CN105661524A - Preparation method of radix pseudostellariae oral liquid - Google Patents
Preparation method of radix pseudostellariae oral liquid Download PDFInfo
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- CN105661524A CN105661524A CN201610093055.0A CN201610093055A CN105661524A CN 105661524 A CN105661524 A CN 105661524A CN 201610093055 A CN201610093055 A CN 201610093055A CN 105661524 A CN105661524 A CN 105661524A
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of radix pseudostellariae oral liquid. According to the preparation method, traditional Chinese medicine, namely radix pseudostellariae, serves as the main raw material, starch contained in the radix pseudostellariae is subjected to sugar conversion through a biological enzyme technology, maltose and glucose which can be absorbed by children easily are formed, application of cane sugar which is high in caloric value to the oral liquid is replaced, sweetness is increased, cost of additives is lowered, a radix pseudostellariae solution obtained after enzymolysis is subjected to extraction and sterilization through high-voltage pulsed electric field extraction equipment, then membrane separation and superhigh temperature flash disinfection treatment are conducted, and the obtained oral liquid is safer. The radix pseudostellariae oral liquid can improve the gastrointestinal function of children and help to achieve high immunity of the human body, nutritive value is extremely high, the oral liquid is original in taste and flavor, abundant in nutrition, light, tasty and suitable for taste requirements of children, no preservative is contained, and therefore the oral liquid is a safe health-care drink drunk by children.
Description
Technical field
The present invention relates to a kind of oral liquid, in particular with the preparation method that Chinese medicine Radix Pseudostellariae is fabricated to a kind of health care oral liquid, belong to pharmaceutical processing techniques field.
Background technology
Radix Pseudostellariae, another name: Radix Ginseng, sweet in the mouth, micro-hardship, property is put down, and returning spleen, lung meridian is the one of Radix Ginseng, belongs to qi-restoratives, Qi-tonifying drug. Have the effect mending strengthening spleen and lung, supplementing QI for promoting the production of body fluid, be usually used in weakness of the spleen and stomach, fatigue and weakness, inappetence, dry cough few expectorant, after being ill body void, night sweat, metal fatigue, night shy cry, Infantile Summer Fever etc. Experimentation confirms, Radix Pseudostellariae can improve immune function of human body, improves cardiac function, compared with the Radix Ginseng of tonifying QI to produce body fluid effect, Radix Codonopsis, Radix Panacis Quinquefolii, the efficacy of a drug of Radix Pseudostellariae nourishing is not by a long sight, but its property of medicine is very steady, and applicable chronic patient is taken for a long time in a large number. Therefore be deeply unable to bear the crowd nourishing the high benefit of medicine by those bodies void, children taking Radix Pseudostellariae does not cause the suspicion of precocity. Radix Pseudostellariae can be rated as rare good merchantable brand of mending clearly, research show child often take Radix Pseudostellariae can health invigorating, long-term taking is also there are no side effect.
Radix Pseudostellariae is a kind of good Chinese crude drug of effect, is listed in " can be used for the Chinese crude drug list of health food " by Ministry of Public Health. Pharmacological research shows, Radix Pseudostellariae chemical composition mainly contains Radix Pseudostellariae Saponin, Palmic acid, linoleic acid, cupreol etc., the highest with arginine, glutamic acid, aspartate content, accounting for the 30%-40% of free amino acid, Radix Pseudostellariae is also containing fructose, starch, phospholipid, aminoacid, volatile oil and trace element manganese, ferrum, copper, zinc etc. There are resisting fatigue, anti-stress advantage, and have promotion immunity and life-saving effect.
The method that oral liquid is prepared in " ZL:201310014407.5 " " a kind of compound Taizi ginsen oral liquid and preparation method thereof " its employing decocting in water, filtrate, the concentration etc. announced in State Patent Office, in preparation process, Radix Pseudostellariae to pass through decoction and the concentration of high temperature, nutrition and functional component are destroyed, the food active substance of high-temperature process runs off in a large number, and the product of making also exists precipitate and is not easy the shortcoming preserved.
Summary of the invention
High-voltage pulse electric field technology is the emerging non-thermal technology technology that development in recent years is got up, and overcomes traditional extraction and there is extraction cost height, and efficiency is low, extracts the shortcomings such as slow. Have that the process time is short, transmit safety quick, uniform, energy consumption low, it is possible to the effectively protection feature such as food nutrient composition and natural color, smell and taste, therefore become an emerging extractive technique.
Along with the enhancing of the raising of people's living standard and health care consciousness, safety and the effectiveness of food and natural product are increasingly subject to people's attention, and non-thermal technology technology can retain the original nutrition of wholefood and active substance to greatest extent. Its prominent advantage is that extract at room temperature, process time are short, and material damage is little, and the modernization high efficiency extraction for Chinese medicine opens up a new field.
Utilize high-pressure pulse electric not only can extract at low temperature but also have sterilization advantage, extracting and kill antibacterial at normal temperatures is a very important link in food production, and the quality of sterilization directly affects the quality of food. There is operating condition gentleness, it is possible to food nutrient composition is destroyed the advantages such as few by seriality operation, is very suitable for the extraction of food sterilization and natural active matter. Taizi ginsen oral liquid preparation adopts low temperature enzymolysis to be combined with high-voltage pulse electric field technology, has both avoided the loss of the effective ingredient that high temperature process is brought, has improve again the extraction ratio of Radix Pseudostellariae effective ingredient.
Taizi ginsen oral liquid prepared by the present invention has that Production Time is short, cost is low, reduce external food additive, the introducing of processing aid and chemical substance, remains natural nutrient component and the local flavor of Radix Pseudostellariae to greatest extent. Extraction does not use organic solvent, economizes on resources, decrease exhaust emission, it is ensured that the Taizi ginsen oral liquid of children taking is safe and reliable. Enzymolysis additional high pressure impulse electric field improves the extraction ratio of Pseudostellaria Polysaccharide and trace element, shortens extraction time, meets the genuineness of Taizi ginsen oral liquid, nutritional labeling, natural safe requirement.
The present invention is with Chinese medicine Radix Pseudostellariae for primary raw material, by the starch contained by Radix Pseudostellariae, adopt biological enzymolysis technology that starch carries out sugar conversion, form the maltose and glucose that are easily absorbed by child, substitute the use in oral liquid of the heat higher sucrose, add sugariness and reduce the cost of additive. Starch in Radix Pseudostellariae is by enzymatic saccharification, and no longer starch material containing macromole in oral liquid, the Taizi ginsen oral liquid of making is limpider, pure, has stopped sedimentary generation. Radix Pseudostellariae solution after enzymolysis is extracted and sterilizing by high-pressure pulse electric extraction equipment, and again through membrance separation and ultrahigh-temperature instant sterilization treatment, the oral liquid obtained is safer. Oral liquid adds oligomeric isomaltose and adds sweet taste, and promote the growth and breeding of beneficial bacteria bacillus bifidus in child's body, improve gastrointestinal function and prevent the generation of children caries.
The Taizi ginsen oral liquid that the present invention develops can improve the gastrointestinal function of child, there is again the immunity high nutritive value of relatively strong man's body, the taste requirements of this oral liquid numerous children of good to eat adaptation genuine, nutritious, light, because without preservative being the safe healthcare beverage of a kind of drinking of children. Still rare with the health-care oral liquid for children that Radix Pseudostellariae is development of raw materials, enzymolysis additional high pressure impulse electric field extraction is utilized to prepare Taizi ginsen oral liquid, day by day move towards nutrition and health care in oral liquid market to lay equal stress under the trend developed, wide market prospect and social benefit will be had.
Detailed description of the invention
The preparation method of a kind of Taizi ginsen oral liquid, makes according to following steps:
1. clean and pulverize: take fresh Radix Pseudostellariae material 100kg, be immersed in the clear water of flowing, rinse, rub the silt impurity removing Radix Pseudostellariae surface, dry after rinsed clean, put into pulverizer and crush, be broken into 2～4mm size particles.
2. the pre-heat treatment: the Radix Pseudostellariae after broken is poured in rustless steel enzymatic vessel, and the clean water adding Radix Pseudostellariae material 2 times is stirred, and passes into steam and be heated to 60～70 DEG C in rustless steel enzymatic vessel.
3. enzymatic saccharification: when the Radix Pseudostellariae solution temperature after preheating drops to 45～55 DEG C, adjust pH value of solution to 5.0～5.5, adding a-amylase 0.1kg in the solution, the enzymatic saccharification time maintains 12～20h, in enzymolysis process, solution is constantly stirred.
4. electric field extracts: the Radix Pseudostellariae solution after enzymatic saccharification, put into dynamic coaxial formula high-pressure pulse electric extraction equipment to extract, impulse electric field strength is set as 10～25kV/cm, pulse frequency is 50～150Hz, umber of pulse is 15, burst length 80～140 μ s, solution flow rate is 1～2mL/s.
5. melt cinder separates: pour the solution after extracting into carry out solution and medicinal residues in centrifugal separator separation, centrifuge speed controls within the scope of 2000～3000r/Minf, centrifugation time is 5～10min, separates the Radix Pseudostellariae solution obtaining Radix Pseudostellariae clarification, and medicinal residues remove outdoor.
6. mixing preparation: put into separate the Radix Pseudostellariae solution obtained in blend tank, add oligomeric isomaltose 8kg, start agitator and seasoning liquid is stirred homogenizing.
7. membrane filtration: adopt nuclepore membrane filter to carry out microfiltration after Radix Pseudostellariae solution homogenizing, selects membrane aperture at the microporous filter membrane of 0.1～2 μm, and Stress control, at 0.1～0.3MPa, is filtered under flow velocity 1.5～3.5m/s.
8. sterile filling: the Radix Pseudostellariae solution obtained through microfiltration is poured in Bottle for oral medicine in an aseptic environment and seals in time, put into ultrahigh-temperature instant sterilizer.
9. instantaneously sterilising: the temperature of ultrahigh-temperature instant sterilizing controls at 130～150 DEG C, and steam pressure is 0.78MPa, and sterilization time is 2～5s.
10. test package: after sterilizing cooling, is incubated 7d at 37 DEG C, broadly falls into qualified products without aerogenesis, suspension, lamination, it is possible to date printed, vanning.
Claims (1)
1. a preparation method for Taizi ginsen oral liquid, is characterized in that preparing according to following steps:
(1) clean pulverizing: take fresh Radix Pseudostellariae material 100kg, be immersed in the clear water of flowing, rinse, rub the silt impurity removing Radix Pseudostellariae surface, dry after rinsed clean, put into pulverizer and crush, be broken into 2～4mm size particles;
(2) the pre-heat treatment: the Radix Pseudostellariae after broken is poured in rustless steel enzymatic vessel, and the clean water adding Radix Pseudostellariae material 2 times is stirred, and passes into steam and be heated to 60～70 DEG C in rustless steel enzymatic vessel;
(3) enzymatic saccharification: when the Radix Pseudostellariae solution temperature after preheating drops to 45～55 DEG C, adjust pH value of solution to 5.0～5.5, adding a-amylase 0.1kg in the solution, the enzymatic saccharification time maintains 12～20h, in enzymolysis process, solution is constantly stirred;
(4) electric field extracts: the Radix Pseudostellariae solution after enzymatic saccharification, put into dynamic coaxial formula high-pressure pulse electric extraction equipment to extract, impulse electric field strength is set as 10～25kV/cm, pulse frequency is 50～150Hz, umber of pulse is 15, burst length 80～140 μ s, solution flow rate is 1～2mL/s;
(5) melt cinder separates: pour the solution after extracting into carry out solution and medicinal residues in centrifugal separator separation, centrifuge speed controls within the scope of 2000～3000r/Minf, centrifugation time is 5～10min, separates the Radix Pseudostellariae solution obtaining Radix Pseudostellariae clarification, and medicinal residues remove outdoor;
(6) mixing preparation: put into separate the Radix Pseudostellariae solution obtained in blend tank, add oligomeric isomaltose 8kg, start agitator and seasoning liquid is stirred homogenizing;
(7) membrane filtration: adopt nuclepore membrane filter to carry out microfiltration after Radix Pseudostellariae solution homogenizing, selects membrane aperture at the microporous filter membrane of 0.1～2 μm, and Stress control, at 0.1～0.3MPa, is filtered under flow velocity 1.5～3.5m/s;
(8) sterile filling: the Radix Pseudostellariae solution obtained through microfiltration is poured in Bottle for oral medicine in an aseptic environment and seals in time, put into ultrahigh-temperature instant sterilizer;
(9) instantaneously sterilising: the temperature of ultrahigh-temperature instant sterilizing controls at 130～150 DEG C, and steam pressure is 0.78MPa, and sterilization time is 2～5s;
(10) test package: after sterilizing cooling, is incubated 7d at 37 DEG C, broadly falls into qualified products without aerogenesis, suspension, lamination, it is possible to date printed, vanning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610093055.0A CN105661524A (en) | 2016-02-21 | 2016-02-21 | Preparation method of radix pseudostellariae oral liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610093055.0A CN105661524A (en) | 2016-02-21 | 2016-02-21 | Preparation method of radix pseudostellariae oral liquid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107822140A (en) * | 2017-12-09 | 2018-03-23 | 李宇星 | A kind of ginseng functional beverage |
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| JP2003113030A (en) * | 2001-09-28 | 2003-04-18 | Ts Aasu:Kk | Skin care preparation |
| CN101574395A (en) * | 2009-06-17 | 2009-11-11 | 赵景辉 | Method for producing schisandra extract by adopting high voltage pulse electric field technology |
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