EA017510B1 - Ингибиторы mpo для лечения множественной системной атрофии - Google Patents
Ингибиторы mpo для лечения множественной системной атрофии Download PDFInfo
- Publication number
- EA017510B1 EA017510B1 EA201000202A EA201000202A EA017510B1 EA 017510 B1 EA017510 B1 EA 017510B1 EA 201000202 A EA201000202 A EA 201000202A EA 201000202 A EA201000202 A EA 201000202A EA 017510 B1 EA017510 B1 EA 017510B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- mpo
- mice
- pharmaceutically acceptable
- treatment
- salts
- Prior art date
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| PCT/SE2008/050950 WO2009025618A1 (en) | 2007-08-23 | 2008-08-22 | Mipo inhibitors for the treatment of huntington's disease and multiple system atrophy |
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| WO2012051036A1 (en) | 2010-10-11 | 2012-04-19 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| BR112014011254A2 (pt) | 2011-11-11 | 2017-05-16 | Pfizer | 2-tiopirimidinonas |
| ES2587954T3 (es) * | 2012-03-29 | 2016-10-27 | Basf Se | Compuestos de hetero-bicíclicos N-sustituidos y derivados para combatir plagas animales II |
| US9616063B2 (en) * | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| CR20170498A (es) | 2015-05-05 | 2018-01-26 | Pfizer | 2-tiopirimidinonas |
| CA3067591A1 (en) * | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| IL272043B (en) * | 2017-07-17 | 2022-09-01 | Astrazeneca Ab | mpo inhibitors for use in medicine |
| AU2020363903A1 (en) * | 2019-10-10 | 2022-03-24 | Biohaven Therapeutics Ltd. | Prodrugs of myeloperoxidase inhibitors |
| AU2021230370A1 (en) * | 2020-03-05 | 2022-10-20 | Biohaven Therapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with myeloperoxidase inhibitor |
| WO2021226161A1 (en) * | 2020-05-06 | 2021-11-11 | Biohaven Therapeutics Ltd. | Process for the preparation of verdiperstat |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| JP2025528217A (ja) | 2022-08-18 | 2025-08-26 | アストラゼネカ・アクチエボラーグ | ミエロペルオキシダーゼの阻害剤 |
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| EP4624473A1 (en) * | 2022-12-09 | 2025-10-01 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof |
| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
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- 2008-08-22 CN CN201310681047.4A patent/CN103638029A/zh active Pending
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- 2008-08-22 EP EP08794174A patent/EP2200616B1/en active Active
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