CN101574395A - Method for producing schisandra extract by adopting high voltage pulse electric field technology - Google Patents
Method for producing schisandra extract by adopting high voltage pulse electric field technology Download PDFInfo
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- CN101574395A CN101574395A CNA2009100671236A CN200910067123A CN101574395A CN 101574395 A CN101574395 A CN 101574395A CN A2009100671236 A CNA2009100671236 A CN A2009100671236A CN 200910067123 A CN200910067123 A CN 200910067123A CN 101574395 A CN101574395 A CN 101574395A
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Abstract
The invention provides a method for producing schisandra extract by adopting high voltage pulse electric field technology. As the high voltage pulse electric field extraction technology is adopted to extract schisandra active ingredients at normal temperature, the raw type state of schisandra is remained to the maximum degree and simultaneously, the product quality and productivity are improved while the production cost is reduced. The process is advanced, the extracting time is short, the technology is novel and the extraction rate is high. The method realizes the integration of normal-temperature extraction and sterilization, guarantees no degradation of thermosensitive substances, continuously and quickly extracts and is energy-saving, environment-friendly and high-efficiency.
Description
Technical field:
The present invention relates to the method for a kind of non-heat, rapid extraction Fructus Schisandrae Chinensis extrat, particularly relate to a kind of method that adopts high-voltage pulse electric field technology rapid extraction Fructus Schisandrae Chinensis extrat, belong to Chinese herbal medicine effective ingredients extractive technique field.
Background technology:
Radix Schisandrae Bicoloris [Schisandra chinensis (Turcz.) Baill] is the perennial bejuco of Magnoliaceae.Fruit medicine, root and ratan also can be used as medicine.Have astringe the lung, nourishing kidney, hidroschesis, promote the production of body fluid, the function of antidiarrheal, arresting seminal emission.Cure mainly cough with asthma, thirst due to body fluid deficiency, spontaneous sweating, seminal emission, chronic diarrhea, neurasthenia.The recent studies proof also has blood pressure regulation, protects the liver and the effect of " adaptogen " sample.It is a kind of genuine northern rare medicinal herbs.The recent studies proof also has blood pressure regulation, protects the liver and the effect of " adaptogen " sample, is a kind of genuine northern rare medicinal herbs, and its rapid extraction technology has big practical significance.
That Fructus Schisandrae Chinensis extraction process of effective component at present commonly used has is ultrasonic, carbon dioxide supercritical fluid extraction, reflux etc., its schisandrin yield is low only to be: about 0.2 ~ 0.5%, shortcoming is cost height, time-consuming, effort, and it is huge to consume energy, and can't satisfy the production needs of field of medicaments.
Summary of the invention:
The invention provides a kind of method that adopts high-voltage pulse electric field technology rapid extraction Fructus Schisandrae Chinensis extrat, have characteristics such as quick, energy-conservation, extract at low temperature.
Technical scheme of the present invention is achieved in that a kind of method that adopts high-voltage pulse electric field technology to produce Fructus Schisandrae Chinensis extrat, comprises that following processing step is
(1) do not select the Fructus Schisandrae Chinensis damaging by worms, pollute as raw material;
(2) with about raw material pulverizing to 100 order;
(3) by material: liquid=1: (10-14) (kg/l) adds raw material and extracted solvent soaking 0.5 hour.Extracting solvent is 70-90% ethanol.
(4) raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 10-15kv, umber of pulse 10-12 is a parameter extraction, collects extracting solution continuously;
(5) extracting solution being pumped into flame filter press filters;
(6) filtrate is carried out vacuum concentration to fluid extract;
(7) fluid extract spray drying or lyophilization are become powder;
(8) in the clean dried chamber, powder packed in the plastic packaging bag, seal warehouse-in.
The schisandrin that the inventive method is extracted in the Fructus Schisandrae Chinensis reaches 0.70 ~ 0.85% of medical material weight.
" high-voltage pulse electric field " that the present invention relates to is to utilize synthetic high frequency electric directly to act on biological material, makes material molecule produce concussion, excited biomolecule activity, and effective ingredient is dissolved in the solvent fast.Energy needed exchange when this extractive technique has been omitted general extraction, the energy conduction process, directly acting is on biomolecule to extract required energy, and therefore relatively other extracting method are energy-conservation more than 50%.
Because energy directly acts on biomolecule, molecule obtains the instantaneous increase of energy, thereby the effective ingredient dissolution rate is fast, becomes stripping state by force by the free stripping state that relies on the solvent strength difference.So not needing long dissolution time during extraction waits for and multipass extraction repeatedly.
When this extraction element extracts, be, soak into, make it under flow regime, once to finish continuously comminuting matter and solvent.
Because it is big that molecule obtains energy, dissolution rate is fast, so there is not higher heat to produce in the leaching process, extracts 3-8 ℃ of temperature rise, has kept that heat-sensitive substance is not destroyed in the biological material, has better kept biological primordial condition.Extraction element is applicable to water, ethanol, and acid, alkalescence is extracted solvent.
The extracting method that below is the present invention and routine compares the effect that Fructus Schisandrae Chinensis extracts:
Good effect of the present invention is: adopt the high-pressure pulse electric extractive technique to extract schisandra active component, owing to be extract at room temperature, kept Fructus Schisandrae Chinensis ecosystem state to greatest extent, product quality and production efficiency have been improved simultaneously, reduced production cost, its technology advanced person, extraction time is short, technology is novel, extraction ratio is high, has realized extract at room temperature and sterilization one, guarantees that heat-sensitive substance do not degrade; Continuously, rapid extraction, energy-saving and environmental protection, efficient.
The specific embodiment:
For the ease of understanding the present invention, especially exemplified by following examples.Its effect is understood that it is to explaination of the present invention but not to any type of restriction of the present invention.
Embodiment 1:
Do not select the Fructus Schisandrae Chinensis 10kg that damages by worms, pollutes, be crushed to about 100 orders; 100 liters of stirring and evenly mixings of the ethanol of adding 80% soak; Place 0.5h restir mixing static reserve; Raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 10kv, umber of pulse 10 is a parameter extraction, collects extracting solution continuously; Extracting solution is pumped into flame filter press to be filtered; Filtrate is carried out vacuum concentration to fluid extract; Fluid extract spray drying or lyophilization are become powder, and the schisandrin yield is 76g.
Embodiment 2:
The 10kg Fructus Schisandrae Chinensis powder is broken to the ethanol extraction solvent soaking of 12 liter 70% of 100 orders adding; With raw material and after extracting the stirring solvent mixing, place 0.5h restir mixing static reserve; Raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15kv, umber of pulse 10 is a parameter extraction, collects extracting solution continuously; Extracting solution is pumped into flame filter press to be filtered; Filtrate is carried out vacuum concentration to fluid extract; Fluid extract spray drying or lyophilization are become powder, and the schisandrin yield is 80g.
Embodiment 3:
Select the 10kg Fructus Schisandrae Chinensis powder to be broken to about 100 orders; By material: liquid=1: 14 adds raw material and 90% ethanol extraction solvent soaking; With raw material and after extracting the stirring solvent mixing, place 0.5h restir mixing static reserve; Raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 10kv, umber of pulse 12 is a parameter extraction, collects extracting solution continuously; Extracting solution is pumped into flame filter press to be filtered; Filtrate is carried out vacuum concentration to fluid extract; Fluid extract spray drying or lyophilization are become powder, and the schisandrin yield is 85g.
Claims (1)
1, a kind of method that adopts high-voltage pulse electric field technology to produce Fructus Schisandrae Chinensis extrat comprises following processing step:
(1) do not select the Fructus Schisandrae Chinensis damaging by worms, pollute as raw material;
(2) Fructus Schisandrae Chinensis powder is broken to about 100 orders;
(3) by material: liquid=1: (10-14) (kg/l) adds raw material and 70-90% ethanol extraction solvent soaking 0.5h;
(4) raw material after will soaking is continuously pumped in the potential pulse extraction unit, and with field intensity 10-15kv, umber of pulse 10-12 is a parameter extraction, collects extracting solution continuously;
(5) extracting solution being pumped into flame filter press filters;
(6) filtrate is carried out vacuum concentration to fluid extract;
(7) fluid extract spray drying or lyophilization are become powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100671236A CN101574395B (en) | 2009-06-17 | 2009-06-17 | Method for producing schisandra extract by adopting high voltage pulse electric field technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100671236A CN101574395B (en) | 2009-06-17 | 2009-06-17 | Method for producing schisandra extract by adopting high voltage pulse electric field technology |
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| CN101574395A true CN101574395A (en) | 2009-11-11 |
| CN101574395B CN101574395B (en) | 2012-04-25 |
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| CN2009100671236A Expired - Fee Related CN101574395B (en) | 2009-06-17 | 2009-06-17 | Method for producing schisandra extract by adopting high voltage pulse electric field technology |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101973980A (en) * | 2010-09-28 | 2011-02-16 | 无限极（中国）有限公司 | Method for extracting fructus schizandrae lignans from dry fructus schizandrae fruit |
| CN102153504A (en) * | 2011-01-19 | 2011-08-17 | 长沙华康生物技术开发有限公司 | Method for preparing 1-deoxynojirimycin in mulberry leaves |
| CN102657684A (en) * | 2012-05-30 | 2012-09-12 | 赵景辉 | Method for quickly producing Lucid Ganoderma extract by utilizing high-voltage pulsed electric field |
| CN105661524A (en) * | 2016-02-21 | 2016-06-15 | 寿素贞 | Preparation method of radix pseudostellariae oral liquid |
| CN109122816A (en) * | 2018-08-21 | 2019-01-04 | 江苏大学 | A kind of preparation method and application of the black angle orchid extract of corona treatment |
-
2009
- 2009-06-17 CN CN2009100671236A patent/CN101574395B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101973980A (en) * | 2010-09-28 | 2011-02-16 | 无限极（中国）有限公司 | Method for extracting fructus schizandrae lignans from dry fructus schizandrae fruit |
| CN102153504A (en) * | 2011-01-19 | 2011-08-17 | 长沙华康生物技术开发有限公司 | Method for preparing 1-deoxynojirimycin in mulberry leaves |
| CN102153504B (en) * | 2011-01-19 | 2013-10-30 | 长沙华康生物技术开发有限公司 | Method for preparing 1-deoxynojirimycin in mulberry leaves |
| CN102657684A (en) * | 2012-05-30 | 2012-09-12 | 赵景辉 | Method for quickly producing Lucid Ganoderma extract by utilizing high-voltage pulsed electric field |
| CN105661524A (en) * | 2016-02-21 | 2016-06-15 | 寿素贞 | Preparation method of radix pseudostellariae oral liquid |
| CN109122816A (en) * | 2018-08-21 | 2019-01-04 | 江苏大学 | A kind of preparation method and application of the black angle orchid extract of corona treatment |
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| Publication number | Publication date |
|---|---|
| CN101574395B (en) | 2012-04-25 |
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Granted publication date: 20120425 Termination date: 20130617 |