CN105687199A - 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 - Google Patents
用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 Download PDFInfo
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- CN105687199A CN105687199A CN201610055826.7A CN201610055826A CN105687199A CN 105687199 A CN105687199 A CN 105687199A CN 201610055826 A CN201610055826 A CN 201610055826A CN 105687199 A CN105687199 A CN 105687199A
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- sulfo
- tetrahydrochysene
- methyl
- purine
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95752507P | 2007-08-23 | 2007-08-23 | |
| US95752307P | 2007-08-23 | 2007-08-23 | |
| US60/957,525 | 2007-08-23 | ||
| US60/957,523 | 2007-08-23 | ||
| CN200880111701A CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880111701A Division CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105687199A true CN105687199A (zh) | 2016-06-22 |
Family
ID=40378392
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610055826.7A Pending CN105687199A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN201310681047.4A Pending CN103638029A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN202110874748.4A Pending CN113633641A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310681047.4A Pending CN103638029A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN202110874748.4A Pending CN113633641A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US20090054468A1 (enExample) |
| EP (1) | EP2200616B1 (enExample) |
| JP (2) | JP5247804B2 (enExample) |
| KR (1) | KR101588464B1 (enExample) |
| CN (4) | CN105687199A (enExample) |
| AU (1) | AU2008289653B2 (enExample) |
| BR (1) | BRPI0815681A2 (enExample) |
| CA (1) | CA2698205C (enExample) |
| CY (1) | CY1113714T1 (enExample) |
| DK (1) | DK2200616T3 (enExample) |
| EA (1) | EA017510B1 (enExample) |
| ES (1) | ES2399846T3 (enExample) |
| HR (1) | HRP20130139T1 (enExample) |
| IL (2) | IL203738A (enExample) |
| ME (1) | ME01510B (enExample) |
| MX (1) | MX2010001983A (enExample) |
| MY (1) | MY155633A (enExample) |
| NZ (1) | NZ584135A (enExample) |
| PH (1) | PH12014501180A1 (enExample) |
| PL (1) | PL2200616T3 (enExample) |
| PT (1) | PT2200616E (enExample) |
| RS (1) | RS52665B (enExample) |
| SI (1) | SI2200616T1 (enExample) |
| WO (1) | WO2009025618A1 (enExample) |
| ZA (1) | ZA201000848B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
| SG11201401531RA (en) | 2011-11-11 | 2014-07-30 | Pfizer | 2-thiopyrimidinones |
| MX2014011752A (es) * | 2012-03-29 | 2015-04-17 | Basf Se | Compuestos heterobiciclicos n-sustituidos y derivados para combatir plagas de animales ii. |
| US9616063B2 (en) | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| BR112017022340A2 (pt) | 2015-05-05 | 2018-07-10 | Pfizer | 2-tiopirimidinonas |
| MX2019015578A (es) * | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| US11246870B2 (en) * | 2017-07-17 | 2022-02-15 | Astrazenca Ab | MPO inhibitors for use in medicine |
| US20240067651A1 (en) * | 2019-10-10 | 2024-02-29 | Biohaven Therapeutics Ltd. | Prodrugs of myeloperoxidase inhibitors |
| CA3173805A1 (en) * | 2020-03-05 | 2021-09-10 | Biohaven Therapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with myeloperoxidase inhibitor |
| EP4146219A4 (en) * | 2020-05-06 | 2024-05-22 | Biohaven Therapeutics Ltd. | PROCESS FOR PREPARING VERDIPERSTAT |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| US20240166642A1 (en) | 2022-08-18 | 2024-05-23 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2024047094A1 (en) * | 2022-08-31 | 2024-03-07 | Astrazeneca Ab | Pharmaceutical formulation |
| EP4624473A4 (en) * | 2022-12-09 | 2026-03-25 | Shenzhen Salubris Pharm Co Ltd | DERIVATIVE OF PYRROLO[3,2-D]PYRIMIDIN-4-ONE, ITS PREPARATION PROCESS AND ITS MEDICAL USE |
| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003089430A1 (en) * | 2002-04-19 | 2003-10-30 | Astrazeneca Ab | Thioxanthine derivatives as myeloperoxidase inhibitors |
| WO2005037835A1 (en) * | 2003-10-17 | 2005-04-28 | Astrazeneca Ab | Novel thioxanthine derivatives for use as inhibitors of mpo |
| WO2006062465A1 (en) * | 2004-12-06 | 2006-06-15 | Astrazeneca Ab | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69834500T2 (de) * | 1997-09-05 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | Xanthinderivative zur behandlung von hirnischämie |
| GB0100620D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical cokpounds V |
| GB0100623D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
| BR0306919A (pt) * | 2002-01-28 | 2004-11-09 | Kyowa Hakko Kogyo Kk | Métodos para reduzir ou suprimir a efetividade adversa da terapia de l-dopa e/ou do agonista da dopamina, e para tratamento moderado de l-dopa, composição para tratamento moderado de l-dopa, método para tratar doença de parkinson e/ou complicações motoras de l-dopa, composição para o tratamento da doença de parkinson, e, métodos para prolongar o tratamento eficaz da doença de parkinson, e para tratar os distúrbios de movimento |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| US20090124640A1 (en) * | 2006-06-05 | 2009-05-14 | Astrazeneca Ab | Pyrrolo[3,2-D]Pyrimidin-4-One Derivative as Myeloperoxidase Inhibitor |
| AR066936A1 (es) * | 2007-06-13 | 2009-09-23 | Astrazeneca Ab | 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas. |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
-
2008
- 2008-08-21 US US12/195,527 patent/US20090054468A1/en not_active Abandoned
- 2008-08-22 JP JP2010521817A patent/JP5247804B2/ja active Active
- 2008-08-22 ME MEP-2013-49A patent/ME01510B/me unknown
- 2008-08-22 CN CN201610055826.7A patent/CN105687199A/zh active Pending
- 2008-08-22 EA EA201000202A patent/EA017510B1/ru not_active IP Right Cessation
- 2008-08-22 PT PT87941746T patent/PT2200616E/pt unknown
- 2008-08-22 CN CN201310681047.4A patent/CN103638029A/zh active Pending
- 2008-08-22 CA CA2698205A patent/CA2698205C/en not_active Expired - Fee Related
- 2008-08-22 KR KR1020107003835A patent/KR101588464B1/ko not_active Expired - Fee Related
- 2008-08-22 BR BRPI0815681-6A2A patent/BRPI0815681A2/pt not_active IP Right Cessation
- 2008-08-22 DK DK08794174.6T patent/DK2200616T3/da active
- 2008-08-22 PL PL08794174T patent/PL2200616T3/pl unknown
- 2008-08-22 CN CN200880111701A patent/CN101873857A/zh active Pending
- 2008-08-22 EP EP08794174A patent/EP2200616B1/en active Active
- 2008-08-22 WO PCT/SE2008/050950 patent/WO2009025618A1/en not_active Ceased
- 2008-08-22 HR HRP20130139AT patent/HRP20130139T1/hr unknown
- 2008-08-22 NZ NZ584135A patent/NZ584135A/en not_active IP Right Cessation
- 2008-08-22 MX MX2010001983A patent/MX2010001983A/es active IP Right Grant
- 2008-08-22 CN CN202110874748.4A patent/CN113633641A/zh active Pending
- 2008-08-22 RS RS20130070A patent/RS52665B/sr unknown
- 2008-08-22 MY MYPI2010000753A patent/MY155633A/en unknown
- 2008-08-22 AU AU2008289653A patent/AU2008289653B2/en not_active Ceased
- 2008-08-22 ES ES08794174T patent/ES2399846T3/es active Active
- 2008-08-22 SI SI200830893T patent/SI2200616T1/sl unknown
-
2010
- 2010-02-04 ZA ZA2010/00848A patent/ZA201000848B/en unknown
- 2010-02-04 IL IL203738A patent/IL203738A/en not_active IP Right Cessation
-
2011
- 2011-02-23 US US13/033,220 patent/US20110207755A1/en not_active Abandoned
-
2012
- 2012-11-01 US US13/666,504 patent/US20130059870A1/en not_active Abandoned
-
2013
- 2013-02-21 CY CY20131100166T patent/CY1113714T1/el unknown
- 2013-04-08 JP JP2013080125A patent/JP2013151547A/ja active Pending
- 2013-11-08 US US14/075,790 patent/US20140221400A1/en not_active Abandoned
-
2014
- 2014-05-26 PH PH12014501180A patent/PH12014501180A1/en unknown
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2015
- 2015-07-23 IL IL240130A patent/IL240130A0/en unknown
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2018
- 2018-08-30 US US16/117,020 patent/US10772890B2/en active Active
-
2020
- 2020-09-13 US US17/019,276 patent/US20200405724A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003089430A1 (en) * | 2002-04-19 | 2003-10-30 | Astrazeneca Ab | Thioxanthine derivatives as myeloperoxidase inhibitors |
| WO2005037835A1 (en) * | 2003-10-17 | 2005-04-28 | Astrazeneca Ab | Novel thioxanthine derivatives for use as inhibitors of mpo |
| WO2006062465A1 (en) * | 2004-12-06 | 2006-06-15 | Astrazeneca Ab | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
Non-Patent Citations (4)
| Title |
|---|
| DONG-KUG CHOI等: "Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson’s Disease in Mice", 《THE JOURNAL OF NEUROSCIENCE,》 * |
| DONG-KUG CHOI等: "Ablation of the Inflammatory Enzyme Myeloperoxidase Mitigates Features of Parkinson’s Disease in Mice", 《THE JOURNAL OF NEUROSCIENCE》 * |
| JOSE´M.SOUZA等: "Dityrosine Cross-linking Promotes Formation of Stable α-Synuclein Polymers", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 * |
| NADIA STEFANOVA等: "Animal models of multiple system atrophy", 《TRENDS IN NEUROSCIENCES》 * |
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Application publication date: 20160622 |