CN104306781A - Soft capsule for relieving cough as well as preparation method and application of soft capsule - Google Patents
Soft capsule for relieving cough as well as preparation method and application of soft capsule Download PDFInfo
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- CN104306781A CN104306781A CN201410621454.0A CN201410621454A CN104306781A CN 104306781 A CN104306781 A CN 104306781A CN 201410621454 A CN201410621454 A CN 201410621454A CN 104306781 A CN104306781 A CN 104306781A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a soft capsule for relieving cough. The soft capsule is prepared from the following traditional Chinese medicines: rubus corchorifolius, hawkweed, acanthaceae, fruit of fiverleaf akebia, ambrosia artemisiifolia and the like. In addition, a conventional preparation method is adopted, and plant oil is added, so that the soft capsule is prepared. The soft capsule has the good function of relieving the cough.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of soft capsule and preparation method and application of antitussive.
Background technology
Cough is the protectiveness respiratory reflex action that human body removes secretions in respiratory tract or foreign body.Although there is the one side that it is favourable, violent chronic cough can cause respiratory tract hemorrhage.Cough is because of diseases caused by exogenous pathogenic factor six climate exopathogens, internal organs internal injury, affects the sound disease having expectorant caused by the lung.See " Plain Questions the five internal organs generate a section "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi is hindered and also unclear; It is noiseless and have expectorant for coughing, spleen wet dynamic and be expectorant also.Cough meaning has expectorant and sound, and lid moves in lung qi due to wound and wets in spleen, cough and for coughing also ".Because exopathogen violates lung, or internal organs internal injury, involves caused by the lung.Should and early treatment, lack effective ways at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of soft capsule and preparation method and application of antitussive.
Technical scheme: the object of the invention is by following scheme realize:
A soft capsule for antitussive, it is prepared by the crude drug of following parts by weight: Herba Rubi parvifolii 10 parts, Herba Hieracii Umbellati 12 parts, Herba Rostellulariae 8 parts, fried 14 parts of August, Herba stachydis kouyangensis 16 parts, Lycopodium fargesii 12 parts, Magnolia Delavayi 15 parts, Caulis Vitis Amurensis 12 parts, Mosla dianthera 10 parts, Radix Coicis 8 parts, alizarin 14 parts of well limit.
The soft capsule of described antitussive, preparation method comprises the steps: to get above Chinese medicine, decocts with water 2 times, and each amount of water is 10 times amount of medical material weight, each 2 hours, merge extractive liquid, filtered, filtrate reduced in volume is to thick extractum, and vacuum drying, pulverizes to obtain dry extract; Cross 100 mesh sieves, add vegetable oil in right amount, mixing, with colloid mill grinding, be chilled to room temperature, be pressed into 1000, dry, deoil, dry, to obtain final product.
The application of soft capsule in preparation antitussive soft gelatin pharmaceutical of described antitussive.
Herba Rubi parvifolii, Latin is called Rubus corchorifolius L.f., leaf: antiinflammatory, synthetism.For severed finger.Root: dispelling, collateral-activating, heat clearing away is relieving convulsion.For infantile convulsion, bones and muscles pain due to rheumatism.The present invention uses leaf.
Herba Hieracii Umbellati source Compositae hawk weed Herba Hieracii Umbellati HieraciumumbelatumL., with root and all herbal medicine, heat-clearing and toxic substances removing, dampness removing removing food stagnancy.For carbuncle furuncle, urinary tract infection, the long-pending block of stomachache, dysentery.The present invention is with root and all herbal medicine.
Herba Rostellulariae (Classification system: Rostellularia procumbens (L.) Nees) annual draft of crawling, leaf is to life; Avette, oblong or wide lanceolar, spike top is raw or axil is raw, corolla pale red or band aubergine, and filigree base portion and attachment region surrounding have fine hair, style is thread, stigma head, capsule is linear, the short point of tip, base portion is ashamed narrow, all in flattening shape, light brown, upper surface has white pubescence.Seed oval and micro-flat, pitchy, it is protruding that surface has netted stricture of vagina.8 ~ November of florescence.: heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain, infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria; External is controlled carbuncle furuncle and is swollen, traumatic injury.
August explodes, Classification system Holboellia fargesii Reaub., is fallen leaves woody climber, high 10m.Bark has obvious point-like protruding, the brown or brown of branch; Minor matters place has place to deposit perula, and bottom person is slightly with wooden, top papery, all without hair.Trifoliolate leaf, cluster in branch end, petiole is thin and delicate, long 6 ~ 8cm, vanelets oval, width egg shape or long oval etc., length and width change greatly, the blunt circle of tip, central nick or the short point of tool, basal circular or wide wedge shape, sometimes in micro-heart, full edge or in wavy, lateral vein is usual 5 ~ 6 right.Flower unisexuality, hermaphroditism, aubergine, raceme axil is raw, and be about 8cm, male flower is less, and most, and be born in inflorescence top, tool squamella, perianth 3, stamen 6, filigree is flat; Female flower 1 ~ 3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, stamen 6, and filigree is flat; Female flower 1 ~ 3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, and wide ellipse is blunt nosed, tool staminodium 6, carpel 3 ~ 12, and from life, stigma head, ovary cylindrical shape or slightly bending, upper Room 1, parietal placenta, ovule is most.Follicle radish sarcocarp matter, oblong, aubergine time ripe, ftractures along ventral suture.Seed sealene triangle, slightly flat, rufous, it is fine and closely woven and glossy that tool indulges wrinkle, and be embedded in canescence fruit flesh, hilum is slightly partial to, the spongy strophiole of its other visible white.4 ~ May of florescence, really 8 ~ October of phase.Soothing the liver, the kidney invigorating, pain relieving, diuresis, parasite killing.Cure mainly: stomachache, colic, painful and swollen testis, lumbago, seminal emission, menoxenia, leucorrhea, uterine prolapse.For gastral cavity side of body distending pain, amenorrhea dysmenorrhea, dysuria, snake bite and insect sting.
Herba stachydis kouyangensis is herb or the root of the wild manna of labiate.Summer, autumn gather, and clean and dry.Eliminating inflammation and expelling toxin, draws out the pus.Control furuncle, osteomyelitis, mash deposited affected part with fresh grass.The present invention is with all herbal medicine.
Lycopodium fargesii is fern Lycopodiaceae Lycopodium plant Lycopodium fargesii Lycopodium fargesii Hert., with all herbal medicine.The whole year can adopt, and cleans and dries.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For rheumatic arthritis, muscle spasm, traumatic injury, hypertrophic spondylitis, rheumatoid arthritis.
Magnolia Delavayi, Classification system Magnolia delavayi Franch., Magnoliaceae Magnolia, bark: warming middle-JIAO is regulated the flow of vital energy, invigorating spleen to remove dampness.For dyspepsia, chronic gastritis, vomiting, stomachache, abdominal distention, diarrhoea.Flower (or alabastrum): lung qi dispersing cough-relieving.For rhinitis, sinusitis, bronchitis, cough.The present invention is used as medicine with bark.
Caulis Vitis Amurensis is root or the ratan of vitaceae Vitis Amurensis.Chinese formal name used at school: Caulis Vitis Amurensis Classification system Vitis amurensis Rupr, autumn, winter gather, and clean, and section or section, dry.Root, rattan: wind-expelling pain-stopping.For the outer pain of injury, rheumatic ostalgia, stomachache, stomachache, nervous headache, postoperative pain.Really: clearing away heat and promoting diuresis.Thirsty for dysphoria with smothery sensation, urinary tract infection, dysuria.The present invention is used as medicine with root.
Mosla dianthera, Classification system is Mosla dianthera (Buch.-Ham.ex Roxb.) Maxim., is that Labiatae stone shepherd's purse rather belongs to annual herb plant.Stems to 1 m tall, into four prism shape.Leaf egg shape lanceolar or Pedicellus et Pericarpium Trapae volt lanceolar, raceme is born in the top of stem and branch, pyrene taupe, subsphaeroidal.Flower, fruit phase are in the 5-11 month.With all herbal medicine, Xia Qiu gathers, and cleans, using fresh herb or dry, has multiple pharmaceutical value.Dispel the wind and deliver, dampness removing is antipruritic.For headache due to common cold, tonsillitis, heatstroke, Peptic Ulcers, dysentery; Eczema is controlled in external, miliaria, skin pruritus, furuncle, centipete bite.Get the herb burning cigarette partly dried in the shade and can smoke mosquito.The present invention is with all herbal medicine.
Radix Coicis is the root welding technology of grass Semen Coicis.Latin name Coix lacryma-jobi L.var.monilifer Watt, heat clearing away, dampness removing, parasite killing.For urinary tract infection, lithangiuria, edema, beriberi, ascariasis, leukorrhagia.
Well limit madder is the herb of Pteridaceae plant Herba Pteridis Multifidae.Classification system Chinese Brake Herb, heat-clearing and toxic substances removing, diuresis.For icterohepatitis, dysentery, mastitis, dysuria.
Beneficial effect: the present invention has good antitussive effect.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1 preparation embodiment: get Herba Rubi parvifolii 10g, Herba Hieracii Umbellati 12g, Herba Rostellulariae 8g, August explode 14g, Herba stachydis kouyangensis 16g, Lycopodium fargesii 12g, Magnolia Delavayi 15g, Caulis Vitis Amurensis 12g, Mosla dianthera 10g, Radix Coicis 8g, the alizarin 14g in well limit, decoct with water 2 times, each amount of water is 10 times amount of medical material weight, each 2 hours, merge extractive liquid, filters, and filtrate reduced in volume is to thick extractum, vacuum drying, pulverizes to obtain dry extract; Cross 100 mesh sieves, add vegetable oil in right amount, mixing, with colloid mill grinding, be chilled to room temperature, be pressed into 1000, dry, deoil, dry, obtain soft capsule.
2 antitussive drug effect testing datas of the present invention
2.1 animals: healthy ICR mice, male and female half and half, heavy 18-22g, is provided by Nanjing Medical University's animal center, production licence number SCXK (Soviet Union) 2002-0031.
2.2 medicines and reagent: prepare the present invention by above-described embodiment, specification: 4g crude drug/g), pentoxyverine citrate sheet (carbetapentane citrate, Suzhou Pharmaceutical Group company limited, specification: 25mg/ sheet, lot number: 130118-2).
2.3 instruments and reagent: soniclizer, S-888F type, Chinese-foreign joint Nanjing Dao Fen Electronics Co., Ltd.; Ammonia (25%) AR. Nanjing chemical reagent one factory, lot number: 12033157.
2.4 methods: ammonia causes mouse cough test
2.4.1 divide into groups: mice is divided into 5 groups at random: model control group (isometric(al) 0.5%CMC-Na), carbetapentane citrate group (0.013g/kg), the present invention high (20g/kg), in (10g/kg), low (5g/kg) three dosage groups.
2.4.2 method: after each group gastric infusion 1h, be placed in by mice in experimental box, spray into 25 ~ 28% ammonia 20s in experimental box, record self-spray plays mice incubation period and cough number of times in 5 minutes.
2.5 results: the high, medium and low dosage of the present invention and positive drug carbetapentane citrate all obviously can reduce ammonia and cause cough number of times in mice 5min, extend cough latent period, significance (P<0.05 or P<0.01, in table 1) is all had with model control group comparing difference.
The impact that table 1. the present invention coughs on ammonia spraying induced mice
Note: compare with model control group, * P<0.05; * P<0.01
2.6 conclusions: the present invention's three dosage all can reduce the cough number of times that ammonia causes mouse cough model, all have significance with model group comparing difference.
Claims (3)
1. the soft capsule of an antitussive, it is characterized in that, it is prepared by the crude drug of following parts by weight: Herba Rubi parvifolii 10 parts, Herba Hieracii Umbellati 12 parts, Herba Rostellulariae 8 parts, fried 14 parts of August, Herba stachydis kouyangensis 16 parts, Lycopodium fargesii 12 parts, Magnolia Delavayi 15 parts, Caulis Vitis Amurensis 12 parts, Mosla dianthera 10 parts, Radix Coicis 8 parts, alizarin 14 parts of well limit.
2. the soft capsule of antitussive according to claim 1, it is characterized in that, preparation method comprises the steps: to get above Chinese medicine, decocts with water 2 times, and each amount of water is 10 times amount of medical material weight, each 2 hours, merge extractive liquid, filters, and filtrate reduced in volume is to thick extractum, vacuum drying, pulverizes to obtain dry extract; Cross 100 mesh sieves, add vegetable oil in right amount, mixing, with colloid mill grinding, be chilled to room temperature, be pressed into 1000, dry, deoil, dry, to obtain final product.
3. the application of soft capsule in antitussive soft gelatin pharmaceutical of antitussive according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410621454.0A CN104306781A (en) | 2014-11-05 | 2014-11-05 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410621454.0A CN104306781A (en) | 2014-11-05 | 2014-11-05 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
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| CN104306781A true CN104306781A (en) | 2015-01-28 |
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| CN201410621454.0A Pending CN104306781A (en) | 2014-11-05 | 2014-11-05 | Soft capsule for relieving cough as well as preparation method and application of soft capsule |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582191A (en) * | 2016-03-23 | 2016-05-18 | 卞毓平 | Evening primrose capsule |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413691A (en) * | 2002-11-13 | 2003-04-30 | 贵州省安顺制药厂 | Drug for treating cough |
| KR20070064211A (en) * | 2005-12-15 | 2007-06-20 | 조명호 | Preparation method of drink for protect breathing disease |
-
2014
- 2014-11-05 CN CN201410621454.0A patent/CN104306781A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1413691A (en) * | 2002-11-13 | 2003-04-30 | 贵州省安顺制药厂 | Drug for treating cough |
| KR20070064211A (en) * | 2005-12-15 | 2007-06-20 | 조명호 | Preparation method of drink for protect breathing disease |
Non-Patent Citations (2)
| Title |
|---|
| 郑伟彬等: "慢性咳嗽的中医治疗研究进展", 《山东中医杂志》 * |
| 陶汉华: "《中医内科临症诊疗备要》", 30 April 2013, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582191A (en) * | 2016-03-23 | 2016-05-18 | 卞毓平 | Evening primrose capsule |
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