CN103656343B

CN103656343B - Medicine for treating gastric ulcer, and preparation method of medicine

Info

Publication number: CN103656343B
Application number: CN201310586657.6A
Authority: CN
Inventors: 蒋学
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-11-21
Filing date: 2013-11-21
Publication date: 2015-07-01
Anticipated expiration: 2033-11-21
Also published as: CN103656343A

Abstract

The invention discloses a medicine for treating gastric ulcer, and a preparation method of the medicine. The medicine is mainly prepared by cuttlebone, semen euryale, semen coicis, concha arcae, rhizoma corydalis, radix polygonati officinalis, fructus perillae, stalactite, liquorice, rhizoma cyperi and the like according to a certain weight proportion. The medicine has functions of regulating a middle warmer, relieving contracture, resolving phlegm, moistening a lung, and coordinating drug actions, has a fast effect on treating the gastric ulcer, and is short in treatment course, and the gastric ulcer does not relapse after cured.

Description

A kind of medicine for the treatment of gastric ulcer and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of gastric ulcer and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Gastric ulcer is a kind of common digestive tract disease, esophagus, stomach or duodenum can be betided, the traditional Chinese medical science thinks that primary disease the belongs to category such as " gastral cavilty is sick ", " stomachache due to hyperactive liver-QI attacking the stomach " or " epigastric pain ", be more common in person between twenty and fifty, autumn and winter season is easily sent out, the painful area of gastric ulcer hits exactly or to the left under xiphoid-process, outbreak with alleviate alternately, occur to 2 hours more than step is later half.At present, western medicine gastric ulcer poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating gastric ulcer in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment gastric ulcer, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating gastric ulcer.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Endoconcha Sepiae, Semen Euryales, Semen Coicis, Concha Arcae, Rhizoma Corydalis, Rhizoma Polygonati Odorati, Fructus Perillae, Stalactitum, Radix Glycyrrhizae, Rhizoma Cyperi, Herba Schizonepetae, Semen Pruni, Arillus Longan, Radix Bupleuri, Pollen Typhae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Pericarpium Arecae, Rhizoma Dioscoreae, Fructus Cannabis, Caulis Bambusae In Taenia, Herba Dendrobii, Radix Ophiopogonis, Lignum Aquilariae Resinatum, Massa Medicata Fermentata, Herba Eupatorii, Fructus Toosendan medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of gastric ulcer.Wherein select Endoconcha Sepiae to be that tepor, enters liver, kidney channel, have dehumidifying, antacid because its nature and flavor are salty, hemostasis, the function of sore, treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.Select Semen Euryales to be because its property sweet-puckery flavor, flat, enter spleen, kidney channel, have reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak, controls seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea.Semen Coicis is selected to be that cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea because its property slightly sweet flavor.Concha Arcae is selected to be that flat, enter liver, spleen channel, have and reduce phlegm, softening the hard mass, dissipating blood stasis, the function of removing food stagnancy, controls accumulation of phlegm because its nature and flavor are sweet, salty, stomachache, noisy, acid regurgitation ， mass in the abdomen, scrofula, ulcerative gingivitis.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Rhizoma Polygonati Odorati to be that flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst because its nature and flavor are sweet, control calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Fructus Perillae is selected to be that temperature, enter lung, large intestine channel, have the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation because its nature and flavor are pungent.Stalactitum is selected to be that temperature, enter lung, kidney channel, have warming the lung gas, kidney-Yang invigorating, the function of lower milk, controls asthenia and breath with cough, cough of cold type, sexual impotence, cold arthralgia of loins and legs, galactostasis because its nature and flavor are sweet.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Rhizoma Cyperi is selected to be because the pungent micro-hard work of its nature and flavor, flat, enter liver, tri-jiao channel, resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Select Semen Pruni to be because its nature and flavor are worked hard sweet, flat, enter spleen, intestine and small intestine warp, have and moisturize, laxation, the therapeutic method to keep the adverse QI flowing downwards, the function of diuretic, controls QI stagnation of the large intestine, dry puckery obstructed, dysuria, extensive abdominal edema, extremity edema, beriberi.Select Arillus Longan to be because its nature and flavor are sweet, temperature, enter the heart, spleen channel, have heart-spleen boosting, fill blood, the function of calming the nerves, controls virtual work thin and weak, insomnia, forgetful, palpitation with fear, severe palpitation.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select Pollen Typhae to be because its nature and flavor are sweet arduous, cool, enter liver, heart channel, have cooling blood for hemostasis, the function of activating blood circulation and dissipating blood stasis, raw with controlling amenorrhea stomachache, postpartum stagnation is had a pain, and falls that to flutter blood vexed, furuncle toxic swelling, fries black emesis blood, epistaxis, metrorrhagia, rush down blood, hematuria, dysentery, leukorrhagia, external treatment congenital deformity of the tongue, aphtha, Ting discharging ear, hemorrhage in ear, uncontrolled urination is itched.Select Herba Hedyotidis Diffusae to be because its property bitter but sweet flavor, cold, enter the heart, liver, spleen three warp, have heat clearing away, dampness removing, the function of removing toxic substances, controls dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.Select Herba Scutellariae Barbatae to be that cold, have heat clearing away, the function of removing toxic substances, controls laryngopharynx swelling and pain because its nature and flavor are bitter, scald, traumatic injury, eczema.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforce the kidney, the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Fructus Cannabis is selected to be that flat, enter spleen, stomach, large intestine channel, have and moisturize, laxation, treating stranguria, the function of invigorating blood circulation, control dryness of the intestine constipation, quench one's thirst, pyretic stranguria, migratory arthralgia, dysentery, menoxenia, scabies, tinea is insane because its nature and flavor are sweet.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduce phlegm, the function of emesis, control dysphoria with smothery sensation vomiting, singultus, expectorant heat syndrome cough is breathed heavily, and spits blood, epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, have the stomach reinforcing that promotes the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, and it is dark that the moon hinders order.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Lignum Aquilariae Resinatum to be because its nature and flavor are worked hard, enter kidney, spleen, stomach warp, have sending down the abnormal ascending QI warming middle-JIAO, the function of warming the kidney improving inspiration by invigorating kidney-QI, control QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm, enter upright stone tablet, stomach warp, have invigorating the spleen and regulating the stomach, the function helped digestion in adjusting, controls retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, and postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.Select Herba Eupatorii to be that flat, enter spleen, stomach warp, have clearing away summer-heat, ward off dirty, removing dampness, the function of regulating menstruation, controls and experience heat-damp in summer because its nature and flavor are pungent, cold and heat are had a headache, and accumulate in damp, gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.Select Fructus Toosendan to be because its nature and flavor are bitter, cold, poisonous, enter liver, stomach, small intestine meridian, have wet down heat, clearing away liver-fire, pain relieving, the function of parasite killing, controls epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Endoconcha Sepiae 25-35 gram of Semen Euryales 10-20 gram of Semen Coicis 10-20 gram

Concha Arcae 5-15 gram of Rhizoma Corydalis 10-20 gram of Rhizoma Polygonati Odorati 10-20 gram

Fructus Perillae 15-25 gram of Stalactitum 5-15 gram of Radix Glycyrrhizae 10-20 gram

Rhizoma Cyperi 10-20 gram of Herba Schizonepetae 5-15 gram of Semen Pruni 3-9 gram

Arillus Longan 3-9 gram of Radix Bupleuri 10-20 gram of Pollen Typhae 5-15 gram

Herba Hedyotidis Diffusae 10-20 gram of Herba Scutellariae Barbatae 10-20 gram of Pericarpium Arecae 5-15 gram

Rhizoma Dioscoreae 5-15 gram of Fructus Cannabis 25-35 gram of Caulis Bambusae In Taenia 3-9 gram

Herba Dendrobii 5-15 gram of Radix Ophiopogonis 25-35 gram of Lignum Aquilariae Resinatum 5-15 gram

Massa Medicata Fermentata 6-12 gram of Herba Eupatorii 25-35 gram of Fructus Toosendan 3-9 gram

Preferable amount is

Endoconcha Sepiae 30 grams of Semen Euryaless 15 grams of Semen Coiciss 15 grams

Concha Arcae 10 grams of Rhizoma Corydalis 15 grams of Rhizoma Polygonati Odorati 15 grams

15 grams, Fructus Perillae 20 grams of Stalactitums 10 grams of Radix Glycyrrhizaes

Rhizoma Cyperi 15 grams of Herba Schizonepetae 10 grams of Semen Prunis 6 grams

Arillus Longan 6 grams of Radix Bupleuri 15 grams of Pollen Typhaes 10 grams

Herba Hedyotidis Diffusae 15 grams of Herba Scutellariae Barbataes 15 grams of Pericarpium Arecae 10 grams

Rhizoma Dioscoreae 10 grams of Fructus Cannabiss 30 grams of Caulis Bambusae In Taenia 6 grams

Herba Dendrobii 10 grams of Radix Ophiopogonis 30 grams of Lignum Aquilariae Resinatum 10 grams

Massa Medicata Fermentata 9 grams of Herba Eupatoriis 30 grams of Fructus Toosendans 6 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;

2, Semen Euryales: first rise frying in wheat bran heat release pot to cigarette, then poured into by clean Semen Euryales, stir to micro-yellow, take out, well sifted wheat bran, cools;

3, Semen Coicis: get crude drug, removing residual cot, impurity;

4, Concha Arcae (calcined): get Concha Arcae and put in crucible, put in smokeless stove fire to be calcined to and be popular in, taking-up cools, and pulverizes use;

5, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

6, Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

7, Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;

8, Stalactitum: wash, is broken into fritter;

9, Radix Glycyrrhizae Preparata: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

10, Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;

11, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;

12, Semen Pruni: sieve removes spare, wash in a pan clean, pick clean impurity and broken shell, dry, the used time smashs to pieces;

13, Arillus Longan: get crude drug, removing impurity;

14, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry;

15, Pollen Typhae: rub broken caking, sieve, removing impurity;

16, Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;

17, Herba Scutellariae Barbatae: removing impurity, cleans, slightly moistens, cutting, dry;

18, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;

19, Rhizoma Dioscoreae: pick clean impurity, be soaked in water evenly softening to Rhizoma Dioscoreae central part, pull out and slightly dry in the air, section is dried or is dried;

20, Fructus Cannabis: pick decontamination and residual shell, get clean core;

21, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

22, Herba Dendrobii: get dry Herba Dendrobii, saturating with blister to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, hits thin film, dries;

23, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

24, Lignum Aquilariae Resinatum: outwash, is split into fritter, and the used time smashs to pieces or is ground into fine powder;

25, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in hot pot, cigarette of having waited, pours into Massa Medicata Fermentata, fry to yellow, take out, sieve removes wheat bran, cools;

26, Herba Eupatorii: pick clean impurity, wash, pull out, slightly after profit, removing undesirable root, cutting, dries;

27, Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two.

Two, prepare

1, by the Endoconcha Sepiae of described weight, Semen Euryales, Semen Coicis, Concha Arcae (calcined), Rhizoma Corydalis, Rhizoma Polygonati Odorati, Fructus Perillae, Stalactitum, Radix Glycyrrhizae, Rhizoma Cyperi, Herba Schizonepetae, Semen Pruni, Arillus Longan, Radix Bupleuri, Pollen Typhae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Pericarpium Arecae, Rhizoma Dioscoreae, Fructus Cannabis, Caulis Bambusae In Taenia, Herba Dendrobii, Radix Ophiopogonis, Lignum Aquilariae Resinatum, Massa Medicata Fermentata, Herba Eupatorii, Fructus Toosendan drug decocting secondary, add water 6 times amount for the first time, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor.

3, twice decoction liquor is carried out mixing and stirring, be divided into 4 doses and take.

Medicine of the present invention has and middle emergency, expectorant, lung moistening, removing toxic substances, and the function of coordinating the actions of various ingredients in a prescription, is used for the treatment of gastric ulcer, short treating period, instant effect, non-relapse after healing, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] Drug therapy gastric ulcer of the present invention

1, physical data

Accept out-patient's totally 210 examples for medical treatment, its male patient 120 example, female patient 90 example.

2, diagnostic criteria

Clinical manifestation: epigastrium pain is the cardinal symptom of primary disease.Multidigit in epigastrium, after also can appearing at left upper abdomen or breastbone, xiphoid-process.Be often dull pain, dull pain, distending pain, burn sample pain.The pain of gastric ulcer is many to be occurred in 1 hour after the meal, alleviated gradually after 1 ~ 2 hour, until reappear the above-mentioned rhythm and pace of moving things again after the feed of lower meal.Some patients can be asymptomatic, or using complication such as hemorrhage, perforation as onset symptoms.

Endoscopy: under scope, ulcer can be divided into three stadium: 1. active stage: ulcer basilar part is covered with white or yellow-white thick fur, mucosa hyperemia around, edema (A1), or periphery mucosa is congested, edema starts to disappear, there is the blush (A2) that re-epithelialize is formed in surrounding.2. healing stage: ulcer reduces and shoals, and tongue is thinning, the blush that surrounding re-epithelialize is formed is crowded around to ulcer, and duplicature concentrates (H1) to ulcer, or ulcer surface is almost re-epithelialize and covers, and duplicature is more to ulcer concentrated (H2).3. cicatricial phase: ulcer basilar part white fur disappears, and presents red cicatrix (S1), finally changes white cicatrix (S2) into.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: gastric ulcer transference cure, body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: gastric ulcer symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy patients w ith peptic ulcer disease 210 example of the present invention, effective 198 examples of result, obvious effective rate is 94.29%, and take a turn for the better 9 examples, and improvement rate is 4.29%, and invalid 3 examples, total effective rate is 98.58%.

Claims

1. treat a medicine for gastric ulcer, it is characterized in that: it is made up of the crude drug in following weight range:

Arillus Longan 3-9 gram of Radix Bupleuri 10-20 gram of Pollen Typhae 5-15 gram

Massa Medicata Fermentata 6-12 gram of Herba Eupatorii 25-35 gram of Fructus Toosendan 3-9 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Rhizoma Cyperi 15 grams of Herba Schizonepetae 10 grams of Semen Prunis 6 grams

Arillus Longan 6 grams of Radix Bupleuri 15 grams of Pollen Typhaes 10 grams

Massa Medicata Fermentata 9 grams of Herba Eupatoriis 30 grams of Fructus Toosendans 6 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;

(2) Semen Euryales: first rise frying in wheat bran heat release pot to cigarette, then poured into by clean Semen Euryales, stir to micro-yellow, take out, well sifted wheat bran, cools;

(3) Semen Coicis: get crude drug, removing residual cot, impurity;

(4) Concha Arcae (calcined): get Concha Arcae and put in crucible, put in smokeless stove fire to be calcined to and be popular in, taking-up cools, and pulverizes use;

(5) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(6) Rhizoma Polygonati Odorati: removing impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

(7) Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;

(8) Stalactitum: wash, is broken into fritter;

(9) Radix Glycyrrhizae Preparata: extracting liquorice sheet adds cooked Mel and boiled water is a little, mixes thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

(10) Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls;

(11) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;

(12) Semen Pruni: sieve removes spare, wash in a pan clean, pick clean impurity and broken shell, dry, the used time smashs to pieces;

(13) Arillus Longan: get crude drug, removing impurity;

(14) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry;

(15) Pollen Typhae: rub broken caking, sieve, removing impurity;

(16) Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;

(17) Herba Scutellariae Barbatae: removing impurity, cleans, slightly moistens, cutting, dry;

(18) Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;

(19) Rhizoma Dioscoreae: pick clean impurity, be soaked in water evenly softening to Rhizoma Dioscoreae central part, pull out and slightly dry in the air, section is dried or is dried;

(20) Fructus Cannabis: pick decontamination and residual shell, get clean core;

(21) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shakes off ash bits, is kneaded into little group or cutting;

(22) Herba Dendrobii: get dry Herba Dendrobii, saturating with blister to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, hits thin film, dries;

(23) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

(24) Lignum Aquilariae Resinatum: outwash, is split into fritter, and the used time smashs to pieces or is ground into fine powder;

(25) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in hot pot, cigarette of having waited, pours into Massa Medicata Fermentata, fry to yellow, take out, sieve removes wheat bran, cools;

(26) Herba Eupatorii: pick clean impurity, wash, pull out, slightly after profit, removing undesirable root, cutting, dries;

(27) Fructus Toosendan: pick decontamination, cleans, and dries, grating or cleave in two;

(2) prepare

(1) by the Endoconcha Sepiae of described weight, Semen Euryales, Semen Coicis, Concha Arcae (calcined), Rhizoma Corydalis, Rhizoma Polygonati Odorati, Fructus Perillae, Stalactitum, Radix Glycyrrhizae, Rhizoma Cyperi, Herba Schizonepetae, Semen Pruni, Arillus Longan, Radix Bupleuri, Pollen Typhae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Pericarpium Arecae, Rhizoma Dioscoreae, Fructus Cannabis, Caulis Bambusae In Taenia, Herba Dendrobii, Radix Ophiopogonis, Lignum Aquilariae Resinatum, Massa Medicata Fermentata, Herba Eupatorii, Fructus Toosendan drug decocting secondary, add water 6 times amount for the first time, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor;

(2) add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor;

(3) twice decoction liquor is carried out mixing and stirring, be divided into 4 doses and take.