CN105664185A - 一种具有解除肠胃痉挛效果的造影剂 - Google Patents

一种具有解除肠胃痉挛效果的造影剂 Download PDF

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CN105664185A
CN105664185A CN201610077185.5A CN201610077185A CN105664185A CN 105664185 A CN105664185 A CN 105664185A CN 201610077185 A CN201610077185 A CN 201610077185A CN 105664185 A CN105664185 A CN 105664185A
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王艳丽
郭成
刘桂芳
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Qingdao Central Hospital
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Abstract

本发明涉及一种具有解除肠胃痉挛效果的造影剂，由以下组分按照重量分数组成：硫酸钡(Ⅱ型)干混悬剂50-60份，中药提取物3-9份；所述中药提取物由以下组分按照重量分数组成：高良姜3-6份，伏龙肝15-25份，刀豆3-9份，半夏3-9份，艾纳香5-15份，勾儿茶5-15份，杠木5-15份，茯苓5-15份，丛毛榕5-15份，白苏子5-15份，远志3-9份，五味子3-6份，甘松：3-6份，土木香3-9份，甘草3-9份。本发明中的中药提取物，以中医理论为基础，以温中止呕、健脾化湿、宁心安神、行气止痛为主要治则本发明的含中药提取物的胃肠造影剂，毒副作用小，不但能够满足胃肠道造影功能，而且具有解除胃肠道痉挛，达到临床所追求的低张效果，造影清晰。

Description

一种具有解除肠胃痉挛效果的造影剂
技术领域
本发明涉及含有来源于植物、动物或矿物组份的医用配制品及其制备技术，特别涉及一种具有解除肠胃痉挛效果的造影剂。
背景技术
造影剂(又称对比剂，contrastmedia)是为增强影像观察效果而注入(或服用)到人体组织或器官的化学制品。这些制品的密度高于或低于周围组织，形成的对比用某些器械显示图像。如X线观察常用的碘制剂、硫酸钡等。
临床胃肠道检查实践中，要想得到较好的消化道造影效果，需要胃肠低张造影，以更好的达到气体、造影剂的双重对比。要想达到低张效果，需要解除消化道痉挛，以便于更好的涂抹胃肠黏膜，从而有利于显示细小病变，有利于早期诊断，早期治疗。目前临床中，在患者检查前经常注射药物来达到解除胃肠道痉挛、低张的效果，但是这种方法存在缺陷，大部分患者注射后会产生嘴干、胃肠麻痹、肠胀气等不良反应，增加了患者的痛苦，不利于诊断及后续的治疗。
发明内容
本发明的目的在于提供一种具有解除肠胃痉挛效果的造影剂，为达到以上目的，本发明采取的技术方案是：
一种具有解除肠胃痉挛效果的造影剂，由以下组分按照重量分数组成：
硫酸钡(Ⅱ型)干混悬剂50-60份，中药提取物3-9份；
所述中药提取物由以下组分按照重量分数组成：
高良姜3-6份，伏龙肝15-25份，刀豆3-9份，半夏3-9份，艾纳香5-15份，勾儿茶5-15份，杠木5-15份，茯苓5-15份，丛毛榕5-15份，白苏子5-15份，远志3-9份，五味子3-6份，甘松：3-6份，土木香3-9份，甘草3-9份。
在上述方案的基础上，一种具有解除肠胃痉挛效果的造影剂，所述中药提取物由以下组分按照重量分数组成：
高良姜4份，伏龙肝20份，刀豆6份，半夏6份，艾纳香10份，勾儿茶10份，杠木10份，茯苓10份，丛毛榕10份，白苏子10份，远志6份，五味子4份，甘松：4份，土木香6份，甘草6份。
在上述方案的基础上，所述中药提取物由以下方法制备而成：
(1)称取各组分并粉碎成细粉，将粉碎后的各组分加入10-12倍量的清水中浸泡4小时；
(2)煮沸30分钟；
(3)过滤，弃掉滤渣；
(4)滤液减压浓缩后冷冻干燥，即得。
在上述方案的基础上，所述的具有解除肠胃痉挛效果的造影剂，由以下组分按照重量分数组成：
硫酸钡(Ⅱ型)干混悬剂55份，中药提取物6份；
所述中药提取物由以下组分按照重量分数组成：
高良姜4份，伏龙肝20份，刀豆6份，半夏6份，艾纳香10份，勾儿茶10份，杠木10份，茯苓10份，丛毛榕10份，白苏子10份，远志6份，五味子4份，甘松：4份，土木香6份，甘草6份。
本发明中的中药提取物，以中医理论为基础，以温中止呕、健脾化湿、宁心安神、行气止痛为主要治则；提取物中：高良姜：温胃止呕，散寒止痛；伏龙肝：温中燥湿，止呕止血；刀豆：温中下气、止呃；半夏：降逆止呕，燥湿化痰，消痞散结；艾纳香：温中，杀虫，祛风除湿，避秽；五药合用为君药；勾儿茶：健脾益气，活血通络，止咳化痰；杠木：健脾止泻，收敛止血；茯苓：利水渗湿、健脾、宁心；丛毛榕：祛风行气，健脾利湿；四药共为臣药；白苏子：下气，消痰，润肺，宽肠；远志：宁心安神、祛痰开窍；五味子：宁心安神、生津敛汗、涩精止泻、敛肺滋肾；甘松：理气止痛，开郁醒脾；土木香：行气止痛、健脾和胃；五药共为佐药；甘草：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药；为使药；十五药合用，共奏：温中止呕、健脾化湿、宁心安神、行气止痛之功效。本发明的含中药提取物的胃肠造影剂，毒副作用小，不但能够满足胃肠道造影功能，而且具有解除胃肠道痉挛，达到临床所追求的低张效果，造影清晰。中药提取物温中止呕、健脾化湿、宁心安神、行气止痛，改善胃肠黏膜层微循环、促进胃肠液吸收，解除胃脘痛、胃肠痉挛等。
具体实施方式
实施例1
一种具有解除肠胃痉挛效果的造影剂，由以下组分按照重量份数组成：
硫酸钡(Ⅱ型)干混悬剂55份，中药提取物6份；
所述中药提取物由以下组分按照重量分数组成：
高良姜4份，伏龙肝20份，刀豆6份，半夏6份，艾纳香10份，勾儿茶10份，杠木10份，茯苓10份，丛毛榕10份，白苏子10份，远志6份，五味子4份，甘松：4份，土木香6份，甘草6份。
所述中药提取物由以下方法制备而成：
(1)称取各组分并粉碎成细粉，将粉碎后的各组分加入10-12倍量的清水中浸泡4小时；
(2)煮沸30分钟；
(3)过滤，弃掉滤渣；
(4)滤液减压浓缩后冷冻干燥，即得。
使用时，按上述比例取硫酸钡(Ⅱ型)干混悬剂和中药提取物总150-300g，加水调匀，浓度50-80％，口服或钡灌肠。
典型病例：
1、王某，男，34岁，2014年5月出现腹痛、呕吐症状，持续1周，透视可见小肠内潴留较多，局部小肠痉挛性蠕动明显；口服本发明实施例1制备的造影剂，小肠痉挛明显减弱，可见空肠黏膜皱襞均匀涂抹造影剂，黏膜皱襞沟清晰显示，空肠区多个带蒂状黏膜息肉，表面可见斑点状龛影，周围黏膜水肿。诊断为小肠黏膜息肉、伴溃疡形成。造影后，病人感觉良好。
2、唐某，女，47岁，2014年8月出现上腹痛、恶心，持续2周。空腹透视可见胃内潴留，胃痉挛明显；口服本发明实施例1制备的造影剂，不但明显缓解症状，病人的恶心症状解除，较清楚显示胃体窦角切区大小约2x2cm的溃疡面，腔外龛影，溃疡周围的黏膜纠集征象，胃壁蠕动、扩张度尚好；诊断为良性胃溃疡。造影后，病人感觉良好。
3、于某，男，58岁，上腹钝痛，疼痛呈节律性、呕吐、贫血，使用本发明造影剂前胃肠道痉挛明显，使用本发明实施例1制备的造影剂进行造影后，明显解除了胃肠道痉挛，分泌物较少，造影清晰，诊断为十二指肠溃疡。造影后，病人感觉良好。
上面以举例方式对本发明进行了说明，但本发明不限于上述具体实施例，凡基于本发明所做的任何改动或变型均属于本发明要求保护的范围。

Claims (4)

1.一种具有解除肠胃痉挛效果的造影剂，其特征在于：由以下组分按照重量分数组成：
硫酸钡(Ⅱ型)干混悬剂50-60份，中药提取物3-9份；
所述中药提取物由以下组分按照重量分数组成：
高良姜3-6份，伏龙肝15-25份，刀豆3-9份，半夏3-9份，艾纳香5-15份，勾儿茶5-15份，杠木5-15份，茯苓5-15份，丛毛榕5-15份，白苏子5-15份，远志3-9份，五味子3-6份，甘松：3-6份，土木香3-9份，甘草3-9份。
2.根据权利要求1所述的具有解除肠胃痉挛效果的造影剂，其特征在于：所述中药提取物由以下组分按照重量分数组成：
高良姜4份，伏龙肝20份，刀豆6份，半夏6份，艾纳香10份，勾儿茶10份，杠木10份，茯苓10份，丛毛榕10份，白苏子10份，远志6份，五味子4份，甘松：4份，土木香6份，甘草6份。
3.根据权利要求1或2所述的具有解除肠胃痉挛效果的造影剂，其特征在于：所述中药提取物由以下方法制备而成：
(1)称取各组分并粉碎成细粉，将粉碎后的各组分加入10-12倍量的清水中浸泡4小时；
(2)煮沸30分钟；
(3)过滤，弃掉滤渣；
(4)滤液减压浓缩后冷冻干燥，即得。
4.根据权利要求4所述的具有解除肠胃痉挛效果的造影剂，其特征在于：由以下组分按照重量分数组成：
硫酸钡(Ⅱ型)干混悬剂55份，中药提取物6份；
所述中药提取物由以下组分按照重量分数组成：
高良姜4份，伏龙肝20份，刀豆6份，半夏6份，艾纳香10份，勾儿茶10份，杠木10份，茯苓10份，丛毛榕10份，白苏子10份，远志6份，五味子4份，甘松：4份，土木香6份，甘草6份。
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