CN105582191A - Evening primrose capsule - Google Patents
Evening primrose capsule Download PDFInfo
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- CN105582191A CN105582191A CN201610169582.5A CN201610169582A CN105582191A CN 105582191 A CN105582191 A CN 105582191A CN 201610169582 A CN201610169582 A CN 201610169582A CN 105582191 A CN105582191 A CN 105582191A
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides an evening primrose capsule. The capsule is prepared from, by weight, 2 parts of evening primrose, 28 parts of roots of Yunna cowparsnip, 30 parts of Diplazium donianum(Mett.)Tard-Blot., 25 parts of spiraea, 20 parts of lepidium apetalum, 18 parts of roots and stems of typha angustata and 5 parts of liquorice roots according to a conventional production process. The capsule can relieve cough.
Description
Technical field
The present invention relates to health product technology field, be specifically related to a kind of Evening Primrose Oil for antibechic.
Background technology
From EPDML angle analysis, the age of onset of chronic bronchitis is many more than 40 years old, and smoking patients is obviousHigher than non-smoking patient. According to China's national part analysis of statistical data in 1973, illness rate is about 3.82%, along withThe growth illness rate at age increases gradually, more than 50 years old person, and illness rate can be up to 15% left and right. 1992 domestic generalThe part information of looking into shows, illness rate slightly drops to 3.2%. This sick illness rate because of area, age, occupation,Environmental sanitation is different from smoking habit etc. and have larger difference. The more southern damp-heat area of north of China extremely frigid zones illness rate is high;Rural area is higher than cities and towns; The serious big city of atmosphere pollution is high compared with suburb rural; The work of dust exposure and poisonous chemical gasesThe more general workman of people is high; The younger artificial height of the elderly. Anxious slow is respiratory tract common disease, frequently-occurring disease, particularly childrenYoungster and 40 years old above man, pathogenesis is clear and definite, and research is thorough, the domestic expense dimension that is used for the treatment of every year anxious slowBe held in more than 2,000,000,000 yuan, according to authoritative institution to becoming in the market survey of market, Guangzhou in spring in 2002 antitussive and antiasthmatic drugsMedicine sales volume accounts for 75% left and right of overall market. Therefore research and develop the new drug these diseases to good result for the treatment of,Just seem very meaningful, generally treat from antibechic, the aspect such as antipyretic, antibacterial.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of Evening Primrose Oil and application thereof.
In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Evening Primrose Oil, its contained active component is by following raw materials in part by weight medicine extraction preparationBecome: 2 parts of evening primrose oil, 28 parts of turniplike cowparsnip roots, 30 parts, comb leaf, 25 parts of meadow sweets, 20 parts of, Pu Konjac of Lepidium apetalum5 parts of 18 parts, Radix Glycyrrhizae.
Described Evening Primrose Oil, preparation process is: beyond getting evening primrose oil, medicinal material merges, boiling twice mergesDecocting liquid, while being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirs, and makes containing by volume percentage of alcohol amountCalculating reaches 65-85%, leaves standstill, and filters, and when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20-1.30 and reclaims ethanolObtain concentrate, by dry concentrate spraying, add evening primrose oil, add auxiliary material and make soft capsule.
Described Evening Primrose Oil, decocting condition is: amount of water is that the 8-12 of medicinal material weight doubly measures for the first time, decocts 1-2h,Amount of water is that the 6-10 of medicinal material weight doubly measures for the second time, decocts 1-2h.
Described Evening Primrose Oil, described spraying drying condition is: EAT is 90-110 DEG C, and leaving air temp is60-90 DEG C, temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described Evening Primrose Oil promotes the application in defecation health products in preparation.
Evening primrose oil EveningPrimroseOil of the present invention, original name primrose, main component: r-linolenic acid, magnesium,Zinc, copper, vitamin C, E, B6, B5. Can blending base oil and the grease of essential oil, there is multinomial treatment, whiteningFunction, making that capsule is for oral administration can Cardiovarscular, premenstrual syndrome, climacteric metancholia, is used in aromatotherapyIn, can be in harmonious proportion emulsion, breast frost, improve eczema, psoriasis, helps wound healing, and nail is grown, and solves hair and asksTopic is generally that 10% dosage uses. No. CAS: 90028-66-3. Hubei far becomes medicine company raw material Co., Ltd to produce.
Turniplike cowparsnip root is the root of Umbelliferae radix heraclei hemaleyani platymiscium yunna cowparsnip HeracleumrepulaFranch.. Excavate autumn,Clean section is dried. Nature and flavor hardship, pungent, warm. Be distributed in the ground such as Yunnan, dispel rheumatism, activating collaterals to relieve pain, relieving cough and asthma.For rheumatism arthralgia and myalgia, traumatic injury, pain in the back, stomachache, flu, cough, chronic bronchitis, asthma, amenorrhoea,Leukorrhea.
Comb leaf is the herb of Athyriaceae plant Diplazium donianum (Mett.) Tard. Blet. Latin name: Diplaziumdonianum (Mett.)Tard-Blot.[AspleniumdonianumMett.], clearing heat and promoting diuresis; Removing pattogenic heat from the blood and toxic material from the body. Cure mainly jaundice with damp-heat pathogen; Snake bite;Traumatism and bleeding; Dysmenorrhoea.
Spiraea Rosales, the upright shrub of the rose family, Latin formal name used at school SpiraeaSalicifoliaL., meadow sweet, leaf,Root all can be done medicinal, can be clearing heat and detoxicating. For red eye, swell pain, headache, toothache, cough with lung heat; Traumatic bleeding is controlled in external application.The present invention is used as medicine with meadow sweet.
Lepidium apetalum (formal name used at school: Lepidiumapetalum) is the plant of Cruciferae separate row Vegetable spp. Cough-relieving, eliminates the phlegm,Relieving asthma, heat-clearing, removing toxic substances. The present invention is with all herbal medicine.
Pu Konjac is the rhizome with the tender stem of part that Typhaceae plant typha angustata or its belong to various plants together. Clearing heat and cooling blood,Inducing diuresis for removing edema. Control pregnant woman Lao Re, vaginal bleeding with fetal movement, quenches one's thirst, aphtha, hot dysentery, gonorrhoea, leukorrhea, oedema, scrofula. ItsRemaining Chinese medicine is pharmacopeia kind.
Beneficial effect: turniplike cowparsnip root of the present invention, comb leaf, meadow sweet clearing heat and promoting diuresis; Removing pattogenic heat from the blood and toxic material from the body is monarch drug in a prescription, walks aloneDish, Pu Konjac is clearing heat and detoxicating; Inducing diuresis for removing edema is ministerial drug, and evening primrose oil, Radix Glycyrrhizae are adjuvant, full side compatibility mutually, heat-clearingRemoving toxic substances, antibechic successful.
Detailed description of the invention
Form by the following examples, is described in further detail foregoing of the present invention again, but should be by thisThe scope that is interpreted as the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present inventionAll belong to scope of the present invention.
Embodiment 1: get 2 parts of evening primrose oil, 28 parts of turniplike cowparsnip roots, 30 parts, comb leaf, 25 parts of meadow sweets, Lepidium apetalum18 parts of 20 parts of, Pu Konjac, 5 parts, Radix Glycyrrhizae are for subsequent use, get the outer medicinal material of evening primrose oil and merge, and boiling twice, adds for the first timeThe water yield is 8 times of amounts of medicinal material weight, decocts 2h, and amount of water is 6 times of amounts of medicinal material weight for the second time, decocts 2h, closesAnd decocting liquid, while being concentrated into 65 DEG C, relative density is 1.10, adds ethanol, stirs, and makes containing by volume percentage calculation of alcohol amountReach 85%, leave standstill, filter, when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20 and reclaims ethanol and obtain concentrate,By dry concentrate spraying, add evening primrose oil, add auxiliary material and make capsule and pill. Described spraying drying condition is: air intakeTemperature is 90 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 60 DEG C, and atomizing pressure is 0.5 MPa, and spray velocity is1ml/s。
Embodiment 2: get 2 parts of evening primrose oil, 28 parts of turniplike cowparsnip roots, 30 parts, comb leaf, 25 parts of meadow sweets, Lepidium apetalum18 parts of 20 parts of, Pu Konjac, 5 parts, Radix Glycyrrhizae are for subsequent use, get the outer medicinal material of evening primrose oil and merge, and boiling twice, adds for the first timeThe water yield is 12 times of amounts of medicinal material weight, decocts 1h, and amount of water is 10 times of amounts of medicinal material weight for the second time, decocts 1h.Collecting decoction, while being concentrated into 65 DEG C, relative density is 1.20, adds ethanol, stirs, and makes containing by volume percentage meter of alcohol amountCalculation reaches 65%, leaves standstill, and filters, and when filtrate decompression is concentrated into 65 DEG C, relative density is 1.30 and reclaims ethanol and obtain concentrate,By dry concentrate spraying, add evening primrose oil, add auxiliary material and make capsule and pill, described spraying drying condition is: air intakeTemperature is 110 DEG C, and leaving air temp is 60 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.2 MPa, spray velocityFor 10ml/s.
Embodiment 3. antibechic drug effect of the present invention testing data
Animal: healthy ICR mouse, male and female half and half, heavy 18-22g, is provided by Nanjing Medical University's animal center, producesCredit number SCXK (Soviet Union) 2002-0031.
Medicine and reagent: prepare the present invention by above-described embodiment 1, Pentoxyverine sheet (carbetapentane citrate, Suzhou medicineGroup Co.,Ltd, specification: 25mg/ sheet, lot number: 130118-2).
Instrument and reagent: ultrasonic ultrasonic delay line memory, S-888F type, Chinese-foreign joint Nanjing Dao Fen Electronics Co., Ltd.; Ammoniacal liquor (25%)AR. Nanjing chemical reagent one factory, lot number: 12033157.
Ammoniacal liquor causes mouse cough test: mouse is divided into 5 groups at random: model control group (isometric(al) 0.5%CMC-Na),Carbetapentane citrate group (0.013g/kg), the present invention high (20g/kg), in (10g/kg), low (5g/kg) three dosage groups.
Method: respectively organize after gastric infusion 1h, mouse is placed in experimental box, in experimental box, spray into 25~28% ammoniacal liquor 20s,Record self-spray and play mouse incubation period and cough number of times in 5 minutes.
Result: the high, medium and low dosage of the present invention and positive drug carbetapentane citrate all can obviously reduce ammoniacal liquor and cause in mouse 5minCough number of times, extends cough latent period, and (P < 0.05 or P < 0.01, see all to have conspicuousness with model control group comparing differenceTable 1).
The impact of table 1. the present invention on the cough of ammonia spraying induced mice
Note: with model control group comparison, * P < 0.05; * P < 0.01
Three dosage of the present invention all can reduce ammoniacal liquor and cause the cough number of times of mouse cough model, all have with model group comparing differenceConspicuousness.
Claims (5)
1. an Evening Primrose Oil, is characterized in that, its contained active component is by following raw materials in part by weight medicine extraction preparationBecome: 2 parts of evening primrose oil, 28 parts of turniplike cowparsnip roots, 30 parts, comb leaf, 25 parts of meadow sweets, 20 parts of, Pu Konjac 18 of Lepidium apetalum5 parts, part, Radix Glycyrrhizae.
2. Evening Primrose Oil as claimed in claim 1, is characterized in that preparation process is: beyond getting evening primrose oil, medicinal material merges,Boiling twice, collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirs, and makes containing alcohol amountBy volume percentage calculation reaches 65-85%, leave standstill, filter, when filtrate decompression is concentrated into 65 DEG C relative density be 1.20-1.30 alsoReclaim ethanol and obtain concentrate, by dry concentrate spraying, add evening primrose oil, add auxiliary material and make capsule and pill.
3. Evening Primrose Oil as claimed in claim 2, is characterized in that, decocting condition is: amount of water is medicinal material weight for the first timeThe 8-12 of amount doubly measures, and decocts 1-2h, and amount of water is that the 6-10 of medicinal material weight doubly measures for the second time, decocts 1-2h.
4. Evening Primrose Oil as claimed in claim 2, is characterized in that, described spraying drying condition is: EAT is90-110 DEG C, leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, spray velocityFor 1-10ml/s.
5. the application of Evening Primrose Oil in antibechic medicine according to claim 1.
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CN201610169582.5A CN105582191A (en) | 2016-03-23 | 2016-03-23 | Evening primrose capsule |
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CN201610169582.5A CN105582191A (en) | 2016-03-23 | 2016-03-23 | Evening primrose capsule |
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CN201610169582.5A Withdrawn CN105582191A (en) | 2016-03-23 | 2016-03-23 | Evening primrose capsule |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104306781A (en) * | 2014-11-05 | 2015-01-28 | 李正梅 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
CN104435393A (en) * | 2014-05-20 | 2015-03-25 | 南京正亮医药科技有限公司 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
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- 2016-03-23 CN CN201610169582.5A patent/CN105582191A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104435393A (en) * | 2014-05-20 | 2015-03-25 | 南京正亮医药科技有限公司 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
CN104306781A (en) * | 2014-11-05 | 2015-01-28 | 李正梅 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
Non-Patent Citations (1)
Title |
---|
何东平等主编: "《粮油食品》", 30 June 2014, 中国轻工业出版社 * |
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Application publication date: 20160518 |