CN105561274A - 一种用于食管癌的中药制剂及其制备方法 - Google Patents
一种用于食管癌的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于食管癌的中药制剂,它是以附子、细辛、干姜、桂枝、花椒、郁金、姜黄、川芎、马钱子、大黄、干漆、蟾皮、生天南星、红花、乳香、没药、半枝莲、半边莲、白芷、元胡、雄黄、山慈菇、冰片、麝香为原料,属于中药发明领域。根据每味中药的不同特性,以洗净切块预处理后,按比例配制,经特殊方法制作,具有祛风散寒、散结止痛、清热解毒、燥湿化痰的作用,本发明产品组合及制作方法独特,经临床验证,该药治疗效果显著,治疗周期短,价格低廉,无不良反应和任何毒副作用,具有广阔的市场应用前景。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种用于食管癌的中药制剂,本发明还涉及该中药制剂的制备方法。
背景技术
食管癌是我国常见的恶性肿瘤之一,我国是食管癌的高发国家,又是食管癌死亡率最高的国家。
中医学认为,食管癌病因七情郁结,脾胃受损或气滞血瘀,痰湿不化而致。
目前,食管癌尚无特效疗法。化疗药物对食管癌仅有姑息疗效,可用环磷酰胺、博来霉素、放线菌素D、顺铂、中氨蝶呤、氟尿嘧啶等药物,但效果很差。但长期或短时间使用这些药物进行治疗,可引起肥胖、多毛、痤疮、血糖升高、高血压、水肿、恶心、呕吐、头晕,便秘等等一系列副作用症状,而化疗或放疗治疗不但对患者身体正常细胞造成极大伤害还对患者产生心理阴影,使患者产生很大的痛苦,治疗过程反反复复,效果不明显,费用高等,给患者的造成较大的心里压力和病痛压力。
发明内容
本发明的目的在于提供一种用于食管癌的中药制剂,该中药制剂对于治疗食管癌具有治疗效果显著,治愈时间短,价格低廉,无不良反应和副毒作用的特点。
发明人在多年的临床医疗实践中,根据该病症的发展规律,以及中药的配伍原则,并通过大量的临床验证,反复探索总结出用于治疗食管癌的中药制剂的新配方。本发明具有治疗效果显著,治愈时间短,价格低廉,无不良反应和副毒作用的特点。
本发明中药物的作用:
其中:
附子:为毛茛科植物乌头AconitumcarmichaeliDebx.的子根的加工品。性味:辛、甘,大热;有毒。归心、肾、脾经。功效:回阳救逆,补火助阳,逐风寒湿邪。用于亡阳虚脱,肢冷脉微,阳萎,宫冷,心腹冷痛,虚寒吐泻,阴寒水肿,阳虚外感,寒湿痹痛。《别录》中记载:脚疼冷弱,腰脊风寒,心腹冷痛,霍乱转筋,下痢赤白,坚肌骨,强阴,又堕眙,为百药长。
细辛:为马兜铃科植物北细辛AsarumheterotropoidesFr.Schmidtvar.mandshuricum(Maxim.)Kitag.、汉城细辛AsarumsieboldiiMiq.var.seoulenseNakai或华细辛AsarumsieboldiiMiq.的干燥全草。性味:辛,温。归心、肺、肾经。功效:祛风散寒,通窍止痛,温肺化饮。用于风寒感冒,头痛,牙痛,鼻塞鼻渊,风湿痹痛,痰饮喘咳。《本经》中记载:主咳逆,头痛脑动,百节拘挛,风湿痹痛,死肌。明目,利九窍。
干姜:为姜科植物姜ZingiberofficinaleRosc.的干燥根茎。性味:辛、热。归脾、胃、肾、心、肺经。功效:干姜温中散寒,回阳通脉,燥湿消痰。用于脘腹冷痛,呕吐泄泻,肢冷脉微,痰饮喘咳。《纲目》中记载:干姜,能引血药入血分、气药入气分。又能去恶养新,有阳生阴长之意。
桂枝:为樟科植物肉桂CinnamomumcassiaPresl的干燥嫩枝。春、夏二季采收,除去叶,晒干,或切片晒干。性味:辛、甘,温。归心、肺、膀胱经。主治发汗解肌,温通经脉,助阳化气,平冲降气。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
花椒:为芸香科植物青椒(香椒、青花椒、山椒、狗椒)ZanthoxylumschinifoliumSieb.etZucc.或花椒(蜀椒、川椒、红椒、红花椒、大红袍)ZanthoxylumbungeanumMaxim.的干燥成熟果皮(花椒)及种子(椒目)入药。性味:辛,温。归脾、胃、肾经。功效:温中止痛,杀虫止痒。用于脘腹冷痛,呕吐泄泻,虫积腹痛,蛔虫症;外治湿疹瘙痒。
郁金:为姜科植物温郁金CurcumawenyujinY.H.ChenetC.Ling、姜黄CurcumalongaL.、广西莪术CurcumakwangsiensisS.G.LeeetC.F.Liang或蓬莪术CurcumaphaeocaulisVal.的干燥块根。性味:辛、苦,寒。归肝、心、肺经。功效:行气化瘀,清心解郁,利胆退黄。用于经闭痛经,胸腹胀痛、刺痛,热病神昏,癫痫发狂,黄疸尿赤。《本草备要》中记载:行气,解郁;泄血,破瘀。凉心热,散肝郁。
姜黄:为姜科植物姜黄CurcumalongaL.的干燥根茎。性味:辛、苦,温。归脾、肝经。功效:破血行气,通经止痛。用于胸胁剌痛,闭经,癓瘕,风湿肩臂疼痛,跌扑肿痛。《唐本草》中记载:主心腹结积,疰忤,下气,破血,除风热,消痈肿。功力烈于郁金。
川芎:为伞形科植物川芎LigusticumchuanxiongHort.(或LigusticumwallichiiFranch.)的干燥根茎。性味:辛,温。归肝、胆、心包经。功能主治:活血行气,祛风止痛。用于月经不调,经闭痛经,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。《纲目》中记载:燥湿,止泻痢,行气开郁。
马钱子:为马钱科植物马钱StrychnosnuxvomicaL.的干燥成熟种子。性味:苦,温;有大毒。归肝、脾经。功效:通络止痛,散结消肿。用于风湿顽痹,麻木瘫痪,跌扑损伤,痈疽肿痛;小儿麻痹后遗症,类风湿性关节痛。《中药志》:散血热,消肿毒。治痈疽,恶疮。
大黄:为蓼科植物掌叶大黄RheumpalmatumL。、唐古特大黄RheumtanguticumMaxim。exBalf。或药用大黄RheumofficinaleBaill。的干燥根及根茎。性味:苦,寒。归脾、胃、大肠、肝、心包经。功效:泻热通肠,凉血解毒,逐瘀通经。用于实热便秘,积滞腹痛,泻痢不爽,湿热黄疸,血热吐衄,目赤,咽肿,肠痈腹痛,痈肿疔疮,瘀血经闭,跌打损伤,外治水火烫伤;上消化道出血。酒大黄善清上焦血分热毒。用于目赤咽肿,齿龈肿痛。熟大黄泻下力缓,泻火解毒。用于火毒疮疡。大黄炭凉血化瘀止血。用于血热有瘀出血症。《别录》中记载:平胃,下气,除痰实,肠间结热,心腹胀满,女子寒血闭胀,小腹痛,诸老血留结。
干漆:味辛,温,无毒、有毒。主绝伤,补中,续筋骨,填髓脑,安五脏,五缓六急,风寒痹,疗咳嗽,消瘀血,痞结,腰痛,女子疝瘕,利小肠,去蛔虫。
蟾皮:为蟾蜍科动物中华大蟾蜍或黑眶蟾蜍除去内脏的干燥体。性味:味苦;性凉;有毒。归心;肺;脾;大肠经。功效:清热解毒;利水消肿。主痈疽;肿毒;瘰疬;肿瘰;疳积腹胀;慢性气管炎。
天南星:为天南星科植物天南星Arisaemaerubescens(Wall.)Schott.、异叶天南星ArisaemaheterophyllumBlume或东北天南星ArisaemaamurenseMaxim.的干燥块茎。生天南星:除去杂质,洗净,干燥。性味:苦、辛,温;有毒。归肺、肝、脾经。功效:燥湿化痰,祛风止痉,散结消肿。用于顽痰咳嗽,风痰眩晕,中风痰壅,口眼歪斜,半身不遂,癫痫,惊风,破伤风。生用外治痈肿,蛇虫咬伤。《本经》中记载:主心痛,寒热,结气,积聚,伏梁,伤筋,痿,拘缓,利水道。
红花:为菊科植物红花CarthamustinctoriusL.的干燥花。性味:辛,温。归心、肝经。功效:活血通经,散瘀止痛。用于经闭,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。《纲目》:活血,润燥,止痛,散肿,通经。
乳香:为橄榄科乳香树属植物乳香树BoswelliacarteriiBirdw.[B.sacraFluek.]、药胶香树B.bhawdajianaBirdw.及野乳香树B.neglectaM.Moore等,其树干皮部伤口渗出的油胶树脂。性味:辛、苦,温。功效:活血止痛。用于心腹诸痛,筋脉拘挛,跌打损伤,疮痈肿痛;外用消肿生肌。《纲目》中记载:"消痈疽诸毒,托里护心,活血定痛,伸筋,治妇人难产,折伤。
没药:为橄榄科没药属植物没药树CommiphoramyrrhaEngl.[C.molmolEngl.]及同属他种植物的树干皮部渗出的油胶树脂。性味:苦,辛,平。归脾、肾、肝、心经。功效:散血去瘀,消肿定痛。主治胸腹瘀痛、痛经、经闭、症瘕、跌打损伤、痈肿疮疡、肠痈、目赤肿痛。有活血止痛、消肿生肌等功效。
半枝莲:为唇形科植物半枝莲ScutellariabarbataDon[S.rivularisWall]的干燥全草。性味:辛、苦,寒。归肺、肝、肾经。功效:清热解毒,化瘀利尿。用于疔疮肿毒,咽喉肿痛,毒蛇咬伤,跌扑伤痛,水肿,黄疸。《广西药植图志》中记载:消炎,散瘀,止血。治跌打伤,血痢。
半边莲:为桔梗科植物半边莲LobeliachinensisLour.的干燥全草。性味:辛,平。归心、小肠、肺经。功效:利尿消肿,清热解毒。用于大腹水肿,面足浮肿,痈肿疔疮,蛇虫咬伤;晚期血吸虫病腹水。《陆川本草》中记载:解毒消炎,利尿,止血生肌。治腹水,小儿惊风,双单乳蛾,漆疮,外伤出血,皮肤疥癣,蛇蜂蝎伤。
白芷:为伞型科植物白芷Angelicadahurica(Fisch.exHoffm.)Benth.etHook.f.或杭白芷Angelicadahurica(Fisch.exHoffm.)Benth.etHook.f.var.formosana(Boiss.)ShanetYuan的干燥根。性味:辛,温。归胃、大肠、肺经。功效:散风除湿,通窍止痛,消肿排脓。用于感冒头痛,眉棱骨痛,鼻塞,鼻渊,牙痛,白带,疮疡肿痛。《日华子本草》中记载:治目赤胬肉,及补胎漏滑落,破宿血,补新血,乳痈、发背、瘰疬、肠风、痔瘘,排脓,疮痍、疥癣,止痛生肌,去面皯疵瘢。
延胡索:为罂粟科植物延胡索CorydalisyanhusuoW.T.Wang的干燥块茎。性味:辛、苦,温。归肝、脾经。功效:活血,利气,止痛。用于胸胁、脘腹疼痛,经闭痛经,产后瘀阻,跌扑肿痛。《日华子本草》中记载:除风,治气,暖腰膝,破症癖,扑损瘀血,落胎,及暴腰痛。
雄黄:为硫化物类矿物雄黄族雄黄,主含二硫化二砷(As2S2)。性味:辛,温;有毒。归肝、大肠经。功效:解毒杀虫,燥湿祛痰,截疟。用于痈肿疔疮,蛇虫咬伤,虫积腹痛,惊痫,疟疾。《别录》中记载:疗疥虫,匿疮,目痛,鼻中息肉及绝筋破骨。百节中大风,积聚,癖气,中恶腹痛,杀诸蛇虺毒,解藜芦毒。
山慈菇:为兰科植物杜鹃兰Cremastraappendiculata(D.Don)Makino、独蒜兰Pleionebulbocodioides(Franch.)Rolfe或云南独蒜兰PleioneyunnanensisRolfe的干燥假鳞茎。性味:甘、微辛,凉。归肝、脾经。功效:清热解毒,化痰散结。用于痈肿疔毒,瘰疬痰核,淋巴结结核,蛇虫咬伤。
冰片:为菊科植物艾纳香Blumeabalsamifera(L.)DC.的新鲜茎叶经提取加工制成的结晶。性味:辛苦,凉。归肝、心经。功效:通诸窍,散郁火,去翳明目,消肿止痛,清热散毒,散火解毒。《本草经疏》中记载:凡中风非外来之风邪,乃因气血虚而病者忌之;小儿吐泻后成惊者为慢脾风,切不可服,急惊属实热可用,慢惊属虚寒不可用;眼目昏暗属肝肾虚者不宜入点药。
麝香:为鹿科动物林麝MoschusberezovskiiFlerov、马麝MoschussifanicusPrzewalski或原麝MoschusmoschiferusLinnaeus成熟雄体香囊中的干燥分泌物。性味:辛,温。归心、脾经。功效:开窍醒神,活血通经,消肿止痛。用于热病神昏,中风痰厥,气郁暴厥,中恶昏迷,经闭,癓瘕,难产死胎,心腹暴痛,痈肿瘰疬,咽喉肿痛,跌扑伤痛,痹痛麻木。《别录》中记载:疗中恶,心腹暴痛,胀急痞满,风毒,妇人难产,堕胎,去面鼠,目中肤翳。
本发明的方解是:附子回阳救逆、逐风寒邪,细辛祛风散寒、通窍止痛,花椒温中止痛、杀虫止痒,川芎活血行气、祛风止痛,马钱子通络止痛、散结消肿,大黄凉血解毒、逐瘀通经,白芷散风除湿、消肿排脓,雄黄解毒杀虫、燥湿祛痰,以上八味药作为方中君药,均归肝经,具有祛风散寒、散结止痛的作用。中医学认为,本病是因七情郁结,脾胃受损或气滞血瘀,痰湿不化而引发本病。所以祛风散寒、散结止痛是治疗食管癌的基础,以上八味药均为君药,首先从根本上祛风散寒、散结止痛,使病症得到根本的控制。蟾皮清热解毒、利水消肿,生天南星燥湿化痰、散结消肿,红花活血通经、散瘀止痛,乳香活血止痛,没药散血去瘀、消肿定痛,半枝莲清热解毒、化瘀利尿,半边莲利尿消肿、清热解毒,元胡活血利气,山慈菇清热解毒、化痰散结,冰片清热散毒、散火解毒,麝香活血通经、消肿止痛,姜黄破血行气、通经止痛,以上十二味药为方中臣药,一方面辅助君药祛风散寒、散结止痛的功效;另一方面作为臣药具有清热解毒、燥湿化痰的功效。干姜温中散寒、回阳通脉,桂枝温通经脉、助阳化气,郁金行气化瘀、清心解郁,干漆补中续筋、填髓安脏,以上四味药作为佐药,从病理上治疗引起食管癌的诱因,作为佐药既能促进君臣二药的祛风散寒、散结止痛的功效,又能反佐君臣二药促进机体清热解毒、燥湿化痰的作用。同时作为具有助阳化气的功效。此方诸药合用,君臣协力,臣佐共辅,具有祛风散寒、散结止痛、清热解毒、燥湿化痰的功效,能够有效治疗食管癌。
本发明另一个重要特点是该中药制剂含有丰富的营养成分,富含氨基酸有17种以上,其中人体必需氨基酸有苏氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、赖氨酸和苯丙氨酸,含有人体必需的微量元素有铁、铬、铜、硼、锰、锶、和锌,另含钙、钾、镁、磷几种人体宏量元素。以上营养成分都是人体必需物质,能有效增强人体免疫力。
本发明药物原料用量是经发明人进行大量摸索总结得出的,各原料用量为在下述重量份范围都具有较好的疗效:附子8-12g、细辛4-8g、干姜10-14g、桂枝10-14g、花椒3-7g、郁金8-12g、姜黄8-12g、川芎10-14g、马钱子4-8g、大黄7-11g、干漆8-12g、蟾皮1-5g、生天南星7-11g、红花7-11g、乳香4-8g、没药4-8g、半枝莲10-14g、半边莲10-14g、白芷10-14g、元胡28-32g、雄黄1-5g、山慈菇13-17g、冰片1-5g、麝香0.1-0.3g。
其中优选为:附子10g、细辛6g、干姜12g、桂枝12g、花椒5g、郁金10g、姜黄10g、川芎12g、马钱子6g、大黄9g、干漆10g、蟾皮3g、生天南星9g、红花9g、乳香6g、没药6g、半枝莲12g、半边莲12g、白芷12g、元胡30g、雄黄3g、山慈菇15g、冰片3g、麝香0.2g。
一种用于食管癌的中药制剂的制备方法如下:
步骤一:按本发明重量份配比,分别取雄黄、冰片、生天南星、干姜,粉碎,过200目筛,备用;
步骤二:按本发明重量份配比,分别取乳香、麝香、没药,粉碎,过200目筛,备用;
步骤三:按本发明重量份配比,取川芎药材置于砂锅中,加入3倍体积的水,武火熬煮20-30分钟,转文火熬煮30-40分钟,过滤滤液,反复熬煮三次,合并三次滤液,备用;
步骤四:按本发明重量配比,取花椒、郁金、姜黄、马钱子、大黄、白芷、元胡、山慈菇药材置于砂锅中,加入8倍体积的水,武火熬煮20-30分钟后,加入附子、细辛、桂枝、干漆、蟾皮、半枝莲、半边莲及分别用纱布包扎好的附子,武火熬煮10-20分钟,转文火熬煮30~40分钟得滤液,反复熬煮三次合并所得滤液,备用;
步骤五:合并步骤三、步骤四所得滤液并趁热与步骤二所得粉末,混合,搅匀,最后与步骤一所得粉末混合,搅匀,既得本发明所述的治疗食管癌的外用涂抹剂。
本发明使用方法:取外用涂抹剂,上药研末,加醋适量,调匀,用纱布包裹外敷患处,每天二次。
本发明药物具有祛风散寒、散结止痛、清热解毒、燥湿化痰的作用,且止痛效果好,价格低廉,无毒副作用,使用方便,该中药制剂采用的方式治疗可以减少西药对患者身体的伤害,减轻患者的病痛,据对临床240例患者观察统计,使用本发明药物一个疗程总有效率82.5%,两个疗程总有效率95%。
具体实施方式
实施例一:附子10g、细辛6g、干姜12g、桂枝12g、花椒5g、郁金10g、姜黄10g、川芎12g、马钱子6g、大黄9g、干漆10g、蟾皮3g、生天南星9g、红花9g、乳香6g、没药6g、半枝莲12g、半边莲12g、白芷12g、元胡30g、雄黄3g、山慈菇15g、冰片3g、麝香0.2g。
实施例二:附子11g、细辛7g、干姜11g、桂枝11g、花椒6g、郁金9g、姜黄10g、川芎11g、马钱子8g、大黄8g、干漆12g、蟾皮2g、生天南星9g、红花9g、乳香7g、没药7g、半枝莲11g、半边莲11g、白芷11g、元胡31g、雄黄3g、山慈菇14g、冰片4g、麝香0.2g。
实施例三:附子11g、细辛8g、干姜13g、桂枝12g、花椒7g、郁金10g、姜黄10g、川芎13g、马钱子7g、大黄7g、干漆11g、蟾皮4g、生天南星8g、红花8g、乳香7g、没药7g、半枝莲13g、半边莲13g、白芷11g、元胡31g、雄黄3g、山慈菇14g、冰片4g、麝香0.2g。
下面是患者使用本发明药物的临床统计资料:
一、一般资料
收治门诊患者240例,将患者随机分为观察组和对照组各120例,其中男性120例,女性120例,男女比例1:1,最大年龄60岁,最小年龄15岁,病程几个月到几年不等。两组患者年龄、性别、病程等各项基本资料基本相同,差异无统计学意义(P>0.05)。
二、诊断标准
1.X线钡餐检查时见食管蠕动停顿或逆蠕动,食管壁局部僵硬不能充分扩张,食管粘膜紊乱、中断和破坏,食管管腔狭窄、不规则充盈缺损、溃疡或瘘管形成。
2.CT扫描能充分显示食管癌病灶大小、肿瘤外侵范围及程度,且能帮助外科医师决定手术方式,指导放疗定位。
3.食管镜检查可在直视下观察肿瘤大小、形态和部位,可在病变部位作活检或镜刷检查以明确细胞病理学诊断,它是确诊食管癌的决定性手段。
4.病理及细胞学检查食管镜下取粘膜活检或浅表淋巴结活检,作细胞病理学检查,有恶性肿瘤细胞者即可确诊。
三、治疗方法:
1、观察组按照本发明药物实施例一,取外用涂抹剂,上药研末,加醋适量,调匀,用纱布包裹外敷患处,每天二次,7天为一个疗程。
2、对照组采用常规西药环磷酰胺治疗,7天为一疗程。
四、疗效评定标准:
1、治愈:X线食管钡餐造影肿瘤X线征消失,基本恢复正常;体检无肿瘤存在的征象,超过一个月。
2、好转:X线食管钡餐造影及体检可测量肿瘤病灶的两径乘积缩小90%以下,无新病灶出现,持续超过一个月。
3、无效:经治疗1周以上,症状均不见好转者。
五、治疗结果统计:
对照组结果统计
使用该中药制剂两个疗程两组患者的疗效对比情况
其中:总有效率=治愈率+好转率
通过对比两组患者的治疗总有效率可以发现观察组明显高于对照组,由此说明,本发明中药在治疗食管癌上具有良好的临床效果,能有效提高治疗的治愈率,效果显著,价格低廉,无不良反应和任何毒副作用,具有广阔的市场应用前景。
典型病例及疗效:
病例一、患者王某,女,36岁,青岛市人,2015年1月20日来我处就诊。主诉:前期胸骨后不适、烧灼感或疼痛,食物通过时局部有异物感或摩擦感,吞咽时有梗阻感,上腹不适,呃逆、嗳气。后转变胸骨后或背部肩肿间区持续性钝痛,伴消化道出血、声音嘶哑、体重减轻、厌食,经医院诊断患有食管癌,遂来我处治疗,采用本发明实施例一中所制制剂,以及所选的制备方法,症状减退,用药7天后,疼痛消失,患处恢复良好,继续用药7天,彻底治愈,电话随访半年未复发。
病例二、患者李某,男,32岁,山东临沂人。2014年5月14日来我处就诊,经诊断症状如下:胸骨后不适、烧灼感或疼痛,食物通过时局部有异物感,上腹不适,呃逆、嗳气。后期进行性吞咽困难,胸骨后持续性钝痛,厌食,甚至出现恶液质、衰竭等,确诊为食管癌。采用本发明实施例一中所制制剂,以及所选的制备方法,症状减退,疼痛感稍有减轻,用药7天后,疼痛消失,患处恢复良好,继续用药7天,彻底治愈,电话随访半年未复发。
Claims (4)
1.一种用于食管癌的中药制剂,其特征在于,该中药制剂是由以下重量份的药物制成:附子8-12g、细辛4-8g、干姜10-14g、桂枝10-14g、花椒3-7g、郁金8-12g、姜黄8-12g、川芎10-14g、马钱子4-8g、大黄7-11g、干漆8-12g、蟾皮1-5g、生天南星7-11g、红花7-11g、乳香4-8g、没药4-8g、半枝莲10-14g、半边莲10-14g、白芷10-14g、元胡28-32g、雄黄1-5g、山慈菇13-17g、冰片1-5g、麝香0.1-0.3g。
2.根据权利要求1所述的用于食管癌的中药制剂,其特征在于,由以下重量份的药物制成:附子10g、细辛6g、干姜12g、桂枝12g、花椒5g、郁金10g、姜黄10g、川芎12g、马钱子6g、大黄9g、干漆10g、蟾皮3g、生天南星9g、红花9g、乳香6g、没药6g、半枝莲12g、半边莲12g、白芷12g、元胡30g、雄黄3g、山慈菇15g、冰片3g、麝香0.2g。
3.根据权利要求1或2所述的用于食管癌的中药制剂,其特征在于:所述中药制剂为外用涂抹剂。
4.一种用于食管癌的中药制剂的制备方法,其特征在于,制备方法如下:步骤一:按本发明重量份配比,分别取雄黄、冰片、生天南星、干姜,粉碎,过200目筛,备用;步骤二:按本发明重量份配比,分别取乳香、麝香、没药,粉碎,过200目筛,备用;步骤三:按本发明重量份配比,取川芎药材置于砂锅中,加入3倍体积的水,武火熬煮20-30分钟,转文火熬煮30-40分钟,过滤滤液,反复熬煮三次,合并三次滤液,备用;步骤四:按本发明重量配比,取花椒、郁金、姜黄、马钱子、大黄、白芷、元胡、山慈菇药材置于砂锅中,加入8倍体积的水,武火熬煮20-30分钟后,加入附子、细辛、桂枝、干漆、蟾皮、半枝莲、半边莲及分别用纱布包扎好的附子,武火熬煮10-20分钟,转文火熬煮30~40分钟得滤液,反复熬煮三次合并所得滤液,备用;步骤五:合并步骤三、步骤四所得滤液并趁热与步骤二所得粉末,混合,搅匀,最后与步骤一所得粉末混合,搅匀,既得本发明所述的治疗食管癌的外用涂抹剂。
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CN104771538A (zh) * | 2015-03-31 | 2015-07-15 | 朱振胜 | 一种用于肝癌疼痛的中药制剂及制备方法 |
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