CN102657694A - Quick production process for liquorice extract by high-voltage pulsed electric field - Google Patents
Quick production process for liquorice extract by high-voltage pulsed electric field Download PDFInfo
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- CN102657694A CN102657694A CN2012101722928A CN201210172292A CN102657694A CN 102657694 A CN102657694 A CN 102657694A CN 2012101722928 A CN2012101722928 A CN 2012101722928A CN 201210172292 A CN201210172292 A CN 201210172292A CN 102657694 A CN102657694 A CN 102657694A
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Abstract
The invention discloses a quick production process for liquorice extract by high-voltage pulsed electric field. The quick production process includes: crushing lucid ganoderma into 30-60 sections and adding 10-14 times of water by weight to soak the crushed lucid ganoderma for 0.5 hour, pumping the soaked raw materials of lucid ganoderma into a high-voltage pulsed extractor unit continuously by the aid of a liquid pump, extracting the raw materials by the parameters of field strength of 15kv-20kv and pulse number of 8-10, continuously collecting extract, filtering, concentrating to obtain fluid extract and spray-drying or freeze-drying to obtain powder . The high-voltage pulsed electric field extracting technology is adopted to extract active ingredients of the liquorice at a normal temperature, so that protogenesis of the liquorice is kept maximally, product quality and production efficiency are improved, production cost is reduced, process is advanced, extracting time is short, technology is novel, extracting rate is high, extracting at the normal temperature and sterilizing are integrated, and thermal-sensitive substances cannot be subjected to degradation. In addition, the quick production process for the liquorice extract by the high-voltage pulsed electric field is continuous and quick in extraction, energy-saving, environment-friendly and efficient.
Description
Technical field:
The invention discloses a kind of quick production technology of high-voltage pulse electric field of Radix Glycyrrhizae extract
, it also is provided simultaneouslyPreparation technology belongs to Chinese herbal medicine effective ingredients extractive technique field.
Background technology:
Radix Glycyrrhizae is for being the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Its property of medicine is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.In the prescription of Chinese patent medicine preparation, the frequency of utilization of Radix Glycyrrhizae is very high.Radix Glycyrrhizae extract is the part of from Radix Glycyrrhizae, extracting that medical value is arranged.Radix Glycyrrhizae extract generally comprises: glycyrrhizin, glycyrrhizic acid, liquirtin, flavonoids of Glycyrrhiza, back curtain are than wingceltis element, formoononetin, Quercetin etc.Be the extremely pale brown toner of yellow end.Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Be used to treat weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, diseases such as gastral cavity abdomen, the anxious pain of extremity contraction.Its rapid extraction technology has big practical significance.
Effective liquorice method for distilling commonly used at present has microwave-assisted extraction method, heat reflow method, soxhlet extraction, room temperature extraction method, supersound extraction etc.Hot reflux extraction time is long, and the impurity dissolution rate is high, and operational ton is big.Soxhlet extraction is owing to keep higher concentration difference, so extraction efficiency is high, immersion impurity is few, but extraction time is longer, and the solvent for use amount is bigger.Though the room temperature extraction method does not need heating, extraction time is long, and efficient is lower, is prone to moldy metamorphism when especially using water as solvent.
Summary of the invention:
The present invention provides a kind of technology that adopts high-voltage pulse electric field to produce Radix Glycyrrhizae extract fast, has characteristics such as quick, energy-conservation, extract at low temperature.
The Radix Glycyrrhizae extract that employing high-voltage pulse electric field disclosed by the invention is produced, extract through following method:
(1) Radix Glycyrrhizae powder is broken to 30 ~ 60 orders;
(2) 50%～70% edible ethanol that adds (10～12) times weight is soaked 0.5h;
(3) raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15 kv～20 kv, umber of pulse 10～12 is a parameter extraction, collects extracting solution continuously;
(4) extracting solution being pumped into flame filter press filters;
(5) filtrate is carried out vacuum concentration to fluid extract;
(6) fluid extract spray drying or lyophilization are become powder, promptly get.
The quick production technology of the high-voltage pulse electric field of Radix Glycyrrhizae extract provided by the invention comprises following processing step:
(1) Radix Glycyrrhizae powder is broken to 30 ~ 60 orders;
(2) 50%～70% edible ethanol that adds (10～12) times weight is soaked 0.5h;
(3) raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15 kv～20 kv, umber of pulse 10～12 is a parameter extraction, collects extracting solution continuously;
(4) extracting solution being pumped into flame filter press filters;
(5) filtrate is carried out vacuum concentration to fluid extract;
(6) fluid extract spray drying or lyophilization are become powder, promptly get.
The present invention utilizes the synthetic high frequency electric of high-voltage pulse electric field directly to act on the Radix Glycyrrhizae, makes the molecule of Radix Glycyrrhizae produce concussion, has excited biomolecule activity, and effective ingredient is dissolved in the solvent fast.Energy needed exchange when having omitted general extraction, the energy conduction process, directly acting is on the biomolecule of Radix Glycyrrhizae to extract required energy, and therefore relatively other method for distilling are energy-conservation more than 50%.Because energy directly acts on biomolecule, molecule obtains the instantaneous increase of energy, thereby the effective ingredient dissolution rate is fast, becomes stripping state by force by the free stripping state that relies on the solvent strength difference.So not needing long dissolution time during extraction waits for and multipass extraction repeatedly.The present invention is with pulverizing Radix Glycyrrhizae and solvent, soaks into, and makes it under flow regime, once to accomplish continuously.Because it is big that molecule obtains energy, dissolution rate is fast, so there is not higher heat to produce in the leaching process, extracts 3-8 ℃ of temperature rise, has kept that heat-sensitive substance is not destroyed in the Radix Glycyrrhizae, has better kept biological primordial condition.
Good effect of the present invention is:Adopt the high-pressure pulse electric extractive technique to extract the Radix Glycyrrhizae active component; Owing to be extract at room temperature, kept Radix Glycyrrhizae ecosystem state to greatest extent, improved product quality and production efficiency simultaneously; Reduced production cost; Its technology is advanced, extraction time is short, technology is novel, extraction ratio is high, has realized extract at room temperature and antibacterial one, and the assurance heat-sensitive substance is not degraded; Continuously, rapid extraction, energy-saving and environmental protection, efficient.
The specific embodiment:
Below in conjunction with embodiment the present invention is done further description:
Embodiment 1:
Not selecting the Radix Glycyrrhizae 1kg that damages by worms, pollutes is crushed to about 60 orders; Soak after adding 70% edible ethanol 10kg stirring and evenly mixing, place 0.5h restir mixing static reserve; Raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 20kv, umber of pulse 10 is a parameter extraction, collects extracting solution continuously; Extracting solution is pumped into flame filter press filter (800 order); Filtrate is carried out vacuum concentration to fluid extract; Fluid extract spray drying or lyophilization are become powder; In the clean dried chamber, powder is packed in the plastic packaging bag, seal, warehouse-in.High by this condition Angelica Polysaccharide yield, reach 4.5% (accounting for the crude drug amount).
Embodiment 2:
Not selecting the Radix Glycyrrhizae 1kg that damages by worms, pollutes is crushed to about 60 orders; 50% edible ethanol of 12kg is extracted solvent soaking, with raw material and after extracting the stirring solvent mixing, places 0.5h restir mixing static reserve; Raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15kv, umber of pulse 12 is a parameter extraction, collects extracting solution continuously; Extracting solution is pumped into flame filter press filter (800 order); Filtrate is carried out vacuum concentration to fluid extract; Fluid extract spray drying or lyophilization are become powder; In the clean dried chamber, powder is packed in the plastic packaging bag, seal, warehouse-in.High by this condition yield of extract, reach 17.982% (accounting for the crude drug amount).
Claims (2)
1. the Radix Glycyrrhizae extract that adopts high-voltage pulse electric field technology to produce, extract through following method:
(1) Radix Glycyrrhizae powder is broken to 30 ~ 60 orders;
(2) 50%～70% edible ethanol that adds (10～12) times weight is soaked 0.5h;
(3) raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15 kv～20 kv, umber of pulse 10～12 is a parameter extraction, collects extracting solution continuously;
(4) extracting solution being pumped into flame filter press filters;
(5) filtrate is carried out vacuum concentration to fluid extract;
(6) fluid extract spray drying or lyophilization are become powder, promptly get.
2. the quick production technology of the high-voltage pulse electric field of the said Radix Glycyrrhizae extract of claim 1 comprises following processing step:
(1) Radix Glycyrrhizae powder is broken to 30 ~ 60 orders;
(2) 50%～70% edible ethanol that adds (10～12) times weight is soaked 0.5h;
(3) raw material after will soaking with liquor pump is continuously pumped in the potential pulse extraction unit, and with field intensity 15 kv～20 kv, umber of pulse 10～12 is a parameter extraction, collects extracting solution continuously;
(4) extracting solution being pumped into flame filter press filters;
(5) filtrate is carried out vacuum concentration to fluid extract;
(6) fluid extract spray drying or lyophilization are become powder, promptly get.
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| CN2012101722928A CN102657694A (en) | 2012-05-30 | 2012-05-30 | Quick production process for liquorice extract by high-voltage pulsed electric field |
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| CN2012101722928A CN102657694A (en) | 2012-05-30 | 2012-05-30 | Quick production process for liquorice extract by high-voltage pulsed electric field |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107586715A (en) * | 2017-10-09 | 2018-01-16 | 复旦大学 | Utilize the apparatus and method of electroporation technology extraction Chinese medicine drug ingedient |
| CN107973731A (en) * | 2018-01-09 | 2018-05-01 | 金乡县大蒜研究所 | A kind of method for extracting garlic alliin |
| CN113854509A (en) * | 2021-10-08 | 2021-12-31 | 瑞昌市溢香农产品有限公司 | Extraction method and extraction system of preserved egg pickling liquid |
| CN114748526A (en) * | 2022-04-02 | 2022-07-15 | 长春中医药大学 | Method for extracting effective components from dicotyledonous plants |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736534A (en) * | 2005-07-12 | 2006-02-22 | 吉林大学 | Method for lixiviating effective components from biomass material |
| CN101138686A (en) * | 2007-07-23 | 2008-03-12 | 沈军 | Method for extracting active ingredient of natural product and uses thereof |
| CN101550284A (en) * | 2009-05-11 | 2009-10-07 | 王振宇 | Method for extracting pigment of hazelnut shell |
-
2012
- 2012-05-30 CN CN2012101722928A patent/CN102657694A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736534A (en) * | 2005-07-12 | 2006-02-22 | 吉林大学 | Method for lixiviating effective components from biomass material |
| CN101138686A (en) * | 2007-07-23 | 2008-03-12 | 沈军 | Method for extracting active ingredient of natural product and uses thereof |
| CN101550284A (en) * | 2009-05-11 | 2009-10-07 | 王振宇 | Method for extracting pigment of hazelnut shell |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107586715A (en) * | 2017-10-09 | 2018-01-16 | 复旦大学 | Utilize the apparatus and method of electroporation technology extraction Chinese medicine drug ingedient |
| CN107973731A (en) * | 2018-01-09 | 2018-05-01 | 金乡县大蒜研究所 | A kind of method for extracting garlic alliin |
| CN113854509A (en) * | 2021-10-08 | 2021-12-31 | 瑞昌市溢香农产品有限公司 | Extraction method and extraction system of preserved egg pickling liquid |
| CN114748526A (en) * | 2022-04-02 | 2022-07-15 | 长春中医药大学 | Method for extracting effective components from dicotyledonous plants |
| CN114748526B (en) * | 2022-04-02 | 2023-07-04 | 长春中医药大学 | Method for extracting effective components from dicotyledonous plants |
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Application publication date: 20120912 |