CN105705147B - 新颖的噁唑烷酮抗菌化合物 - Google Patents

新颖的噁唑烷酮抗菌化合物 Download PDF

Info

Publication number
CN105705147B
CN105705147B CN201480060357.7A CN201480060357A CN105705147B CN 105705147 B CN105705147 B CN 105705147B CN 201480060357 A CN201480060357 A CN 201480060357A CN 105705147 B CN105705147 B CN 105705147B
Authority
CN
China
Prior art keywords
formula
compound
base
methyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480060357.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN105705147A (zh
Inventor
拉古·米特拉·阿拉
阿贾伊·库马尔·迪贝
斯里尼瓦斯·雷迪·马勒帕里
拉玛克里什那·雷迪·庞吉拉蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lee Pharma Ltd
Original Assignee
Lee Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lee Pharma Ltd filed Critical Lee Pharma Ltd
Publication of CN105705147A publication Critical patent/CN105705147A/zh
Application granted granted Critical
Publication of CN105705147B publication Critical patent/CN105705147B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480060357.7A 2013-11-08 2014-07-28 新颖的噁唑烷酮抗菌化合物 Expired - Fee Related CN105705147B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN5063/CHE/2013 2013-11-08
IN5063CH2013 2013-11-08
IN2254CH2014 2014-05-05
IN2254/CHE/2014 2014-05-05
PCT/IN2014/000497 WO2015068173A1 (en) 2013-11-08 2014-07-28 Novel oxazolidinone antibacterial compound

Publications (2)

Publication Number Publication Date
CN105705147A CN105705147A (zh) 2016-06-22
CN105705147B true CN105705147B (zh) 2019-06-28

Family

ID=53040992

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480060357.7A Expired - Fee Related CN105705147B (zh) 2013-11-08 2014-07-28 新颖的噁唑烷酮抗菌化合物

Country Status (6)

Country Link
US (1) US9573910B2 (https=)
EP (1) EP3065740B1 (https=)
JP (1) JP6286536B2 (https=)
CN (1) CN105705147B (https=)
ES (1) ES2699001T3 (https=)
WO (1) WO2015068173A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117597337A (zh) * 2021-05-03 2024-02-23 迪斯库瓦有限公司 抗菌化合物的制备方法
CN115707685A (zh) * 2021-08-20 2023-02-21 中国石油化工股份有限公司 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统
CN114230547A (zh) * 2021-12-29 2022-03-25 江苏广域化学有限公司 取代苯甲醛缩醇的合成方法
CN116919954A (zh) * 2023-05-22 2023-10-24 成都大学 噁唑烷酮类化合物在制备抑制细菌群体感应的药物中的应用
CN118515624B (zh) * 2024-04-29 2025-01-24 聊城金歌合成材料有限公司 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1355165A (zh) * 2001-12-19 2002-06-26 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
CN102112471A (zh) * 2008-07-01 2011-06-29 菲尔若国际公司 作为抗菌剂的3-氰基吡咯烷基-苯基-噁唑烷酮

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
KR20010015910A (ko) * 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
BR0111280A (pt) * 2000-06-05 2003-06-10 Dong A Pharm Co Ltd Novos derivados de oxazolidinona e um processo para a preparação dos mesmos
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
EP2163547A1 (en) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
WO2015068171A1 (en) 2013-11-08 2015-05-14 Lee Pharma Limited Novel oxazolidinone compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1355165A (zh) * 2001-12-19 2002-06-26 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
CN102112471A (zh) * 2008-07-01 2011-06-29 菲尔若国际公司 作为抗菌剂的3-氰基吡咯烷基-苯基-噁唑烷酮

Also Published As

Publication number Publication date
EP3065740A1 (en) 2016-09-14
US20160272597A1 (en) 2016-09-22
CN105705147A (zh) 2016-06-22
ES2699001T3 (es) 2019-02-06
EP3065740A4 (en) 2017-04-19
JP2016535039A (ja) 2016-11-10
WO2015068173A1 (en) 2015-05-14
EP3065740B1 (en) 2018-08-22
JP6286536B2 (ja) 2018-02-28
US9573910B2 (en) 2017-02-21

Similar Documents

Publication Publication Date Title
RU2569307C1 (ru) Азотсодержащие соединения и их применение
US8900625B2 (en) Antimicrobial compounds and methods of use
CN105705147B (zh) 新颖的噁唑烷酮抗菌化合物
CN101232884B (zh) 作为抗菌剂的喹啉衍生物
US12234238B2 (en) Antimicrobial compounds and methods of making and using the same
CN113614092A (zh) 提供抗革兰氏阳性细菌增强的抗菌活性的组合物及其用途
CN104884092A (zh) 用于治疗细菌感染的组合物和方法
CN107106533B (zh) 用于治疗微生物感染的增效组合物
US12152031B2 (en) Biodefense agents
US20180185332A1 (en) Leukotriene Receptor Antagonists and Their Derivatives for Use as Antibacterial Agents
TWI385168B (zh) 作為抗菌劑之喹啉衍生物
US20050209248A1 (en) Plymorphic forms of phenyl oxazolidinone derivatives
US20260041683A1 (en) Compounds with Anti-Acinetobacter Baumannii Activity
JP2017508769A (ja) セフェピムまたはスルバクタムを含む医薬組成物
CN111606900A (zh) 一种抗感染药物及其制备方法和应用
WO2006018682A2 (en) Oxazolidinone derivatives as antimicrobials
US20240239800A1 (en) Pyrrolo[2,3-d]pyrimidin-2-one antimicrobial compounds

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190628