CN104436062A - Traditional Chinese medicine composition for treating bovine grainsick and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating bovine grainsick and preparation method of traditional Chinese medicine composition Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a traditional Chinese medicine composition for treating bovine grainsick. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 10-30 parts of scutellaria baicalensis, 15-25 parts of pericarpium citri reticulatae, 12-28 parts of fructus aurantii, 10-20 parts of elecampane, 15-35 parts of semen raphani, 5-25 parts of endothelium corneum gigeriae galli, 15-25 parts of areca-nut, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of curcuma zedoary, 14-28 parts of edestan, 5-25 parts of medicated leaven, 18-36 parts of rheum officinale, 4-16 parts of hawthorn and 5-15 parts of liquorice. The invention also provides a prepration process of the traditional Chinese medicine composition. Compared with the prior art, the traditional Chinese medicine composition prepared by the process is low in cost, simple in process, and free of a toxic or side effect on cattle; the bovine grainsick can be effectively treated; and the recurrence rate of the bovine grainsick can be significantly lowered.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of bovine rumen impaction and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.
Background technology
Bovine rumen impaction is due to roughage stagnant too much in cud, and cause the long-pending increase of body of stomach, cud wall is expanded, and cud digests the disease with motion function disorder normally.Palpation is hard, and rumen peristalsis sound weakens or disappears.Bovine rumen impaction also makes acute cud expand, cattle their early stage, appetite, ruminate, belch reduces or stops, dry under asoscope, show as haunch, later turn round and look at abdomen, rear tripe plays abdomen, wag the tail, sleeping vertical uneasy.Cud distension during palpation and the solid sand pocket sample that presents, and have pain.Percussion is voiced sound.Weaken at the beginning of auscultation rumen peristalsis sound, disappear later.Time serious, dyspnea, groan, vomiting feces water, flow out from nasal cavity sometimes.Add and treat not in time, how because of dehydration, poisoning, exhaustion or be choked to death wide.
At present, the medicine of existing treatment bovine rumen impaction, majority is Western medicine, although these medicines have certain curative effect, side effect is large, and after drug withdrawal, relapse rate is high.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of bovine rumen impaction and preparation method thereof.
Technical scheme: for achieving the above object, the invention provides a kind of Chinese medicine composition for the treatment of bovine rumen impaction, it primarily of following weight portion crude drug made by:
The Radix Astragali 20 parts, Radix Scutellariae 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Fructus Aurantii 12-28 part, Radix Aucklandiae 10-20 part,
Semen Raphani 15-35 part, Endothelium Corneum Gigeriae Galli 5-25 part, Semen Arecae 15-25 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Curcumae 10-20 part,
Fructus Cannabis 14-28 part, Massa Medicata Fermentata 5-25 part, Radix Et Rhizoma Rhei 18-36 part, Fructus Crataegi 4-16 part, Radix Glycyrrhizae 5-15 part.
As preferably, the Chinese medicine composition of described treatment bovine rumen impaction is mainly made by the crude drug of following weight portion:
The Radix Astragali 20 parts, Radix Scutellariae 15-25 part, Pericarpium Citri Reticulatae 18-22 part, Fructus Aurantii 16-24 part, Radix Aucklandiae 12-18 part,
Semen Raphani 20-30 part, Endothelium Corneum Gigeriae Galli 10-20 part, Semen Arecae 18-22 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Rhizoma Curcumae 12-18 part,
Fructus Cannabis 18-24 part, Massa Medicata Fermentata 10-20 part, Radix Et Rhizoma Rhei 22-32 part, Fructus Crataegi 8-12 part, Radix Glycyrrhizae 8-12 part.
Preferred as another kind, the Chinese medicine composition of described treatment bovine rumen impaction is mainly made by the crude drug of following weight portion:
The Radix Astragali 20 parts, Radix Scutellariae 20 parts, Pericarpium Citri Reticulatae 20 parts, Fructus Aurantii 20 parts, the Radix Aucklandiae 15 parts,
Semen Raphani 25 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Arecae 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Curcumae 15 parts,
Fructus Cannabis 21 parts, Massa Medicata Fermentata 15 parts, Radix Et Rhizoma Rhei 27 parts, Fructus Crataegi 10 parts, 10 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of described treatment bovine rumen impaction Chinese medicine composition, it is mainly made up of following steps:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 6-10 times of volume, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.10-1.16, to obtain final product.
As preferably, described total extractum conveniently formulation method makes decoction, oral liquid or granule.
Beneficial effect: relative to prior art, gained Chinese medicine composition of the present invention, cost is low, and technique is simple, has no side effect, effectively can treat bovine rumen impaction, and can significantly reduce bovine rumen impaction relapse rate to cattle.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Radix Astragali 20g, Radix Scutellariae 10g, Pericarpium Citri Reticulatae 15g, Fructus Aurantii 12g, Radix Aucklandiae 10g,
Semen Raphani 15g, Endothelium Corneum Gigeriae Galli 5g, Semen Arecae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Curcumae 10g,
Fructus Cannabis 14g, Massa Medicata Fermentata 5g, Radix Et Rhizoma Rhei 18g, Fructus Crataegi 4g, Radix Glycyrrhizae 5g.
Preparation technology:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add 60% alcohol reflux 2 times of 6 times of volumes, each 1 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8 times of volumes, each 1 hour, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.10, to obtain final product.
Decoction made by described total extractum conveniently formulation method.
Embodiment 2
Prescription:
Radix Astragali 20g, Radix Scutellariae 30g, Pericarpium Citri Reticulatae 25g, Fructus Aurantii 28g, Radix Aucklandiae 20g,
Semen Raphani 35g, Endothelium Corneum Gigeriae Galli 25g, Semen Arecae 25g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Curcumae 20g,
Fructus Cannabis 28g, Massa Medicata Fermentata 25g, Radix Et Rhizoma Rhei 36g, Fructus Crataegi 16g, Radix Glycyrrhizae 15g.
Preparation technology:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add 80% alcohol reflux 2 times of 10 times of volumes, each 3 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 12 times of volumes, each 3 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.16, to obtain final product.
Oral liquid made by described total extractum conveniently formulation method.
Embodiment 3
Prescription:
Radix Astragali 20g, Radix Scutellariae 20g, Pericarpium Citri Reticulatae 20g, Fructus Aurantii 20g, Radix Aucklandiae 15g,
Semen Raphani 25g, Endothelium Corneum Gigeriae Galli 15g, Semen Arecae 20g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Curcumae 15g,
Fructus Cannabis 21g, Massa Medicata Fermentata 15g, Radix Et Rhizoma Rhei 27g, Fructus Crataegi 10g, Radix Glycyrrhizae 10g.
Preparation technology:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 8 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 10 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.13, to obtain final product.
Decoction made by described total extractum conveniently formulation method.
Embodiment 4
Prescription:
Radix Astragali 20g, Radix Scutellariae 15g, Pericarpium Citri Reticulatae 18g, Fructus Aurantii 16g, Radix Aucklandiae 12g,
Semen Raphani 20g, Endothelium Corneum Gigeriae Galli 10g, Semen Arecae 18g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Curcumae 12g,
Fructus Cannabis 18g, Massa Medicata Fermentata 10g, Radix Et Rhizoma Rhei 22g, Fructus Crataegi 8g, Radix Glycyrrhizae 8g.
Preparation technology:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 7 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 9 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.12, to obtain final product.
Described total extractum conveniently formulation method oral liquid.
Embodiment 5
Prescription:
Radix Astragali 20g, Radix Scutellariae 25g, Pericarpium Citri Reticulatae 22g, Fructus Aurantii 24g, Radix Aucklandiae 18g,
Semen Raphani 30g, Endothelium Corneum Gigeriae Galli 20g, Semen Arecae 22g, Rhizoma Atractylodis Macrocephalae 25g, Rhizoma Curcumae 18g,
Fructus Cannabis 24g, Massa Medicata Fermentata 20g, Radix Et Rhizoma Rhei 32g, Fructus Crataegi 12g, Radix Glycyrrhizae 12g.
Preparation technology:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 9 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 11 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.14, to obtain final product.
Granule made by described total extractum conveniently formulation method.
Experimental example traditional Chinese medicine composition for treating bovine rumen impaction of the present invention clinical experimental study
1, physical data
80 ill cattle of grainsick, clinical diagnosis: their early stage, appetite, ruminate, belch reduces or stops, dry under asoscope, show as haunch, later turn round and look at abdomen, rear tripe plays abdomen, wag the tail, sleeping vertical uneasy.Cud distension during palpation and the solid sand pocket sample that presents, and have pain.Percussion is voiced sound.Weaken at the beginning of auscultation rumen peristalsis sound, disappear later.Time serious, dyspnea, groan, vomiting feces water, flow out from nasal cavity sometimes.
Above-mentioned sick cattle stochastic averagina is divided into four groups, is respectively matched group, embodiment 3 groups, embodiment 4 groups and embodiment 5 groups, often organize 20.
2, Therapeutic Method
1. matched group intravenous injection 10% Hypertonic NaCl solution 400 milliliters three days is a course for the treatment of.
2. embodiment 3 groups, embodiment 4 groups and embodiment 5 groups give embodiment of the present invention example 3, embodiment 4 and embodiment 5 gained Chinese medicine composition respectively, and consumption is one day consumption, within three days, are a course for the treatment of.
3, diagnostic criteria
Invalid-sick cattle symptom is not improved completely, and has and increase the weight of sign;
Effective-sick cattle symptom is significantly improved, but disappears completely not yet;
Effectively-sick cattle symptom disappears completely.
4, therapeutic outcome
After treating two courses for the treatment of as stated above, investigate each group of total effective rate (%) for the treatment of eventually, and the relapse rate of drug withdrawal after one week (%), the results are shown in Table 1
Result (%) investigated by the table 1 respectively sick cattle totall effective rate in clinical treatment of group and relapse rate
Note: compared with matched group, * P<0.05.
From upper table 1 result, compared with matched group, the embodiment of the present invention 3,4 and 5 gained Chinese medicine composition, the total effective rate for bovine rumen impaction is significantly increased, and proves that it effectively can treat bovine rumen impaction; And in relapse rate, the relapse rate after traditional Chinese medicine composition for treating of the present invention, only up to 10.0%, well below 45.0% of matched group, proves that Chinese medicine composition of the present invention can significantly reduce bovine rumen impaction relapse rate.
And over the course for the treatment of, matched group generation side reaction 8 example, and each treatment group all occurs without side reaction.
Claims (5)
1. treat a Chinese medicine composition for bovine rumen impaction, it is characterized in that, it primarily of following weight portion crude drug made by:
The Radix Astragali 20 parts, Radix Scutellariae 10-30 part, Pericarpium Citri Reticulatae 15-25 part, Fructus Aurantii 12-28 part, Radix Aucklandiae 10-20 part,
Semen Raphani 15-35 part, Endothelium Corneum Gigeriae Galli 5-25 part, Semen Arecae 15-25 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Curcumae 10-20 part,
Fructus Cannabis 14-28 part, Massa Medicata Fermentata 5-25 part, Radix Et Rhizoma Rhei 18-36 part, Fructus Crataegi 4-16 part, Radix Glycyrrhizae 5-15 part.
2. the Chinese medicine composition for the treatment of bovine rumen impaction according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
The Radix Astragali 20 parts, Radix Scutellariae 15-25 part, Pericarpium Citri Reticulatae 18-22 part, Fructus Aurantii 16-24 part, Radix Aucklandiae 12-18 part,
Semen Raphani 20-30 part, Endothelium Corneum Gigeriae Galli 10-20 part, Semen Arecae 18-22 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Rhizoma Curcumae 12-18 part,
Fructus Cannabis 18-24 part, Massa Medicata Fermentata 10-20 part, Radix Et Rhizoma Rhei 22-32 part, Fructus Crataegi 8-12 part, Radix Glycyrrhizae 8-12 part.
3. the Chinese medicine composition for the treatment of bovine rumen impaction according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
The Radix Astragali 20 parts, Radix Scutellariae 20 parts, Pericarpium Citri Reticulatae 20 parts, Fructus Aurantii 20 parts, the Radix Aucklandiae 15 parts,
Semen Raphani 25 parts, Endothelium Corneum Gigeriae Galli 15 parts, Semen Arecae 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Curcumae 15 parts,
Fructus Cannabis 21 parts, Massa Medicata Fermentata 15 parts, Radix Et Rhizoma Rhei 27 parts, Fructus Crataegi 10 parts, 10 parts, Radix Glycyrrhizae.
4. the preparation method of the treatment bovine rumen impaction Chinese medicine composition described in any one of claim 1-3, it is characterized in that, it is mainly made up of following steps:
(1) take the Radix Astragali, Radix Scutellariae, Fructus Aurantii, the Radix Aucklandiae, Semen Raphani, Semen Arecae, the Rhizoma Atractylodis Macrocephalae and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 6-10 times of volume, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Cannabis, Massa Medicata Fermentata, Radix Et Rhizoma Rhei, Fructus Crataegi and Radix Glycyrrhizae in proportion, soak 2 hours, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, when being condensed into 30 DEG C, relative density is total extractum of 1.10-1.16, to obtain final product.
5. the preparation method for the treatment of bovine rumen impaction Chinese medicine composition according to claim 4, is characterized in that, described total extractum conveniently formulation method makes decoction, oral liquid or granule.
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