medicine is looked for the truth ": Fructus Crataegi, so-called spleen invigorating person because of its spleen has food stagnation, with the salty flavor of this acid, thinks and wears down that expectorant disappears in order to do the food row, broken and the letting out of gas, meaning for strong, only belong to being good for of food stagnation removing.Fructus Crataegi contains citric acid, malic acid, ascorbic acid, candy and protein, carbohydrate.Blood pressure lowering is arranged, promote the effect of gastro-intestinal digestion.Chemical compounds such as the vitexin that contains in the Fructus Crataegi have antitumaous effect, and Fructus Crataegi commonly used helps anti-cancer.It is reported that Fructus Crataegi slice decocting liquid can prolong the life-span of long tumor animal, as can suppressing the effect of mice ehrlich ascites cell, cervical cancer TCC～26 suppression ratio of people are reached 70%; Active anticancer has been explained in the effect of bright crataegus pin natifida var. Major tool antiphagin; To uterus carcinoma early stage patient lochiorrhea, colorectal cancer etc., sharp intestinal can be good for the stomach; Anticancer logical silt effect is arranged again.
Fructus Mume: sour, puckery, flat.Return liver, spleen, lung, large intestine channel, have YIN nourishing and the production of body fluid promoting, and it is aid digestion to whet the appetite.Suitable deficiency-heat is thirsty, the anorexia lack of appetite, and achlorhydria (comprising atrophic gastritis hypochlorhydria person), dyspepsia, the people of chronic dysentery enteritis is edible; Fructus Mume contains citric acid, malic acid, succinic acid, and saccharide compound, paddy stays alcohol, ceroidlike material, compositions such as oleanolic acid appearance material.Modern pharmacological research proves: Fructus Mume has tangible antiinflammatory action, and these article water decoction has inhibitory action external to multiple morbific antibacterial and dermatophytes; Can also enhancing body's immunological function.
The Radix Paeoniae Alba: picric acid, liver, spleen channel are gone in cold.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Root contains paeoniflorin, paeonol, paeoniflorin, and benzoic acid is about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, β～sitosterol and triterpenes.Sichuan product person contains a kind of acidic materials in addition, and staphylococcus aureus is had inhibitory action." medicine origin ": " the peace spleen channel is controlled stomachache, receives gastric qi, and antidiarrheal is sharp, and blood, fixing striae, eliminating pathogen in the liver, tonifying the spleen and stomach." " heart " cloud: the medicine of spleen channel, receive cloudy gas, can remove stomachache, sour flavor having the property of astringing, invigorating YANG and receive cloudy gas is let out pathogen, holds up the moon.With the same usefulness of Rhizoma Zingiberis Recens, warming the meridian wet dissipation, logical plug, sharp abdominal pain, gastric qi is obstructed, dryness of the lung gas heat.Acid is received sweet slow, the unfavorable medicine that must use." book on Chinese herbal medicine performance ": become merely to take the photograph cloud: Radix Paeoniae is mended and red rushing down in vain, receives and red loosing also in vain.Cloud again: the acid of Radix Paeoniae, convergence body fluid and benefit is flourish.Cloud again: deficiency of vital QI, receive and row.The acid of Radix Paeoniae is to receive healthy energy.Cloud again: acid is received also, lets out also.The acid of Radix Paeoniae is received cloudy gas and is let out pathogen.Cloud again: dryness of the lung gas heat, with acid receipts, delay it with sweet.The acid of Radix Paeoniae is to hold back contrary gas.Have antibiotic, analgesia, spasmolytic, hepatoprotective pharmacological action
Radix Salviae Miltiorrhizae: nature and flavor: hardship is slightly cold the GUIXIN Liver Channel.The ability promoting blood flow to regulate menstruation, the removing heat from blood eliminating carbuncle is calmed the nerves.Modern pharmacological research proves: can coronary artery dilator, increase coronary flow, improve myocardial ischemia, infraction and cardiac function; Have hepatoprotective effect, promote liver cell regeneration, and the effect of fibrosis is arranged; Can improve the hypoxia-bearing capability of body; Various bacteria and tubercule bacillus there is inhibitory action; Also have enhancing human body immunity power and antineoplastic action in addition.
Fructus Hordei Germinatus: sweet, flat.Return spleen, stomach warp.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.Be used for food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, women's ablactation, Fructus Hordei Germinatus invigorating the spleen and regulating the stomach lactogenesis.Fructus Hordei Germinatus mainly contains α～and β～amylase (amylase), catalyzing enzyme (catalyticase), peroxidating isomerase (peroxidisomerase) etc.Other contains hordenine (hordenine), Fructus Hordei Germinatus guanidine alkali (hordatine) A, B, adenine (choline (choline) of ade～nine), protein, aminoacid, vitamin D, D, E, cytochrome (cytochrome) C.Still contain Fructus Hordei Germinatus poison poison, i.e. candicine (candici～ne).Have pharmacological actions such as aid digestion, blood sugar lowering, antifungal." book on Chinese herbal medicine converge with speech ": Fructus Hordei Germinatus and in the medicine that helps digestion also.Mend and can be sharp, sharp and can mend, like the distension of abdomen, the pent-up of diaphragm, or not the receiving of diet, middle gas unfavorable, the gas of switch lattice with this thing that takes place, then effect is very than also.
Rhizoma Corydalis: nature and flavor: arduous, warm, return liver, spleen, heart channel.Effect: invigorate blood circulation, circulation of qi promoting, pain relieving.Compendium of Material Medica: " stagnation of QI in the promoting the circulation of blood of Rhizoma Corydalis ability, stasis in the gas are gone up all pains of purgation all over the body so specially control." the various pain of qi depression to blood stasis there is analgesic effect.And there are tranquilizing soporific, inhibition cardiac muscle, decreased heart rate, increase coronary flow, gastric acid inhibitory to secrete and antiulcer action.
Semen Raphani: nature and flavor: hot, sweet, flat.Return spleen, stomach, lung meridian.Main effect is to help digestion to remove bloated, lowering the adverse-rising QI to resolve phlegm, cures mainly diseases such as retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots cough with asthma." book on Chinese herbal medicine cover bamboo fish trap " particularly praised highly the effect of Semen Raphani lowering the adverse-rising QI to resolve phlegm, claims that it can " therapeutic method to keep the adverse QI flowing downwards of but breathing with cough, merit be really fallen wall towards wall ", and Zhu Danxi also approves of this viewpoint; Help digestion except that the effect that expands for Semen Raphani, " book on Chinese herbal medicine is looked for the truth " and " Bencao Congxin " has same record, claims it and has the effect of " it is wide swollen to help digestion "; Modern pharmacological research shows, the main fatty acids of Semen Raphani, volatile oil.Contain in the volatile oil methanthiol, α～, β～hexenoic aldehyde and β～, γ～hexenol.Contain erucic acid (Erucicacid), linoleic acid, linolenic acid, sinapic acid, glyceride (GlycerolSinapate) in the fatty oil, also contain antibiotic substance raphanin (Raphanin), positive melissane, β～sitosterol (β～Sitosterol), γ～sitosterol, 18 carbonic acid, phytolaccagenic acid, sinapic acid choline ester. ammonium sulphate salt (Sinapinebisulfate).Semen Raphani has antibiotic and antifungic action, and in vitro tests has inhibitory action to staphylococcus aureus and escherichia coli etc.Semen Raphani preserved material (1:3) has inhibitory action to Trichophyton concentricunm, oidium schoenleinii, Du Ang Shi budlet spore tinea bacterium difficult to understand, rust budlet spore tinea ulotrichy budlet spore tinea bacterium, the sharp nocadia of star etc. in vitro.After from Semen Raphani, isolate a kind of oil again, be called " Sulforphen ", 1% concentration can be to growths such as streptococcus, pyococcus, streptococcus pneumoniae, escherichia coli, the someone thinks that " Sulforphen " and raphanin possibly be same substances.
Radix Pseudostellariae: sweet, little hardship, tepor is mended strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema is quenched one's thirst, and spirit is tired. and " decoction pieces is newly joined ": spleen reinforcing lung vigour, hidroschesis promotes the production of body fluid, and decides void and throbs with fear.
Radix Glycyrrhizae: nature and flavor are sweet, and are flat, GUIXIN, lung, spleen, stomach warp.The invigorating middle warmer of ability QI invigorating, coordinating the actions of various ingredients in a prescription.Sweet person advocates peace, so the merit of the spleen and stomach regulating is arranged; Gan Zhezhu is slow, so though can tonifying the spleen and stomach and the non-high benefit of reality.Modern pharmacological research shows: 1, the antianaphylactic effect of antiinflammatory, can protect the throat and the tunica mucosa tracheae of inflammation; 2, the hyperchlorhydria that histamine is caused has inhibitory action, and effect antiacid and alleviation gastrointestinal smooth muscle spasm is arranged.
Experimental example 1 system is withered and is held up stomach concentrated pill acute toxicity test research
1 material
1.1 laboratory animal
Kunming mouse, the SPF level, body weight 20 ± 2g, each 12h environment of half and half, 20 ± 2 ℃ of temperature controls of male and female and light dark period is raised, and freely drinks water.Quality certification SCXK (sweet) 2004-0006 number, Gansu laboratory animal room of scientific research center of the college of traditional Chinese medicine provides.
1.2 receive test product
System is withered and is held up the stomach concentrated pill, and lot number is provided by Gansu Provincial Hospital of Traditional Chinese Medicine: 20100323, face with preceding preparation suspension confession examination.
2 methods
Get 20 of mices, male and female half and half, water 12h is can't help in fasting, is divided into 5 groups at random by body weight, and per 4, irritate stomach 5%, 10%, 15%, 20%, 25% system respectively and wither and hold up stomach concentrated pill suspension 0.4ml10g-1 body weight, measure mice 0% and 100% dead dosage.If each group mice does not all have death, other gets 20 of mices, male and female half and half, and water 12h is can't help in fasting, gives maximum concentration (33.3%) system and withers and hold up stomach concentrated pill suspension 0.4ml10g-1 body weight, divides 2 times gastric infusion, interval 6h; Observe diet, activity, the mental status, the fur colour of skin, defecation, body weight change and the death condition of each mice, observe 7d continuously.Calculate mice maximum dosage-feeding multiple on the 1st by following formula:
3 results
The system of can't recording is withered and is held up stomach concentrated pill mouse stomach LD50, press mice diet after the administration of the maximum administration capacity of maximum concentration, activity all occur unusual, the fur colour of skin, defecation no abnormality seen, weight increase is normal, continues observation 7d, does not see animal dead.
4 conclusions
Under this experiment condition; System is withered and is held up the stomach concentrated pill with 26.64gkg-1 body weight (being equivalent to 373 times of clinical dosages) filling stomach mice not to be seen obvious acute toxic reaction; The prompting system is withered and is held up stomach concentrated pill mouse stomach LD50 greater than the 26.64gkg-1 body weight, and oral administration safety is higher.
Comparative example 1:
This example is that embodiment 10 products and MOLUO DAN (Handan Pharmaceutical Co., Ltd's production) are observed comparing data at the clinical symptoms total effects, and product of the present invention and existing product therapeutic equivalence have been described.
System is withered and is held up the stomach concentrated pill: oral, and one time 15 ball, 3 times on the one, warm water delivery service, treatment cycle was 1 week.
MOLUO DAN: oral, one time 8 ball, 3 times on the one, warm water delivery service, treatment cycle was 1 week.
The result shows that the total effects obvious effective rate that making withers holds up stomach ball group clinical symptoms is apparently higher than the MOLUO DAN group, and the two has significant difference, and two groups are carried out X 2 test, P＜0.001, but two groups of total effective rates are respectively 98.9%, 97.6%, no significant difference P＞0.05.
The above is merely preferred embodiment of the present invention, in order to restriction the present invention, all any modifications of within spirit of the present invention and principle, being done, is not equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. a system is withered and is held up the stomach concentrated pill, it is characterized in that including following raw materials in weight portion:
Radix Glycyrrhizae: 2～4 weight portions, Radix Notoginseng: 1.0～2.0 weight portions, Radix Pseudostellariae: 4～6 weight portions, Rhizoma Dioscoreae (parched with bran):
5～7 weight portions, Rhizoma Corydalis (processed with vinegar): 4～6 weight portions, Pericarpium Citri Reticulatae: 3～5 weight portions.
2. system as claimed in claim 1 is withered and is held up the stomach concentrated pill, it is characterized in that also including following raw materials in weight portion:
Fructus Mume: 41～45 weight portions, Fructus Crataegi: 61～65 weight portions, Radix Paeoniae Alba (stir-fry): 11～15 weight portions.
3. system as claimed in claim 2 is withered and is held up the stomach concentrated pill, it is characterized in that also including following raw materials in weight portion:
Fructus Hordei Germinatus (stir-fry): 41～45 weight portions, Radix Salviae Miltiorrhizae: 10～12 weight portions, Massa Medicata Fermentata: 3.5～4.5 weight portions.
4. system as claimed in claim 3 is withered and is held up the stomach concentrated pill, it is characterized in that also including following raw materials in weight portion:
Fructus Forsythiae: 5～7 weight portions, Semen Raphani (stir-fry): 9～11 weight portions.
5. a system is withered and is held up the method for preparing of stomach concentrated pill, it is characterized in that may further comprise the steps:
(1) extract, be condensed into extractum: by the weight portion proportioning of claim 1 to 4 Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae respectively being distinguished the flavor of adds 8～12 times of water gagings after medical material mixes or ethanol decocts 2～3 times; Each 1～2 hour; Merge extractive liquid, filters, and it is 1.25～1.30 that filtrating is concentrated into relative density; Temperature is 50～55 ℃ clear paste, and is subsequent use;
(2) pulverize: after by the weight portion proportioning of claim 1 to 4 Radix Paeoniae Alba (stir-fry), Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, each herbal medicine of Radix Notoginseng being mixed, pulverize, medicated powder is crossed 60～80 mesh sieves, and is subsequent use;
(3) with moulding the method for making pill: Fructus Mume, Fructus Crataegi, Fructus Hordei Germinatus (stir-fry), Pericarpium Citri Reticulatae, Fructus Forsythiae, Semen Raphani, Radix Glycyrrhizae extract clear paste and Radix Paeoniae Alba, Rhizoma Corydalis (processed with vinegar), Rhizoma Dioscoreae (parched with bran), Massa Medicata Fermentata, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Notoginseng are used the mixer mix homogeneously by claim 1 to 4; Prepare 1000 ball concentrated pills with moulding method for making; The heavy 60mg of every ball, particle diameter 0.3mm;
(4) drying: will mould pill and put in the dish, thickness is no more than 1cm, in thermostatic drying chamber below 55～65 ℃ dry 20～24 hours, to the moisture content water content be 6%～6.5%;
6. system as claimed in claim 5 is withered and is held up the method for preparing of stomach concentrated pill, it is characterized in that further comprising the steps of:
(5) select ball: with the ball that drying finishes, place in the reciprocating gird, select big or small inequality and odd-shaped pill, to guarantee that pellet sizes is even, dosage is accurate;
(6) coating, polishing: every pot of basic ball 450～550g of bag; With 50～60% ethanol, 10～15ml, Pulvis Talci 10～15g; Activated carbon powder is (120～150 order) 0.4～0.6%, and the coating pan rotating speed is: 30～40r/min, to pill surface compact, smooth, rounding, the consistent degree of being of color and luster; Stop pot and dry up 30～35min, 75～80 ℃ of oven dryings.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103316256A (en) * | 2013-05-17 | 2013-09-25 | 何圣 | Traditional Chinese medicine composition for treating repeated vomiting caused by chronic gastritis |
| CN104547416A (en) * | 2014-12-25 | 2015-04-29 | 姜新帅 | Traditional Chinese medicine composition for treating gastrosis |
| CN104667145A (en) * | 2013-11-26 | 2015-06-03 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating swine gastric ulcer and preparation method thereof |
| WO2017084169A1 (en) * | 2015-11-19 | 2017-05-26 | 黎钧陶 | Medicinal liquor for nourishing stomach and preparation method therefor |
| CN111249396A (en) * | 2020-03-16 | 2020-06-09 | 宁夏医科大学 | Traditional Chinese medicine for treating chronic gastritis and preparation method of micronized particles thereof |
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- 2012-08-19 CN CN2012102945961A patent/CN102824503A/en active Pending
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| 宋宝根等: "正交试验法优选制萎扶胃丸溶散时限及水份的最佳工艺条件", 《中成药》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316256A (en) * | 2013-05-17 | 2013-09-25 | 何圣 | Traditional Chinese medicine composition for treating repeated vomiting caused by chronic gastritis |
| CN103316256B (en) * | 2013-05-17 | 2016-03-09 | 何圣 | A kind of Chinese medicine composition for the treatment of the Recurrent Vomiting caused by chronic gastritis |
| CN104667145A (en) * | 2013-11-26 | 2015-06-03 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating swine gastric ulcer and preparation method thereof |
| CN104547416A (en) * | 2014-12-25 | 2015-04-29 | 姜新帅 | Traditional Chinese medicine composition for treating gastrosis |
| WO2017084169A1 (en) * | 2015-11-19 | 2017-05-26 | 黎钧陶 | Medicinal liquor for nourishing stomach and preparation method therefor |
| CN111249396A (en) * | 2020-03-16 | 2020-06-09 | 宁夏医科大学 | Traditional Chinese medicine for treating chronic gastritis and preparation method of micronized particles thereof |
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Application publication date: 20121219 |