CN105616375A - 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 - Google Patents
消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 Download PDFInfo
- Publication number
- CN105616375A CN105616375A CN201610070632.4A CN201610070632A CN105616375A CN 105616375 A CN105616375 A CN 105616375A CN 201610070632 A CN201610070632 A CN 201610070632A CN 105616375 A CN105616375 A CN 105616375A
- Authority
- CN
- China
- Prior art keywords
- alpha
- benzoate
- amyl group
- racemization
- hydroxy amyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
主药 | 100g |
药用淀粉 | 25g |
微晶纤维素 | 17.5g |
硬脂酸镁 | 0.25 |
滑石粉 | 0.5 |
羧甲基纤维素纳 | 2.5 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610070632.4A CN105616375B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310070228.3A CN103127025B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片的制备方法 |
CN201610070632.4A CN105616375B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310070228.3A Division CN103127025B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105616375A true CN105616375A (zh) | 2016-06-01 |
CN105616375B CN105616375B (zh) | 2018-08-28 |
Family
ID=48487902
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN201610070632.4A Active CN105616375B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 |
CN201310070228.3A Active CN103127025B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片的制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310070228.3A Active CN103127025B (zh) | 2013-03-06 | 2013-03-06 | 消旋2-(α-羟基戊基)苯甲酸盐片的制备方法 |
Country Status (1)
Country | Link |
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CN (2) | CN105616375B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104415021A (zh) * | 2013-08-28 | 2015-03-18 | 云南昊邦制药有限公司 | 一种药物组合物及其制备方法 |
CN103989651A (zh) * | 2014-03-27 | 2014-08-20 | 云南昊邦制药有限公司 | 一种2-(α-羟基戊基)苯甲酸盐控释片及其制备方法 |
CN104510720A (zh) * | 2014-12-25 | 2015-04-15 | 云南昊邦制药有限公司 | 一种2-(α-羟基戊基)苯甲酸盐分散片及其制备方法 |
CN104546748A (zh) * | 2014-12-25 | 2015-04-29 | 云南昊邦制药有限公司 | 一种2-(α-羟基戊基)苯甲酸盐口崩片及其制备方法 |
CN104510721A (zh) * | 2014-12-25 | 2015-04-15 | 云南昊邦制药有限公司 | 一种2-(α-羟基戊基)苯甲酸盐滴丸及其制备方法 |
CN104586779A (zh) * | 2014-12-25 | 2015-05-06 | 云南昊邦制药有限公司 | 一种2-(α-羟基戊基)苯甲酸盐舌下片及其制备方法 |
CN108715579B (zh) * | 2018-05-17 | 2020-03-24 | 四川大学 | 一种2-(α羟基戊基)苯甲酸的有机胺酯衍生物药物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1382682A (zh) * | 2002-05-09 | 2002-12-04 | 中国医学科学院药物研究所 | 2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
EP1535916A1 (en) * | 2002-08-21 | 2005-06-01 | Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology (Shijianzhuang) Co., Ltd. | Clathrates of butylphtualide with cyclodextrin or its derivatives,a process for their preparations and the use there of |
CN101627984A (zh) * | 2008-07-14 | 2010-01-20 | 中国医学科学院药物研究所 | 2-(α-羟基戊基)苯甲酸钾预防和/或治疗老年痴呆的用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100422133C (zh) * | 2003-09-01 | 2008-10-01 | 北京天衡药物研究院 | 2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN100540523C (zh) * | 2004-06-17 | 2009-09-16 | 北京天衡药物研究院 | L-2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN101054346A (zh) * | 2006-04-13 | 2007-10-17 | 温建波 | 一组新化合物及其组合物的制备方法和用途 |
CN101402565B (zh) * | 2008-11-14 | 2012-07-04 | 郑州大学 | 卤代2-(a-羟基戊基)苯甲酸盐及其制法和用途 |
-
2013
- 2013-03-06 CN CN201610070632.4A patent/CN105616375B/zh active Active
- 2013-03-06 CN CN201310070228.3A patent/CN103127025B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1382682A (zh) * | 2002-05-09 | 2002-12-04 | 中国医学科学院药物研究所 | 2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
EP1535916A1 (en) * | 2002-08-21 | 2005-06-01 | Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology (Shijianzhuang) Co., Ltd. | Clathrates of butylphtualide with cyclodextrin or its derivatives,a process for their preparations and the use there of |
CN101627984A (zh) * | 2008-07-14 | 2010-01-20 | 中国医学科学院药物研究所 | 2-(α-羟基戊基)苯甲酸钾预防和/或治疗老年痴呆的用途 |
Non-Patent Citations (2)
Title |
---|
王晓良: "治疗脑卒中前药DL-PHPB的研究", 《中国药理学与毒理学杂志》 * |
赵万红: "2-(α-羟基戊基)苯甲酸钾盐对痴呆动物模型的治疗作用及其机制研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
Also Published As
Publication number | Publication date |
---|---|
CN103127025B (zh) | 2016-03-09 |
CN105616375B (zh) | 2018-08-28 |
CN103127025A (zh) | 2013-06-05 |
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Effective date of registration: 20180308 Address after: 550000 the two phase of innovation and entrepreneurship Park, Guizhou University of Finance and economics, University City, Guizhou Applicant after: Guizhou GUI Shengyuan pharmaceutical science and Technology Co., Ltd. Address before: 050000 Hebei province Shijiazhuang City Tianshan Street high tech Zone lijingwan District 2-2104 Applicant before: Shijiazhuang Yangxing Technology Co., Ltd. |
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Address after: 550000 Guiyang Gui'an New District University Town Guizhou Medical University Bo'an Zhongchuang Space D11 Office Patentee after: Guizhou Xieshengyuan Pharmaceutical Technology Co., Ltd. Address before: 550000 Gui'an New Area University City, Guizhou Province, Second Phase of Innovation and Entrepreneurship Park of Guizhou University of Finance and Economics Patentee before: Guizhou GUI Shengyuan pharmaceutical science and Technology Co., Ltd. |
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Effective date of registration: 20200811 Address after: No.819-8, 8 / F, Guoyao building, No.2 Longsheng street, Tanghuai Park, Taiyuan City, Shanxi Province Patentee after: Shanxi Shouzhi Biotechnology Co., Ltd Address before: 550000 Guiyang Gui'an New District University Town Guizhou Medical University Bo'an Zhongchuang Space D11 Office Patentee before: Guizhou Xieshengyuan Pharmaceutical Technology Co.,Ltd. |
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