CN105727110A - Traditional Chinese medicine washing liquid for treating gynecological inflammation and preparing method thereof - Google Patents

Traditional Chinese medicine washing liquid for treating gynecological inflammation and preparing method thereof Download PDF

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CN105727110A
CN105727110A CN201610228027.5A CN201610228027A CN105727110A CN 105727110 A CN105727110 A CN 105727110A CN 201610228027 A CN201610228027 A CN 201610228027A CN 105727110 A CN105727110 A CN 105727110A
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fructus
radix
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medical material
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冯小林
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Abstract

The invention relates to a traditional Chinese medicine washing liquid for treating gynecological inflammation and a preparing method thereof.The traditional Chinese medicine washing liquid comprises, by weight, 3-30 parts of radix stemonae, 3-30 parts of radix sophorae flavescentis, 3-30 parts of tangerine peels, 3-30 parts of common carpesium fruits, 3-30 parts of cortex dictamni, 3-30 parts of broom cypress fruits, 3-30 parts of cortex phellodendri, 3-30 parts of rhizoma coptidis, 3-30 parts of honeycombs, 3-30 parts of alum, 3-30 parts of dark plum fruits and 3-30 parts of radix geutianae.The preparing method includes the steps that the traditional Chinese medicinal materials are decocted with water and extracted, purification is carried out through water, and then the traditional Chinese medicine washing liquid is prepared.The traditional Chinese medicine washing liquid has the effects of clearing heat, removing toxicity, killing parasites, relieving itching and achieving dehumidifying.

Description

A kind of Chinese medicinal lotion treating gynecological inflammation and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicinal lotion treating gynecological inflammation and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Gynecological inflammation is a big disease of puzzlement Contemporary Female.According to World Health Organization (WHO) (WHO), whole world women is good for The investigation of health state shows: gynaecopathia incidence rate has reached more than 65%, and in Women of Childbearing Age, Gynaecopathia sickness rate has exceeded 70%.The annual urogenital system in the whole world infects the number of the infected of class disease Reach 3.33 hundred million person-times, promote the whole world quick dilatation in Amino-Cerv market.The Epidemiological study that China is done Result also indicates that, the sickness rate of China's city married woman's reproductive tract infection is 42%, and many people are in life Urinary system infection in various degree all can occur.Gynecological inflammation is primarily referred to as the inflammation of female sex organ, female The multiple organ of property can occur acute and chronic inflammation, specifically includes female vulva inflammation, vaginitis, palace Neck is scorching, pelvic inflammatory disease.
Western medical treatment gynecological inflammation at present, if drug main antibiotics used and hormones, treat thoroughly, Relapse rate is high, and side effect is big.Chinese traditional treatment gynecological inflammation is from entirety, or eliminating damp-heat, or spleen invigorating Wet, or liver and kidney tonifying, or soothing liver and strengthening spleen, it being equipped with killing parasites for relieving itching, clinical efficacy is good, and side effect is little.But it is existing There is unsatisfactory curative effect, side effect greatly in the Chinese medicine preparation for the treatment of gynecological inflammation, and the shortcoming for the treatment of time length.
Summary of the invention
Present invention aim at providing a kind of evident in efficacy, Chinese medicinal lotion for the treatment of gynecological inflammation that toxic and side effects is little And preparation method thereof, this Chinese medicinal lotion has effect of heat-clearing and toxic substances removing, killing parasites for relieving itching, dehumidifying.
The present invention treats the Chinese medicinal lotion of gynecological inflammation, and it is made up of the crude drug of following weight proportion: the Radix Stemonae 3-30 part, Radix Sophorae Flavescentis 3-30 part, Pericarpium Citri Reticulatae 3-30 part, Fructus Carpesii 3-30 part, Cortex Dictamni 3-30 part, Fructus Kochiae 3-30 Part, Cortex Phellodendri 3-30 part, Rhizoma Coptidis 3-30 part, Nidus Vespae 3-30 part, Alumen 3-30 part, Fructus Mume 3-30 part, dragon Radix Gentianae 3-30 part.
Preferred as the present invention, the Chinese medicinal lotion of described gynecological inflammation, it is former by following weight proportion Material medicine composition: Radix Stemonae 10-24 part, Radix Sophorae Flavescentis 10-24 part, Pericarpium Citri Reticulatae 6-12 part, Fructus Carpesii 6-12 part, Cortex Dictamni 6-12 part, Fructus Kochiae 6-12 part, Cortex Phellodendri 6-12 part, Rhizoma Coptidis 6-12 part, Nidus Vespae 6-12 part, Alumen 6-12 Part, Fructus Mume 6-12 part, Radix Gentianae 6-12 part.
Preferred as the present invention, the Chinese medicinal lotion of described gynecological inflammation, it is former by following weight proportion Material medicine composition: the Radix Stemonae 18 parts, Radix Sophorae Flavescentis 18 parts, Pericarpium Citri Reticulatae 12 parts, Fructus Carpesii 6 parts, Cortex Dictamni 8 parts, Fructus Kochiae Son 10 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 8 parts, 6 parts of Nidus Vespae, Alumen 10 parts, Fructus Mume 6 parts, Radix Gentianae 8 Part.
Preferred as the present invention, the Chinese medicinal lotion of described gynecological inflammation, it is former by following weight proportion Material medicine composition: the Radix Stemonae 24 parts, Radix Sophorae Flavescentis 24 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Carpesii 10 parts, Cortex Dictamni 6 parts, Fructus Kochiae Son 12 parts, Cortex Phellodendri 10 parts, Rhizoma Coptidis 6 parts, 12 parts of Nidus Vespae, Alumen 12 parts, Fructus Mume 10 parts, Radix Gentianae 6 parts.
Preferred as the present invention, the Chinese medicinal lotion of described gynecological inflammation, it is former by following weight proportion Material medicine composition: the Radix Stemonae 10 parts, Radix Sophorae Flavescentis 10 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Carpesii 12 parts, Cortex Dictamni 12 parts, Fructus Kochiae Son 6 parts, Cortex Phellodendri 12 parts, Rhizoma Coptidis 12 parts, 8 parts of Nidus Vespae, Alumen 6 parts, Fructus Mume 12 parts, Radix Gentianae 12 Part.
The present invention treats the preparation method of the Chinese medicinal lotion of gynecological inflammation, and it is made up of following operating procedure:
(1) take Pericarpium Citri Reticulatae, Radix Gentianae, add medical material weight 8 times amount water, use steam distillation to extract volatile oil, Obtain water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with the Radix Stemonae, Radix Sophorae Flavescentis, Fructus Carpesii, Cortex Dictamni, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Coptidis, Nidus Vespae, Alumen, Fructus Mume, medical material boiling secondary, add the water of medical material weight 7~11 times amount for the first time, Decocting 1~2 hour, second time adds the water of medical material weight 6~10 times amount, decocts 0.5~1.5 hour, closes And twice decocting liquid, filtering, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, adds ethanol and make containing alcohol Amount reaches 50~70%, stands 8~24 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Preferred as the present invention, the present invention treats the preparation method of the Chinese medicinal lotion of gynecological inflammation, and it is by such as Lower operating procedure forms:
(1) take Pericarpium Citri Reticulatae, Radix Gentianae, add medical material weight 8 times amount water, use steam distillation to extract volatile oil, Obtain water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with the Radix Stemonae, Radix Sophorae Flavescentis, Fructus Carpesii, Cortex Dictamni, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Coptidis, Nidus Vespae, Alumen, Fructus Mume, medical material boiling secondary, add the water of medical material weight 9 times amount for the first time, decoct 1.5 hours, second time added the water of medical material weight 8 times amount, decocts 1 hour, merges twice decocting liquid, filter Crossing, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, adds ethanol and makes alcohol content reach 60%, stands 12 hours, filtering, filtrate recycling ethanol, to without alcohol taste, obtains filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
The source of each medical material, nature and flavor in side, return through and function cure mainly.
The Radix Stemonae: for Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq, Radix stemonae japonicae Stemonajaponica (Bl.) Miq. or the dried root of radix stemonae tuberosae Stemona tuberosa Lour..Spring, Qiu Erji excavates, and removes fibrous root, cleans, and puts and slightly scalds in boiling water or steam to without the white heart, takes out, dry.Nature and flavor, Sweet, bitter, tepor.Gui Jing, returns lung meridian.Slightly poisonous.Function cures mainly, nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.For New chronic cough is coughed, pulmonary tuberculosis cough, pertussis;Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae lung moistening Cough-relieving.For deficiency of YIN chronic cough.
Radix Sophorae Flavescentis: for the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Spring, season in autumn two excavate, Remove root head and little supporting root, cleaning, drying, or take advantage of fresh slices, be dried.Nature and flavor, bitter, cold.Gui Jing, returns The heart, liver, stomach, large intestine, bladder warp.Function cures mainly, heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, just Blood, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy;External treatment Trichomonal vaginitis.
Pericarpium Citri Reticulatae: for the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and variety thereof Skin.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying. Nature and flavor, bitter, pungent, temperature.Gui Jing, returns lung, spleen channel.Function cures mainly, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For Fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Carpesii: for the fruit of feverfew Radix Carpesii.Harvesting when autumn, fruit became heat, dries, removes scurf, Impurity.Nature and flavor, toil, flat, poisonous.Gui Jing, enter to faint cloudy Liver Channel.Function cures mainly, parasite killing.Control malnutrition due to parasitic infestation abdomen Bitterly.
Cortex Dictamni: for the dry root bark of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..Spring, autumn Excavate root two seasons, remove silt and rough bark, strip root bark, be dried.Nature and flavor, bitter, cold.Gui Jing, return spleen, Stomach, bladder warp.Function cures mainly, heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, Rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
The Fructus Kochiae: for the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Autumn Gather during season fruit maturation plant, dry, lay fruit, remove impurity.Nature and flavor, pungent, bitter, cold. Gui Jing, returns kidney, bladder warp.Function cures mainly, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus band Under, rubella, eczema, skin pruritus.
Cortex Phellodendri: for rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri The dry bark of Phellodendron amurense Rupr..The former practises title " Cortex Phellodendri ", and the latter practises title " closes Huang Cypress ".After stripping bark, remove rough bark, dry.Nature and flavor, bitter, cold.Gui Jing, returns kidney, bladder warp.Merit Can cure mainly, heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, Tinea pedis, flaccidity { wards off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire. For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Rhizoma Coptidis: for ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis Deltoidea C.Y.Cheng et Hsiao or the dry rhizome of Coptis Teeta Wall Coptis teetaWall..Three of the above is divided Do not practise title " taste is even ", " refined company ", " Coptis Teeta Wall ".Autumn excavates, and removes fibrous root and silt, is dried, hits residual Fibrous root.Nature and flavor, bitter, cold.Gui Jing, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly, heat clearing away Dampness, eliminating fire and detoxication.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, Dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache is quenched one's thirst, carbuncle furuncle;External treatment eczema, eczema, auditory meatus stream Pus.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.
Nidus Vespae: for Vespidae insecticide fruit hornet Polistes olivaceous (DeGeer), Japanese long foot wasp The nest of Polistesjaponicus Saussure or different abdomen wasp Parapolybia varia Fabricius.Autumn, winter two Ji Caishou, dries, or slightly steams, and removes the dead pupa of dead honeybee, dries.Nature and flavor, sweet, flat.Gui Jing, returns stomach warp. Function cures mainly, and dispels the wind, merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, Skin stubborn dermatitis, fungal infection of hand and foot.
Alumen: make for the Sulfates processed refinement of mineral alunite.Nature and flavor, sour, puckery, cold.Gui Jing, Return lung, spleen, liver, large intestine channel.Function cures mainly, external removing toxic substances parasite killing, dampness removing to stop itchin;Hemostasis antidiarrheal for oral administration, Dispel wind-phlegm.External treatment is used for eczema, scabies, discharging ear;Take orally for incessant chronic diarrhea, have blood in stool, metrorrhagia, Epilepsy is gone mad.
Fructus Mume: near ripe for being dried of rose department plant plum Prunus mume (Sieh.) Sieb.et Zucc. Fruit.Gather during fruit closely maturation in summer, vexed black to complexion changed after oven drying at low temperature.Nature and flavor, sour, puckery, flat. Gui Jing, returns liver, spleen, lung, large intestine channel.Function cures mainly, and astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For the deficiency of the lung Chronic cough, chronic dysentery laxation, deficiency-heat quenches one's thirst, ascariasis of biliary tract vomiting stomachache, biliary tract ascarid.
Radix Gentianae: for gentianaceae plant Gentiana manshurica Gentiana manshurica Kitag., Radix Gentianae Gentiana Scabra Bunge, G. triflora Gentiana triflora pall or Gentiana rigescens Franch Gentiana rigescens Franch. Dry root and rhizome.First three is practised and is claimed " Radix Gentianae ", and latter is practised and claimed " Gentiana rigescens Franch ".Spring, season in autumn two excavate, Cleaning, drying.Nature and flavor, bitter, cold.Gui Jing, returns liver, gallbladder meridian.Function cures mainly, heat clearing and damp drying, eliminating pathogen in the liver gallbladder Fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deafness, hypochondriac pain, mouth Hardship, convulsion with spasms.
The present invention compared with prior art, has the advantages that
Present inventor with Chinese medical theory for instructing, evident in efficacy in conjunction with clinical empirical summary for many years Chinese medicinal lotion.The Radix Stemonae in side, Radix Sophorae Flavescentis two medicine mutual reinforcement between for can heat clearing and damp drying, parasite killing.It is equipped with Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, Drying dampness to eliminate phlegm, add Fructus Carpesii, Cortex Dictamni, the Fructus Kochiae can heat clearing and damp drying, killing parasites for relieving itching.It is equipped with Cortex Phellodendri, Huang again The even merit of clearing away heat-fire removing toxic substances in enhancing side;In rearmost in addition Nidus Vespae, Alumen, Fructus Mume, Radix Gentianae, can solve Poisoning worm, dampness removing to stop itchin.All medicines match, and play effect of heat-clearing and toxic substances removing, killing parasites for relieving itching, dehumidifying altogether.Make complete Side has treating both the principal and secondary aspects of a disease, evident in efficacy, the feature that toxic and side effects is little, has aobvious to the patient of various gynecological inflammations Write curative effect.Various gynecological inflammations can also be played the effect got instant result by Chinese medicinal lotion of the present invention, solve numerous The painful topic of patient, makes numerous female patient obtain quick recovery.
Clinical test results shows, the overall clinical efficacy rate of Chinese medicinal lotion of the present invention can reach more than 85%, and faces Bed curative effect is better than matched group (FUYINJIE), and it has evident in efficacy, the feature that relapse rate is low.Be suitable in clinic Upper large-scale promotion.
Detailed description of the invention
The following is the specific embodiment of present invention, be used for illustrating technical problem to be solved in present specification Technical scheme, contribute to skilled artisan understands that present invention, but the realization of technical solution of the present invention It is not limited to these embodiments.
Embodiment 1
(1) take Pericarpium Citri Reticulatae 12g, Radix Gentianae 8g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 18g, Radix Sophorae Flavescentis 18g, Fructus Carpesii 6g, Cortex Dictamni 8g, the Fructus Kochiae 10g, Cortex Phellodendri 6g, Rhizoma Coptidis 8g, Nidus Vespae 6g, Alumen 10g, Fructus Mume 6g, boiling secondary, for the first time Adding the water of medical material weight 9 times amount, decoct 1.5 hours, second time adds the water of medical material weight 8 times amount, decocts Boiling 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, Adding ethanol makes alcohol content reach 60%, stands 12 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtration Liquid;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 2
(1) take Pericarpium Citri Reticulatae 10g, Radix Gentianae 6g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 24g, Radix Sophorae Flavescentis 24g, Fructus Carpesii 10g, Cortex Dictamni 6g, the Fructus Kochiae 12g, Cortex Phellodendri 10g, Rhizoma Coptidis 6g, Nidus Vespae 12g, Alumen 12g, Fructus Mume 10g, boiling secondary, first The water of secondary addition medical material weight 11 times amount, decocts 2 hours, and second time adds the water of medical material weight 10 times amount, Decoct 1.5 hours, merge twice decocting liquid, filter, filtrate be concentrated into relative density be 1.15~1.25 clear Cream, adds ethanol and makes alcohol content reach 70%, stand 24 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains Filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 3
(1) take Pericarpium Citri Reticulatae 6g, Radix Gentianae 12g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 10g, Radix Sophorae Flavescentis 10g, Fructus Carpesii 12g, Cortex Dictamni 12g, the Fructus Kochiae 6g, Cortex Phellodendri 12g, Rhizoma Coptidis 12g, Nidus Vespae 8g, Alumen 6g, Fructus Mume 12g, medical material boiling secondary, the Once adding the water of medical material weight 7 times amount, decoct 1 hour, second time adds the water of medical material weight 6 times amount, Decoct 0.5 hour, merge twice decocting liquid, filter, filtrate be concentrated into relative density be 1.15~1.25 clear Cream, adds ethanol and makes alcohol content reach 50%, stand 8 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtained Filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 4
(1) take Pericarpium Citri Reticulatae 12g, Radix Gentianae 6g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 24g, Radix Sophorae Flavescentis 10g, Fructus Carpesii 6g, Cortex Dictamni 12g, the Fructus Kochiae 6g, Cortex Phellodendri 6g, Rhizoma Coptidis 12g, Nidus Vespae 6g, Alumen 12g, Fructus Mume 12g, boiling secondary, for the first time Adding the water of medical material weight 8 times amount, decoct 1 hour, second time adds the water of medical material weight 8 times amount, decocts 0.5 hour, merging twice decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, Adding ethanol makes alcohol content reach 60%, stands 24 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtration Liquid;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 5
(1) take Pericarpium Citri Reticulatae 6g, Radix Gentianae 12g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 10g, Radix Sophorae Flavescentis 24g Fructus Carpesii 12g, Cortex Dictamni 6g, Fructus Kochiae 12g, Cortex Phellodendri 12g, Rhizoma Coptidis 6g, Nidus Vespae 12g, Alumen 6g, Fructus Mume 6g, medical material boiling secondary, for the first time Adding the water of medical material weight 9 times amount, decoct 1.5 hours, second time adds the water of medical material weight 7 times amount, decocts Boiling 0.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, Adding ethanol makes alcohol content reach 70%, stands 8 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 6
(1) take Pericarpium Citri Reticulatae 30g, Radix Gentianae 30g, add medical material weight 8 times amount water, use steam distillation to carry Take volatile oil, obtain water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 30g, Radix Sophorae Flavescentis 3g, Fructus Carpesii 30g, Cortex Dictamni 3g, the Fructus Kochiae 30g, Cortex Phellodendri 30g, Rhizoma Coptidis 3g, Nidus Vespae 3g, Alumen 30g, Fructus Mume 30g, boiling secondary, first The water of secondary addition medical material weight 10 times amount, decocts 2 hours, and second time adds the water of medical material weight 9 times amount, Decoct 1.5 hours, merge twice decocting liquid, filter, filtrate be concentrated into relative density be 1.15~1.25 clear Cream, adds ethanol and makes alcohol content reach 50%, stand 24 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains Filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
Embodiment 7
(1) take Pericarpium Citri Reticulatae 3g, Radix Gentianae 30g, add medical material weight 8 times amount water, use steam distillation to extract Volatile oil, obtains water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with Radix Stemonae 3g, Radix Sophorae Flavescentis 30g, Fructus Carpesii 3g, Cortex Dictamni 30g, the Fructus Kochiae 3g, Cortex Phellodendri 3g, Rhizoma Coptidis 30g, Nidus Vespae 30g, Alumen 3g, Fructus Mume 3g, boiling secondary, for the first time Adding the water of medical material weight 9 times amount, decoct 1 hour, second time adds the water of medical material weight 10 times amount, decocts Boiling 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, Adding ethanol makes alcohol content reach 70%, stands 12 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtration Liquid;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
In order to verify the curative effect of finished product preparation of the present invention further, we are by above-mentioned specific embodiment 1, in 2,3 The Chinese medicinal lotion of preparation, has carried out corresponding clinical trial, now result is reported as follows.
1 clinical observation and curative effect
1.1 physical data:
Collecting in January, 2015~in March, 2016 gynecological inflammation patient 193 example, all cases all meets gynecological inflammation and examines 193 example patients are randomly divided into 4 groups by disconnected standard, matched group 46 example, age 21~70 years old, the mean age (37.9 ± 7.3) year;The course of disease 8~72 months, individual month of average course of disease (26.1 ± 5.5).Treat 1 group of 47 example, the age 19~ 69 years old, year mean age (39.4 ± 6.5);The course of disease 9~75 months, individual month of average course of disease (24.5 ± 4.8);Treatment 2 group of 51 example, year mean age (38.4 ± 6.2);The course of disease 7~68 months, individual month of average course of disease (22.3 ± 4.9); Treat 3 group of 49 example, age 19~71 years old, year mean age (37.3 ± 5.7);The course of disease 8~73 months, averagely Individual month of the course of disease (21.2 ± 4.8).The physical data of four groups are carried out statistical analysis no significant difference (P > 0.05), has comparability.
1.2 diagnostic criteria
(1) clinical symptoms: all increase medical because of vaginal secretions, major part, with pudendum, pruritus of vagina, is burnt Pain or with frequent micturition dysurea urgent micturition, part vaginal secretions has bad smell;(2) gynecologial examination: secretions increase And to have exception, colpitis mycotica secretions be bean dregs samples, nonspecific vaginitis secretions is yellow green, cloudy Mucous membrane is congested or has petechia;(3) control laboratory inspection: the many persons of vaginal secretions make secretions humidity strip and dry tablet Dyeing, positive 72 examples of infusorian, look for and see that tooth spore and pseudohypha are colpitis mycotica 84 example, double infection 5 example, Secretions white paste, the person of having a fish like smell scrapes vaginal sidewall secretions smear, makees 0.1% methylene blue humidifying, Checking clues cell under 400 power microscopes, clues cell accounts for whole epithelial cell 20% and above person is the positive, It is diagnosed as bacterial vaginitis (PV) and counts 32 examples.
1.3 inclusive criteria
The person that is provided simultaneously with the following, (1) Western medicine diagnose is colpitis mycotica or nonspecific vaginitis person;(2) Married, age 20~60 years old.
1.4 exclusion standard
(1) Western medicine diagnose is not belonging to colpitis mycotica or nonspecific vaginitis person.(2) merge gestation person and with Drug therapy or the those who are allergic to this drug such as outer disease needs to use antibiotic, hormone.(4) severe cervical is merged rotten Rotten person.And have the primary diseases such as serious cardiovascular, liver, kidney, psychotic (5).(6) do not meet and include mark in Standard, cannot not judge curative effect by regulation medication or data is congruent affects the treatment and safety judgement person.
1.5 Therapeutic Method
Therapeutic Method: treat 1 group: use 1 group of Chinese medicinal lotion prepared of the embodiment of the present invention;Treat 2 groups: adopt With 2 groups of Chinese medicinal lotions prepared of the embodiment of the present invention;Treat 3 groups: in using the embodiment of the present invention 3 groups to prepare Medicine washing liquid;Matched group: by FUYINJIE, Yuan An Tang Pharmaceutical Co., Ltd., Guangxi provide.Expose with vaginal speculum Vagina, with sterilization dry cotton ball wiping vagina, removes secretions, takes Chinese medicinal lotion l0mL of the present invention and add ten times of temperature Boiled water dilutes, and with irrigator rinsing vulva and vagina, vulvitis person can be directly applied to affected part, often after rinsing Day 2 times, it is used in conjunction 7 days.Matched group (FUYINJIE) is administered by the same method, forbids sexual life during medication.The course for the treatment of: 7 days It is 1 course for the treatment of, starts after 5 days to be administered from clean period, after terminating the course for the treatment of, carry out therapeutic evaluation.
Observation item: main project and standards of grading: find mycete in (1) leucorrhea: 10 points.(2) leucorrhea is looked into To pathogen: 10 points.(3) pruritus vulvae causalgia: acutely: 5 points;Obvious 3 points;Slight 1 point.(4) leucorrhea increases Many: yellow skin purulence or white chunks smell as of rotten fish 3 points;Yellowish sticky or a small amount of white chunks 2 points;Thin accidental white Block 1 point.(5) vagina cleanness degree: 3 degree 2 points;2 degree 1 point.(6) vaginal mucosa has petechia: extensively accompany ulcer 2 points;It is dispersed in 1 point.(7) sexual anhedonia: 1 point.(8) urine urgency-frequency dysurea 1 point.Indexing: severe: iterated integral exists More than 20 points.Moderate: accumulative 16~19 points.Slight: iterated integral 13~15 points.
1.6 observational technique
(1) record faithfully in strict accordance with requirements of plan.(2) observe 1 time before the treatment, terminate to observe 1 the course for the treatment of, 3 After individual month observe 1 time, record indices change, including check leucorrhea, pathogen turn out cloudy situation and vagina clear Cleanliness.(3) it is not added with other treatment medicine and treatment means during observing and in terminating the course for the treatment of latter 3 months.
2 therapeutic outcomes
2.1 curative effect determinate standard recoveries from illness:
Clinical cardinal symptom (secretions increase, pruritus of vagina) disappears, and doctor trained in Western medicine checks that secretions is normal, laboratory Not finding mycete or pathogen, after drug withdrawal, 3 cycles are without recurrence.Invalid: after treatment symptom and sign substantially free of Change.Recurrence: the patient all disappeared for sings and symptoms after treatment, 3 menstrual cycle are laggard after drug withdrawal Row further consultation checks, has the front same symptoms for the treatment of or lab testing to mycete or pathogen person.
Comparitive study { example (%) } after treatment respectively organized by table 1
Note: compare with matched group,*P<0.05。
2.2 therapeutic outcome
After the treatment of 1 course for the treatment of, the present invention treats 1 group, treats 2 groups, treats the patient treatment vagina of 3 groups Scorching cure rate is 89.36%, 88.23%, 85.71%, and the recovery from illness of matched group (FUYINJIE) is 71.74%, Compare with matched group, treat 3 groups of cure rates and show significant difference (P < 0.05);Relapse rate aspect, this Mingzhi treat 1 group, treat 2 groups, the relapse rate for the treatment of 3 groups is 0,3.92%, 2.04%, far below matched group (skin Cloudy clean) it is 10.87%%, this further illustrates Chinese medicinal lotion of the present invention and has evident in efficacy, low excellent of relapse rate Point.
2.3 untoward reaction
By observing treatment group 147 example patient, not yet find toxic and side effects and untoward reaction, hematuria just Liver and kidney merit Energy and electrocardiogram are the most no abnormal.Having 2 example coming in contact property dermatitis in matched group, pruritus is unbearably at once, uses Normal saline cleans and takes a turn for the better after Claritin treatment, and second day is used Chinese medicinal lotion of the present invention instead and rinsed, without class Occur like phenomenon.

Claims (7)

1. the Chinese medicinal lotion treating gynecological inflammation, it is characterised in that it is by the raw material of following weight proportion Medicine forms: Radix Stemonae 3-30 part, Radix Sophorae Flavescentis 3-30 part, Pericarpium Citri Reticulatae 3-30 part, Fructus Carpesii 3-30 part, Cortex Dictamni 3-30 Part, Fructus Kochiae 3-30 part, Cortex Phellodendri 3-30 part, Rhizoma Coptidis 3-30 part, Nidus Vespae 3-30 part, Alumen 3-30 part, Fructus Mume 3-30 part, Radix Gentianae 3-30 part.
2. treat the Chinese medicinal lotion of gynecological inflammation as claimed in claim 1, it is characterised in that it is by weighing as follows The crude drug composition of amount proportioning: Radix Stemonae 10-24 part, Radix Sophorae Flavescentis 10-24 part, Pericarpium Citri Reticulatae 6-12 part, Fructus Carpesii 6-12 Part, Cortex Dictamni 6-12 part, Fructus Kochiae 6-12 part, Cortex Phellodendri 6-12 part, Rhizoma Coptidis 6-12 part, Nidus Vespae 6-12 part, Alumen 6-12 part, Fructus Mume 6-12 part, Radix Gentianae 6-12 part.
3. treat the Chinese medicinal lotion of gynecological inflammation as claimed in claim 2, it is characterised in that it is by weighing as follows The crude drug composition of amount proportioning: the Radix Stemonae 18 parts, Radix Sophorae Flavescentis 18 parts, Pericarpium Citri Reticulatae 12 parts, Fructus Carpesii 6 parts, Cortex Dictamni 8 parts, the Fructus Kochiae 10 parts, Cortex Phellodendri 6 parts, Rhizoma Coptidis 8 parts, 6 parts of Nidus Vespae, Alumen 10 parts, Fructus Mume 6 parts, Radix Gentianae 8 parts.
4. treat the Chinese medicinal lotion of gynecological inflammation as claimed in claim 2, it is characterised in that it is by weighing as follows The crude drug composition of amount proportioning: the Radix Stemonae 24 parts, Radix Sophorae Flavescentis 24 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Carpesii 10 parts, Cortex Dictamni 6 parts, the Fructus Kochiae 12 parts, Cortex Phellodendri 10 parts, Rhizoma Coptidis 6 parts, 12 parts of Nidus Vespae, Alumen 12 parts, Fructus Mume 10 Part, Radix Gentianae 6 parts.
5. treat the Chinese medicinal lotion of gynecological inflammation as claimed in claim 2, it is characterised in that it is by weighing as follows The crude drug composition of amount proportioning: the Radix Stemonae 10 parts, Radix Sophorae Flavescentis 10 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Carpesii 12 parts, Cortex Dictamni 12 parts, the Fructus Kochiae 6 parts, Cortex Phellodendri 12 parts, Rhizoma Coptidis 12 parts, 8 parts of Nidus Vespae, Alumen 6 parts, Fructus Mume 12 parts, Radix Gentianae 12 parts.
6. the preparation method of Chinese medicinal lotion as described in arbitrary in Claims 1 to 5, it is characterised in that it be by Following operating procedure composition:
(1) take Pericarpium Citri Reticulatae, Radix Gentianae, add medical material weight 8 times amount water, use steam distillation to extract volatile oil, Obtain water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with the Radix Stemonae, Radix Sophorae Flavescentis, Fructus Carpesii, Cortex Dictamni, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Coptidis, Nidus Vespae, Alumen, Fructus Mume, medical material boiling secondary, add the water of medical material weight 7~11 times amount for the first time, Decocting 1~2 hour, second time adds the water of medical material weight 6~10 times amount, decocts 0.5~1.5 hour, closes And twice decocting liquid, filtering, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, adds ethanol and make containing alcohol Amount reaches 50~70%, stands 8~24 hours, filters, and filtrate recycling ethanol, to without alcohol taste, obtains filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
7. the preparation method of Chinese medicinal lotion as claimed in claim 6, it is characterised in that it is by operating step as follows Rapid composition:
(1) take Pericarpium Citri Reticulatae, Radix Gentianae, add medical material weight 8 times amount water, use steam distillation to extract volatile oil, Obtain water distillate standby with volatile oil;
(2) take step medicinal residues (1) again with the Radix Stemonae, Radix Sophorae Flavescentis, Fructus Carpesii, Cortex Dictamni, the Fructus Kochiae, Cortex Phellodendri, Rhizoma Coptidis, Nidus Vespae, Alumen, Fructus Mume, medical material boiling secondary, add the water of medical material weight 9 times amount for the first time, decoct 1.5 hours, second time added the water of medical material weight 8 times amount, decocts 1 hour, merges twice decocting liquid, filter Crossing, filtrate is concentrated into the clear paste that relative density is 1.15~1.25, adds ethanol and makes alcohol content reach 60%, stands 12 hours, filtering, filtrate recycling ethanol, to without alcohol taste, obtains filtrate;
The most again by step (1) water distillate, step (2) filtrate, mixing, add sodium benzoate, Polysorbate 80, after mix homogeneously, to obtain final product.
CN201610228027.5A 2016-04-13 2016-04-13 Traditional Chinese medicine washing liquid for treating gynecological inflammation and preparing method thereof Pending CN105727110A (en)

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CN107929490A (en) * 2017-12-15 2018-04-20 唐东 A kind of Chinese medicinal lotion its preparation method for treating gynecology colpitis
CN109512966A (en) * 2018-10-31 2019-03-26 饶正军 One kind is for treating gynaecological imflammation sterilization medicine and preparation method thereof
CN111991296A (en) * 2020-09-15 2020-11-27 刘圆霖 Preparation method of acne-removing essence

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CN107929490A (en) * 2017-12-15 2018-04-20 唐东 A kind of Chinese medicinal lotion its preparation method for treating gynecology colpitis
CN109512966A (en) * 2018-10-31 2019-03-26 饶正军 One kind is for treating gynaecological imflammation sterilization medicine and preparation method thereof
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Application publication date: 20160706

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