CN1056058C - 药物制剂的制备方法 - Google Patents

药物制剂的制备方法 Download PDF

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Publication number
CN1056058C
CN1056058C CN91100547A CN91100547A CN1056058C CN 1056058 C CN1056058 C CN 1056058C CN 91100547 A CN91100547 A CN 91100547A CN 91100547 A CN91100547 A CN 91100547A CN 1056058 C CN1056058 C CN 1056058C
Authority
CN
China
Prior art keywords
water
preparation
penciclovir
oil
propylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN91100547A
Other languages
English (en)
Chinese (zh)
Other versions
CN1053547A (zh
Inventor
黑兹尔-安·格里菲思
艾伦·维翰·古多尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis International Pharmaceutical Ltd
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of CN1053547A publication Critical patent/CN1053547A/zh
Application granted granted Critical
Publication of CN1056058C publication Critical patent/CN1056058C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN91100547A 1990-01-26 1991-01-26 药物制剂的制备方法 Expired - Lifetime CN1056058C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001886A GB9001886D0 (en) 1990-01-26 1990-01-26 Pharmaceutical formulation
GB9001886.2 1990-01-26

Publications (2)

Publication Number Publication Date
CN1053547A CN1053547A (zh) 1991-08-07
CN1056058C true CN1056058C (zh) 2000-09-06

Family

ID=10669997

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91100547A Expired - Lifetime CN1056058C (zh) 1990-01-26 1991-01-26 药物制剂的制备方法

Country Status (29)

Country Link
EP (1) EP0511991B1 (de)
JP (1) JP2545317B2 (de)
KR (1) KR0170414B1 (de)
CN (1) CN1056058C (de)
AP (1) AP197A (de)
AT (1) ATE142880T1 (de)
AU (1) AU643975B2 (de)
CA (1) CA2074503C (de)
CY (2) CY1984A (de)
DE (1) DE69122229T2 (de)
DK (1) DK0511991T3 (de)
ES (1) ES2092559T3 (de)
FI (1) FI101600B (de)
GB (1) GB9001886D0 (de)
GR (1) GR3021385T3 (de)
HK (1) HK218996A (de)
HU (1) HU215842B (de)
IE (1) IE910249A1 (de)
IL (1) IL97008A (de)
LU (1) LU90110I2 (de)
MA (1) MA22051A1 (de)
MY (1) MY110074A (de)
PL (1) PL166678B1 (de)
PT (1) PT96563B (de)
SA (1) SA91110341B1 (de)
SG (1) SG49144A1 (de)
TW (1) TW307687B (de)
WO (1) WO1991011187A1 (de)
ZA (1) ZA91525B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9114939D0 (en) * 1991-07-11 1991-08-28 Smithkline Beecham Plc Pharmaceutical formulation
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
GB9601544D0 (en) 1996-01-26 1996-03-27 Smithkline Beecham Plc Pharmaceuticals
US7223387B2 (en) 1998-11-18 2007-05-29 Medivir Ab Antiviral formulations comprising propylene glycol and an isopropyl alkanoic acid ester
WO2017029298A1 (en) 2015-08-17 2017-02-23 Sanovel Ilac Sanayi Ve Ticaret A.S. A topical antiviral composition
US11364198B2 (en) 2018-04-05 2022-06-21 Bausch Health Ireland Limited Polymeric emulsion delivery systems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044543A1 (de) * 1980-07-18 1982-01-27 The Wellcome Foundation Limited Äusserlich anzuwendende Zubereitungen mit 9-(2-Hydroxyethoxymethyl) guanin
EP0141927A2 (de) * 1983-08-18 1985-05-22 Beecham Group Plc Antivirale Guanin-Derivate
EP0216459A1 (de) * 1985-07-27 1987-04-01 Beecham Group Plc 9-Substituierte Guaninmonohydrate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
KR830005852A (ko) * 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
EP0095813A3 (de) * 1982-06-01 1985-05-08 THE PROCTER & GAMBLE COMPANY Durchdringende topische pharmazeutische Präparate, die 9-(2-Hydroxyäthoxymethyl)-guanin enthalten
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (de) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituierte Butylguanine und ihre Verwendung in antiviralen Zusammensetzungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044543A1 (de) * 1980-07-18 1982-01-27 The Wellcome Foundation Limited Äusserlich anzuwendende Zubereitungen mit 9-(2-Hydroxyethoxymethyl) guanin
EP0141927A2 (de) * 1983-08-18 1985-05-22 Beecham Group Plc Antivirale Guanin-Derivate
EP0216459A1 (de) * 1985-07-27 1987-04-01 Beecham Group Plc 9-Substituierte Guaninmonohydrate

Also Published As

Publication number Publication date
HU215842B (hu) 2001-02-28
SA91110341B1 (ar) 2004-05-25
KR920703060A (ko) 1992-12-17
FI923371A0 (fi) 1992-07-24
IL97008A0 (en) 1992-03-29
CY1999020I2 (en) 2009-11-04
SG49144A1 (en) 1998-05-18
DE69122229T2 (de) 1997-03-06
MA22051A1 (fr) 1991-10-01
ES2092559T3 (es) 1996-12-01
IE910249A1 (en) 1991-07-31
AU643975B2 (en) 1993-12-02
PT96563B (pt) 1998-07-31
AP9000236A0 (en) 1991-01-31
LU90110I2 (fr) 1997-09-25
DK0511991T3 (da) 1996-11-11
AP197A (en) 1992-06-30
FI923371A (fi) 1992-07-24
EP0511991A1 (de) 1992-11-11
FI101600B1 (fi) 1998-07-31
CA2074503A1 (en) 1991-07-27
PL166678B1 (pl) 1995-06-30
JPH05503695A (ja) 1993-06-17
ATE142880T1 (de) 1996-10-15
CA2074503C (en) 1999-12-14
EP0511991B1 (de) 1996-09-18
FI101600B (fi) 1998-07-31
PT96563A (pt) 1991-10-15
HU9202431D0 (en) 1992-10-28
CN1053547A (zh) 1991-08-07
AU7155891A (en) 1991-08-21
DE69122229D1 (de) 1996-10-24
GB9001886D0 (en) 1990-03-28
WO1991011187A1 (en) 1991-08-08
KR0170414B1 (ko) 1999-02-18
TW307687B (de) 1997-06-11
MY110074A (en) 1997-12-31
CY1984A (en) 1997-09-05
HUT62472A (en) 1993-05-28
HK218996A (en) 1997-01-03
ZA91525B (en) 1992-02-26
GR3021385T3 (en) 1997-01-31
IL97008A (en) 1995-05-26
JP2545317B2 (ja) 1996-10-16

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: BELLSOS INTELLECTUAL PROPERTY CO., LTD.

Free format text: FORMER OWNER: BEECHAM GROUP P.L.C.

Effective date: 20011102

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20011102

Address after: Bermuda Hamilton

Patentee after: Novartis Int Pharm Ltd.

Address before: The Middlesex County

Patentee before: Beecham Group P. L. C.

C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20110126

Granted publication date: 20000906