IL203738A - Use of 1- (2-Isopropoxyethyl) -2-Theoxo-1, 2, 3, 5-Tetrahydro-Pyrolo [3, 2-d] Pyrimidine-4-On or its Acceptable Pharmaceutical Salt for the Preparation of a Multi-Systemic Degenerative Drug - Google Patents

Use of 1- (2-Isopropoxyethyl) -2-Theoxo-1, 2, 3, 5-Tetrahydro-Pyrolo [3, 2-d] Pyrimidine-4-On or its Acceptable Pharmaceutical Salt for the Preparation of a Multi-Systemic Degenerative Drug

Info

Publication number
IL203738A
IL203738A IL203738A IL20373810A IL203738A IL 203738 A IL203738 A IL 203738A IL 203738 A IL203738 A IL 203738A IL 20373810 A IL20373810 A IL 20373810A IL 203738 A IL203738 A IL 203738A
Authority
IL
Israel
Prior art keywords
isopropoxyethyl
thioxo
pyrrolo
pyrimidin
tetrahydro
Prior art date
Application number
IL203738A
Other languages
English (en)
Hebrew (he)
Inventor
Werner Poewe
Hakan Eriksson
Original Assignee
Astrazeneca Ab
Werner Poewe
Hakan Eriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Werner Poewe, Hakan Eriksson filed Critical Astrazeneca Ab
Publication of IL203738A publication Critical patent/IL203738A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL203738A 2007-08-23 2010-02-04 Use of 1- (2-Isopropoxyethyl) -2-Theoxo-1, 2, 3, 5-Tetrahydro-Pyrolo [3, 2-d] Pyrimidine-4-On or its Acceptable Pharmaceutical Salt for the Preparation of a Multi-Systemic Degenerative Drug IL203738A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95752507P 2007-08-23 2007-08-23
US95752307P 2007-08-23 2007-08-23
PCT/SE2008/050950 WO2009025618A1 (en) 2007-08-23 2008-08-22 Mipo inhibitors for the treatment of huntington's disease and multiple system atrophy

Publications (1)

Publication Number Publication Date
IL203738A true IL203738A (en) 2015-08-31

Family

ID=40378392

Family Applications (2)

Application Number Title Priority Date Filing Date
IL203738A IL203738A (en) 2007-08-23 2010-02-04 Use of 1- (2-Isopropoxyethyl) -2-Theoxo-1, 2, 3, 5-Tetrahydro-Pyrolo [3, 2-d] Pyrimidine-4-On or its Acceptable Pharmaceutical Salt for the Preparation of a Multi-Systemic Degenerative Drug
IL240130A IL240130A0 (en) 2007-08-23 2015-07-23 mipo inhibitors for the treatment of Huntington's disease and multiple system degeneration

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL240130A IL240130A0 (en) 2007-08-23 2015-07-23 mipo inhibitors for the treatment of Huntington's disease and multiple system degeneration

Country Status (25)

Country Link
US (6) US20090054468A1 (enExample)
EP (1) EP2200616B1 (enExample)
JP (2) JP5247804B2 (enExample)
KR (1) KR101588464B1 (enExample)
CN (4) CN101873857A (enExample)
AU (1) AU2008289653B2 (enExample)
BR (1) BRPI0815681A2 (enExample)
CA (1) CA2698205C (enExample)
CY (1) CY1113714T1 (enExample)
DK (1) DK2200616T3 (enExample)
EA (1) EA017510B1 (enExample)
ES (1) ES2399846T3 (enExample)
HR (1) HRP20130139T1 (enExample)
IL (2) IL203738A (enExample)
ME (1) ME01510B (enExample)
MX (1) MX2010001983A (enExample)
MY (1) MY155633A (enExample)
NZ (1) NZ584135A (enExample)
PH (1) PH12014501180A1 (enExample)
PL (1) PL2200616T3 (enExample)
PT (1) PT2200616E (enExample)
RS (1) RS52665B (enExample)
SI (1) SI2200616T1 (enExample)
WO (1) WO2009025618A1 (enExample)
ZA (1) ZA201000848B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
UY30267A1 (es) * 2006-04-13 2007-11-30 Astrazeneca Ab Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938
US8927559B2 (en) 2010-10-11 2015-01-06 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as CRTH2 antagonists
GEP201706656B (en) 2011-11-11 2017-04-25 Pfizer 2-thiopyrimidinones
WO2013144088A1 (en) * 2012-03-29 2013-10-03 Basf Se N-substituted hetero-bicyclic compounds and derivatives for combating animal pests ii
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
MA42035A (fr) 2015-05-05 2018-03-14 Pfizer 2-thiopyrimidinones
CA3067591A1 (en) * 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
CA3068910A1 (en) * 2017-07-17 2019-01-24 Astrazeneca Ab Mpo inhibitors for use in medicine
WO2021072140A1 (en) 2019-10-10 2021-04-15 Biohaven Therapeutics Ltd. Prodrugs of myeloperoxidase inhibitors
MX2022010902A (es) * 2020-03-05 2022-10-07 Biohaven Therapeutics Ltd Metodo para tratar la esclerosis lateral amiotrofica con un inhibidor de la mieloperoxidasa.
EP4146219A4 (en) * 2020-05-06 2024-05-22 Biohaven Therapeutics Ltd. PROCESS FOR PREPARING VERDIPERSTAT
CN115403584B (zh) * 2021-05-26 2024-04-02 长春金赛药业有限责任公司 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用
UY40399A (es) 2022-08-18 2024-02-15 Astrazeneca Ab Inhibidores de mieloperoxidasa
AU2023332020A1 (en) * 2022-08-31 2025-04-17 Astrazeneca Ab Pharmaceutical formulation
EP4624473A4 (en) * 2022-12-09 2026-03-25 Shenzhen Salubris Pharm Co Ltd DERIVATIVE OF PYRROLO[3,2-D]PYRIMIDIN-4-ONE, ITS PREPARATION PROCESS AND ITS MEDICAL USE
WO2024163892A1 (en) * 2023-02-02 2024-08-08 University Of Virginia Patent Foundation Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah)
WO2025172474A1 (en) 2024-02-15 2025-08-21 Astrazeneca Ab Inhibitors of myeloperoxidase
WO2025190901A1 (en) 2024-03-13 2025-09-18 Institut National de la Santé et de la Recherche Médicale Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses
CN121378265A (zh) * 2025-10-30 2026-01-23 乐平市康鑫医药化工有限公司 一种吡唑类化合物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69834500T2 (de) * 1997-09-05 2007-05-03 Kyowa Hakko Kogyo Co., Ltd. Xanthinderivative zur behandlung von hirnischämie
GB0100620D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
GB0100623D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds IV
ES2686123T3 (es) * 2002-01-28 2018-10-16 Kyowa Hakko Kogyo Co., Ltd Antagonistas del receptor A2A para su uso en el tratamiento de trastornos del movimiento
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
UY30267A1 (es) * 2006-04-13 2007-11-30 Astrazeneca Ab Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones
WO2007142577A1 (en) * 2006-06-05 2007-12-13 Astrazeneca Ab Pyrrolo[3,2-d]pyrimidin-4-one derivative as myeloperoxidase inhibitor
AR066936A1 (es) * 2007-06-13 2009-09-23 Astrazeneca Ab 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas.
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938

Also Published As

Publication number Publication date
JP5247804B2 (ja) 2013-07-24
CN105687199A (zh) 2016-06-22
CA2698205C (en) 2016-06-21
PL2200616T3 (pl) 2013-04-30
US10772890B2 (en) 2020-09-15
EA201000202A1 (ru) 2010-10-29
US20090054468A1 (en) 2009-02-26
US20140221400A1 (en) 2014-08-07
WO2009025618A1 (en) 2009-02-26
JP2010536849A (ja) 2010-12-02
JP2013151547A (ja) 2013-08-08
KR101588464B1 (ko) 2016-01-25
IL240130A0 (en) 2015-09-24
CY1113714T1 (el) 2016-06-22
US20190099423A1 (en) 2019-04-04
ME01510B (me) 2014-04-20
CA2698205A1 (en) 2009-02-26
US20110207755A1 (en) 2011-08-25
ZA201000848B (en) 2012-07-25
AU2008289653B2 (en) 2012-06-28
NZ584135A (en) 2012-04-27
BRPI0815681A2 (pt) 2015-02-18
EP2200616A4 (en) 2010-08-25
SI2200616T1 (sl) 2013-03-29
CN101873857A (zh) 2010-10-27
MX2010001983A (es) 2010-03-10
KR20100055434A (ko) 2010-05-26
CN113633641A (zh) 2021-11-12
US20200405724A1 (en) 2020-12-31
HK1145141A1 (en) 2011-04-08
ES2399846T3 (es) 2013-04-03
US20130059870A1 (en) 2013-03-07
EA017510B1 (ru) 2013-01-30
AU2008289653A1 (en) 2009-02-26
PT2200616E (pt) 2013-02-27
EP2200616B1 (en) 2012-12-26
EP2200616A1 (en) 2010-06-30
MY155633A (en) 2015-11-13
RS52665B (sr) 2013-06-28
PH12014501180A1 (en) 2015-08-24
HRP20130139T1 (hr) 2013-03-31
CN103638029A (zh) 2014-03-19
DK2200616T3 (da) 2013-03-04

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees