CN105687984A - Traditional Chinese medicine composition for preventing and treating cestodosis of chicken and preparation method thereof - Google Patents

Traditional Chinese medicine composition for preventing and treating cestodosis of chicken and preparation method thereof Download PDF

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CN105687984A
CN105687984A CN201610197794.4A CN201610197794A CN105687984A CN 105687984 A CN105687984 A CN 105687984A CN 201610197794 A CN201610197794 A CN 201610197794A CN 105687984 A CN105687984 A CN 105687984A
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herba
chinese medicine
fructus
medicine composition
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李佃场
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating cestodosis of chicken and a preparation method thereof. The composition is prepared from the following medicinal raw materials: desmodium triquetrum, quisqualis indica, folium bruceae, common carpesium fruit, cyrtomium fortunei, verbena officinalis, fructus alpiniae zerumbet, averrhoa carambola, cortex dictamni, gentiana macrophylla, cortex ailanthi, berberis dasystachya maxim, feather cockscomb, pycnonotus sinensis, humifuse euphorbia herb, agrimonia pilosa, sanguisorba officinalis, melastoma dodecandrum lour, japanese clover, acalypha australis, celosia cristata, oyster rhoeo, codonopsis pilosula, gomphocarpus fruticosus, radix aucklandiae and pyracantha fortuneana. The traditional Chinese medicine composition can be used for preventing and treating cestodosis of chicken to enhance immunity, and has the beneficial effects of high cure rate, relapse prevention, pure nature, no toxic or side effect and low cost and price.

Description

A kind of Chinese medicine composition for preventing and treating chicken taeniasis and preparation method thereof
Technical field
The present invention relates to technical field of animal, particularly to a kind of Chinese medicine composition for preventing and treating chicken taeniasis and preparation method thereof。
Background technology
Chicken taeniasis is that the multiple cestode belonged to by Lai Li parasitizes in the duodenum of chicken and causes, and common bad profit cestode has spine ditch to rely profit cestode, corner rely profit cestode and have wheel to rely profit cestode etc. three kinds。The chicken at various ages all can infect, and other also can infect such as turkey, pheasant, galeeny, peafowl etc., and the chickling susceptibility of 17～40 ages in days is the strongest, and mortality rate is also the highest。Spine ditch relies profit cestode and corner to rely profit cestode to be large-scale cestode, and both profiles and size are much like, long 25 centimetres, wide 1～4 millimeter。Spine ditch relies the sucker on the profit scolices of tapeworm rounded, above has 8～10 little hooks of row, and rostellum is relatively big, above has hook 2 to arrange, and intermediate host is Formica fusca。Corner relies profit cestode, and the sucker on cephalomere is oval, above has 8～10 little hooks of row, and neck joint is more elongated, and rostellum is smaller, above has 1～3 row hook, and intermediate host is Formica fusca or housefly。Having wheel to rely profit cestode shorter and smaller, the sucker on cephalomere is rounded, Wugou, the roomy plumpness of rostellum, is similar to colyliform, and prominent sub-polypide front end, intermediate host is beetle。Spine ditch relies profit cestode and corner to rely the worm's ovum of profit cestode to wrap in egg capsule, and each egg capsule includes 6～12 worm's ovums。Having wheel to rely the worm of profit cestode to incubate and also wrap in egg capsule, each egg capsule includes 1 worm's ovum。
Clinical symptoms: rely due to spine ditch the various cestodes such as profit cestode all to colonize in the small intestinal of chicken, destroy the integrity of intestinal wall with cephalomere, cause mucosal bleeding, enteritis, have a strong impact on digestive function。Sick chicken shows as dysentery, is sometimes mixed with blood sample mucus in feces。Low-grade infection causes chickling impaired development, becomes chicken egg productivity to decline or stops。When parasitic cestode amount is many, intestinal tube can being made to block, intestinal contents, by being obstructed, causes intestinal tube to break and causes peritonitis。Cestode metabolite can cause chicken body poisoning, nervous symptoms occurs。Sick chicken inappetence, spirit is depressed, anemia, cockscomb and mucosal pallor, and extremely weak, two foots are often paralysed, it is impossible to stand, finally die because dying of exhaustion。
Western medical treatment chicken taeniasis, main adopts the anthelmintic treatments such as praziquantel, and toxicity is big, and side effect is big, and the physiological function such as resultant anti-stress, anti-disease and food meat quality (quality) have been greatly reduced, and drug residue then constantly raises。
Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can strengthen chicken immunity, control difficulty in relapse after healing, and cost price is cheap。Therefore, Chinese herbal medicine is of great practical significance in treatment chicken taeniasis。
Summary of the invention
The technical problem to be solved is to be in that to provide a kind of Chinese medicine composition for preventing and treating chicken taeniasis, it is possible to overcomes the defect of prior art Chinese medicine and western medicine and Chinese medicine, controls difficulty in relapse after healing, cost price is cheap, and the course for the treatment of is shorter, and curative effect is better, prolonged application has no drug resistance, drug residue free
In order to realize foregoing invention purpose, the invention provides a kind of Chinese medicine composition for preventing and treating chicken taeniasis, described Chinese medicine composition includes following raw medicinal material:
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 25-41 weight portion, Fructus Quisqualis 23-38 weight portion, Folium Bruceae 20-35 weight portion, Fructus Carpesii 4-9 weight portion, Rhizoma Osmundae 2-7 weight portion, Herba Verbenae 18-30 weight portion, Semen alpinia zerumbet 11-25 weight portion, Flos Averrhoae Carambolae 8-19 weight portion, Cortex Dictamni 11-25 weight portion, Radix Gentianae Macrophyllae 10-26 weight portion, Cortex Ailanthi 13-27 weight portion, Cortex berberidis dasystachyae 7-19 weight portion, Herba Celosiae argenteae 12-22 weight portion, Radix Pulsatillae 18-30 weight portion, Herba Euphorbiae Humifusae 19-31 weight portion, Herba Agrimoniae 11-28 weight portion, Radix Sanguisorbae 20-32 weight portion, DIGEN 7-18 weight portion, Herba Kummerowiae Striatae 11-25 weight portion, Herba Acalyphae 8-20 weight portion, Flos Celosiae Cristatae 12-24 weight portion, Flos Rhoeo discolorae 10-23 weight portion, Radix Codonopsis 20-33 weight portion, Fructus Gomphocarpi futicosi 8-19 weight portion, Radix Aucklandiae 15-26 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 7-18 weight portion。
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 29-36 weight portion, Fructus Quisqualis 26-34 weight portion, Folium Bruceae 24-31 weight portion, Fructus Carpesii 5-8 weight portion, Rhizoma Osmundae 3-6 weight portion, Herba Verbenae 20-25 weight portion, Semen alpinia zerumbet 14-20 weight portion, Flos Averrhoae Carambolae 11-15 weight portion, Cortex Dictamni 14-19 weight portion, Radix Gentianae Macrophyllae 13-23 weight portion, Cortex Ailanthi 17-23 weight portion, Cortex berberidis dasystachyae 9-15 weight portion, Herba Celosiae argenteae 15-20 weight portion, Radix Pulsatillae 20-26 weight portion, Herba Euphorbiae Humifusae 21-27 weight portion, Herba Agrimoniae 14-24 weight portion, Radix Sanguisorbae 22-28 weight portion, DIGEN 9-15 weight portion, Herba Kummerowiae Striatae 14-20 weight portion, Herba Acalyphae 10-17 weight portion, Flos Celosiae Cristatae 15-20 weight portion, Flos Rhoeo discolorae 12-19 weight portion, Radix Codonopsis 23-30 weight portion, Fructus Gomphocarpi futicosi 10-16 weight portion, Radix Aucklandiae 18-23 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9-16 weight portion。
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 36 weight portion, Fructus Quisqualis 26 weight portion, Folium Bruceae 28 weight portion, Fructus Carpesii 8 weight portion, Rhizoma Osmundae 3 weight portion, Herba Verbenae 20 weight portion, Semen alpinia zerumbet 17 weight portion, Flos Averrhoae Carambolae 13 weight portion, Cortex Dictamni 19 weight portion, Radix Gentianae Macrophyllae 23 weight portion, Cortex Ailanthi 17 weight portion, Cortex berberidis dasystachyae 9 weight portion, Herba Celosiae argenteae 18 weight portion, the Radix Pulsatillae 26 weight portion, Herba Euphorbiae Humifusae 24 weight portion, Herba Agrimoniae 14 weight portion, Radix Sanguisorbae 22 weight portion, DIGEN 15 weight portion, Herba Kummerowiae Striatae 14 weight portion, Herba Acalyphae 10 weight portion, Flos Celosiae Cristatae 17 weight portion, Flos Rhoeo discolorae 12 weight portion, Radix Codonopsis 27 weight portion, Fructus Gomphocarpi futicosi 10 weight portion, the Radix Aucklandiae 21 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9 weight portion。
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 33 weight portion, Fructus Quisqualis 34 weight portion, Folium Bruceae 24 weight portion, Fructus Carpesii 6 weight portion, Rhizoma Osmundae 6 weight portion, Herba Verbenae 25 weight portion, Semen alpinia zerumbet 14 weight portion, Flos Averrhoae Carambolae 15 weight portion, Cortex Dictamni 17 weight portion, Radix Gentianae Macrophyllae 13 weight portion, Cortex Ailanthi 23 weight portion, Cortex berberidis dasystachyae 15 weight portion, Herba Celosiae argenteae 20 weight portion, the Radix Pulsatillae 23 weight portion, Herba Euphorbiae Humifusae 27 weight portion, Herba Agrimoniae 24 weight portion, Radix Sanguisorbae 28 weight portion, DIGEN 12 weight portion, Herba Kummerowiae Striatae 16 weight portion, Herba Acalyphae 13 weight portion, Flos Celosiae Cristatae 20 weight portion, Flos Rhoeo discolorae 15 weight portion, Radix Codonopsis 30 weight portion, Fructus Gomphocarpi futicosi 16 weight portion, the Radix Aucklandiae 23 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 16 weight portion。
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 29 weight portion, Fructus Quisqualis 31 weight portion, Folium Bruceae 31 weight portion, Fructus Carpesii 5 weight portion, Rhizoma Osmundae 4 weight portion, Herba Verbenae 23 weight portion, Semen alpinia zerumbet 20 weight portion, Flos Averrhoae Carambolae 11 weight portion, Cortex Dictamni 14 weight portion, Radix Gentianae Macrophyllae 18 weight portion, Cortex Ailanthi 20 weight portion, Cortex berberidis dasystachyae 12 weight portion, Herba Celosiae argenteae 15 weight portion, the Radix Pulsatillae 20 weight portion, Herba Euphorbiae Humifusae 21 weight portion, Herba Agrimoniae 17 weight portion, Radix Sanguisorbae 26 weight portion, DIGEN 9 weight portion, Herba Kummerowiae Striatae 20 weight portion, Herba Acalyphae 17 weight portion, Flos Celosiae Cristatae 15 weight portion, Flos Rhoeo discolorae 19 weight portion, Radix Codonopsis 23 weight portion, Fructus Gomphocarpi futicosi 14 weight portion, the Radix Aucklandiae 18 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 12 weight portion。
In order to realize goal of the invention better, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating chicken taeniasis, when the dosage form of Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
In order to realize goal of the invention better, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating chicken taeniasis, when the dosage form of Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition composition powders。
The technical scheme that the embodiment of the present invention provides has the benefit that the Chinese medicine composition of the present invention can overcome the various defects of Chinese medicine of the prior art and Western medicine, improve the immunity of organisms of ill chicken, the course for the treatment of is shorter, curative effect is better, controlling difficulty in relapse after healing, have no drug resistance, prolonged application has no drug resistance, drug residue free, cost price is cheap。
Detailed description of the invention
The invention provides a kind of Chinese medicine composition for preventing and treating chicken taeniasis, Chinese medicine composition includes following raw medicinal material: Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Fructus Quisqualis, Folium Bruceae, Fructus Carpesii, Rhizoma Osmundae, Herba Verbenae, Semen alpinia zerumbet, Flos Averrhoae Carambolae, Cortex Dictamni, Radix Gentianae Macrophyllae, Cortex Ailanthi, Cortex berberidis dasystachyae, Herba Celosiae argenteae, the Radix Pulsatillae, Herba Euphorbiae Humifusae, Herba Agrimoniae, Radix Sanguisorbae, DIGEN, Herba Kummerowiae Striatae, Herba Acalyphae, Flos Celosiae Cristatae, Flos Rhoeo discolorae, Radix Codonopsis, Fructus Gomphocarpi futicosi, the Radix Aucklandiae and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae)。
The pharmacology of each raw medicinal material is as follows:
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): another name razor handle, Cordyceps, Anisomeles indica (L.) Kuntze, cured fish grass, hundred labor tongues, Manitis tongue。Pulse family beggar-ticks plant gourd tea, is used as medicine with Herb。Micro-hardship, puckery, cool。Heat-clearing and toxic substances removing, removing food stagnancy dampness removing, parasite killing anticorrosion。For preventing heatstroke, cold, fever, laryngopharynx swelling and pain, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, Fructus Ananadis comosi is poisoning, children's's scleroderma。
Folium Bruceae: medical material Ji Yuan: for the leaf of quassia Fructus Bruceae。Bitter in the mouth；Cold in nature。Heat-clearing and toxic substances removing；Removing dampness and killing parasites。Main carbuncle furuncle；Venom；Eczema。
Fructus Quisqualis: another name quisqualis,fructus。This product is the dry mature fruit of Combretum Racemosum plant Fructus Quisqualis。Gather during peel purpling black in autumn, remove impurity, dry。Sweet, temperature。Return spleen, stomach warp。Killing insect and eliminating accumulation。
Fructus Carpesii: another name Fructus Carpesii, ghost louse, FRUCTUS CARPESII。Fruit for feverfew Radix Carpesii。Harvesting when autumn, fruit became hot, dries, and removes scurf, impurity。Toil, flat。Parasite killing。Control abdominal pain due to worm stagnation。
Rhizoma Osmundae: the another name membrane inside the rush stalk, Luo, pass through joint, pass through canal, hundred, tiger volume, flat symbol, in passing through, pass through clock, pass through, canal is female, uncle celery, medicine canal, bronze bell, uncle duckweed, happy algae, careless Caput Circi cyanei, primary medicine, medicine algae, Herba Pteridis Multifidae, Herba pteridii latiusculi common vetch dish root, black dog ridge, cyrtomium fortunei, Herba potentillae fulgentis。It is mainly Dryopteridaceae plant dryopteris crassirhizoma, Athyriaceae plant lunathyrium acrostichoidesChing, ball Pteridiaceae plant Matteuccia strthiopteris, Osmundaceae plant osmund, the rhizome of Blechnaceae plant Blechnum orientale Linn., Brainea insignis, Rhizoma Osmundae etc.。Spring, autumn excavate, petiole of pruning, fibrous root, and Ex-all earth dries。Hardship, cool。Enter liver, stomach warp。Kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis。
Herba Verbenae: this product is the dry aerial parts of Verbenaceae Herba Verbenae。Tap when 6～August, the flowers are in blossom, remove impurity, dry。Return liver, spleen channel。Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema。
Semen alpinia zerumbet: another name Fructus Alpinia Japanicae, false Fructus Amomi。Fruit for zingiberaceous plant shellflower。Pluck when fruit is ripe, dry or oven drying at low temperature。Warm in nature, acrid in the mouth is puckery。Dry temperature cold relieving, expectorant preventing the attack (or recurrence) of malaria, spleen invigorating warming the stomach。
Flos Averrhoae Carambolae: medical material Ji Yuan: for the flower of medicine Oxalidaceae plant Fructus Averrhoae Carambolae。Sweet in the mouth；Property is put down。Liver；Gallbladder meridian。Preventing the attack (or recurrence) of malaria；Pain relieving；Removing toxic substances；Parasite killing。
Cortex Dictamni: another name Cortex Dictamni, stereotyped writing cattle, Cortex Argyreiae Seguinii Radicis, the fresh grass of sheep。This product is the dry root bark of rutaceae shaggy-fruited dittany。Spring, excavate root season in autumn two, remove silt and rough bark, strip root bark, dry。Hardship, cold。Return spleen, stomach, bladder warp。Heat clearing and damp drying, removing toxic substances of dispeling the wind。
Radix Gentianae Macrophyllae: another name gentiana straminea, Gentiana dahurica, Radix Gentianae Marcrophyllae, western Radix Gentianae Marcrophyllae, left torsion, left twist, RADIX GENTIANAE MACROPHYLLAE, RADIX GENTIANAE MACROPHYLLAE, Radix Raphani Macrophylla, plait Macrophylla。This product is the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica。First three practises title " Radix Gentianae Macrophyllae " and " gentiana straminea " respectively by character difference, and latter is practised and claimed " Gentiana dahurica "。Spring, season in autumn two excavate, and remove silt；Radix Gentianae Macrophyllae and gentiana straminea shine soft, when " diaphoresis " to surface of banking up is reddish yellow or lark, spreads out and dry, or directly dry without " diaphoresis "；Rub de-black skin when Gentiana dahurica is taken advantage of fresh with the hands, dry。Pungent, bitter, flat。Return stomach, liver, gallbladder meridian。Wind-damp dispelling, clearing away damp-heat, stopping numbness pain。
Cortex Ailanthi: another name ailanthus altissima (mill.) swingle, Cortex Ailanthi, Cortex Ailanthi, Cortex Ailanthi skin。This product is dry root bark or the dried bark of quassia ailanthus altissima (mill.) swingle。The whole year all can strip, and dries, or scrape off rough bark and dry。Bitter, puckery, cold。Return large intestine, stomach, Liver Channel。Heat clearing and damp drying, astringent therapy leukorrhagia stopping, antidiarrheal, hemostasis。
Cortex berberidis dasystachyae: call yellow three peroniums。Peel of stem for the straight fringe Radix Berberidis Amurensis of Berberidaceae plant。Between 4～May, start to sprout when coming into leaves, cut and take the stem relatively rented, scrape off rough bark, remove core, extracting yellow cortex and bast zone, dry。Hardship, cold。Heat clearing and damp drying, eliminating fire and detoxication。
Herba Celosiae argenteae: another name grass Artemisia, luxuriant Artemisia, the Kunlun grass, pheasant hat, cockscomb Herba Amaranthi tricoloris, wolf tail fruit, Meristotheca papulosa (Mont) J. Ag, common chicken hat, Herba Urariae Lagopodioidis, refer to sky pen, cow's tail is spent, dog tail Flos Celosiae Cristatae。Stem and leaf and root for amaranthaceous plant Herba Celosiae argenteae。Bitter in the mouth, is slightly cold。Dampness heat clearing away, parasite killing, hemostasis。
The Radix Pulsatillae: call Mao aunt piece flower, old biddy spends, Lao Gonghua。This product is the dry root of the ranunculaceae plant Radix Pulsatillae。Spring, season in autumn two excavate, and remove silt, dry。Hardship, cold。Return stomach, large intestine channel。Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery。
Herba Euphorbiae Humifusae: call Euphorbia helioscopia, Hydrocotyle sibthorpioides, floor file is red, Herba Chenopodii Hybridi, sleeping egg are careless, the sleeping egg of passeris montani saturati, the sleeping egg of small worm。This product is the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae or Herba Euphorbiae supinae。Summer, season in autumn two gather, and remove impurity, dry。Pungent, flat。Return liver, large intestine channel。Heat-clearing and toxic substances removing, cooling blood for hemostasis。
Herba Agrimoniae: another name Agrimony, Herba silenes fortunei, Indigofera pseudotinctoria, goldentop fossilia dentis mastodi, HUANGLONG tail, dry foot mattress。This product is the dry aerial parts of rosaceous plant Radix Agrimoniae。Summer, season in autumn two stem and leaf luxuriant time tap, remove impurity, dry。Bitter, puckery, flat。GUIXIN, Liver Channel。Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances。
Radix Sanguisorbae: Matteuccia struthiopteri, beautiful letter, Fructus Choerospondiatis。This product is rosaceous plant Radix Sanguisorbae or the dry root of the Radix Sanguisorbae that comes into leaves。The latter practises title " continuous Radix Sanguisorbae "。When spring is by germination or autumn plant withered after excavate, remove fibrous root, cleaning, drying, or take advantage of fresh slices, dry。Bitter, sour, puckery, it is slightly cold。Cooling blood for hemostasis, sore of detoxifying。
DIGEN: another name ground Radix Solani Melongenae, Herba Melastomatis dodecandri root。Root for Melastomateae plants ground。Enter liver, kidney, spleen, lung four warp。Invigorate blood circulation, hemostasis, dampness removing, removing toxic substances。
Herba Kummerowiae Striatae: another name Kummerowia striata (Thunb.) Schindl, Kummerowia Striata, Herba lespedezae virgatae, LAOYAXU, Hydrocotyle sibthorpioides, white macula turtledove nest。This product is pulse family Herba Kummerowiae Striatae platymiscium Herba Kummerowiae Striatae, with all herbal medicine。Xia Qiu gathers, and cleans to chop up and dries。Also can using fresh herb。
Herba Acalyphae: containing pearl, wild flax grass in another name people Herba Amaranthi tricoloris, Herba Chenopodii Hybridi, Acalypha australis, summarized bucket dress Margarita, leaf。Euphorbiaceae Acalypha plant iron Amaranthus mangostanus L., with all herbal medicine。Xia Qiu gathers herb, removes earth, dries。Bitter, puckery, cool。Heat-clearing and toxic substances removing, removing food stagnancy, dysentery relieving, hemostasis。
Flos Celosiae Cristatae: another name cock flower, chicken hair worn in a bun or coil flower, cockscomb head。This product is the dry inflorescence of amaranthaceous plant Flos Celosiae Cristatae。Gather when autumn is spent in full bloom, dry。Sweet, puckery, cool。Return liver, large intestine channel。Astringing to arrest bleeding, leukorrhagia stopping, dysentery relieving。
Flos Rhoeo discolorae: another name freshwater mussel flower, purple Flos Rohdeae Japonicae, pocket orchid, freshwater mussel orchid clothing, Pedicellus et Pericarpium Trapae flower, red Flos Rhoeo discolorae, state army。Flower for Commelianaceae plant purple Rohdea japonica Roth。Sweet；Cool；Light。Removing heat from the lung and dissipating phlegm；Cooling blood for hemostasis；Removing toxic substances dysentery relieving。
Radix Codonopsis: another name east party, platform party, the Lushui River party, mouth party。This product is the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen。Autumn excavates, and cleans, dries。Sweet, flat。Return spleen, lung meridian。Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting。
Fructus Gomphocarpi futicosi: for the aerial parts of trailing plants section plant Fructus Gomphocarpi futicosi。Sweet；Flat。Spleen；Stomach warp。Invigorating the spleen and regulating the stomach；Lung benefiting。
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae。Autumn, season in winter two excavate, and remove silt and fibrous root, cutting, and big vertical profile again becomes lobe, hits rough bark after drying。Pungent, bitter, temperature。Return spleen, stomach, large intestine, three burnt, gallbladder meridians。Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion。
Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae): another name rescues army provisions, red fruit, Chinese firethom, torch fruit, Fructus Pyracanthae, Fortune Firethorn Fruit, water sand, bean gold ma, little Fructus Pyracanthae, fire spine。Fruit for rosaceous plant fire spine。Sweet；Acid；Puckery；Flat。Liver；Spleen；Stomach warp。Spleen invigorating removing food stagnancy；Convergence dysentery relieving；
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this。
Embodiment 1 Chinese medicine composition 1
Embodiments provide a kind of Chinese medicine composition for preventing and treating chicken taeniasis, be made up of the raw medicinal material of following weight: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 36g, Fructus Quisqualis 26g, Folium Bruceae 28g, Fructus Carpesii 8g, Rhizoma Osmundae 3g, Herba Verbenae 20g, Semen alpinia zerumbet 17g, Flos Averrhoae Carambolae 13g, Cortex Dictamni 19g, Radix Gentianae Macrophyllae 23g, Cortex Ailanthi 17g, Cortex berberidis dasystachyae 9g, Herba Celosiae argenteae 18g, Radix Pulsatillae 26g, Herba Euphorbiae Humifusae 24g, Herba Agrimoniae 14g, Radix Sanguisorbae 22g, DIGEN 15g, Herba Kummerowiae Striatae 14g, Herba Acalyphae 10g, Flos Celosiae Cristatae 17g, Flos Rhoeo discolorae 12g, Radix Codonopsis 27g, Fructus Gomphocarpi futicosi 10g, Radix Aucklandiae 21g and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9g。
The dosage form of Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 3 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 90% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 30 hours when 9 DEG C, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, concentrate and dry, and pulverizing 50 minutes in super micron mill are put at this, the mixed powder that the micron particles of 4 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1.5g needle-use activated carbon, is sufficiently stirred for 40 minutes；Decarbonization filtering；With 0.23 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
Embodiment 2 Chinese medicine composition 2
Embodiments provide the Chinese medicine composition for preventing and treating chicken taeniasis, be made up of the raw medicinal material of following parts by weight: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 33g, Fructus Quisqualis 34g, Folium Bruceae 24g, Fructus Carpesii 6g, Rhizoma Osmundae 6g, Herba Verbenae 25g, Semen alpinia zerumbet 14g, Flos Averrhoae Carambolae 15g, Cortex Dictamni 17g, Radix Gentianae Macrophyllae 13g, Cortex Ailanthi 23g, Cortex berberidis dasystachyae 15g, Herba Celosiae argenteae 20g, Radix Pulsatillae 23g, Herba Euphorbiae Humifusae 27g, Herba Agrimoniae 24g, Radix Sanguisorbae 28g, DIGEN 12g, Herba Kummerowiae Striatae 16g, Herba Acalyphae 13g, Flos Celosiae Cristatae 20g, Flos Rhoeo discolorae 15g, Radix Codonopsis 30g, Fructus Gomphocarpi futicosi 16g, Radix Aucklandiae 23g and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 16g。
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10 minutes, heating, to boiling 40 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1 times after concentration is 80% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtain filtrate after taking its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C, leaving air temp 70 DEG C, be ground into 300 orders subsequently, it is thus achieved that Powdered Chinese medicine composition composition powders。
Embodiment 3 Chinese medicine composition 3
Embodiments provide the Chinese medicine composition for preventing and treating chicken taeniasis, be made up of the raw medicinal material of following parts by weight: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 29g, Fructus Quisqualis 31g, Folium Bruceae 31g, Fructus Carpesii 5g, Rhizoma Osmundae 4g, Herba Verbenae 23g, Semen alpinia zerumbet 20g, Flos Averrhoae Carambolae 11g, Cortex Dictamni 14g, Radix Gentianae Macrophyllae 18g, Cortex Ailanthi 20g, Cortex berberidis dasystachyae 12g, Herba Celosiae argenteae 15g, Radix Pulsatillae 20g, Herba Euphorbiae Humifusae 21g, Herba Agrimoniae 17g, Radix Sanguisorbae 26g, DIGEN 9g, Herba Kummerowiae Striatae 20g, Herba Acalyphae 17g, Flos Celosiae Cristatae 15g, Flos Rhoeo discolorae 19g, Radix Codonopsis 23g, Fructus Gomphocarpi futicosi 14g, Radix Aucklandiae 18g and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 12g。
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10 minutes, heating, to boiling 40 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1 times after concentration is 80% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtain filtrate after taking its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C, leaving air temp 70 DEG C, be ground into 300 orders subsequently, it is thus achieved that Powdered Chinese medicine composition composition powders。
The toxicity test of Chinese medicine composition:
1, trial drug
Choose Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 36g, Fructus Quisqualis 26g, Folium Bruceae 28g, Fructus Carpesii 8g, Rhizoma Osmundae 3g, Herba Verbenae 20g, Semen alpinia zerumbet 17g, Flos Averrhoae Carambolae 13g, Cortex Dictamni 19g, Radix Gentianae Macrophyllae 23g, Cortex Ailanthi 17g, Cortex berberidis dasystachyae 9g, Herba Celosiae argenteae 18g, Radix Pulsatillae 26g, Herba Euphorbiae Humifusae 24g, Herba Agrimoniae 14g, Radix Sanguisorbae 22g, DIGEN 15g, Herba Kummerowiae Striatae 14g, Herba Acalyphae 10g, Flos Celosiae Cristatae 17g, Flos Rhoeo discolorae 12g, Radix Codonopsis 27g, Fructus Gomphocarpi futicosi 10g, Radix Aucklandiae 21g and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9g mixing, be ground into powder；To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue；Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the second filtrate；Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml。
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed。Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks。Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities。These parameters drug withdrawal also had no change after 2 weeks。180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher。
The toxicity test of Chinese medicine composition:
1, trial drug
Choose Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 33g, Fructus Quisqualis 34g, Folium Bruceae 24g, Fructus Carpesii 6g, Rhizoma Osmundae 6g, Herba Verbenae 25g, Semen alpinia zerumbet 14g, Flos Averrhoae Carambolae 15g, Cortex Dictamni 17g, Radix Gentianae Macrophyllae 13g, Cortex Ailanthi 23g, Cortex berberidis dasystachyae 15g, Herba Celosiae argenteae 20g, Radix Pulsatillae 23g, Herba Euphorbiae Humifusae 27g, Herba Agrimoniae 24g, Radix Sanguisorbae 28g, DIGEN 12g, Herba Kummerowiae Striatae 16g, Herba Acalyphae 13g, Flos Celosiae Cristatae 20g, Flos Rhoeo discolorae 15g, Radix Codonopsis 30g, Fructus Gomphocarpi futicosi 16g, Radix Aucklandiae 23g and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 16g mixing, be ground into powder；To obtain powder and add immersion 25 hours in 1400g cold water, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, it is thus achieved that the first filtrate, collects filtering residue；Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, decoct 1 hour every time, filter and merge filtrate, it is thus achieved that the second filtrate；Merging twice filtrate, concentrating under reduced pressure removes part water, it is thus achieved that decoction, the crude drug concentration of decoction is 3g/ml。
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed。Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks。Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities。These parameters drug withdrawal also had no change after 2 weeks。180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher。
Clinical trial
(1) material prepares
, there is chicken taeniasis symptom in various degree in chicken farm, From Shijiazhuang City of Hebei Province, and the ill chicken that random choose has been made a definite diagnosis 320, as treatment contrast test object；Another random crawl healthy chicken 320, as prevention contrast test object。
(2) laboratory diagnosis:
To 100 chickens that die of illness in chicken farm, From Shijiazhuang City of Hebei Province, dissect sick Cor Gigeriae Galli, liver, spleen no abnormality seen speckle, splenomegaly, hepatomegaly be khaki, and with steatosis；Hydroabdomen is serious；Small intestinal has petechial hemorrhage, blocks intestinal situation with polypide；Pathological changes intestinal has yellow lesser tubercle, and intestinal wall can find polypide。Take 5g feces, through crossing Bian Shi worm's ovum concentration method, it has been found that taeniasis proglottid relies profit cestode worm's ovum, spine ditch cestode worm's ovum with having to take turns。
(3) prevention contrast test
The 320 of random choose healthy chickens are randomly divided into 4 groups (embodiment group 1, embodiment group 2, embodiment group 3 and matched groups)。
Embodiment group 1 hello tradition chicken feed, and inject the injectable powder of embodiment 1, injectable powder adopts subcutaneous injection, each 2g, once a day, injects 3 days continuously；
Embodiment group 2 adds the Chinese medicine composition in the embodiment of the present invention 2 in conventional feed, is added in feedstuff according to the part by weight of 1:100, feeds 3 days；
Embodiment group 3 adds the Chinese medicine composition in the embodiment of the present invention 3 in conventional feed, is added in feedstuff according to the part by weight of 1:100, feeds 3 days；
Control group fed conventional feed；
After above-mentioned test 3 days, matched group and embodiment group 1, embodiment group 2, embodiment group 3 being carried out artificial challenge, observed and recorded respectively organizes sickness rate and the mortality rate of chicken, and result is as shown in table 1。
Table 1 preventive effect synopsis
Group Sum Morbidity number Sickness rate Death toll Mortality rate Protective rate
Embodiment group 1 80 0 0% 0 0% 100%
Embodiment group 2 80 0 0% 0 0% 100%
Embodiment group 3 80 2 2.5% 0 0% 100%
Matched group 80 68 85% 30 37.5% 62.5%
Data from table 1: chicken taeniasis is had obvious preventive effect by the feedstuff that the present invention contains Chinese medicine composition。
(4) treatment contrast test:
The ill chicken 320 made a definite diagnosis randomly selected only is randomly divided into 4 groups (treatment by Chinese herbs group 1, treatment by Chinese herbs group 2, treatment by Chinese herbs group 3 and western medicine groups), treats with different medicines,
Wherein, treatment by Chinese herbs group 1 injects the injectable powder of embodiment 1, and injectable powder adopts subcutaneous injection, each 2g, once a day, injects 3 days continuously；
Treatment by Chinese herbs group 2 selects the Chinese medicine composition 2 of embodiment 2, is added in feedstuff according to the part by weight of 3:100, feeds 3 days；
Treatment by Chinese herbs group 3 selects the Chinese medicine composition 3 of embodiment 3, is added in feedstuff according to the part by weight of 3:100, feeds 3 days；
Western medicine praziquantel 15 mg kg of body weight, No. one time batch mixing is fed, and takes once after 2 days again。
Table 2 therapeutic effect synopsis
Group Morbidity number Sickness rate Death toll Mortality rate Cure number Cure rate
Treatment by Chinese herbs group 1 80 100% 0 0% 80 100%
Treatment by Chinese herbs group 2 80 100% 1 1.25% 79 98.75%
Treatment by Chinese herbs group 3 80 100% 2 2.5% 78 97.5%
Western medicine group 80 100% 17 21.3% 63 78.8%
Data from table 2: the therapeutic effect of chicken taeniasis is substantially better than western medicine group by Chinese medicine composition of the present invention, reduce mortality rate, improve cure rate。
Model case:
Dongying city one raise chickens more than 2000 chicken 75 age in days of family Lee's raising time sudden onset, large quantities of death, sick chicken occur inappetence, feather slightly disorderly, lethargy, reproduce paralysis。Cockscomb mucosa occurs that anemia changes, and row's white, with clot loose stool, occasionally has white taeniasis proglottid to discharge。Veterinary confirms as chicken taeniasis after diagnosing。Selecting the injectable powder of embodiment 1, a 2g subcutaneous injection, 1 times/day, after inject 1 time, sick chicken starts to discharge polypide, and appetite increases, and continuously after injection 2 days, disease chicken transference cure, spirit, diet, action are normal。
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention。

Claims (10)

1. the Chinese medicine composition being used for preventing and treating chicken taeniasis, it is characterized in that, described Chinese medicine composition includes following raw medicinal material: Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Fructus Quisqualis, Folium Bruceae, Fructus Carpesii, Rhizoma Osmundae, Herba Verbenae, Semen alpinia zerumbet, Flos Averrhoae Carambolae, Cortex Dictamni, Radix Gentianae Macrophyllae, Cortex Ailanthi, Cortex berberidis dasystachyae, Herba Celosiae argenteae, the Radix Pulsatillae, Herba Euphorbiae Humifusae, Herba Agrimoniae, Radix Sanguisorbae, DIGEN, Herba Kummerowiae Striatae, Herba Acalyphae, Flos Celosiae Cristatae, Flos Rhoeo discolorae, Radix Codonopsis, Fructus Gomphocarpi futicosi, the Radix Aucklandiae and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae)。
2. the Chinese medicine composition for preventing and treating chicken taeniasis according to claim 1, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 25-41 weight portion, Fructus Quisqualis 23-38 weight portion, Folium Bruceae 20-35 weight portion, Fructus Carpesii 4-9 weight portion, Rhizoma Osmundae 2-7 weight portion, Herba Verbenae 18-30 weight portion, Semen alpinia zerumbet 11-25 weight portion, Flos Averrhoae Carambolae 8-19 weight portion, Cortex Dictamni 11-25 weight portion, Radix Gentianae Macrophyllae 10-26 weight portion, Cortex Ailanthi 13-27 weight portion, Cortex berberidis dasystachyae 7-19 weight portion, Herba Celosiae argenteae 12-22 weight portion, Radix Pulsatillae 18-30 weight portion, Herba Euphorbiae Humifusae 19-31 weight portion, Herba Agrimoniae 11-28 weight portion, Radix Sanguisorbae 20-32 weight portion, DIGEN 7-18 weight portion, Herba Kummerowiae Striatae 11-25 weight portion, Herba Acalyphae 8-20 weight portion, Flos Celosiae Cristatae 12-24 weight portion, Flos Rhoeo discolorae 10-23 weight portion, Radix Codonopsis 20-33 weight portion, Fructus Gomphocarpi futicosi 8-19 weight portion, Radix Aucklandiae 15-26 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 7-18 weight portion。
3. the Chinese medicine composition for preventing and treating chicken taeniasis according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 29-36 weight portion, Fructus Quisqualis 26-34 weight portion, Folium Bruceae 24-31 weight portion, Fructus Carpesii 5-8 weight portion, Rhizoma Osmundae 3-6 weight portion, Herba Verbenae 20-25 weight portion, Semen alpinia zerumbet 14-20 weight portion, Flos Averrhoae Carambolae 11-15 weight portion, Cortex Dictamni 14-19 weight portion, Radix Gentianae Macrophyllae 13-23 weight portion, Cortex Ailanthi 17-23 weight portion, Cortex berberidis dasystachyae 9-15 weight portion, Herba Celosiae argenteae 15-20 weight portion, Radix Pulsatillae 20-26 weight portion, Herba Euphorbiae Humifusae 21-27 weight portion, Herba Agrimoniae 14-24 weight portion, Radix Sanguisorbae 22-28 weight portion, DIGEN 9-15 weight portion, Herba Kummerowiae Striatae 14-20 weight portion, Herba Acalyphae 10-17 weight portion, Flos Celosiae Cristatae 15-20 weight portion, Flos Rhoeo discolorae 12-19 weight portion, Radix Codonopsis 23-30 weight portion, Fructus Gomphocarpi futicosi 10-16 weight portion, Radix Aucklandiae 18-23 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9-16 weight portion。
4. according to the arbitrary described Chinese medicine composition for preventing and treating chicken taeniasis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 36 weight portion, Fructus Quisqualis 26 weight portion, Folium Bruceae 28 weight portion, Fructus Carpesii 8 weight portion, Rhizoma Osmundae 3 weight portion, Herba Verbenae 20 weight portion, Semen alpinia zerumbet 17 weight portion, Flos Averrhoae Carambolae 13 weight portion, Cortex Dictamni 19 weight portion, Radix Gentianae Macrophyllae 23 weight portion, Cortex Ailanthi 17 weight portion, Cortex berberidis dasystachyae 9 weight portion, Herba Celosiae argenteae 18 weight portion, the Radix Pulsatillae 26 weight portion, Herba Euphorbiae Humifusae 24 weight portion, Herba Agrimoniae 14 weight portion, Radix Sanguisorbae 22 weight portion, DIGEN 15 weight portion, Herba Kummerowiae Striatae 14 weight portion, Herba Acalyphae 10 weight portion, Flos Celosiae Cristatae 17 weight portion, Flos Rhoeo discolorae 12 weight portion, Radix Codonopsis 27 weight portion, Fructus Gomphocarpi futicosi 10 weight portion, the Radix Aucklandiae 21 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 9 weight portion。
5. according to the arbitrary described Chinese medicine composition for preventing and treating chicken taeniasis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 33 weight portion, Fructus Quisqualis 34 weight portion, Folium Bruceae 24 weight portion, Fructus Carpesii 6 weight portion, Rhizoma Osmundae 6 weight portion, Herba Verbenae 25 weight portion, Semen alpinia zerumbet 14 weight portion, Flos Averrhoae Carambolae 15 weight portion, Cortex Dictamni 17 weight portion, Radix Gentianae Macrophyllae 13 weight portion, Cortex Ailanthi 23 weight portion, Cortex berberidis dasystachyae 15 weight portion, Herba Celosiae argenteae 20 weight portion, the Radix Pulsatillae 23 weight portion, Herba Euphorbiae Humifusae 27 weight portion, Herba Agrimoniae 24 weight portion, Radix Sanguisorbae 28 weight portion, DIGEN 12 weight portion, Herba Kummerowiae Striatae 16 weight portion, Herba Acalyphae 13 weight portion, Flos Celosiae Cristatae 20 weight portion, Flos Rhoeo discolorae 15 weight portion, Radix Codonopsis 30 weight portion, Fructus Gomphocarpi futicosi 16 weight portion, the Radix Aucklandiae 23 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 16 weight portion。
6. according to the arbitrary described Chinese medicine composition for preventing and treating chicken taeniasis of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 29 weight portion, Fructus Quisqualis 31 weight portion, Folium Bruceae 31 weight portion, Fructus Carpesii 5 weight portion, Rhizoma Osmundae 4 weight portion, Herba Verbenae 23 weight portion, Semen alpinia zerumbet 20 weight portion, Flos Averrhoae Carambolae 11 weight portion, Cortex Dictamni 14 weight portion, Radix Gentianae Macrophyllae 18 weight portion, Cortex Ailanthi 20 weight portion, Cortex berberidis dasystachyae 12 weight portion, Herba Celosiae argenteae 15 weight portion, the Radix Pulsatillae 20 weight portion, Herba Euphorbiae Humifusae 21 weight portion, Herba Agrimoniae 17 weight portion, Radix Sanguisorbae 26 weight portion, DIGEN 9 weight portion, Herba Kummerowiae Striatae 20 weight portion, Herba Acalyphae 17 weight portion, Flos Celosiae Cristatae 15 weight portion, Flos Rhoeo discolorae 19 weight portion, Radix Codonopsis 23 weight portion, Fructus Gomphocarpi futicosi 14 weight portion, the Radix Aucklandiae 18 weight portion and Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 12 weight portion。
7. the Chinese medicine composition for preventing and treating chicken taeniasis according to any one of claim 1-6, it is characterised in that the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
8. the Chinese medicine composition for preventing and treating chicken taeniasis according to any one of claim 1-6, it is characterised in that the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition composition powders。
9. the preparation method of the Chinese medicine composition for preventing and treating chicken taeniasis according to any one of claim 1-8, it is characterised in that the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
10. the preparation method of the Chinese medicine composition for preventing and treating chicken taeniasis according to any one of claim 1-8, it is characterised in that the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, puts into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, after soaking 10-25 minute, heating, to boiling 40-70 minute, separates fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；
Second step, after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentration is 80-90% ethanol, it is sufficiently mixed uniformly, places overnight so that it is precipitation, obtaining filtrate after taking its supernatant liquid filtering next day, the ethanol that precipitate determining alcohol is 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer dry, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, be ground into 300 order-400 orders subsequently, it is thus achieved that Powdered Chinese medicine composition composition powders。
CN201610197794.4A 2016-03-31 2016-03-31 Traditional Chinese medicine composition for preventing and treating cestodosis of chicken and preparation method thereof Withdrawn CN105687984A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953962A (en) * 2010-10-15 2011-01-26 新乡医学院 Chinese traditional medicine and granular preparation for treating cestodosis and preparation method thereof
CN103947890A (en) * 2014-05-13 2014-07-30 山东新希望六和集团有限公司 Feed and traditional Chinese medicine composition for preventing and treating coccidiosis in duck, and preparation method of feed
CN105267765A (en) * 2015-12-04 2016-01-27 山东新希望六和集团有限公司 Medicine composition for treating dysentery of pigs and preparing method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953962A (en) * 2010-10-15 2011-01-26 新乡医学院 Chinese traditional medicine and granular preparation for treating cestodosis and preparation method thereof
CN103947890A (en) * 2014-05-13 2014-07-30 山东新希望六和集团有限公司 Feed and traditional Chinese medicine composition for preventing and treating coccidiosis in duck, and preparation method of feed
CN105267765A (en) * 2015-12-04 2016-01-27 山东新希望六和集团有限公司 Medicine composition for treating dysentery of pigs and preparing method thereof

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