CN102533433A - Method for supercritical extraction of sea buckthorn oil - Google Patents
Method for supercritical extraction of sea buckthorn oil Download PDFInfo
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Abstract
The invention mainly relates to a method for supercritical extraction of sea buckthorn oil, which includes: using fresh sea buckthorn fruits as raw materials, smashing, performing enzymolysis, and supercritically extracting to obtain sea buckthorn seed oil. The method makes full use of proteins in the sea buckthorn fruits in the whole extraction process, enables the sea buckthorn oil to contain a large amount of free essential amino acid and more free unsaturated fatty acid, greatly improves quality of the sea buckthorn oil. The method for supercritical extraction of the sea buckthorn oil avoids the problem of blocking of a device after enzymolysis lipid substances are adopted, guarantees use safety of the device, and improves utilization ratio of the device.
Description
Technical field
The invention belongs to the natural product chemistry field, be specifically related to a kind of method of supercritical extraction Oleum Hippophae.
Background technology
Sea-buckthorn (
Hippophae hanmoides Linn.) belong to the Elaeangnaceae hippophae plant, belong to machaka or dungarunga, have another name called sour willow fruit, sour willow, it is examined a day loud, high-pitched sound and examines (covering name), a Da Pu (hide), Ji Han (Uygur's name).Mainly be distributed in more than ten provinces and regions such as NORTHWEST CHINA, North China, northeast and southwest, the whole nation has 1,000,000 hm approximately
2It is Ancient Times in China Tibetan medicine, Mongolian medicine's common drug, is formally listed in China's pharmacopeia in 1977.Sea-buckthorn is a kind of medicinal plant that contains 190 various active materials such as VITAMINs, trace element, amino acid and flavones.In recent years side such as chemistry, biology, medical science and RR to the mankind showed Seabuckthorm Seed Oil in antibiotic, enhancing human immune, side such as antitumor and good result.The method of from sea-buckthorn, extracting Oleum Hippophae mainly contains milling process, solvent method, diffusion process and supercritical CO
24 kinds of extraction processs etc.Because supercritical CO
2Advantages such as extraction process has that oily yield is high, activity substance content is high, non-environmental-pollution, oil quality are good are just obtaining application more and more widely at present.
Publication number is that the Chinese patent of CN1435415 has been introduced a kind of Oleum Hippophae and Fructus Hippophae flavone combined extraction technology: with pulp; Pericarp or leaf are put into extractor, squeeze into No. 1 solvent (R1) then by a certain percentage and soak certain hour, open indirect steam and heat; Opening whisking appliance simultaneously stirs; Emit head when time is up all over mixed solution, carry out the above lixiviate of secondary successively, and the mixed solution that will at every turn obtain focuses in the concentration tank.Residue after the lixiviate feeds open steam and takes off wherein residual No. 1 solvent (R1) to the greatest extent, gets into the extracting solution in the concentration tank, behind the heating precipitation; CE, (solvent gas gets into condensate recovery system equally) gets in the separator then, adds No. 2 solvents (R2) and carries out stage trapping; To tell the lipid material in the CE to greatest extent, draw behind the medicinal extract to pump into medicinal extract and add clear water in the washing tank and wash, after removing wherein entrained water-soluble impurity; Through the filter waste liquid of draining, promptly obtain smart flavones medicinal extract, and in whole process all lipid materials of separating; It is mixing oil; Then merge to get into temporary jar of mixing oil, sent into successively again to steam in vaporizer and the precipitation jar and take off residual No. 2 solvents (R2) and can obtain its sub product Oleum Hippophae, and solvent gas is recovered utilization too.
Publication number is that the Chinese patent of CN1451658 has been introduced the method that a kind of three solvent systems extract the Fructus Hippophae total flavones: the process for extracting that discloses a kind of Fructus Hippophae (being fructus hippophae) total flavones: adopt three solvent systems to make solvent; From Fructus Hippophae, extract total flavones, adopt static stripping technique to remove sea-buckthorn wet goods lipid-soluble substance and the bigger impurity of water eccysis depolarization, and reach the purpose of purification of flavone.Process for extracting of the present invention has shortened extraction time and production cycle, has improved the extraction yield and the purity of Fructus Hippophae total flavones.In whole process of production, eliminated poisonous, deleterious organic solvents such as inflammable, explosive organic solvent such as normal hexane or sherwood oil and chloroform, reduced production cost, guaranteed the security and the environmental requirement of producing.
Publication number is that the Chinese patent of CN101935585A has been introduced a kind of novel process of extracting Oleum Hippophae through the two-stage method of fractional steps: mainly contain organic compositions such as unsaturated fatty acids, unsaponifiables and glycerin fatty acid ester in the Oleum Hippophae, the content of unsaturated fatty acids is up to 68% in the Oleum Hippophae.Because solvent-extraction process destroys very big to the Oleum Hippophae nutritive ingredient and dissolvent residual is arranged, so need then use solvent extraction again with physical method extraction high-quality as much as possible Oleum Hippophae.The present invention adopts the butterfat whizzer tentatively to extract Oleum Hippophae earlier, sea-buckthorn pulp oil yield 6.1%; Sea-buckthorn pulp after centrifugal is handled with the salt solution breakdown of emulsion, removed large quantity of moisture, adjust the moisture of light phase liquid, adopt normal hexane to carry out the extraction of Oleum Hippophae then, i.e. the method for substep extraction as solvent through adding the high temperature dregs of beans through spinning.Optimum process condition: extraction time 6h, the light phase liquid of sea-buckthorn adds than 1: 4 with the high temperature dregs of beans, 5 times of solvent multiples, extraction time 4 times, sea-buckthorn tankage extraction oil yield reaches 98.1%, thereby obtains the Oleum Hippophae of different levels.
Publication number is that the Chinese patent of CN1050216 has been introduced a kind of method of extracting Oleum Hippophae: the method for extracting Oleum Hippophae is with the frequent gentle 37-45 of pulp ℃ following forced dehydration, makes water cut reduce to 50-60% and 10-15% in succession; Return to add by the heavy 10-15% of this dehydrated pulp and replace water and under 30-40 ℃ of condition, force homogenizing to be mixed; Beginning is seen oil impregnate to the pulp top layer; Promptly oil content is gone out at centrifugal device; To its dregs of rice cake with 40-45 ℃ of intensification dewater to water cut be 8-12%, by pressure oil is extruded.This law is simple and easy to do, less investment, without organic solvent, non-toxic and safe, oil are good, the recovery is high.
Publication number is that CN101273764 reduces the method for Seabuckthorn Oil toxic material and the Seabuckthorn Oil that adopts this method to process: relate to a kind of Seabuckthorn Oil that reduces the method for Seabuckthorn Oil toxic material and adopt this method processing; At first the Seabuckthorn Oil that will weigh and measure toxic chemical content heats under vacuum condition; Height according to Seabuckthorn Oil toxic content of material adds a certain amount of adsorbent in Seabuckthorn Oil then, keeps temperature stirring reaction certain hour; Then Seabuckthorn Oil is cooled to about 50 ℃, after filtration Seabuckthorn Oil is separated with adsorbent, can accomplish the work of treatment of Seabuckthorn Oil toxic material, obtain the Seabuckthorn Oil finished product.Method provided by the present invention is easy and simple to handle, high efficiency; Adopt the Oleum Hippophae of this method processing can effectively keep wherein nutrition and local flavor; When reducing benzopyrene content, also can reduce the content of some contained in the Oleum Hippophae other toxicants, to satisfy the food safety requirements of food or protective foods.
Publication number is the process for extracting that the Chinese patent of CN86108906 has been introduced a kind of Oleum Hippophae: relating to a kind of process for extracting of Oleum Hippophae, is to be raw material with hippophae rhamnoides seed, pulp, pomace, fruit juice swimmer, has fully utilized various system light wood material.For retentive activity composition as much as possible; The present invention adopts the mixed solvent of aliphatic hydrocarbon and ketone or single fat hydrocarbon solvent to leach; With the film-type evaporation precipitation, again with the gained crude oil in same container come unstuck under the condition of 15～25 ℃ of temperature, depickling, dewaxing and then be lower than decolouring under 65 ℃ the condition, deodorization promptly gets and makes with extra care the system Oleum Hippophae.
Publication number is that the Chinese patent of CN1038300 has been introduced the removal methods that a kind of extraction is produced residual solvent in Oleum Hippophae and other vegetables oil: this method is about produce the removal methods of residual solvent in Oleum Hippophae and other vegetables oil with solvent extraction method.For reaching the purpose that removes residual solvent, adopted three kinds of technical schemes: the one, molecular sieve adsorption, the 2nd, the rare gas element circulation flushing removes solvent method, and the 3rd, polar-solvent extraction.The three kinds of equal ability of technical scheme effective elimination residual solvents reach edible, medicinal standard, and do not destroy wherein effective active components again, and technology is simple, and facility investment is few, and bigger economic and social benefit is arranged.
Publication number is the method that the Chinese patent of CN1031108 has been introduced a kind of supercritical extraction Oleum Hippophae: relate to a kind of CO
2The method of supercritical gas extracting Oleum Hippophae is characterized in that with seed of Fructus Hippophae or sea-buckthorn pomace be raw material, with CO
2For extracting solvent out, at pressure 10～30Mpa, extracting under the supercritical state that temperature is 32～45 ℃, step-down step by step under 32-45 ℃, Oleum Hippophae and CO
2Separate CO voluntarily
2Recycling is used.
Publication number is that the Chinese patent of CN100998618 has been introduced a kind of supercritical CO of using
2The method of fluid continuous extraction Oleum Hippophae and Fructus Hippophae flavone: disclose a kind of supercritical CO of using
2The method of fluid continuous extraction Oleum Hippophae and Fructus Hippophae flavone, this method places supercritical CO with the sea-buckthorn dry fruit or through the exsiccant sea-buckthorn pomace
2In the extraction equipment, extracted 0.5～1 hour, extraction obtains Oleum Hippophae; Then to supercritical CO
2Inject entrainment agent in the extraction equipment, continue extraction 2～3 hours, extraction obtains Fructus Hippophae flavone; Extraction conditions is 30～50 ℃ of temperature, pressure 20～40MPa, CO
2Flow 15～25kg/h.The present invention can be in same technical process, disposable acquisition Oleum Hippophae and Fructus Hippophae flavone.
Show employing directly extraction sea-buckthorn dry fruit or pomace from aforesaid method; Do not handle sea-buckthorn through any biological method; Owing in the Fructus Hippophae amounts of protein and lipid material are arranged; Protein does not obtain utilization in the process that directly extracts Oleum Hippophae, the lipid material conversion is not thorough, does not form a large amount of free unsaturated fatty acids, causes and only contains less free unsaturated fatty acid and few total free aminoacids in the Oleum Hippophae.In addition, the flowability of its lipid material is poorer than unsaturated fatty acids, causes overcritical equipment to stop up easily with overcritical direct extraction.
Thereby the Oleum Hippophae that the sea-buckthorn dry fruit is developed to health care is significant, explores to extract Oleum Hippophae after biological method is handled the sea-buckthorn dry fruit, and it is of far-reaching significance.
Summary of the invention
The object of the present invention is to provide a kind of method of supercritical extraction Oleum Hippophae; This method is not high and to have proposed a kind of be that raw material and technology are simple with the sea buckthorn fruit in order to overcome existing technical sophistication and the efficient utilized in the sea buckthorn fruit separation and purification Oleum Hippophae; Easy to operate; Cost is low, and yield is high, resource recovery and be suitable for the working method of large-scale industrialization separation and purification Oleum Hippophae from sea-buckthorn.
It is simple that the present invention will disclose a kind of technology, easy to operate, and cost is low, and yield is high and be suitable for the working method of large-scale industrialization extraction separation Seabuckthorm Seed Oil from sea-buckthorn, is raw material with the sea buckthorn fruit, through rubbing, enzymolysis, overcritical Seabuckthorm Seed Oil.
Of the present invention is a kind of method of supercritical extraction Oleum Hippophae, and its operation steps is following:
(1), place incubator after homogenate adds a certain amount of proteolytic enzyme and lypase, at 40 ℃ of insulation 10 h with after sea buckthorn fruit and the homogenate of equivalent volumes water milled mixture;
(2) its enzymolysis solution is put into supercritical CO
2In the barrel of extraction plant, drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃ respectively, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Behind the rate, carry out reflux extraction, the extraction certain hour;
(3) close HPP and extraction kettle separating still heater switch, Open valve 2 reclaims CO
2, from the separating still discharge hole for discharge, collect extract, be the Oleum Hippophae elaboration.
In one embodiment, raw material described in the step 1 is fresh sea buckthorn fruit, and said proteolytic enzyme is made up of neutral protease and aspartic protease balanced mix, and the enzyme amount unit of adding is 10:1-2 with the weight ratio (U/kg) of homogenate; Said lypase, the enzyme amount unit of adding is 20:1-4 with the weight ratio (U/kg) of homogenate.
In another embodiment, the adjusting CO described in the step 2
2Rate is 0 .2-0.3m
3Behind/the h; The described reflux extraction time is about 2-3h.
Technique effect:
1, the present invention compares with existing method, makes full use of the protein in the sea buckthorn fruit, makes to contain a large amount of free indispensable amino acids in the Oleum Hippophae.
2, this method obtains more free unsaturated fatty acid, has improved the Oleum Hippophae quality widely.
3, the equipment blocking problem has been avoided in extraction behind the employing enzymolysis lipid material, has guaranteed the safe in utilization of equipment, has improved the utilising efficiency of its equipment.
Description of drawings
Fig. 1, supercritical CO
2Extraction plant figure.
Embodiment
Below in conjunction with accompanying drawing, further specify essentiality content of the present invention with embodiment of the present invention, but do not limit the present invention with this.
Embodiment 1:
After fresh sea buckthorn fruit 10kg and the homogenate of equivalent volumes water milled mixture; Place incubator (proteolytic enzyme and lypase can be supported bio tech ltd and bought from Hunan, Changsha) after homogenate adds 250U proteolytic enzyme and 450U lypase; At 40 ℃ of insulation 10 h, its enzymolysis solution is placed the barrel of 30L, and the extraction kettle of packing into; Install pressure ring and sealing-ring; The upper plug head of screwing is opened the system refrigerator then, extraction kettle, separating still I, separating still II temperature controller is adjusted to the temperature of required setting respectively; Drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃ respectively, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Rate is at 0 .2-0.3m
3Behind/the h, extract 150min after, close HPP and extraction kettle separating still heater switch again, Open valve 2 reclaims CO
2, from separating still I, separating still II discharge hole for discharge, collect extract, be the Oleum Hippophae elaboration, and the Oleum Hippophae that is extracted has been carried out its composition analysis, the result sees table 1.
Case of comparative examples:
After fresh sea buckthorn fruit 10kg and the homogenate of equivalent volumes water milled mixture, place the barrel of 30L, and the extraction kettle of packing into; Install pressure ring and sealing-ring; The upper plug head of screwing is opened the system refrigerator then, extraction kettle, separating still I, separating still II temperature controller is adjusted to the temperature of required setting respectively; Drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Rate is at 0 .2-0.3m
3Behind/the h, extract 150min after, close HPP and extraction kettle separating still heater switch again, Open valve 2 reclaims CO
2, from separating still I, separating still II discharge hole for discharge, collect extract, be the Seabuckthorm Seed Oil elaboration, and the Oleum Hippophae that is extracted has been carried out its composition analysis, the result sees table 1.
Embodiment 2:
After fresh sea buckthorn fruit 100kg and the homogenate of equivalent volumes water milled mixture, place incubator after homogenate adds 3000U proteolytic enzyme and 5000U lypase, at 40 ℃ of insulation 10 h; Its enzymolysis solution is placed the barrel of 300L; And the extraction kettle of packing into, install pressure ring and sealing-ring, the upper plug head of screwing; Open the system refrigerator then, extraction kettle, separating still I, separating still II temperature controller are adjusted to the temperature of required setting respectively; Drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Rate is at 0 .2-0.3m
3Behind/the h, extract 180min after, close HPP and extraction kettle separating still heater switch again, Open valve 2 reclaims CO
2, from separating still I, separating still II discharge hole for discharge, collect extract, be the Seabuckthorm Seed Oil elaboration, and the Oleum Hippophae that is extracted has been carried out its composition analysis, the result sees table 1.
Embodiment 3:
After fresh sea buckthorn fruit 200kg and the homogenate of equivalent volumes water milled mixture, place incubator after homogenate adds 5500U proteolytic enzyme and 9000U lypase, at 40 ℃ of insulation 10 h; Its enzymolysis solution is placed the barrel of 300L; And the extraction kettle of packing into, install pressure ring and sealing-ring, the upper plug head of screwing; Open the system refrigerator then, extraction kettle, separating still I, separating still II temperature controller are adjusted to the temperature of required setting respectively; Drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Rate is at 0 .2-0.3m
3Behind/the h, extract 120min after, close HPP and extraction kettle separating still heater switch again, Open valve 2 reclaims CO
2, from separating still I, separating still II discharge hole for discharge, collect extract, be the Seabuckthorm Seed Oil elaboration, and the Oleum Hippophae that is extracted has been carried out its composition analysis, the result sees table 1.
Table 1
| Project | Embodiment 1 | Case of comparative examples | Embodiment 2 | Embodiment 3 |
| Oleic acid | 22.58% | 22.94% | 22.52% | 22.61% |
| Linolic acid | 36.71% | 37.02% | 36.68% | 36.76% |
| Arachidonic acid | 0.35% | 0.38% | 0.33% | 0.41% |
| Linolenic acid | 24.83% | 25.26% | 24.86% | 24.75% |
| Amino acid | 3.52% | 0.48% | 3.68% | 3.61% |
| Unsaturated fatty acids amounts to | 85.78% | 86.42% | 85.45% | 86.08% |
| Sfas amounts to | 10.46% | 11.54% | 10.35% | 10.26% |
| Total fat | 96.24% | 99.18% | 95.80% | 96.34% |
Claims (3)
1. the present invention provides a kind of method of supercritical extraction Oleum Hippophae, and step comprises:
(1), place incubator after homogenate adds a certain amount of proteolytic enzyme and lypase, at 40 ℃ of insulation 10 h with after sea buckthorn fruit and the homogenate of equivalent volumes water milled mixture;
(2) its enzymolysis solution is put into supercritical CO
2In the barrel of extraction plant, drop to about 0 ℃ at refrigerator temps, extraction kettle and separating still II reach 45 ℃ respectively, after separating still I temperature reaches 50 ℃, open gas cylinder, open valve 2 (CO
2In cold circulation, liquefy); Opening HPP then pressurizes; When the extracting pressure of extraction kettle reaches 35MPa, regulate the valve that dams and make the extraction kettle pressure equilibrium, then the pressure of regulated valve control extraction kettle separating still I, separating still II; Reach 12 MPa, separate axe II pressure and reach 5.5 Mpa Deng separating axe I pressure, regulate CO
2Behind the rate, carry out reflux extraction, the extraction certain hour;
(3) close HPP and extraction kettle separating still heater switch, Open valve 2 reclaims CO
2, from the separating still discharge hole for discharge, collect extract, be the Oleum Hippophae elaboration.
2. according to the process of claim 1 wherein that the described raw material of step 1 is fresh sea buckthorn fruit, said proteolytic enzyme is made up of neutral protease and aspartic protease balanced mix, and the enzyme amount unit of adding is 10:1-2 with the weight ratio (U/kg) of homogenate; Said lypase, the enzyme amount unit of adding is 20:1-4 with the weight ratio (U/kg) of homogenate.
3. according to the method for claim 1 or 2, the adjusting CO described in the step 2 wherein
2Rate is 0 .2-0.3m
3Behind/the h; The described reflux extraction time is about 2-3h.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102960475A (en) * | 2012-12-25 | 2013-03-13 | 江南大学 | Method for preparing aroma rapeseed oil |
| CN103602518A (en) * | 2013-11-21 | 2014-02-26 | 张森林 | Process method for supercritical vegetable oil extracting by leaching |
| CN105287666A (en) * | 2015-12-02 | 2016-02-03 | 北京诺康达医药科技有限公司 | Method for preparing sea buckthorn seed oil |
| CN105400590A (en) * | 2015-12-24 | 2016-03-16 | 兰州乾源生物科技开发有限公司 | Preparation method of bitter apricot kernel unsaturated fatty acids |
| CN106265785A (en) * | 2016-08-12 | 2017-01-04 | 张掖市润星生物科技有限公司 | A kind of Fructus Hippophae depression capsule and production technology thereof |
| CN106455643A (en) * | 2014-02-26 | 2017-02-22 | 伊诺威有限公司 | Super critical hydrolysis extraction apparatus and hydrolysis method using the same |
| CN106978257A (en) * | 2017-05-12 | 2017-07-25 | 贺州学院 | The extracting method of navel orange pericarp essential oil |
| EP3315174A1 (en) * | 2016-11-01 | 2018-05-02 | Aromtech Ltd | Seed oil, composition comprising seed oil and use of seed oil |
| CN108130185A (en) * | 2017-12-30 | 2018-06-08 | 长沙湘资生物科技有限公司 | Utilize the method for cape jasmine extraction cape jasmine oil |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102960475A (en) * | 2012-12-25 | 2013-03-13 | 江南大学 | Method for preparing aroma rapeseed oil |
| CN102960475B (en) * | 2012-12-25 | 2014-04-30 | 江南大学 | Method for preparing aroma rapeseed oil |
| CN103602518A (en) * | 2013-11-21 | 2014-02-26 | 张森林 | Process method for supercritical vegetable oil extracting by leaching |
| CN106455643A (en) * | 2014-02-26 | 2017-02-22 | 伊诺威有限公司 | Super critical hydrolysis extraction apparatus and hydrolysis method using the same |
| CN105287666A (en) * | 2015-12-02 | 2016-02-03 | 北京诺康达医药科技有限公司 | Method for preparing sea buckthorn seed oil |
| CN105287666B (en) * | 2015-12-02 | 2019-03-19 | 北京诺康达医药科技股份有限公司 | A kind of preparation method of Seabuckthorm Seed Oil |
| CN105400590A (en) * | 2015-12-24 | 2016-03-16 | 兰州乾源生物科技开发有限公司 | Preparation method of bitter apricot kernel unsaturated fatty acids |
| CN106265785A (en) * | 2016-08-12 | 2017-01-04 | 张掖市润星生物科技有限公司 | A kind of Fructus Hippophae depression capsule and production technology thereof |
| EP3315174A1 (en) * | 2016-11-01 | 2018-05-02 | Aromtech Ltd | Seed oil, composition comprising seed oil and use of seed oil |
| CN106978257A (en) * | 2017-05-12 | 2017-07-25 | 贺州学院 | The extracting method of navel orange pericarp essential oil |
| CN108130185A (en) * | 2017-12-30 | 2018-06-08 | 长沙湘资生物科技有限公司 | Utilize the method for cape jasmine extraction cape jasmine oil |
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