CN104257807B

CN104257807B - A kind of Chinese medicine composition and preparation method and application treating posthepatitic cirrhosis

Info

Publication number: CN104257807B
Application number: CN201410543449.2A
Authority: CN
Inventors: 胡亚南; 王淑霞
Original assignee: Individual
Current assignee: Hu Yanan
Priority date: 2014-10-14
Filing date: 2014-10-14
Publication date: 2016-06-01
Anticipated expiration: 2034-10-14
Also published as: CN104257807A

Abstract

The present invention provides a kind of Chinese medicine composition treating posthepatitic cirrhosis, it is prepared by the raw material of following weight part number: folium ilicis chinensis 12 parts, Radix Et Rhizoma Fagopyri Tatarici 12 parts, rank of nobility bed 14 parts, Fructus Bruceae 15 parts, Common Leafflower Herb 10 parts, Tender Catchweed Bedstraw Herb 12 parts, Yangtao Actinidia Root 10 parts, Herba Zornia Diphyllae 10 parts, August fried 8 parts, three add 12 part, three to 14 parts, joint, Root of Java Campanumoea 15 parts, big Japnanese St. John's wort Herb 8 parts, big Herba Kalimeridis 10 parts, Ramulus et Folium Bauhiniae Faberi 10 parts, Root and rhizome of Manyleaf Meadowrue 8 parts, Herba Lysimachiae Congestiflorae 12 parts, little rhizome of cyrtomium 6 parts, the functional treatment posthepatitic cirrhosis of the present invention.

Description

A kind of Chinese medicine composition and preparation method and application treating posthepatitic cirrhosis

Technical field

The present invention relates to technical field of traditional Chinese medicines, it is specifically related to a kind of Chinese medicine composition and the preparation method and application that treat posthepatitic cirrhosis.

Background technology

Owing in hepatitis B patient body, hepatitis B virus long-term existence well enters in liver cell, the nucleic acid moiety of replication-competent virus in liver cell nuclear, and then in cytoplasm, wrap shell, in the process so repeatedly integrated, continuous stimulating immune system, produces primed lymphocyte and corresponding antibody, combines with the liver cell of hepatitis B virus with the primed lymphocyte of antibodies and surface, liver cell is destroyed, and virus is eliminated. In this process, also produce the fiber factor and the effect of fibroblast synthesis collagen is strengthened, cause fibrous tissue constantly hyperplasia in liver, in the course of time, make liver generation fibrosis, define liver cirrhosis. Lack effective medicine at present.

Summary of the invention

Goal of the invention: in order to solve the problem, it is an object of the invention to provide a kind of Chinese medicine composition and the preparation method and application that treat posthepatitic cirrhosis.

Technical scheme: it is an object of the invention to by following scheme realize:

Treating a Chinese medicine composition for posthepatitic cirrhosis, it is prepared by the raw material of following weight part number: folium ilicis chinensis 10 parts, Radix Et Rhizoma Fagopyri Tatarici 12 parts, rank of nobility bed 14 parts, Fructus Bruceae 15 parts, Common Leafflower Herb 9 parts, Tender Catchweed Bedstraw Herb 10 parts, Yangtao Actinidia Root 10 parts, Herba Zornia Diphyllae 14 parts, August fried 8 parts, three add 14 part, three to 14 parts, joint, Root of Java Campanumoea 15 parts, big Japnanese St. John's wort Herb 8 parts, big Herba Kalimeridis 15 parts, Ramulus et Folium Bauhiniae Faberi 10 parts, Root and rhizome of Manyleaf Meadowrue 8 parts, Herba Lysimachiae Congestiflorae 10 parts, little rhizome of cyrtomium 6 parts.

The application of the Chinese medicine composition of described treatment posthepatitic cirrhosis in the medicine of preparation treatment posthepatitic cirrhosis.

In the present invention, folium ilicis chinensis is the plant of Chinese ilex section. It is distributed in various places on the south China the Changjiang river, often it is grown in sparse woods. Its root, leaf all can pharmacy, Classification system IlexpurpureaHassk., clearing heat and detoxicating, promoting blood circulation and hemostasis. For upper respiratory tract hepatitis, chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external application, the ulcer of lower limb, leprosy ulcer, and extra earning is hemorrhage, frostbite, mazoitis, and chapped skin (burns outside ash adjusts oil and puts on the skin).

Radix Et Rhizoma Fagopyri Tatarici has another name called wild Wild Buckwheat Rhizome also known as Rhizoma Fagopyri Dibotryis, is country's II grade of Top-rated protected wild plants (State Council's approval on August 4th, 1999). English name wildbuckwheat, door: Magnoliophyta, Magnoliophyta, guiding principle: lily magnolia guiding principle Magnoliopsida, order: knotweed order Polygonales: clearing heat and detoxicating, scattered silt of invigorating blood circulation, invigorating spleen to remove dampness. For swelling and pain in the throat, lung abscess, pyothorax, pneumonia, stomachache, hepatitis, dysentery, maldigestion, night sweat, dysmenorrhoea, amenorrhoea, leukorrhea; Tuberculous lymphadenitis is controlled in external application, the swollen poison of carbuncle furuncle, wound.

Rank of nobility bed (Classification system: Rostellulariaprocumbens (L.) Nees) annual draft of crawling, leaf is to life; Avette, oblong or wide lanceolar, spike top is raw or armpit is raw, and corolla incarnadine or band red-purple, filigree base portion and attachment region surrounding have fine fleece hair, style is thread, column cap head shape, capsule is linear, the short point of tip, base portion is ashamed narrow, all in flattening shape, light brown, upper surface has white pubescence. Seed oval and micro-flat, chocolate, it is protruding that surface has netted line. 8��November of florescence. : clearing heat and detoxicating, inducing diuresis to remove edema, preventing malaria. For cold, fever, malaria, swelling and pain in the throat, infantile malnutrition, dysentery, enteritis, nephritic edema, urinary system infection, chyluria; External application is controlled carbuncle sore furuncle and is swollen, wound.

Fructus Bruceae is the mature seed of quassia Fructus Bruceae tree. Control dysentery, anti-malaria. For dysentery of a specified duration, chronic dysentery with frequent relapse, malaria.

Common Leafflower Herb, formal name used at school: PhyllanthusurinariaL.), annual herb plant, is permitted to chi for high several cun. Stem band red-purple, has vertical rib. Leaf alternate, does multiple tiles arrangement, forms two row, and very like pinnately compound leaf, blade square is circular, long two, three points, Quan Lv, and tip point or blunt, base portion is circular, several without petiole. Xia Qiu opens white little Hua along stem adaxial surface of the leaf, without anthocaulus. Tying oblate shape fruitlet after spending, shape, such as globule, is arranged in below false compound leaf. Clearing away heat and promoting diuresis, bright order, disappears long-pending. For nephritic edema, urinary system infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition due to digestive disturbances or intestinalparasites, eye keratitis, icterohepatitis; External application is controlled Trimeresurus stejnegeri and is bitten.

Tender Catchweed Bedstraw Herb, Classification system GaliumaparineL.var.tenerumGren.et (Godr.) Rebb., Rubiaceae (Rubiaceae) galium plant. Racemosus, overgrow or climb shape draft, being born in the hillside of height above sea level 20-4600 rice, wilderness, ditch limit, river shoal, Tanaka, border, meadow. About there are moist forest land, 300 the kind distribution whole world, marsh, riverbank and beach. For the Dry crop field malignant weed that ripens in summer, it is again the Chinese medicinal materials having step-down, anticancer function simultaneously. Clearing heat and detoxicating, inducing diuresis to remove edema. Flu, gingival hemorrhage, acute and chronic ecphyaditis, urinary system infection, oedema, dysmenorrhoea, uterine bleeding, leukorrhea, cancer, leukemia; External application controls mazoitis from the beginning of the swollen poison of, carbuncle furuncle, wound.

Yangtao Actinidia Root, formal name used at school: Actinidiaarguta (Sieb.&Zucc) Planch.exMiq., the root of Actinidiaceae plant Kiwifruit plant, cleans the root of Kiwifruit, has dried, and chopping then carries out use of being used as medicine. Clearing heat and detoxicating, to dispel rheumatism, diuresis is stopped blooding. For treating rheumatic ostealgia, and the disease such as jaundice.

Herba Zornia Diphyllae, Classification system ZorniagibbosaSpanog.: clearing heat and detoxicating, removing pattogenic heat from the blood and toxic material from the body. For flu, pharyngolaryngitis, acute icterohepatitis, acute gastroenteritis, acute appendicitis, infantile malnutrition, acute mastitis, eye keratitis; Wound is controlled in external application, the swollen poison of carbuncle furuncle, venomous snake bite.

August explodes, Classification system HolboelliafargesiiReaub., is fallen leaves woody climber, high 10m. Bark has obvious point-like protruding, and branch is brown or brown; Minor matters place has place to deposit perula, and bottom person is slightly with wooden, top thin paper matter, all without hair. Ternately compound leaf, clusters in branch end, and petiole is thin and delicate, long 6��8cm, vanelets oval, width egg shape or long oval etc., length and width change greatly, the blunt circle of tip, the micro-recessed or short point of tool of central authorities, base portion is circular or wide wedge shape, and sometimes in micro-heart, full edge or in wavy, side arteries and veins is usual 5��6 right. Flower unisexuality, monoecism, red-purple, raceme armpit is raw, long about 8cm, and male flower is less, most, and is born in inflorescence top, tool bractlet, perianth 3, stamen 6, and filigree is flat; Female flower 1��3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, stamen 6, and filigree is flat; Female flower 1��3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, wide ellipse, blunt head, tool staminodium 6, carpel 3��12, and from life, column cap head shape, ovary round shape or slightly bending, upper Room 1, side film placenta, ovule is most. Pulp matter, oblong, red-purple time ripe, ftractures along ventral suture. The irregular trilateral of seed, slightly flat, reddish-brown, the vertical wrinkle of tool is fine and closely woven and glossy, is embedded in canescence fruit flesh, and hilum is slightly partial to, its other visible white spongy strophiole. 4��May of florescence, really 8��October of phase. Soothing the liver, kidney tonifying, pain relieving, diuresis, kills worm. Cure mainly: stomachache, hernia pain, painful and swollen testis, pain in the back, seminal emission, menoxenia, leukorrhea, uterine prolapse. Swollen pain is coerced for gastral cavity, through closing dysmenorrhoea, dysuria, snake bite and insect sting.

Three add as Araliaceae acanthopanax plant three adds Acanthopanantrifoliatus (L.) Merr., is used as medicine with root, leaf or complete stool. Root and the complete stool four seasons can adopt, and dry for subsequent use; Ye Xiaqiucai, using fresh herb or use of drying in the shade. Clearing heat and detoxicating, dispel rheumatism, blood stasis removing analgesic. For jaundice, enteritis, stomachache, rheumatic arthritis, lumbago and skelalgia; Wound is controlled in external application, the swollen poison of sore furuncle, eczema.

Three pairs of joints, Classification system Clerodendrumserratum is Verbenaceae shrub. Full grass is containing soap glucoside. Have preventing malaria, refute bone, sterilization, heat-clearing, the effect such as removing toxic substances. Yunnan, Guangxi are mainly used in preventing and treating malaria, dysentery, synthetism; Also control headache, ophthalmia, fall beat, the disease such as rheumatism; Decoct water in right amount with fresh leaf and can control impetigo. Clearing heat and detoxicating, preventing malaria, synthetism, dispels rheumatism. For tonsillitis, pharyngolaryngitis, treating rheumatic ostealgia, malaria, hepatitis; The swollen poison of carbuncle furuncle is controlled in external application, fracture, wound.

Root of Java Campanumoea is from the root of campanulaceae Radix Codonopsis platymiscium tetraphyllous ginseng. Wild product are excavated White Dew in autumn; Cultivation product are excavated in sowing the 2nd year autumn, remove fibrous root and root head, clean, and segment, dries. Root fusiform or cone, many vertical profiles are into two or block sheet. Surface lark, has the wrinkle of closeer ring-type protuberance, and root head is little, has several stem bases or bud trace; The edge inward curl of vertical profile two halves and in conch shape, section yellow-white. Light weight, fracture off-white color: invigorating the spleen and replenishing QI, moistening lung is promoted the production of body fluid. Weak for the deficiency of vital energy, insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, infantile malnutrition, milk is rare

Big Japnanese St. John's wort Herb is Primulaceae row grass red of platymiscium row grass LysimachiafortuneiMaxim., with all herbal medicine. Summer, autumn gather, and clean, dry, and segment or binding are for subsequent use. Clearing heat and promoting diuresis, promoting blood flow to regulate menstruation. For flu, cough spitting of blood, enteritis, dysentery, hepatitis, infantile malnutrition due to digestive disturbances or intestinalparasites, malaria, rheumatic arthritis, dysmenorrhoea, amenorrhoea, leukorrhea; Mazoitis, conjunctivitis, snakebite, wound.

Big Herba Kalimeridis is composite family grass in Autumnal Equinox platymiscium grass in Autumnal Equinox Rhynchospermun; VerticillatumReinw., with all herbal medicine, autumn gathers, and cleans, dries. Removing damp-heat. For acute and chronic hepatitis, hepatic ascites, uterine bleeding, leukorrhea.

Ramulus et Folium Bauhiniae Faberi is the dry full grass of Ramulus et Folium Bauhiniae Faberi EuphorbiahirtaLinn., and annual herb, streptococcus aureus, Pseudomonas aeruginosa are all had restraining effect by Herba Euphoubiae Hirtae water decoction. There are diuresis and middle degree catharsis effect. Clearing heat and detoxicating, profit is wet antipruritic. For bacillary dysentery, amebic dysentery, enteritis, enteron aisle trichomonad, maldigestion, bronchitis, pyelonephritis; Eczema, dermatitis, skin pruritus are controlled in external application.

Horse hair is linked as the leafy Tang pine mushroom ThalictrumfoliolosumDC. of Ranunculaceae thalictrum spp, is used as medicine with root. Root is dug out by spring, autumn, cuts terrestrial stem leaf, washes earth, dries. Leafy Tang pine mushroom: perennial herb, plant is all without hair. Underground have horizontal walk root stock, the root that raw many bars are elongated, equal yellow, long branch is arranged at top. In the middle part of stem, leaf is go out for three times three or nearly pinnately compound leaf; Blade reaches 28 centimetres. Inflorescence circular cone shape, many branches. Achene fusiform, long 3 millimeters. Heat-clearing and damp-drying drug, eliminating fire and detoxication. For enteritis, dysentery, jaundice, conjunctival congestion with pain and swelling of the eye.

Herba Lysimachiae Congestiflorae is the full grass of Primulaceae plant L. congestiflora Hesms. Spring, autumn gather, using fresh herb or dry use: expelling wind and cold, relieving cough and reducing sputum, and disappear long-pending removing toxic substances. For headche due to wind-cold, swelling and pain in the throat, cough ant phlegm, infantile malnutrition, diarrhoea, snakebite.

Little rhizome of cyrtomium, Classification system CyrtomiumfortuneiJ.Smith, the flat liver of heat-clearing, separates poisoning worm, hemostasis. For preventing measles, influenza, flu, meningococcal meningitis; Control and have a dizzy spell, essential hypertension, dysentery, hematuria, have blood in stool, uterine bleeding, leukorrhea, uncinariasis.

Useful effect:

The medicine that the present invention obtains can safe and effective treatment posthepatitic cirrhosis.

Embodiment

Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to following example, and all technology realized based on foregoing of the present invention all belong to the scope of the present invention.

1, specific embodiment 1: take folium ilicis chinensis 10g, Radix Et Rhizoma Fagopyri Tatarici 12g, rank of nobility bed 14g, Fructus Bruceae 15g, Common Leafflower Herb 9g, Tender Catchweed Bedstraw Herb 10g, Yangtao Actinidia Root 10g, Herba Zornia Diphyllae 14g, August fried 8g, three add 14g, three to joint 14g, Root of Java Campanumoea 15g, big Japnanese St. John's wort Herb 8g, big Herba Kalimeridis 15g, Ramulus et Folium Bauhiniae Faberi 10g, Root and rhizome of Manyleaf Meadowrue 8g, Herba Lysimachiae Congestiflorae 10g, little rhizome of cyrtomium 6g, the times amount water that adds 10, decoct and boil 2 hours, filter; Filter residue adds 8 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrated, dry, load capsule shell, the capsule of normal adult 1 day consumption must be met. It is used for the treatment of posthepatitic cirrhosis. Oral, divide every day and sooner or later take for twice.

2, specific embodiment 2: take folium ilicis chinensis 10g, Radix Et Rhizoma Fagopyri Tatarici 12g, rank of nobility bed 14g, Fructus Bruceae 15g, Common Leafflower Herb 9g, Tender Catchweed Bedstraw Herb 10g, Yangtao Actinidia Root 10g, Herba Zornia Diphyllae 14g, August fried 8g, three add 14g, three to joint 14g, Root of Java Campanumoea 15g, big Japnanese St. John's wort Herb 8g, big Herba Kalimeridis 15g, Ramulus et Folium Bauhiniae Faberi 10g, Root and rhizome of Manyleaf Meadowrue 8g, Herba Lysimachiae Congestiflorae 10g, little rhizome of cyrtomium 6g, the times amount water that adds 10, decoct and boil 2 hours, filter; Filter residue adds 8 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, must meet the granule of normal adult 1 day consumption. It is used for the treatment of posthepatitic cirrhosis. Oral, divide every day and sooner or later take for twice.

3, specific embodiment 3: take folium ilicis chinensis 10g, Radix Et Rhizoma Fagopyri Tatarici 12g, rank of nobility bed 14g, Fructus Bruceae 15g, Common Leafflower Herb 9g, Tender Catchweed Bedstraw Herb 10g, Yangtao Actinidia Root 10g, Herba Zornia Diphyllae 14g, August fried 8g, three add 14g, three to joint 14g, Root of Java Campanumoea 15g, big Japnanese St. John's wort Herb 8g, big Herba Kalimeridis 15g, Ramulus et Folium Bauhiniae Faberi 10g, Root and rhizome of Manyleaf Meadowrue 8g, Herba Lysimachiae Congestiflorae 10g, little rhizome of cyrtomium 6g, the times amount water that adds 10, decoct and boil 2 hours, filter; Filter residue adds 8 times amount water, decocts and boils 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, compressing tablet, can obtain the tablet meeting normal adult 1 day consumption. It is used for the treatment of posthepatitic cirrhosis. Oral, divide every day and sooner or later take for twice.

4. granule of the present invention is to the clinical study of posthepatitic cirrhosis

4.1, physical data: contriver collect altogether between in September ,-2013 in July, 2,010 100 example posthepatitic cirrhosises outpatient service patient, the age 28-59 year, course of disease 2-5. It is divided at random: treatment group 60 example, blank group 40 example. Two groups of data there was no significant differences such as age, the state of an illness, have comparability.

Case definition: the positive history of 1. hepatitis b virus infected or hepatitis B surface antigen (HBsAg) was more than 6 months, and existing HBsAg and (or) HBVDNA is still positive person, and diagnosable is chronic HBV infection; 2. HCV infection was more than 6 months, or date of the onset is not clear, without hepatitis history, but pathology of hepar inspection meets chronic hepatitis person, and diagnosable is chronic HCV infection. Liver impedance rheograph pathology does immunohistochemical method detection, can show the expression with or without HBsAg and HbcAg in liver cell. HBsAg endochylema diffuse type and born of the same parents' film type, and HBcAg endochylema type and born of the same parents' film type express, prompting hbv replication enlivens. HBsAg forgives build and periphery type and HBcAg caryogram is expressed then to point out in liver cell and be there is HBV.

Liver cirrhosis clinical diagnosis standard: 1. can have slightly weak, poor appetite or abdominal distension symptom, but show without obvious hepatic insufficiency; 2. liver reserve function is normally or substantially normal, serum bilirubin<2mg/dl (35umol/L), serum albumin is normal or on the low side, but still>=35g/L, Prothrombin activity>60%; 3. can there is portal hypertension, as performance has slight esophageal varicosis, but without seroperitoneum, upper gastrointestinal hemorrhage and hepatogenic encephalopathy etc. Following means contribute to the early diagnosis of liver cirrhosis: 1. to the necessary tight follow-up observation of Patients with Viral Hepatitis; 2. to agnogenic hepatomegaly, particularly liver quality rough person solid, surperficial, there is hepatopathy face person, the sign persons such as spider mole, liver palms and telangiectasis occur, detection methods such as comprising ultrasonic, peritoneoscope and liver impedance rheograph should be adopted to help to determine character.

Also comprise: 1. have obvious hepatic insufficiency to show; 2. liver reserve function is abnormal, and serum albumin<35g/L, A/G<1.0, serum bilirubin>35umol/L, Prothrombin activity<60%; 3. portal hypertension occurs, shows as esophagus fundus ventricularis varication or Rupture haemorrhag etc. that splenomegaly, seroperitoneum and portal hypertension cause.

4.2, test method

4.2.1 the obtained capsule of the oral present invention specific embodiment 1 for the treatment of group, sooner or later respectively once. 15 days courses for the treatment of.

4.2.2 blank group oral placebo capsule, sooner or later respectively once. 15 days courses for the treatment of.

4.3, criterion of therapeutical effect and treatment result

4.3.1 criterion of therapeutical effect

Recovery from illness: clinical symptom all disappears, testing laboratory checks normal. Taking a turn for the better: clinical symptom relief, the state of an illness is controlled, laboratory examination improvement or normal. Invalid: clinical symptom is without obviously taking a turn for the better or increases the weight of.

4.3.2 statistics is treated in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Always there is efficiency (%)
						Treatment group	60	26	15	19	68.3
Blank group	40	1	3	28	10

Visible, the medicine that the present invention obtains can safe and effective treatment posthepatitic cirrhosis.

Claims

1. treat the Chinese medicine composition of posthepatitic cirrhosis for one kind, it is characterized in that, it is prepared by the Chinese medicine material of following weight part number: folium ilicis chinensis 10 parts, Radix Et Rhizoma Fagopyri Tatarici 12 parts, rank of nobility bed 14 parts, Fructus Bruceae 15 parts, Common Leafflower Herb 9 parts, Tender Catchweed Bedstraw Herb 10 parts, Yangtao Actinidia Root 10 parts, Herba Zornia Diphyllae 14 parts, August fried 8 parts, three add 14 part, three to 14 parts, joint, Root of Java Campanumoea 15 parts, big Japnanese St. John's wort Herb 8 parts, big Herba Kalimeridis 15 parts, Ramulus et Folium Bauhiniae Faberi 10 parts, Root and rhizome of Manyleaf Meadowrue 8 parts, Herba Lysimachiae Congestiflorae 10 parts, little rhizome of cyrtomium 6 parts.

2. the Chinese medicine composition treating posthepatitic cirrhosis as claimed in claim 1 is in the application prepared in the medicine treating posthepatitic cirrhosis.