CN110559322A - Sea-buckthorn compound hard capsule for treating depression and preventing anxiety depression and preparation method thereof - Google Patents

Sea-buckthorn compound hard capsule for treating depression and preventing anxiety depression and preparation method thereof Download PDF

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CN110559322A
CN110559322A CN201810562932.3A CN201810562932A CN110559322A CN 110559322 A CN110559322 A CN 110559322A CN 201810562932 A CN201810562932 A CN 201810562932A CN 110559322 A CN110559322 A CN 110559322A
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extract
depression
aquifoliaceae
seabuckthorn
hard capsule
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邹玮
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Powdery Hubei Health Industrial Co ltd
Zou Wei
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

The invention discloses a sea-buckthorn compound hard capsule for treating depression and preventing anxiety and depression and a preparation method thereof, belonging to the field of preparation of health care products, special medical foods and quasi-drugs. The medicine and food dual purpose variety composition comprises the following components in parts by weight: 15-30 parts of seabuckthorn seed procyanidin extract, 35-45 parts of seabuckthorn fruit peel extract and 30-45 parts of ilex latifolia thunb extract in Aquifoliaceae. The preparation method of the composition comprises flash-extracting at room temperature, concentrating at low temperature (below 50 deg.C), and retaining bioactive components to the maximum extent. The composition of the invention is a food and medicine dual-purpose variety, is safe and can be taken for a long time. The product of the invention can effectively treat depression, and particularly provides a safe and effective product for preventing anxiety and depression of the people.

Description

Sea-buckthorn compound hard capsule for treating depression and preventing anxiety depression and preparation method thereof
The technical field is as follows:
the invention relates to a Chinese medicinal composition for treating depression and preventing anxiety and depression, which is prepared from seabuckthorn seed procyanidin extract, seabuckthorn peel extract and ilex latifolia extract.
Background art:
The report of the Beijing psychological crisis intervention center shows that 10 major risk factors can independently influence suicide of Chinese, wherein antemortem depression becomes the leading cause.
depression has increasingly affected people's lives as a modern economic "by-product" of rapid development. According to the world health organization report, depression is now a fourth disease burden worldwide and is one of the major causes of functional disability in patients, and people of about 1/7 suffer from depression at some stage of life. It is expected that depression will be second only to cardiovascular disease in 2020. The incidence rate of the Chinese depression is about 6 percent, and the incidence rate of the depression in people of more than 60 years old is up to 20 to 50 percent. The number of patients with depression diagnosed at present is about 3000 ten thousand. The related data show that various chronic diseases are easy to be combined with depression.
If the patients with depression cannot be treated in time, the depression can be caused to be chronic or develop into more refractory diseases, and serious patients can not only have disability, but also even suicide.
at present, depression is mainly treated by western medicines, and 8 western medicines such as fluoxetine and the like have toxic and side effects with different degrees of severity. Research shows that more than 80 percent of patients have at least one adverse reaction after taking depression drugs, and on average, each patient is simultaneously suffered from 4 adverse reactions, wherein the adverse reactions obviously affect the patients and even influence the daily functions.
a health product, a special medical food and a quasi-character medicine prepared by mixing a sea buckthorn seed procyanidine extract, a sea buckthorn pericarp extract and a broadleaf holly leaf extract in Aquifoliaceae for both food and medicine are blank for treating depression and effectively preventing anxiety and depression.
The technical scheme of the invention is as follows:
The invention relates to a sea-buckthorn compound hard capsule which is a food and medicine dual-purpose variety and comprises the following components in parts by weight: fructus Hippophae procyanidin extract, fructus Hippophae pericarp extract, and Folum Ilicis extract of Aquifoliaceae.
the sea-buckthorn compound hard capsule inner packaging material of the invention consists of the following food and medicine dual-purpose articles in parts by weight: 15-30 parts of seabuckthorn seed procyanidin extract, 35-45 parts of seabuckthorn fruit peel extract and 30-45 parts of ilex latifolia thunb extract in Aquifoliaceae.
the seabuckthorn seed procyanidin extract in the formula mainly contains various active ingredients such as various amino acids, proteins, phenolic substances, flavonoids, procyanidin compounds, alkaloids, cardiac glycosides and various trace elements. The procyanidin content of fructus Hippophae procyanidin extract is greater than 45%. Modern pharmacological studies prove that the procyanidine has the effects of resisting oxidation activity, eliminating free radicals of a human body, resisting mutation and cancer, regulating blood fat, resisting platelet aggregation and thrombus, protecting a cardiovascular system and a cerebrovascular system, resisting inflammation, radiation, virus, depression and ulcer, protecting liver and kidney functions and the like. The seabuckthorn fruit peel extract is rich in bioactive components such as multiple vitamins, carotene, carotenoid, amino acid, alkaloid, ursolic acid, triterpenoids, multiple trace elements and the like. Modern pharmacological research proves that the defatted seabuckthorn fruit peel extract has wide pharmacological effects of enhancing immunity, resisting oxidation, regulating blood fat, resisting inflammation, sterilizing, resisting radiation, resisting depression, resisting virus, protecting liver, protecting cardiovascular system and the like. The extract of Folum Ilicis of Aquifoliaceae is rich in vitamins, amino acids, proteins, polyphenols, flavonoids, Folum Ilicis saponin, caffeine, ursolic acid and trace elements. Modern pharmacological studies prove that the extract of broadleaf holly leaf of Aquifoliaceae has wide pharmacological effects of reducing blood fat, reducing blood pressure, reducing blood sugar, enhancing immunity, increasing myocardial blood supply, increasing coronary blood flow, resisting atherosclerosis, inducing diuresis, strengthening heart, resisting aging, resisting depression and the like. The seabuckthorn seed procyanidin extract, the seabuckthorn peel extract and the ilex latifolia thumb extract in the Aquifoliaceae are combined to form an active ingredient group, the combined additive effect of the active ingredient group plays a more effective role in treating depression, and particularly, the product can effectively prevent anxiety depression!
The invention relates to a preparation method of a sea buckthorn compound hard capsule for treating depression and preventing anxiety and depression, which comprises the following steps:
1. Preparing a sea buckthorn seed procyanidine extract: soaking defatted fructus Hippophae seed meal in 5-10 times of 40-80% ethanol for more than 1 hr; performing flash extraction at normal temperature (below 50 deg.C) for 10-30 min; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) by belt drying device to obtain fructus Hippophae procyanidin extract powder. The content of procyanidine in the fructus Hippophae procyanidine extract is more than 45%;
2. preparing a seabuckthorn fruit peel extract: soaking defatted seabuckthorn peel in 8-15 times of 70-90% ethanol for more than 1 hour; performing flash extraction at normal temperature (below 50 deg.C) for 10-30 min for 2 times, and mixing filtrates; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) by belt drying device to obtain fructus Hippophae pericarp extract powder. The ursolic acid content in the seabuckthorn fruit peel extract is more than 12 percent;
3. Preparation of ilex latifolia Thunb extract of Aquifoliaceae: crushing Folum Ilicis of Aquifoliaceae to 10-20 mesh; soaking for more than 1 hour by using pure water of 8-20 times; heating to 60-90 deg.C, and hot soaking for 3-10 min; filtering with 40-mesh filter cloth; removing caffeine hot infusion; extracting the residue of Folum Ilicis of Aquifoliaceae with 8-15 times of 80-90% ethanol at normal temperature (below 50 deg.C) for 10-30 min for 2 times; mixing the extractive solutions; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) with belt drying device to obtain extract powder of Folum Ilicis of Aquifoliaceae. The extract of Folum Ilicis of Aquifoliaceae contains ursolic acid more than 12%.
4. Preparing a sea-buckthorn compound hard capsule: weighing semen Hippophae procyanidin extract, fructus Hippophae pericarp extract, and Folum Ilicis extract of Aquifoliaceae at a certain proportion, and making into hard capsule product for treating depression in hard capsule production workshop with 100000-grade good production specification (or GMP certification).
Hard capsule content 0.4 g/capsule
Per 100g of the inclusion, contains fructus Hippophae procyanidin more than or equal to 8.5g
Ursolic acid not less than 5.5g
the beneficial results of the invention are as follows:
1. The formula of the invention is a food-medicine dual-purpose variety, has no toxic or side effect, can be taken for a long time, and ensures the safety of the product.
2. The production process of the invention is carried out at low temperature (below 50 ℃) for extracting, recovering ethanol, concentrating the extracting solution and drying, which not only has low temperature but also has short time, fully retains the living activity of the active ingredients and greatly reduces the production cost.
The specific implementation mode is as follows:
Example 1:
(1) Weighing the following varieties in proportion: 4kg of fructus Hippophae procyanidin extract, 7.5kg of fructus Hippophae pericarp extract, 8.5kg of Folum Ilicis extract of Aquifoliaceae, and total amount of inclusion is 20 kg.
(2) entrusting Shijiazhuang to substitute Ling pharmaceutical industry GmbH to produce sea buckthorn compound hard capsules, the content of the inclusion is 0.40 g/granule, the physical yield of the inclusion is 50000 granules in 20kg, the actual yield is 47500 granules, and the yield of the hard capsules is 95%.
(3) The dosage and the method are as follows: 3 times daily, 3 granules each time.
Example 2:
(1) Weighing the following varieties in proportion: 9kg of fructus Hippophae procyanidin extract, 17kg of fructus Hippophae pericarp extract, 18kg of Folum Ilicis extract of Aquifoliaceae, and total 44kg of encapsulated substances.
(2) Entrusting Shijiazhuang to substitute Ling pharmaceutical industry GmbH to produce sea buckthorn compound hard capsules, the content of the inclusion is 0.40 g/granule, the content of the inclusion is 110000 granules in 20kg, the actual yield is 100600 granules, and the yield of the hard capsules is 96%.
(3) the dosage and the method are as follows: 3 times daily, 3 granules each time.

Claims (3)

1. A seabuckthorn compound hard capsule for treating depression and preventing anxiety depression and a preparation method thereof are characterized by comprising the following varieties: the traditional Chinese medicine composition comprises a seabuckthorn seed proanthocyanidin extract, a seabuckthorn fruit peel extract and a ilex latifolia thumb extract in the family of Aquifoliaceae, wherein the extracts comprise the following components in parts by weight: 15-30 parts of seabuckthorn seed procyanidin extract, 35-45 parts of seabuckthorn fruit peel extract and 30-45 parts of ilex latifolia thunb extract in Aquifoliaceae;
(1) preparing a sea buckthorn seed procyanidine extract: soaking defatted fructus Hippophae seed meal in 5-10 times of 40-80% ethanol for more than 1 hr; performing flash extraction at normal temperature (below 50 deg.C) for 10-30 min; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) by belt drying device to obtain fructus Hippophae procyanidin extract powder. The content of procyanidine in the fructus Hippophae procyanidine extract is more than 45%;
(2) Preparing a seabuckthorn fruit peel extract: soaking defatted seabuckthorn peel in 8-15 times of 70-90% ethanol for more than 1 hour; performing flash extraction at normal temperature (below 50 deg.C) for 10-30 min for 2 times, and mixing filtrates; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) by belt drying device to obtain fructus Hippophae pericarp extract powder. The ursolic acid content in the seabuckthorn fruit peel extract is more than 12 percent;
(3) Preparation of ilex latifolia Thunb extract of Aquifoliaceae: crushing Folum Ilicis of Aquifoliaceae to 10-20 mesh; soaking for more than 1 hour by using pure water of 8-20 times; heating to 60-90 deg.C, and hot soaking for 3-10 min; filtering with 40-mesh filter cloth; removing caffeine hot infusion; extracting the residue of Folum Ilicis of Aquifoliaceae with 8-15 times of 80-90% ethanol at normal temperature (below 50 deg.C) for 10-30 min for 2 times; mixing the extractive solutions; filtering with 300 meshes; recovering ethanol by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentration device, and concentrating the extractive solution to solid content above 40%; drying at low temperature (below 50 deg.C) under negative pressure (-0.098 MPa) with belt drying device to obtain extract powder of Folum Ilicis of Aquifoliaceae. The content of ursolic acid in ilex latifolia Thunb extract of Aquifoliaceae is more than 12%;
(4) Preparing a sea-buckthorn compound hard capsule: weighing semen Hippophae procyanidine extract, fructus Hippophae pericarp extract, and Folum Ilicis extract of Aquifoliaceae at a certain proportion, and making into hard capsule product for treating depression in hard capsule production workshop with 100000-grade good production specification (or GMP certification);
hard capsule content 0.4 g/capsule
per 100g of the inclusion, contains fructus Hippophae procyanidin more than or equal to 8.5g
the content of ursolic acid is not less than 5.5 g.
2. The hard capsule of hippophae rhamnoides compound for treating depression and preventing anxiety and depression according to claim 1 and the preparation method thereof, wherein: the production process adopts a normal-temperature flash extraction method at 15-50 ℃ for extraction; recovering ethanol and concentrating the extractive solution by low temperature (below 50 deg.C) and negative pressure (-0.098 Mpa) closed loop heat pump evaporation concentrating device; drying the powder by a low-temperature (below 50 ℃) negative pressure (above-0.098 MPa) belt type drying device.
3. the seabuckthorn compound hard capsule product for treating depression and preventing anxiety and depression according to claim 1 can be prepared into various dosage forms, including oral liquid, powder and the like.
CN201810562932.3A 2018-06-06 2018-06-06 Sea-buckthorn compound hard capsule for treating depression and preventing anxiety depression and preparation method thereof Pending CN110559322A (en)

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CN112316015A (en) * 2020-12-01 2021-02-05 张大宁 Traditional Chinese medicine decoction pieces and preparation method thereof

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CN112316015A (en) * 2020-12-01 2021-02-05 张大宁 Traditional Chinese medicine decoction pieces and preparation method thereof

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Applicant after: POWDERY (HUBEI) HEALTH INDUSTRIAL Co.,Ltd.

Applicant after: Zou Wei

Address before: Room 202, Unit 1, Building 4, Shenxing Binhe District, Xinshibei Road, Qiaoxi District, Shijiazhuang City, Hebei Province

Applicant before: Zou Wei

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20191213