CN105535666A - Traditional Chinese medicine composition for preventing bovine rumen indigestion and preparation method - Google Patents

Traditional Chinese medicine composition for preventing bovine rumen indigestion and preparation method Download PDF

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CN105535666A
CN105535666A CN201610122902.1A CN201610122902A CN105535666A CN 105535666 A CN105535666 A CN 105535666A CN 201610122902 A CN201610122902 A CN 201610122902A CN 105535666 A CN105535666 A CN 105535666A
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radix
chinese medicine
fructus
medicine composition
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李佃场
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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Abstract

The invention discloses traditional Chinese medicine composition for preventing bovine rumen indigestion and a preparation method. The traditional Chinese medicine composition comprises raw materials as follows: radish seeds, nardostachyos root and rhizomes, bitter orange, roots of wilford swallowwort, phoenix tree seeds, rhizomes of broadleaf common valeriana, delavay blueberry roots, hawthorn fruits, rice sprouts, tamarind fruits, abelmoschus crinitus wall, roots of tung oil trees, medicated leaven, hemp seeds, songaria cynomorium herbs, peach kernels, seeds of bird rape, seeds of greenleaf piptanthus, Japanese snakegourd roots, rhubarb, fortune eupatorium herbs, perilla leaves, standing grain worms, Chinese yams, roots of Woods Greenstar and fructrs hippophae. The traditional Chinese medicine composition has the benefits as follows: the traditional Chinese medicine composition can relieve flatulence, relieve stagnation, dispel heat, invigorate the stomach, tonify the spleen and improve the immunity of cattle, is pure natural, does not have toxic or side effects and is low in cost, the cure rate is high, and rumen indigestion is not prone to relapse.

Description

A kind of Chinese medicine composition for preventing and treating bovine rumen impaction and preparation method
Technical field
The present invention relates to veterinary drug technical field, particularly a kind of Chinese medicine composition for preventing and treating bovine rumen impaction and preparation method.
Background technology
Bovine rumen impaction is due to roughage stagnant too much in cud, and cause the long-pending increase of body of stomach, cud wall is expanded, and cud digests the disease with motion function disorder normally.Palpation is hard, and rumen peristalsis sound weakens or disappears.Bovine rumen impaction also makes acute cud expand.This cause of disease is because holding expansive feedstuff, as beans, corn etc. owing to too much searching for food; Search for food in a large number without half-dried not wet Rhizoma Dioscoreae esculentae seedling, seedling of Semen arachidis hypogaeae, beanstalk etc. that hand hay cutter is disconnected; Unexpected replacing feedstuff, is particularly changed to quantity-unlimiting cun again, concentrated feed by roughage; Because of weak, oligopepsia, hypomotility, a large amount of feedstuff and be subimbition of searching for food; Cud relaxes, obstruction of omasum, traumatic reticulitis, abomasitis and hot property are sick etc. also can secondary.
Cardinal symptom: cattle their early stage, appetite, ruminate, belch reduces or stops, dry under asoscope, show as haunch, later turn round and look at abdomen, rear tripe plays abdomen, wag the tail, sleeping vertical uneasy.Cud distension during palpation and the solid sand pocket sample that presents, and have pain.Percussion is voiced sound.Weaken at the beginning of auscultation rumen peristalsis sound, disappear later.Time serious, dyspnea, groan, vomiting feces water, flow out from nasal cavity sometimes.Add and treat not in time, how because dehydration, poisoning, exhaustion or be choked to death is died.
China's western medical treatment bovine rumen impaction often adopts diarrhoea therapy, gastric lavage therapy, fluid transport therapy etc., clinical effectiveness is not obvious, comparatively large to the intestines and stomach damage, prolonged application chemical synthetic drug toxic and side effects is large, drug residue is higher, and consumer eats this type of beef and produces its immunity of organisms.Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, and strengthen cattle immunity, not easily recur after healing, cost price is cheap, has very important reality and clinical meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide one and is used for the treatment of bovine rumen impaction Chinese medicine composition, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have help digestion, pleasant, loosening bowel to relieve constipation, prevention abnormal fermentation, can relieving distension aerofluxus, logical knot purge heat, stomach invigorating spleen reinforcing, not easily recur after healing, cost price is cheap, the course for the treatment of is shorter, curative effect is better, and prolonged application has no drug resistance, drug residue free.
In order to realize foregoing invention object, the invention provides a kind of Chinese medicine composition for preventing and treating bovine rumen impaction, described Chinese medicine composition comprises following raw medicinal material: Semen Raphani, Radix Et Rhizoma Nardostachyos, Fructus Aurantii, Radix cynanchi wilfordii, Semen Firmianae, Rhizoma valerianae latifoliae, Radix Vaccinii Delavayi, Fructus Crataegi, Fructus Setariae Germinatus, Fructus Tamarindi Indicae, Hibiscus cancellatus Roxb., Radix Aleuritis Fordii, Massa Medicata Fermentata, Fructus Cannabis, Herba Cynomorii, Semen Persicae, Semen Brassicae Campestris, Semen piptanthi concoloris, Radix Trichosanthis Cucumeroidis, Radix Et Rhizoma Rhei, Herba Eupatorii, Folium Perillae, Tylorrhynchus heterochaeta Quatrefages, Rhizomadioscoreae, Polyalthia nemoralis A. D C. and fructus hippophae.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 11-20 weight portion, Radix Et Rhizoma Nardostachyos 10-25 weight portion, Fructus Aurantii 20-30 weight portion, Radix cynanchi wilfordii 10-20 weight portion, Semen Firmianae 18-33 weight portion, Rhizoma valerianae latifoliae 12-23 weight portion, Radix Vaccinii Delavayi 10-20 weight portion, Fructus Crataegi 25-40 weight portion, Fructus Setariae Germinatus 20-37 weight portion, Fructus Tamarindi Indicae 8-20 weight portion, Hibiscus cancellatus Roxb. 13-25 weight portion, Radix Aleuritis Fordii 2-6 weight portion, Massa Medicata Fermentata 20-35 weight portion, Fructus Cannabis 7-15 weight portion, Herba Cynomorii 10-25 weight portion, Semen Persicae 11-24 weight portion, Semen Brassicae Campestris 15-30 weight portion, Semen piptanthi concoloris 12-20 weight portion, Radix Trichosanthis Cucumeroidis 5-10 weight portion, Radix Et Rhizoma Rhei 15-25 weight portion, Herba Eupatorii 7-17 weight portion, Folium Perillae 15-25 weight portion, Tylorrhynchus heterochaeta Quatrefages 15-25 weight portion, Rhizomadioscoreae 15-25 weight portion, Polyalthia nemoralis A. D C. 8-15 weight portion and fructus hippophae 23-36 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 13-17 weight portion, Radix Et Rhizoma Nardostachyos 12-20 weight portion, Fructus Aurantii 23-27 weight portion, Radix cynanchi wilfordii 13-17 weight portion, Semen Firmianae 20-30 weight portion, Rhizoma valerianae latifoliae 16-20 weight portion, Radix Vaccinii Delavayi 15-18 weight portion, Fructus Crataegi 27-35 weight portion, Fructus Setariae Germinatus 25-33 weight portion, Fructus Tamarindi Indicae 11-18 weight portion, Hibiscus cancellatus Roxb. 18-22 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Massa Medicata Fermentata 24-30 weight portion, Fructus Cannabis 10-12 weight portion, Herba Cynomorii 14-20 weight portion, Semen Persicae 15-20 weight portion, Semen Brassicae Campestris 19-25 weight portion, Semen piptanthi concoloris 15-18 weight portion, Radix Trichosanthis Cucumeroidis 7-9 weight portion, Radix Et Rhizoma Rhei 17-20 weight portion, Herba Eupatorii 10-15 weight portion, Folium Perillae 17-22 weight portion, Tylorrhynchus heterochaeta Quatrefages 17-22 weight portion, Rhizomadioscoreae 17-22 weight portion, Polyalthia nemoralis A. D C. 10-13 weight portion and fructus hippophae 25-35 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 13 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, Fructus Aurantii 23 weight portion, Radix cynanchi wilfordii 17 weight portion, Semen Firmianae 30 weight portion, Rhizoma valerianae latifoliae 16 weight portion, Radix Vaccinii Delavayi 18 weight portion, Fructus Crataegi 35 weight portion, Fructus Setariae Germinatus 25 weight portion, Fructus Tamarindi Indicae 11 weight portion, Hibiscus cancellatus Roxb. 22 weight portion, Radix Aleuritis Fordii 4 weight portion, Massa Medicata Fermentata 30 weight portion, Fructus Cannabis 10 weight portion, Herba Cynomorii 14 weight portion, Semen Persicae 15 weight portion, Semen Brassicae Campestris 25 weight portion, Semen piptanthi concoloris 15 weight portion, Radix Trichosanthis Cucumeroidis 7 weight portion, Radix Et Rhizoma Rhei 18 weight portion, Herba Eupatorii 10 weight portion, Folium Perillae 22 weight portion, Tylorrhynchus heterochaeta Quatrefages 17 weight portion, Rhizomadioscoreae 17 weight portion, Polyalthia nemoralis A. D C. 13 weight portion and fructus hippophae 25 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 17 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Fructus Aurantii 27 weight portion, Radix cynanchi wilfordii 13 weight portion, Semen Firmianae 20 weight portion, Rhizoma valerianae latifoliae 20 weight portion, Radix Vaccinii Delavayi 15 weight portion, Fructus Crataegi 27 weight portion, Fructus Setariae Germinatus 33 weight portion, Fructus Tamarindi Indicae 18 weight portion, Hibiscus cancellatus Roxb. 18 weight portion, Radix Aleuritis Fordii 3 weight portion, Massa Medicata Fermentata 24 weight portion, Fructus Cannabis 12 weight portion, Herba Cynomorii 20 weight portion, Semen Persicae 20 weight portion, Semen Brassicae Campestris 19 weight portion, Semen piptanthi concoloris 18 weight portion, Radix Trichosanthis Cucumeroidis 9 weight portion, Radix Et Rhizoma Rhei 20 weight portion, Herba Eupatorii 15 weight portion, Folium Perillae 17 weight portion, Tylorrhynchus heterochaeta Quatrefages 22 weight portion, Rhizomadioscoreae 22 weight portion, Polyalthia nemoralis A. D C. 10 weight portion and fructus hippophae 35 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 15 weight portion, Radix Et Rhizoma Nardostachyos 16 weight portion, Fructus Aurantii 25 weight portion, Radix cynanchi wilfordii 15 weight portion, Semen Firmianae 25 weight portion, Rhizoma valerianae latifoliae 18 weight portion, Radix Vaccinii Delavayi 17 weight portion, Fructus Crataegi 30 weight portion, Fructus Setariae Germinatus 30 weight portion, Fructus Tamarindi Indicae 15 weight portion, Hibiscus cancellatus Roxb. 20 weight portion, Radix Aleuritis Fordii 5 weight portion, Massa Medicata Fermentata 27 weight portion, Fructus Cannabis 11 weight portion, Herba Cynomorii 17 weight portion, Semen Persicae 18 weight portion, Semen Brassicae Campestris 21 weight portion, Semen piptanthi concoloris 17 weight portion, Radix Trichosanthis Cucumeroidis 8 weight portion, Radix Et Rhizoma Rhei 17 weight portion, Herba Eupatorii 13 weight portion, Folium Perillae 19 weight portion, Tylorrhynchus heterochaeta Quatrefages 20 weight portion, Rhizomadioscoreae 19 weight portion, Polyalthia nemoralis A. D C. 12 weight portion and fructus hippophae 31 weight portion.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method of the Chinese medicine composition for preventing and treating bovine rumen impaction, and when the dosage form of Chinese medicine composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method of the Chinese medicine composition for preventing and treating bovine rumen impaction, and when the dosage form of Chinese medicine composition is powder, its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Powdered Chinese medicine composition.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: pharmaceutical composition of the present invention can overcome the various defects of Chinese medicine of the prior art and Western medicine, have help digestion, pleasant, loosening bowel to relieve constipation, prevention abnormal fermentation effect, can relieving distension aerofluxus, logical knot purge heat, stomach invigorating spleen reinforcing, improve the immunity of organisms of ill cattle, the course for the treatment of is shorter, curative effect is better, not easily recur after healing, have no drug resistance, prolonged application has no drug resistance, drug residue free, cost price is cheap.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition for preventing and treating bovine rumen impaction, Chinese medicine composition comprises following raw medicinal material: Semen Raphani, Radix Et Rhizoma Nardostachyos, Fructus Aurantii, Radix cynanchi wilfordii, Semen Firmianae, Rhizoma valerianae latifoliae, Radix Vaccinii Delavayi, Fructus Crataegi, Fructus Setariae Germinatus, Fructus Tamarindi Indicae, Hibiscus cancellatus Roxb., Radix Aleuritis Fordii, Massa Medicata Fermentata, Fructus Cannabis, Herba Cynomorii, Semen Persicae, Semen Brassicae Campestris, Semen piptanthi concoloris, Radix Trichosanthis Cucumeroidis, Radix Et Rhizoma Rhei, Herba Eupatorii, Folium Perillae, Tylorrhynchus heterochaeta Quatrefages, Rhizomadioscoreae, Polyalthia nemoralis A. D C. and fructus hippophae.
Wherein, Semen Raphani, Radix Et Rhizoma Nardostachyos, Fructus Aurantii, Radix cynanchi wilfordii, Semen Firmianae, Rhizoma valerianae latifoliae, Radix Vaccinii Delavayi, Fructus Crataegi, Fructus Setariae Germinatus, Fructus Tamarindi Indicae, Hibiscus cancellatus Roxb., Radix Aleuritis Fordii, Massa Medicata Fermentata help digestion pleasant; Fructus Cannabis, Herba Cynomorii, Semen Persicae, Semen Brassicae Campestris, Semen piptanthi concoloris loosening bowel to relieve constipation; Radix Trichosanthis Cucumeroidis, Radix Et Rhizoma Rhei lead to Exchange Settlement heat; Herba Eupatorii, Folium Perillae, Tylorrhynchus heterochaeta Quatrefages, Rhizomadioscoreae, Polyalthia nemoralis A. D C., fructus hippophae stomach invigorating spleen reinforcing.
The pharmacology of each raw medicinal material is as follows:
Semen Raphani: Semen Raphani, pungent, sweet, flat.Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.
Radix Et Rhizoma Nardostachyos: Nardostachys chinensis Batal., product are the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos or spoon Ye Gansong.Spring, Qiu Erji excavate, and removing silt and impurity, dry or dry in the shade.Acrid, sweet, warm.Return spleen, stomach warp.Regulating QI to relieve pain, relieving stagnation and activating the spleen.For distension and fullness in the abdomen, inappetence.
Fructus Aurantii: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..Gather between 7 ~ August, from middle part crosscut into two, dry in the shade, air-dry or low baking temperature dries.Toil, cool, enter lung, spleen, large intestine channel.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.
Radix cynanchi wilfordii: Radix cynanchi wilfordii, mountain on the other way round spade.For the tuber of asclepiadaceae plant cynanchum auriculatum Royle.Autumn gathers, and cleans, dries.Sweetness and bitterness, flat, nontoxic.Yin nourishing tonify deficiency, strengthening the spleen to promote digestion.
Semen Firmianae: wooden dipper fruit, paulownia fiber crops pea.For the seed of Sterculiaceae plant Firmiana platanifolia (Linn. f.) Marsili.Adopted down by Fruit branch during seed maturity in autumn, hit seed down, decontamination of winnowing with a dustpan, dries.Close storage drying place, mothproof.Sweet, flat, enter the heart, lung, kidney three warp.Pleasant, stomach function regulating, helps digestion.
Rhizoma valerianae latifoliae: Herba Asari, TUXIXIN, lobus cardiacus Rhizoma et radix valerianae, lotus of nourishing heart, lotus of nourishing blood, smelly medicine, Wu Can, Radix decaisneae fargesii, tiger seven, Rhizoma et radix valerianae.Valerianaceae valerian Aranea grass, is used as medicine with root stock and root.Autumn and winter excavate, and remove residual leaf, clean and dry.Pungent, micro-hardship, temperature.Promoting digestion and invigorating the stomach, regulating QI to relieve pain, removing toxic substances of dispeling the wind.
Radix Vaccinii Delavayi: mountain Lignum Santali Albi, soil melon, Pyrusussuriensis.Ericaceae Fructus Vaccinii Bracteati platymiscium Cangshan Pericarpium Citri tangerinae., be used as medicine with root.The four seasons can adopt, and section is dried.Sweet, pungent, flat.Circulation of qi promoting, helps digestion.For chest and abdomen swelling and pain, food does not disappear.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.Gather during fruit maturation in autumn, section, dry.Sour, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
Fructus Setariae Germinatus: Fructus Setariae Germinatus, this product is that the mature fruit of grass foxtail millet obtains through drying of germinateing.After foxtail millet paddy is soaked in water, keeps suitable epidemic disaster, when fibrous root grows to about 6mm, dry or cold drying.Sweet, temperature.Return spleen, stomach warp.Help digestion and in, spleen benefiting and stimulating the appetite.
Fructus Tamarindi Indicae: sour dumpling, dark plum, Radix seu Caulis Kadsurae Heteroclitae.For the fruit of leguminous plant tamarind.Spring plucks, and removing seed, dries.Sweet acid, cool.Clearing away summer-heat heat, eliminate indigestion is stagnant.
Hibiscus cancellatus Roxb.: check leaf Hibiscus syriacus L., Herba anemones vitifoliae.Malvaceae Hibiscus cancellatus Roxb.., be used as medicine with root, flower.Light, flat.Spleen reinforcing, eliminating mass and relieving fullness, stimulates the menstrual flow, and helps digestion.
Radix Aleuritis Fordii: seeds of a tung oil tree tree root, Oleum Verniciae fordii tree Jiang, high seeds of a tung oil tree root, Oleum Verniciae fordii tree root.For the tree root of euphorbia plant Aleurites fordii Hemsl., 9 ~ October gathers, using fresh herb or dry.Pungent, cold.Help digestion, diuretic, reduces phlegm.
Massa Medicata Fermentata: Massa Medicata Fermentata, for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Sweet, acrid, warm.Enter spleen, stomach warp.Invigorating the spleen and regulating the stomach, helps digestion in adjusting.
Fructus Cannabis: cannabis,fructus, Urtica cannabina L., hemp.This product is moraceae plants Fructus Cannabis. dry mature fruit.Gather during fruit maturation in autumn, removing impurity, dries.Sweet, flat.Return spleen, stomach, large intestine channel.Loosening bowel to relieve constipation.
Herba Cynomorii: rust iron hammer, ball top, lock swallow.This product is the dry meat stem of Cynomoriaceae plant Herba Cynomorii.Spring excavates, and removing inflorescence, cutting, dries.Sweet, temperature.Return spleen, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Semen Persicae: this product is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.Bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Semen Brassicae Campestris: coleseed.For the seed of crucifer Brassica campestris L.Pungent; Sweet; Flat.Liver; Kidney channel.Blood circulation promoting and blood stasis dispelling; Dispersing swelling and dissipating binds; Loosening bowel to relieve constipation.
Semen piptanthi concoloris: be the seed of leguminous plant Semen piptanthi concoloris.Gather during fruit maturation, dry, lay seed.Sweet light, be slightly cold.Liver heat removing and eyesight improving, diuretic, intestine moistening.
Radix Trichosanthis Cucumeroidis: hang melon, Ipomoea hungaiensis Lingelsh. Et Borza., Fructus Momordicae charantiae lotus.For the root of Cucurbitaceae Trichosanthes Fructus Trichosanthis Cucumeroidis.Late autumn uproots, and washes away earth, and cutting is dried.Hardship, cold.Slightly poisonous.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, eliminating stasis to stop pain.
Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, and removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.Hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Herba Eupatorii: Herba Chlorophyti, Herba Lycopi, circle stalk Herba Lycopi, Ocimum basilicum L. var. pilosum.This product is the dry aerial parts of feverfew Herba Eupatorii.Summer, Qiu Erji tap at twice, and removing impurity, dries.Pungent, flat.Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, appetizing of being amusing.
Folium Perillae: Folium Perillae, this product is the dried leaves (or band twig) of labiate Folium Perillae.Gather when summer, branch and leaf were luxuriant, removing impurity, dries.Pungent, temperature.Return lung, spleen channel.Induce sweat cold expelling, relieving QI stagnancy in the stomach.
Tylorrhynchus heterochaeta Quatrefages: sandworm, clam worm, extra large locust earthworm, medical material Ji Yuan: be the entirety of Nereidae animal Tylorrhynchus heter Ochatetus.Sweet in the mouth; Warm in nature, spleen; Stomach warp.Tonifying the spleen and stomach; QI invigorating.
Rhizomadioscoreae: Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Flat, sweet, nontoxic.Enter lung, spleen, kidney, stomach.Spleen invigorating, thick the intestines and stomach.
Polyalthia nemoralis A. D C.: Lingshui Polyalthia suberosa (Roxb.) Thw, fall bank potato.Annonaceae Polyalthia nemoralis A. D C., is used as medicine with root.Sweet, flat.Spleen reinforcing stomach invigorating, tonifying the kidney to consolidate the essence.
Fructus hippophae: Fructus Elaeagni Angustifoliae, large Er Buxing.For the fruit of Elaeangnaceae plant Fructus Hippophae.10 ~ November, harvesting ripe fruit, dried.Warm in nature, sour-puckery flavor.Enter liver, stomach, intestine and small intestine warp.Promoting blood circulation to remove blood stasis, reduce phlegm the chest stuffiness relieving, spleen reinforcing stomach invigorating.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
Embodiments providing a kind of Chinese medicine composition for preventing and treating bovine rumen impaction, being made up of the raw medicinal material of following weight: Semen Raphani 13g, Radix Et Rhizoma Nardostachyos 12g, Fructus Aurantii 23g, Radix cynanchi wilfordii 17g, Semen Firmianae 30g, Rhizoma valerianae latifoliae 16g, Radix Vaccinii Delavayi 18g, Fructus Crataegi 35g, Fructus Setariae Germinatus 25g, Fructus Tamarindi Indicae 11g, Hibiscus cancellatus Roxb. 22g, Radix Aleuritis Fordii 4g, Massa Medicata Fermentata 30g, Fructus Cannabis 10g, Herba Cynomorii 14g, Semen Persicae 15g, Semen Brassicae Campestris 25g, Semen piptanthi concoloris 15g, Radix Trichosanthis Cucumeroidis 7g, Radix Et Rhizoma Rhei 18g, Herba Eupatorii 10g, Folium Perillae 22g, Tylorrhynchus heterochaeta Quatrefages 17g, Rhizomadioscoreae 17g, Polyalthia nemoralis A. D C. 13g and fructus hippophae 25g.
The dosage form of Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2 Chinese medicine composition 2
Embodiments providing the Chinese medicine composition for preventing and treating bovine rumen impaction, being made up of the raw medicinal material of following parts by weight: Semen Raphani 17g, Radix Et Rhizoma Nardostachyos 20g, Fructus Aurantii 27g, Radix cynanchi wilfordii 13g, Semen Firmianae 20g, Rhizoma valerianae latifoliae 20g, Radix Vaccinii Delavayi 15g, Fructus Crataegi 27g, Fructus Setariae Germinatus 33g, Fructus Tamarindi Indicae 18g, Hibiscus cancellatus Roxb. 18g, Radix Aleuritis Fordii 3g, Massa Medicata Fermentata 24g, Fructus Cannabis 12g, Herba Cynomorii 20g, Semen Persicae 20g, Semen Brassicae Campestris 19g, Semen piptanthi concoloris 18g, Radix Trichosanthis Cucumeroidis 9g, Radix Et Rhizoma Rhei 20g, Herba Eupatorii 15g, Folium Perillae 17g, Tylorrhynchus heterochaeta Quatrefages 22g, Rhizomadioscoreae 22g, Polyalthia nemoralis A. D C. 10g and fructus hippophae 35g.
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10 minutes, be heated to boiling after 40 minutes, be separated fried liquid, medicinal residues again add water and carry out decoction 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 1 times is 80% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Powdered Chinese medicine composition.
Embodiment 3 Chinese medicine composition 3
Embodiments providing the Chinese medicine composition for preventing and treating bovine rumen impaction, being made up of the raw medicinal material of following parts by weight: Semen Raphani 15g, Radix Et Rhizoma Nardostachyos 16g, Fructus Aurantii 25g, Radix cynanchi wilfordii 15g, Semen Firmianae 25g, Rhizoma valerianae latifoliae 18g, Radix Vaccinii Delavayi 17g, Fructus Crataegi 30g, Fructus Setariae Germinatus 30g, Fructus Tamarindi Indicae 15g, Hibiscus cancellatus Roxb. 20g, Radix Aleuritis Fordii 5g, Massa Medicata Fermentata 27g, Fructus Cannabis 11g, Herba Cynomorii 17g, Semen Persicae 18g, Semen Brassicae Campestris 21g, Semen piptanthi concoloris 17g, Radix Trichosanthis Cucumeroidis 8g, Radix Et Rhizoma Rhei 17g, Herba Eupatorii 13g, Folium Perillae 19g, Tylorrhynchus heterochaeta Quatrefages 20g, Rhizomadioscoreae 19g, Polyalthia nemoralis A. D C. 12g and fructus hippophae 31g.
The dosage form of Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10 minutes, be heated to boiling after 40 minutes, be separated fried liquid, medicinal residues again add water and carry out decoction 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 1 times is 80% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Powdered Chinese medicine composition.
The toxicity test of Chinese medicine composition:
1, trial drug
Choose Semen Raphani 15g, Radix Et Rhizoma Nardostachyos 16g, Fructus Aurantii 25g, Radix cynanchi wilfordii 15g, Semen Firmianae 25g, Rhizoma valerianae latifoliae 18g, Radix Vaccinii Delavayi 17g, Fructus Crataegi 30g, Fructus Setariae Germinatus 30g, Fructus Tamarindi Indicae 15g, Hibiscus cancellatus Roxb. 20g, Radix Aleuritis Fordii 5g, Massa Medicata Fermentata 27g, Fructus Cannabis 11g, Herba Cynomorii 17g, Semen Persicae 18g, Semen Brassicae Campestris 21g, Semen piptanthi concoloris 17g, Radix Trichosanthis Cucumeroidis 8g, Radix Et Rhizoma Rhei 17g, Herba Eupatorii 13g, Folium Perillae 19g, Tylorrhynchus heterochaeta Quatrefages 20g, Rhizomadioscoreae 19g, Polyalthia nemoralis A. D C. 12g and fructus hippophae 31g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
The toxicity test of Chinese medicine composition:
1, trial drug
Choose Semen Raphani 13g, Radix Et Rhizoma Nardostachyos 12g, Fructus Aurantii 23g, Radix cynanchi wilfordii 17g, Semen Firmianae 30g, Rhizoma valerianae latifoliae 16g, Radix Vaccinii Delavayi 18g, Fructus Crataegi 35g, Fructus Setariae Germinatus 25g, Fructus Tamarindi Indicae 11g, Hibiscus cancellatus Roxb. 22g, Radix Aleuritis Fordii 4g, Massa Medicata Fermentata 30g, Fructus Cannabis 10g, Herba Cynomorii 14g, Semen Persicae 15g, Semen Brassicae Campestris 25g, Semen piptanthi concoloris 15g, Radix Trichosanthis Cucumeroidis 7g, Radix Et Rhizoma Rhei 18g, Herba Eupatorii 10g, Folium Perillae 22g, Tylorrhynchus heterochaeta Quatrefages 17g, Rhizomadioscoreae 17g, Polyalthia nemoralis A. D C. 13g and fructus hippophae 25g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Clinical trial
(1) for examination animal
Experiment cattle and place are chosen:
80, cattle farm, 30, Lanzhou City, Gansu Province is selected to suffer from the cattle of bovine rumen impaction disease for treatment contrast test object.Another in these 30 cattle farms random selecting 180 healthy cattle as prevention contrast test object.
(2) contrast experiment is prevented:
180 of random choose cattle are divided at random 4 groups (embodiment group 1, embodiment group 2, embodiment group 3 and matched groups),
Wherein, matched group uses traditional cattle feedstuff to feed cattle, does not use any medicine;
Embodiment group 1 is fed traditional cattle feedstuff, and injects the injectable powder of embodiment 1, and injectable powder adopts subcutaneous injection, only injects once each 60mg/kg every day, within one week, injects 3 times;
Embodiment group 2 adds the Chinese medicine composition in the embodiment of the present invention 2 in conventional feed, is added in feedstuff according to the part by weight of 1:100, within one week, feeds 3 times;
Embodiment group 3 adds the Chinese medicine composition in the embodiment of the present invention 3 in conventional feed, is added in feedstuff according to the part by weight of 1:100, within one week, feeds 3 times;
The cattle of embodiment group 1, embodiment group 2, embodiment group 3 and matched group is fed a large amount of feeding, without half-dried not wet Rhizoma Dioscoreae esculentae seedling, seedling of Semen arachidis hypogaeae, beanstalk etc. that hand hay cutter is disconnected; Middle replacing feedstuff, is changed to quantity-unlimiting cun again, concentrated feed by roughage; Follow the tracks of 1 year, observed and recorded respectively organizes sickness rate and the mortality rate of cattle, and result is as shown in table 1.
Observed and recorded respectively organizes sickness rate and the mortality rate of cattle, and result is as shown in table 1.
Table 1 preventive effect synopsis
Group Sum Morbidity number Sickness rate Death toll Mortality rate Protective rate 7-->
Embodiment group 1 45 1 0% 0 0% 100%
Embodiment group 2 45 1 2.2% 0 0% 97.8%
Embodiment group 3 45 0 0% 0 0 100%
Matched group 45 43 95.6% 3 6.7% 4.4%
Data from table 1: Chinese medicine composition of the present invention has obvious preventive effect to bovine rumen impaction disease, the i.e. cattle of the Chinese medicine composition of the routine use embodiment of the present invention 1, embodiment 2, embodiment 3, too much search for food once in a while, or change feedstuff suddenly, or search for food in a large number without half-dried not wet Rhizoma Dioscoreae esculentae seedling, seedling of Semen arachidis hypogaeae, beanstalk etc. that hand hay cutter is disconnected, also greatly can reduce its probability occurring the appearance of grainsick disease.
(3) contrast test is treated:
80 are suffered from the sick cattle of bovine rumen impaction disease, be divided at random 4 groups (embodiment group 1 treatment group, embodiment group 2 treatment group, embodiment group 3 treatment group and matched groups), use different medicine to treat;
Wherein, the injectable powder of embodiment group 1 treatment group injection embodiment 1, injectable powder adopts subcutaneous injection, and each 60mg/kg, once a day, discontinues medication after recovery from illness;
Embodiment group 2 treatment group selects the Chinese medicine composition 2 of embodiment 2, and dose is 0.6g/kg, one day twice, discontinues medication after recovery from illness;
Embodiment group 3 treatment group selects the Chinese medicine composition 3 of embodiment 3, and dose is 0.6g/kg, one day twice, discontinues medication after recovery from illness.
Western medicine group magnesium sulfate or sodium sulfate 500-800g, add water 1000mL, saxol or vegetable oil 1000-1500mL, then the medicinal liquid of dissolving is poured in the feedstuff weighed up, fully stir, cattle of feeding after Homogeneous phase mixing, one day twice, discontinue medication after recovery from illness;
Recovery from illness: test cattle abdominal distention after medication and disappear, spirit, diet wish, feces, ruminates and recovers normal, invalid: after medication, and test cattle spirit diet is for having no improvement, and left abdominal distention is large, breathing dyspnea with rapid respiration, and extremity open, and mouth color is livid purple, and pulse condition slides number; In the later stage, painful groan, sleeping ground is difficult to be risen or remains unconscious.
Table 2 therapeutic effect synopsis
Group Sum Cure number Death toll Mortality rate
Embodiment group 1 treatment group 20 20 0 0%
Embodiment group 2 treatment group 20 20 0 0%
Embodiment group 3 treatment group 20 20 0 0%
Western medicine group 20 17 3 15%
The sick cattle of embodiment of the present invention group 1 treatment group is all injected the symptom that obviously takes effect afterwards for 1 time and alleviates, the lighter 1 dose recovery from illness, severe one 3 doses recovery from illness; The symptom that obviously takes effect after the sick cattle of embodiment of the present invention group 2 treatment group all takes 1 dose alleviates, the lighter 2 doses recovery from illness, severe one 8 doses recovery from illness; The symptom that obviously takes effect after the sick cattle of embodiment of the present invention group 3 treatment group all takes 1 dose alleviates, the lighter 2 doses recovery from illness, severe one 6 doses recovery from illness; After the equal medication of sick cattle 2 times of western medicine group, the 80% sick cattle symptom that obviously takes effect alleviates, and the lighter's medication 4 recoveries from illness, severe one is used in conjunction recovery from illness in 7 days, wherein 3 example death.
Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to bovine rumen impaction therapeutic effect, reduce mortality rate, improve cure rate.
Model case:
In July, 2014, veterinary station was seen and treated patients 3 years old cattle, came that institute is medical suffers from bovine rumen impaction after diagnosing.Select the injectable powder of embodiment 1, dose is 60mg/kg, injects 1 time, starts belch after 5 minutes, and after 15 minutes, gastric peristalsis sound strengthens, and abdominal circumference reduces gradually, and after 40 minutes, start defecation abdominal distention substantially disappear, its symptom also takes a turn for the better gradually, within second day, recovers normal.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. one kind for preventing and treating the Chinese medicine composition of bovine rumen impaction, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Semen Raphani, Radix Et Rhizoma Nardostachyos, Fructus Aurantii, Radix cynanchi wilfordii, Semen Firmianae, Rhizoma valerianae latifoliae, Radix Vaccinii Delavayi, Fructus Crataegi, Fructus Setariae Germinatus, Fructus Tamarindi Indicae, Hibiscus cancellatus Roxb., Radix Aleuritis Fordii, Massa Medicata Fermentata, Fructus Cannabis, Herba Cynomorii, Semen Persicae, Semen Brassicae Campestris, Semen piptanthi concoloris, Radix Trichosanthis Cucumeroidis, Radix Et Rhizoma Rhei, Herba Eupatorii, Folium Perillae, Tylorrhynchus heterochaeta Quatrefages, Rhizomadioscoreae, Polyalthia nemoralis A. D C. and fructus hippophae.
2. the Chinese medicine composition for preventing and treating bovine rumen impaction according to claim 1, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 11-20 weight portion, Radix Et Rhizoma Nardostachyos 10-25 weight portion, Fructus Aurantii 20-30 weight portion, Radix cynanchi wilfordii 10-20 weight portion, Semen Firmianae 18-33 weight portion, Rhizoma valerianae latifoliae 12-23 weight portion, Radix Vaccinii Delavayi 10-20 weight portion, Fructus Crataegi 25-40 weight portion, Fructus Setariae Germinatus 20-37 weight portion, Fructus Tamarindi Indicae 8-20 weight portion, Hibiscus cancellatus Roxb. 13-25 weight portion, Radix Aleuritis Fordii 2-6 weight portion, Massa Medicata Fermentata 20-35 weight portion, Fructus Cannabis 7-15 weight portion, Herba Cynomorii 10-25 weight portion, Semen Persicae 11-24 weight portion, Semen Brassicae Campestris 15-30 weight portion, Semen piptanthi concoloris 12-20 weight portion, Radix Trichosanthis Cucumeroidis 5-10 weight portion, Radix Et Rhizoma Rhei 15-25 weight portion, Herba Eupatorii 7-17 weight portion, Folium Perillae 15-25 weight portion, Tylorrhynchus heterochaeta Quatrefages 15-25 weight portion, Rhizomadioscoreae 15-25 weight portion, Polyalthia nemoralis A. D C. 8-15 weight portion and fructus hippophae 23-36 weight portion.
3. the Chinese medicine composition for preventing and treating bovine rumen impaction according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 13-17 weight portion, Radix Et Rhizoma Nardostachyos 12-20 weight portion, Fructus Aurantii 23-27 weight portion, Radix cynanchi wilfordii 13-17 weight portion, Semen Firmianae 20-30 weight portion, Rhizoma valerianae latifoliae 16-20 weight portion, Radix Vaccinii Delavayi 15-18 weight portion, Fructus Crataegi 27-35 weight portion, Fructus Setariae Germinatus 25-33 weight portion, Fructus Tamarindi Indicae 11-18 weight portion, Hibiscus cancellatus Roxb. 18-22 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Massa Medicata Fermentata 24-30 weight portion, Fructus Cannabis 10-12 weight portion, Herba Cynomorii 14-20 weight portion, Semen Persicae 15-20 weight portion, Semen Brassicae Campestris 19-25 weight portion, Semen piptanthi concoloris 15-18 weight portion, Radix Trichosanthis Cucumeroidis 7-9 weight portion, Radix Et Rhizoma Rhei 17-20 weight portion, Herba Eupatorii 10-15 weight portion, Folium Perillae 17-22 weight portion, Tylorrhynchus heterochaeta Quatrefages 17-22 weight portion, Rhizomadioscoreae 17-22 weight portion, Polyalthia nemoralis A. D C. 10-13 weight portion and fructus hippophae 25-35 weight portion.
4. according to the arbitrary described Chinese medicine composition for preventing and treating bovine rumen impaction of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 13 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, Fructus Aurantii 23 weight portion, Radix cynanchi wilfordii 17 weight portion, Semen Firmianae 30 weight portion, Rhizoma valerianae latifoliae 16 weight portion, Radix Vaccinii Delavayi 18 weight portion, Fructus Crataegi 35 weight portion, Fructus Setariae Germinatus 25 weight portion, Fructus Tamarindi Indicae 11 weight portion, Hibiscus cancellatus Roxb. 22 weight portion, Radix Aleuritis Fordii 4 weight portion, Massa Medicata Fermentata 30 weight portion, Fructus Cannabis 10 weight portion, Herba Cynomorii 14 weight portion, Semen Persicae 15 weight portion, Semen Brassicae Campestris 25 weight portion, Semen piptanthi concoloris 15 weight portion, Radix Trichosanthis Cucumeroidis 7 weight portion, Radix Et Rhizoma Rhei 18 weight portion, Herba Eupatorii 10 weight portion, Folium Perillae 22 weight portion, Tylorrhynchus heterochaeta Quatrefages 17 weight portion, Rhizomadioscoreae 17 weight portion, Polyalthia nemoralis A. D C. 13 weight portion and fructus hippophae 25 weight portion.
5. according to the arbitrary described Chinese medicine composition for preventing and treating bovine rumen impaction of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 17 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Fructus Aurantii 27 weight portion, Radix cynanchi wilfordii 13 weight portion, Semen Firmianae 20 weight portion, Rhizoma valerianae latifoliae 20 weight portion, Radix Vaccinii Delavayi 15 weight portion, Fructus Crataegi 27 weight portion, Fructus Setariae Germinatus 33 weight portion, Fructus Tamarindi Indicae 18 weight portion, Hibiscus cancellatus Roxb. 18 weight portion, Radix Aleuritis Fordii 3 weight portion, Massa Medicata Fermentata 24 weight portion, Fructus Cannabis 12 weight portion, Herba Cynomorii 20 weight portion, Semen Persicae 20 weight portion, Semen Brassicae Campestris 19 weight portion, Semen piptanthi concoloris 18 weight portion, Radix Trichosanthis Cucumeroidis 9 weight portion, Radix Et Rhizoma Rhei 20 weight portion, Herba Eupatorii 15 weight portion, Folium Perillae 17 weight portion, Tylorrhynchus heterochaeta Quatrefages 22 weight portion, Rhizomadioscoreae 22 weight portion, Polyalthia nemoralis A. D C. 10 weight portion and fructus hippophae 35 weight portion.
6. according to the arbitrary described Chinese medicine composition for preventing and treating bovine rumen impaction of claim 1-3, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Semen Raphani 15 weight portion, Radix Et Rhizoma Nardostachyos 16 weight portion, Fructus Aurantii 25 weight portion, Radix cynanchi wilfordii 15 weight portion, Semen Firmianae 25 weight portion, Rhizoma valerianae latifoliae 18 weight portion, Radix Vaccinii Delavayi 17 weight portion, Fructus Crataegi 30 weight portion, Fructus Setariae Germinatus 30 weight portion, Fructus Tamarindi Indicae 15 weight portion, Hibiscus cancellatus Roxb. 20 weight portion, Radix Aleuritis Fordii 5 weight portion, Massa Medicata Fermentata 27 weight portion, Fructus Cannabis 11 weight portion, Herba Cynomorii 17 weight portion, Semen Persicae 18 weight portion, Semen Brassicae Campestris 21 weight portion, Semen piptanthi concoloris 17 weight portion, Radix Trichosanthis Cucumeroidis 8 weight portion, Radix Et Rhizoma Rhei 17 weight portion, Herba Eupatorii 13 weight portion, Folium Perillae 19 weight portion, Tylorrhynchus heterochaeta Quatrefages 20 weight portion, Rhizomadioscoreae 19 weight portion, Polyalthia nemoralis A. D C. 12 weight portion and fructus hippophae 31 weight portion.
7. the Chinese medicine composition for preventing and treating bovine rumen impaction according to any one of claim 1-6, is characterized in that, the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. the Chinese medicine composition for preventing and treating bovine rumen impaction according to any one of claim 1-6, is characterized in that, the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Powdered Chinese medicine composition.
9. a preparation method for the Chinese medicine composition for preventing and treating bovine rumen impaction according to any one of claim 1-8, is characterized in that, the dosage form of described Chinese medicine composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
10. a preparation method for the Chinese medicine composition for preventing and treating bovine rumen impaction according to any one of claim 1-8, is characterized in that, the dosage form of described Chinese medicine composition is powder, and its preparation method comprises the following steps:
The first step, each component in described Chinese medicine composition is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Powdered Chinese medicine composition.
CN201610122902.1A 2016-03-04 2016-03-04 Traditional Chinese medicine composition for preventing bovine rumen indigestion and preparation method Withdrawn CN105535666A (en)

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CN105267765A (en) * 2015-12-04 2016-01-27 山东新希望六和集团有限公司 Medicine composition for treating dysentery of pigs and preparing method thereof

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CN103947890A (en) * 2014-05-13 2014-07-30 山东新希望六和集团有限公司 Feed and traditional Chinese medicine composition for preventing and treating coccidiosis in duck, and preparation method of feed
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