CN106265785A - A kind of Fructus Hippophae depression capsule and production technology thereof - Google Patents
A kind of Fructus Hippophae depression capsule and production technology thereof Download PDFInfo
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- CN106265785A CN106265785A CN201610660187.7A CN201610660187A CN106265785A CN 106265785 A CN106265785 A CN 106265785A CN 201610660187 A CN201610660187 A CN 201610660187A CN 106265785 A CN106265785 A CN 106265785A
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- seed
- fructus hippophae
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- sarcocarp
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- 241000229143 Hippophae Species 0.000 title claims abstract description 124
- 235000003935 Hippophae Nutrition 0.000 title claims abstract description 119
- 239000002775 capsule Substances 0.000 title claims abstract description 76
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 30
- 238000005516 engineering process Methods 0.000 title abstract description 7
- 239000000203 mixture Substances 0.000 claims abstract description 57
- 239000002893 slag Substances 0.000 claims abstract description 46
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 46
- 235000019198 oils Nutrition 0.000 claims abstract description 37
- 235000012054 meals Nutrition 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 20
- 238000007710 freezing Methods 0.000 claims abstract description 14
- 230000008014 freezing Effects 0.000 claims abstract description 14
- 235000021022 fresh fruits Nutrition 0.000 claims abstract description 14
- 238000010009 beating Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000000227 grinding Methods 0.000 claims abstract description 8
- 238000004513 sizing Methods 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 239000007788 liquid Substances 0.000 claims description 25
- 108010010803 Gelatin Proteins 0.000 claims description 17
- 239000012153 distilled water Substances 0.000 claims description 17
- 239000008273 gelatin Substances 0.000 claims description 17
- 229920000159 gelatin Polymers 0.000 claims description 17
- 235000019322 gelatine Nutrition 0.000 claims description 17
- 235000011852 gelatine desserts Nutrition 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 15
- 239000003292 glue Substances 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 11
- 235000015203 fruit juice Nutrition 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000005119 centrifugation Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 238000007654 immersion Methods 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims 1
- 230000000857 drug effect Effects 0.000 abstract description 10
- 239000004615 ingredient Substances 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 21
- 235000016709 nutrition Nutrition 0.000 description 18
- 239000000126 substance Substances 0.000 description 15
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 14
- -1 triterpene alkenes Chemical class 0.000 description 14
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 13
- 229930003944 flavone Natural products 0.000 description 13
- 235000011949 flavones Nutrition 0.000 description 13
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 13
- 238000002372 labelling Methods 0.000 description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
- 229930003231 vitamin Natural products 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 8
- 150000003722 vitamin derivatives Chemical class 0.000 description 8
- 229930182558 Sterol Natural products 0.000 description 7
- 229930013930 alkaloid Natural products 0.000 description 7
- 150000003797 alkaloid derivatives Chemical class 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 210000003710 cerebral cortex Anatomy 0.000 description 7
- 235000013399 edible fruits Nutrition 0.000 description 7
- 150000002212 flavone derivatives Chemical class 0.000 description 7
- 210000005036 nerve Anatomy 0.000 description 7
- 235000015097 nutrients Nutrition 0.000 description 7
- 150000007524 organic acids Chemical class 0.000 description 7
- 230000035479 physiological effects, processes and functions Effects 0.000 description 7
- 230000000717 retained effect Effects 0.000 description 7
- 235000015096 spirit Nutrition 0.000 description 7
- 150000003432 sterols Chemical class 0.000 description 7
- 235000003702 sterols Nutrition 0.000 description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000003001 depressive effect Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- 230000003381 solubilizing effect Effects 0.000 description 6
- 230000009469 supplementation Effects 0.000 description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 5
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 5
- 229930003268 Vitamin C Natural products 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- 238000005096 rolling process Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Fructus Hippophae depression capsule and production technology thereof, the present invention comprises the following steps (1) making beating: pull an oar after sea-buchthorn fresh fruit is peace and quiet, through filtering to obtain primary pulp and seed slag, skin slag mixture；(2) it is centrifuged primary pulp separating, takes sarcocarp；(3) described sarcocarp is first carried out freezing, then be dried；(4) dried sarcocarp is grinding to obtain pulp powder；(5), after seed slag, skin slag mixture being dried, seed of Fructus Hippophae is screened out；(6) seed processed oil: prepare seed oil with seed of Fructus Hippophae, mix with pulp powder, obtain oil meal mixture；(7) capsule is prepared；(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.Using the present invention to prepare Fructus Hippophae depression capsule, prevention and treatment to depressed disease have good result, and higher to Fructus Hippophae effective ingredient reservation degree, finished product drug effect is more preferably.
Description
Technical field
The present invention relates to a kind of capsule and production technology thereof, be specifically related to a kind of Fructus Hippophae depression capsule and produce work
Skill.
Background technology
Fructus Hippophae is a kind of fallen leaves property shrub, and its characteristic is drought-enduring, anti-blown sand, can survive on wetland with saline-alkaline, therefore
It is widely used in water and soil conservation.Northwest China plants Fructus Hippophae in a large number, for desert afforestation.Vitamin C content in sea buckthorn fruit
Height, have the laudatory title of the king of vitamin C.Fructus Hippophae is the general designation of plant and its fruit.Plant Fructus Hippophae is Elaeangnaceae Hippophae, is
A kind of fallen leaves property shrub.Domestic it is distributed in the ground such as North China, northwest, southwest.Fructus Hippophae is medicinal and edible plant.The root of Fructus Hippophae, stem,
Leaf, flower, really, particularly sea buckthorn fruit contains abundant nutrient substance and bioactive substance, can be widely applied to food, doctor
Many fields of the national economy such as medicine, light industry, space flight, farming, animal husbandry and fishery.Sea buckthorn fruit be used as medicine have relieving cough and resolving phlegm, invigorating the stomach and promoting digestion,
Effect of promoting blood circulation to remove blood stasis.Modern medicine study, Fructus Hippophae can reduce cholesterol, and allevating angina pectoris shows effect, and also prevents and treats coronary artery
The effect of atherosclerotic heart disease.It is used for cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, falls and flutter congestive edema, blood stasis amenorrhea.
Sea buckthorn fruit is nutritious, according to surveying and determination in its fruit containing multivitamin, fatty acid, trace element, sub-oil element,
Fructus Hippophae flavone, superoxides isoreactivity material and the various aminoacid of needed by human body.Wherein Vitamin C content is high, every 100 grams
In fruit juice, Vitamin C content can reach 825 1100 milligrams, is 23 times of Fructus actinidiae chinensis, have the laudatory title of the king of vitamin C.
Sugary 7.5% 10%, containing acid 3% 5%.
Containing 206 kinds of active substances useful to human body in Oleum Hippophae, wherein there are 46 kinds of bioactive substances, containing a large amount of
Vitamin E, vitamin A, flavone etc., there is resisting fatigue and enhancing body vigor and the special pharmacological performance such as anticancer, there is guarantor
Protect and accelerate gastric mucosa reparation, the property of medicine of increase intestinal bifidobacteria, have fall to subtract plasma cholesterol, reduce cholesterol in blood vessel wall
The effect of content, the anti-curing hyperlipemia of energy and atherosclerosis, and have the effect promoting wound healing.
What Fructus Hippophae played a major role in beauty treatment is Oleum Hippophae, a large amount of vitamin Es of wherein containing, vitamin A, flavone and
SOD active component can effectively prevent free radical to reach the effect of defying age, and therefore Fructus Hippophae is used as important by cosmetic industry
Superior cosmetics raw material, through advanced technologies extract cosmetics-stage Oleum Hippophae purity, activity the highest.
Fructrs Hippophae seed oil, brown color to brownish red transparent oily liquid, integrate the high enrichment thing of Effective Compositions of Seabuckthorn.
Include more than the 140 kind of bioactive ingredients such as flavone, organic acid, alkaloid, sterols, triterpene alkenes and various vitamin.Fructus Hippophae
In composition 5-hydroxy tryptamine effective to treatment depression and climacteric syndrome, VC, VE to neural protected function, Oleum Hippophae and
Terpene substances dredging neutral net, regulation hormone and Endocrine Levels, cerebral cortex can be stimulated, lax nerve, pressure of releiving,
Help physiology and psychology to coordinate, make people be emotionally stable, in high spirits, improve the judgement to things.
The most in the ascendant to the exploitation of Fructus Hippophae, based on the health care property of medicine that Fructus Hippophae is unique, its product exists
Fallen over each other panic buying on international market, its effective ingredient is manufactured into capsule and will certainly obtain the heat handful of consumer, in prior art,
To the production procedure of Related product without industry standard, complex manufacturing, product effective ingredient is destroyed more, causes product to imitate
Fruit is the best.
Summary of the invention
It is an object of the invention to provide a kind of Fructus Hippophae depression capsule and production technology thereof, solve to produce Fructus Hippophae at present and press down
Strongly fragrant disease capsule manufacturing techniques is complicated, destroys more to product effective ingredient, the problem causing product poor effect, and specific aim
Exploitation Fructus Hippophae treatment depression medical value.
For solving above-mentioned technical problem, the present invention by the following technical solutions: a kind of Fructus Hippophae depression capsule manufacture work
Skill, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp so that finished product drug effect is more preferably.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, described pulp powder, seed oil is mixed, obtains
Oil meal mixture.Seed oil includes flavone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, presses down treatment
Strongly fragrant disease has extremely well effect, can stimulate cerebral cortex, lax nerve, pressure of releiving, and helps physiology and psychology to coordinate, makes people
It is emotionally stable, in high spirits.Use different technique for sarcocarp from seed of Fructus Hippophae, process respectively so that it is interior nutritional labeling is equal
Preferably retained, and according to the difference of the two composition, mixed, mutually promoted so that finished product drug effect is more preferably.
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin put into immersion in distilled water and makes it expand,
After gel solubilizing, add glycerol, heated and stirred mix homogeneously, obtain capsule material glue, then capsule material glue is coated in smooth plate table
On face, make thickness uniform, then heat by the temperature of 85～95 DEG C, make surface moisture evaporate so that it is to have certain toughness, bullet
Property, prepare cushion compound, more repressed prepared capsule；
(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.
As preferably, described sarcocarp is dried employing steam heat drying, and temperature controls at 70～80 DEG C, and the time is 30 points
Clock.Sarcocarp is the most chilled, and its interior water becomes ice crystal, then heats through steam so that it is interior water sublimed, and this method de-water ratio is high,
And best to the nutrient substance retention in sarcocarp, temperature can not be the highest, it is to avoid in high temperature makes it, chemical substance changes
Become, desirable effect can be reached in this temperature.
As preferably, in described seed oil step processed, use supercritical CO2Extraction extracts, and uses liquid CO2At height
Carry out in pressure equipment extracting broken seed of Fructus Hippophae, make contained oil be leached out, then by Fructrs Hippophae seed oil and liquid CO2?
High-pressure separator separates to obtain Fructrs Hippophae seed oil, the CO being separated2For gas-liquid mixture, more pressurized after become again liquid and quilt
Recycling, extraction temperature is 50 DEG C.The Fructrs Hippophae seed oil of this method gained due to extract time temperature remain at 50 DEG C, and
And liquid CO 2 is again volatile matter, being difficult to stay in oil, without residual molten in the Oleum Hippophae of gained, effective ingredient is not destroyed, husky
Spine seed oil quality is fine.
As preferably, in described oil meal mixture, calculate by weight, seed oil: pulp powder=20:80.This ratio pair
Treatment depression best results.
As preferably, described prepares in capsule step, calculates by weight, gelatin: glycerol: distilled water=7:2:1,
Described heated and stirred, temperature is 40～45 DEG C, and the time is 30 minutes.In this ratio and temperature, prepared film is neither too hard, nor too soft,
And easy-formation.
A kind of Fructus Hippophae depression capsule, uses any of the above one technique to produce.
Compared with prior art, the present invention at least can produce following a kind of beneficial effect: production procedure of the present invention is simple, right
Fructus Hippophae each several part is used, and prepares Fructus Hippophae depression capsule, the prevention of depression and treatment can be played good effect；This
Invention uses lyophilization, supercritical CO2Fructus Hippophae nutrient substance is retained more preferably by extraction processing technique so that finished product drug effect
More preferably；The capsule that the present invention prepares is neither too hard, nor too soft, and more conducively human body is swallowed；The accurate each composition proportion of the present invention so that finished medicines
Effect is optimal.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, to the present invention
It is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to
Limit the present invention.
Embodiment 1:
A kind of Fructus Hippophae depression capsule manufacturing techniques, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp so that finished product drug effect is more preferably.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, described pulp powder, seed oil is mixed, obtains
Oil meal mixture.Seed oil includes flavone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, presses down treatment
Strongly fragrant disease has extremely well effect, can stimulate cerebral cortex, lax nerve, pressure of releiving, and helps physiology and psychology to coordinate, makes people
It is emotionally stable, in high spirits.Use different technique for sarcocarp from seed of Fructus Hippophae, process respectively so that it is interior nutritional labeling is equal
Preferably retained, and according to the difference of the two composition, mixed, mutually promoted so that finished product drug effect is more preferably.
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin put into immersion in distilled water and makes it expand,
After gel solubilizing, add glycerol, heated and stirred mix homogeneously, obtain capsule material glue, then capsule material glue is coated in smooth plate table
On face, make thickness uniform, then heat by the temperature of 85～95 DEG C, make surface moisture evaporate so that it is to have certain toughness, bullet
Property, prepare cushion compound, more repressed prepared capsule, during small lot batch manufacture, with the manual compacting of pelleting mould；During production in enormous quantities, often
Rotation rolling capsule machine automatically is used to produce.
(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.
Embodiment 2:
A kind of Fructus Hippophae depression capsule manufacturing techniques, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp, and it is dry that sarcocarp is dried employing steam heating
Dry, temperature controls at 70～80 DEG C, and the time is 30 minutes.Sarcocarp is the most chilled, and its interior water becomes ice crystal, then adds through steam
Heat so that it is interior water sublimed, this method de-water ratio is high, and best to the nutrient substance retention in sarcocarp, and temperature can not
The highest, it is to avoid in high temperature makes it, chemical substance changes, desirable effect can be reached in this temperature.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, described pulp powder, seed oil is mixed, obtains
Oil meal mixture.Seed oil includes flavone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, presses down treatment
Strongly fragrant disease has extremely well effect, can stimulate cerebral cortex, lax nerve, pressure of releiving, and helps physiology and psychology to coordinate, makes people
It is emotionally stable, in high spirits.Use different technique for sarcocarp from seed of Fructus Hippophae, process respectively so that it is interior nutritional labeling is equal
Preferably retained, and according to the difference of the two composition, mixed, mutually promoted so that finished product drug effect is more preferably.
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin put into immersion in distilled water and makes it expand,
After gel solubilizing, add glycerol, heated and stirred mix homogeneously, obtain capsule material glue, then capsule material glue is coated in smooth plate table
On face, make thickness uniform, then heat by the temperature of 85～95 DEG C, make surface moisture evaporate so that it is to have certain toughness, bullet
Property, prepare cushion compound, more repressed prepared capsule, during small lot batch manufacture, with the manual compacting of pelleting mould；During production in enormous quantities, often
Rotation rolling capsule machine automatically is used to produce.
(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.
Embodiment 3:
A kind of Fructus Hippophae depression capsule manufacturing techniques, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp, and it is dry that sarcocarp is dried employing steam heating
Dry, temperature controls at 70～80 DEG C, and the time is 30 minutes.Sarcocarp is the most chilled, and its interior water becomes ice crystal, then adds through steam
Heat so that it is interior water sublimed, this method de-water ratio is high, and best to the nutrient substance retention in sarcocarp, and temperature can not
The highest, it is to avoid in high temperature makes it, chemical substance changes, desirable effect can be reached in this temperature.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, uses supercritical CO2Extraction extracts, and uses liquid
State CO2In high pressure equipment, carry out extracting broken seed of Fructus Hippophae, make contained oil be leached out, then by Fructrs Hippophae seed oil and
Liquid CO2Fructrs Hippophae seed oil is separated to obtain, the CO being separated in high-pressure separator2For gas-liquid mixture, more pressurized after become again
Liquid and be recycled, extraction temperature is 50 DEG C.The Fructrs Hippophae seed oil of this method gained due to extract time temperature remain
At 50 DEG C, and liquid CO 2 is again volatile matter, is difficult to stay in oil, and without residual molten in the Oleum Hippophae of gained, effective ingredient is not
Destroyed, Fructrs Hippophae seed oil quality is fine.Described pulp powder, seed oil are mixed, obtains oil meal mixture.Seed oil includes Huang
Ketone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, have extremely well effect to treatment depression,
Cerebral cortex can be stimulated, lax nerve, pressure of releiving, help physiology and psychology to coordinate, make people be emotionally stable, in high spirits.Pin
Sarcocarp is used different technique from seed of Fructus Hippophae, processes respectively so that it is interior nutritional labeling is the most preferably retained, and according to
The difference of the two composition, mixes, mutually promotes so that finished product drug effect is more preferably.
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin put into immersion in distilled water and makes it expand,
After gel solubilizing, add glycerol, heated and stirred mix homogeneously, obtain capsule material glue, then capsule material glue is coated in smooth plate table
On face, make thickness uniform, then heat by the temperature of 85～95 DEG C, make surface moisture evaporate so that it is to have certain toughness, bullet
Property, prepare cushion compound, more repressed prepared capsule, during small lot batch manufacture, with the manual compacting of pelleting mould；During production in enormous quantities, often
Rotation rolling capsule machine automatically is used to produce.
(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.
Embodiment 4:
A kind of Fructus Hippophae depression capsule manufacturing techniques, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp, and it is dry that sarcocarp is dried employing steam heating
Dry, temperature controls at 70～80 DEG C, and the time is 30 minutes.Sarcocarp is the most chilled, and its interior water becomes ice crystal, then adds through steam
Heat so that it is interior water sublimed, this method de-water ratio is high, and best to the nutrient substance retention in sarcocarp, and temperature can not
The highest, it is to avoid in high temperature makes it, chemical substance changes, desirable effect can be reached in this temperature.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, uses supercritical CO2Extraction extracts, and uses liquid
State CO2In high pressure equipment, carry out extracting broken seed of Fructus Hippophae, make contained oil be leached out, then by Fructrs Hippophae seed oil and
Liquid CO2Fructrs Hippophae seed oil is separated to obtain, the CO being separated in high-pressure separator2For gas-liquid mixture, more pressurized after become again
Liquid and be recycled, extraction temperature is 50 DEG C.The Fructrs Hippophae seed oil of this method gained due to extract time temperature remain
At 50 DEG C, and liquid CO 2 is again volatile matter, is difficult to stay in oil, and without residual molten in the Oleum Hippophae of gained, effective ingredient is not
Destroyed, Fructrs Hippophae seed oil quality is fine.Described pulp powder, seed oil are mixed, obtains oil meal mixture.Seed oil includes Huang
Ketone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, have extremely well effect to treatment depression,
Cerebral cortex can be stimulated, lax nerve, pressure of releiving, help physiology and psychology to coordinate, make people be emotionally stable, in high spirits.Pin
Sarcocarp is used different technique from seed of Fructus Hippophae, processes respectively so that it is interior nutritional labeling is the most preferably retained, and according to
The difference of the two composition, mixes, mutually promotes so that finished product drug effect is more preferably.
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin put into immersion in distilled water and makes it expand,
After gel solubilizing, add glycerol, heated and stirred mix homogeneously, obtain capsule material glue, then capsule material glue is coated in smooth plate table
On face, make thickness uniform, then heat by the temperature of 85～95 DEG C, make surface moisture evaporate so that it is to have certain toughness, bullet
Property, prepare cushion compound, more repressed prepared capsule, during small lot batch manufacture, with the manual compacting of pelleting mould；During production in enormous quantities, often
Rotation rolling capsule machine automatically is used to produce.
(8) oil meal mixture is loaded on capsule, in oil meal mixture, calculates by weight, seed oil: pulp powder=20:
80, this ratio is to treatment depression best results.Again through sizing, it is dried prepared Fructus Hippophae depression capsule.
Optimum embodiment:
A kind of Fructus Hippophae depression capsule manufacturing techniques, comprises the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；Can be run off when fresh fruit is dried macrometabolic element
Matter, and first freezing is dried again, can answer nutritional labeling with retaining of high degree in sarcocarp, and it is dry that sarcocarp is dried employing steam heating
Dry, temperature controls at 70～80 DEG C, and the time is 30 minutes.Sarcocarp is the most chilled, and its interior water becomes ice crystal, then adds through steam
Heat so that it is interior water sublimed, this method de-water ratio is high, and best to the nutrient substance retention in sarcocarp, and temperature can not
The highest, it is to avoid in high temperature makes it, chemical substance changes, desirable effect can be reached in this temperature.
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；Rich in flavone compound in Fructus Hippophae sarcocarp,
Depression risk can be significantly reduced, and Fructus Hippophae sarcocarp is rich in vitamin and aminoacid, plays the nutritional supplementation of depressive patients
Pivotal role, is more conducive to the rehabilitation of its depression.
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag,
Take seed seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, uses supercritical CO2Extraction extracts, and uses liquid
State CO2In high pressure equipment, carry out extracting broken seed of Fructus Hippophae, make contained oil be leached out, then by Fructrs Hippophae seed oil and
Liquid CO2Fructrs Hippophae seed oil is separated to obtain, the CO being separated in high-pressure separator2For gas-liquid mixture, more pressurized after become again
Liquid and be recycled, extraction temperature is 50 DEG C.The Fructrs Hippophae seed oil of this method gained due to extract time temperature remain
At 50 DEG C, and liquid CO 2 is again volatile matter, is difficult to stay in oil, and without residual molten in the Oleum Hippophae of gained, effective ingredient is not
Destroyed, Fructrs Hippophae seed oil quality is fine.Described pulp powder, seed oil are mixed, obtains oil meal mixture.Seed oil includes Huang
Ketone, organic acid, alkaloid, sterols, triterpene alkenes etc., and 5-hydroxy tryptamine, have extremely well effect to treatment depression,
Cerebral cortex can be stimulated, lax nerve, pressure of releiving, help physiology and psychology to coordinate, make people be emotionally stable, in high spirits.Pin
Sarcocarp is used different technique from seed of Fructus Hippophae, processes respectively so that it is interior nutritional labeling is the most preferably retained, and according to
The difference of the two composition, mixes, mutually promotes so that finished product drug effect is more preferably.
(7) capsule is prepared: raw material includes gelatin, glycerol, distilled water, calculates by weight, gelatin: glycerol: distilled water=
7:2:1, puts into gelatin immersion in distilled water and makes it expand, add glycerol, heated and stirred mix homogeneously, temperature after gel solubilizing
Degree is 40～45 DEG C, and the time is 30 minutes, obtains capsule material glue, then is coated on smooth plate surface by capsule material glue, makes thickness
Uniformly, then heat by the temperature of 90 DEG C, make surface moisture evaporate so that it is to have certain toughness, elasticity, prepare cushion compound, then
Repressed prepared capsule, during small lot batch manufacture, with the manual compacting of pelleting mould；During production in enormous quantities, roll capsule frequently with automatically rotating
Machine produces.
(8) oil meal mixture is loaded on capsule, in oil meal mixture, calculates by weight, seed oil: pulp powder=20:
80, this ratio is to treatment depression best results.Again through sizing, it is dried prepared Fructus Hippophae depression capsule.
Spoken of multiple explanatory embodiment, refers to combine the concrete grammar bag that this embodiment describes
Include at least one embodiment that the application generality describes.The most multiple local appearance statement of the same race is not certain
Refer to same embodiment.Furthermore, it is understood that combine any one embodiment when describing a method, to be advocated is to combine
Other embodiments realize this method and fall within the scope of the present invention.
Claims (6)
1. a Fructus Hippophae depression capsule manufacturing techniques, it is characterised in that: comprise the following steps:
(1) making beating: use sea-buchthorn fresh fruit, pull an oar after cleaning up, and through filtering, screenings is separated, obtain primary pulp
With seed slag, skin slag mixture；
(2) centrifugation: be centrifuged described primary pulp separating, obtain sarcocarp and fruit juice, take sarcocarp；
(3) sarcocarp is dried: described sarcocarp first carries out freezing, then is dried；
(4) sarcocarp is pulverized: dried sarcocarp is grinding to obtain pulp powder；
(5) seed, skin slag separate: after described seed slag, skin slag mixture being dried, screen out seed of Fructus Hippophae and skin slag, take seed
Seed of Fructus Hippophae；
(6) seed processed oil: seed of Fructus Hippophae is prepared after crushing, extracting seed oil, described pulp powder, seed oil is mixed, obtains
Oil meal mixture；
(7) prepare capsule: raw material includes gelatin, glycerol, distilled water, gelatin is put into immersion in distilled water and makes it expand, treat bright
Add glycerol, heated and stirred mix homogeneously after peptized, obtain capsule material glue, then capsule material glue is coated in smooth plate surface
On, make thickness uniform, then heat by the temperature of 85～95 DEG C, prepare cushion compound, more repressed prepared capsule；
(8) oil meal mixture is loaded on capsule, then through sizing, dry prepared Fructus Hippophae depression capsule.
A kind of Fructus Hippophae depression capsule manufacturing techniques the most according to claim 1, it is characterised in that: described sarcocarp is dried
Using steam heat drying, temperature controls at 70～80 DEG C, and the time is 30 minutes.
A kind of Fructus Hippophae depression capsule manufacturing techniques the most according to claim 1, it is characterised in that: described seed oil processed step
In Zhou, use supercritical CO2Extraction extracts, and uses liquid CO2Carry out extracting broken seed of Fructus Hippophae in high pressure equipment,
Make contained oil be leached out, then Fructrs Hippophae seed oil and liquid CO 2 are separated to obtain Fructrs Hippophae seed oil in high-pressure separator, divided
The CO separated out2For gas-liquid mixture, more pressurized after become liquid again and be recycled, extraction temperature is 50 DEG C.
A kind of Fructus Hippophae depression capsule manufacturing techniques the most according to claim 1, it is characterised in that: described oil meal mixing
In thing, calculate by weight, seed oil: pulp powder=20:80.
A kind of Fructus Hippophae depression capsule manufacturing techniques the most according to claim 1, it is characterised in that: described prepares capsule
In step, calculating by weight, gelatin: glycerol: distilled water=7:2:1, described heated and stirred, temperature is 40～45 DEG C, time
Between be 30 minutes.
6. a Fructus Hippophae depression capsule, it is characterised in that use any one technique in claim 1 to 5 to produce.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559322A (en) * | 2018-06-06 | 2019-12-13 | 邹玮 | Sea-buckthorn compound hard capsule for treating depression and preventing anxiety depression and preparation method thereof |
| CN112159714A (en) * | 2020-09-25 | 2021-01-01 | 赵英 | Sea-buckthorn oil extraction device |
| CN116115706A (en) * | 2023-03-01 | 2023-05-16 | 汉中市华瑞牡丹生物科技有限公司 | Sea buckthorn seed oil soft capsule for repairing gastric mucosa and preparation method thereof |
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| CN103865638A (en) * | 2014-02-20 | 2014-06-18 | 北京宝得瑞食品有限公司 | Supercritical carbon dioxide extraction method of sea-buckthorn seeds |
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| CN112159714A (en) * | 2020-09-25 | 2021-01-01 | 赵英 | Sea-buckthorn oil extraction device |
| CN116115706A (en) * | 2023-03-01 | 2023-05-16 | 汉中市华瑞牡丹生物科技有限公司 | Sea buckthorn seed oil soft capsule for repairing gastric mucosa and preparation method thereof |
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Application publication date: 20170104 |