CN105561272A - 一种用于缓解雷诺病的中药制剂及其制备方法 - Google Patents
一种用于缓解雷诺病的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于缓解雷诺病的中药制剂,它是由桂枝、细辛、花椒、当归、白芍、红花、姜黄、丹参、毛冬青、川牛膝、附子、干姜、马钱子、川芎、地龙、黄芪、刘寄奴、鸡血藤、白芥子、麻黄、乳香、没药、苍术、防己、延胡索、艾叶、夏天无、儿茶按照一定的重量配比组成,具有温经通脉、散结消肿、活血化瘀、通络止痛的功效,能够有效缓解雷诺病的症状,减少并发症,减轻病人痛苦,进而达到治疗的目的。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种用于缓解雷诺病的中药制剂。本发明还涉及该中药制剂的制备方法。
背景技术
雷诺综合症,又称肢端动脉痉挛症,是由于支配周围血管的交感神经功能紊乱引起的肢端小动脉痉挛性疾病。是肢端小动脉痉挛引起手或足部一系列皮肤颜色改变的综合症,本病于1862年由雷诺首先提出故名。传统上将雷诺症状者分为二类型:1、原发性即雷诺病,不能找到任何潜在疾病而症状和病情缓和者。2、继发性者又称雷诺现象兼患一种或几种疾病,症状和病程比较严重者。目前多已把雷诺病和雷诺现象归并,统称为雷诺综合症。病人常因受寒或手指接触低温后发作,亦有因情绪激动,精神紧张而诱发者。其发作时的特征是指(趾)部皮肤颜色突然变白,继而变为青紫,然后转为潮红,呈间歇性发作。以手指多见而足趾少见。发作常自小指与环指尖开始,随着病变进展逐渐扩展至整个手指甚至掌部,但拇指较少发病,伴有局部发凉、麻木、刺痛和酸胀不适或其他异常感觉。全身和局部温度时有降低,但桡动脉或足背动脉搏动正常。初发时,发作时间多为数分钟至半小时左右即自行缓解。皮肤转为潮红时,常伴有烧灼刺痛感,然后转为正常色泽。若在发作时局部加温,揉擦患肢,挥动肢体等,可使发作中止。病情进展时症状加重,发作频繁,每次发作可持续一小时以上,有时需将手足浸入温水中才能中止发作。
目前雷诺症的发病原因尚不完全明确,与多种因素有关。雷诺症还可引起许多并发症,可使小血管闭塞,结果导致指端缺血坏死。严重者可出现指(趾)末端指腹变平、坏疽,末节指骨可因缺血而坏死、被吸收、溶解,出现变短或截指现象。在一些抵抗力低的患者,指端缺血而发生溃疡有可能导致骨髓炎、败血症等疾病,这也是本病最严重的并发症,正确而及时地应用抗感染药物有助于防止这些并发症的发生。
目前临床上治疗此病多采用药物疗法、生物反馈和手术的治疗方法,使用西药进行治疗往往引起严重的副作用,如潮热、晕厥、头痛、恶心、呕吐、鸡皮肤等,长期服用还会累及患者的肝肾功能,给患者的身体带来不可逆的伤害,手术治疗不仅要求高、费用高,据报道术后症状能改善者仅占40%~60%,但症状缓解时间不长,往往术后2年症状复发。中医在治疗此病上可以发挥优势,从整体上进行把握,缓解患者症状,进而治疗疾病。
发明内容
本发明的目的是提供一种中药制剂,该中药制剂对于用于缓解雷诺病具有治疗效果明显,有效率高,价格低廉,无毒副作用,使用方便的特点。
本发明的另一目的是提供该用于缓解雷诺病的中药制剂的制备方法。
发明人在多年的临床医疗实践中,观察到雷诺病给患者带来的痛苦,根据该病症的发展规律,以及中药的配伍原则,并通过大量的临床验证,反复探索总结出一种用于缓解雷诺病的中药制剂的新配方,本发明选择桂枝、细辛、花椒、当归、白芍、红花、姜黄、丹参、毛冬青、川牛膝、附子、干姜、马钱子、川芎、地龙、黄芪、刘寄奴、鸡血藤、白芥子、麻黄、乳香、没药、苍术、防己、延胡索、艾叶、夏天无、儿茶进行组合,将这些药物组合使得各药物功效产生协同作用,使之具有温经通脉、散结消肿、活血化瘀、通络止痛的功效,能够有效缓解雷诺病的症状,减少并发症,减轻病人痛苦,进而达到治疗的目的。
本发明中药物的作用:
其中:
桂枝:为樟科植物肉桂CinnamomumcassiaPresl的干燥嫩枝。性味:辛、甘,温。归心、肺、膀胱经。功效:发汗解肌,温通经脉,助阳化气,平冲降气。主治风寒表证;寒湿痹痛;癓瘕结块;胸痹;心悸;痰饮。《长沙药解》载:“入肝家而行血分,定经络而达荣郁。善解风邪,最调木气。升清阳之脱陷,降浊阴之冲逆,舒筋脉之急挛;利关节之壅阻,散遏抑,止痛楚,通经络,开痹涩,甚去湿寒。止奔豚,更安惊悸。”现代医学研究证实,桂枝能有效扩张血管、促进发汗,所含的桂皮醛、桂皮酸钠有解热、镇痛、镇静、抗惊厥作用,此外桂枝还有抗菌、抗病毒的功效。桂枝性温,善通阳气,能化阴寒,温通经络,用于寒凝血滞诸痛证。
细辛:为马兜铃科植物北细辛AsarumheterotropoidesFr.Schmidtvar.mandshuricum(Maxim.)Kitag.、汉城细辛AsarumsieboldiiMiq.var.seoulenseNakai或华细辛AsarumsieboldiiMiq.的干燥全草。性味:辛;温;小毒。归肺经、肾经、心经、肝经、胆经、脾经。功效:散结消肿;解表散寒;祛风止痛;温肺化饮;下气祛痰,通窍。抗菌、抗病毒作用细辛醇浸剂、挥发油等对革兰阳性菌、枯草杆菌和伤寒杆菌有一定的体外抑制作用,煎剂对结核杆菌和伤寒杆菌亦有抑制作用。细辛挥发油对多种真菌如黄曲霉菌、黑曲霉菌、白色念珠菌等均有抑制作用,抗菌的有效成分为黄樟醚。α-细辛醚有抑制呼吸道合胞病毒增殖的作用。细辛辛香走窜,有较好的祛风寒,止疼痛的作用,用治风湿痹痛,腰膝酸冷,常配伍独活等药物。
花椒:为芸香科植物青椒(香椒、青花椒、山椒、狗椒)ZanthoxylumschinifoliumSieb.etZucc.或花椒(蜀椒、川椒、红椒、红花椒、大红袍)ZanthoxylumbungeanumMaxim.的干燥成熟果皮(花椒)及种子(椒目)入药。性味:辛,温。归脾、胃、肾经。功效:温中止痛,杀虫止痒。用于脘腹冷痛,呕吐泄泻,虫积腹痛,蛔虫症;外治湿疹瘙痒。
当归:为伞形科植物当归Angelicasinensis(Oliv.)Diels的干燥根。性味:甘、辛、苦,温。归肝、心、脾经。功效:补血;活血;调经止痛;润燥滑肠。当归对中枢神经系统有抑制作用,挥发油有镇静、催眠、镇痛、麻醉等作用。用于血虚萎黄、眩晕心悸、虚寒腹痛、风湿痹痛、跌扑损伤、痈疽疮疡。据《本草正》载:“其味甘而重,故专能补血,其气轻而辛,故又能行血,能养营养血,补气生精,安五脏,强形体,益神志,凡有形虚损之病,无所不宜。”现代医学研究证实,当归具有抗菌、消炎作用,当归热水提取物对慢性风湿关节炎急性发作时有明显的抑制作用。
白芍:为双子叶植物毛茛科植物芍药PaeonialactifloraPall.的干燥根。性味:凉,苦酸,微寒。功效:补血柔肝、平肝止痛,敛阴收汗。研究表明:白芍中含有的芍药甙有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。白芍煎剂能抑制痢疾杆菌、肺炎链球菌、大肠杆菌、伤寒杆菌、溶血性链球菌、绿脓杆菌等。本品能养肝血、敛肝阴、抑肝阳、疏肝气,又能缓挛急、止疼痛,为治疗肝经各种疼痛之良药。《滇南本草》:"泻脾热,止腹疼,止水泻,收肝气逆疼,调养心肝脾经血,舒经降气,止肝气疼痛。"《本经》芍药,虽未分别赤白,二者各有所主。然寻绎其主治诸病,一为补血养肝脾真阴,而收摄脾气之散乱,肝气之恣横,则白芍。
红花:为菊科植物红花CarthamustinctoriusL.的筒状花冠。性味:温,辛。归心、肝经。功效:活血通经、散瘀止痛。红花辛散温通,专入血分,能活血祛瘀,通经调脉,常与桃仁、当归、川芎等相须为用。红花有扩张血管作用。红花黄色素可明显延长血浆复钙时间、凝血酶原时间和凝血时间。《本草衍义补遗》:“红花,破留血,养血。多用则破血,少用则养血。”红花水提取物有轻度兴奋心脏、增加冠脉流量的作用,对心肌缺血有减轻作用,并使心率减慢,心电图S-T段抬高的幅度显著下降,还有抑制血小板聚集和增加纤溶作用。
姜黄:为姜科植物姜黄CurcumalongaL.的干燥根茎。性味:辛、苦,温。归脾、肝经。功效:破血行气,通经止痛。用于胸胁剌痛,闭经,癓瘕,风湿肩臂疼痛,跌扑肿痛。
丹参:为双子叶植物唇形科Labiatae鼠尾草属植物丹参Salvia/miltiorrhizaBge的干燥根及根茎。性味:苦,微寒。归经:入心、肝经。功效:活血调经,祛瘀止痛,凉血消痈,清心除烦,养血安神。用于胸肋胁痛,风湿痹痛,症瘕结块。《日华子本草》:养神定志,通利关脉。治冷热劳,骨节疼痛,四肢不遂;排脓止痛,生肌长肉;破宿血,补新生血;安生胎,落死胎;止血崩带下,调妇人经脉不匀,血邪心烦;恶疮疥癣,瘿赘肿毒,丹毒;头痛,赤眼,热温狂闷。
毛冬青:为冬青科冬青属植物毛冬青IlexpubescensHook.etArn.,以根及叶入药。性味:苦,平。功效:活血通脉,消肿止痛,清热解毒。用于心绞痛,心肌梗死,血栓闭塞性脉管炎,中心性视网膜炎,扁桃体炎,咽喉炎,小儿肺炎,冻疮。《新编中医学概要》:活血通脉。治血栓闭塞性脉管炎、冠心病,脑血管意外所致的偏瘫。
川牛膝:为苋科植物川牛膝CyathulaofficinalisKuan的干燥根。性味:甘、微苦、平。归肝、肾经。功效:逐瘀通经,通利关节,利尿通淋。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
附子:为毛茛科植物乌头AconitumcarmichaeliDebx.的子根的加工品。性味:辛、甘,大热;有毒。归心、肾、脾经。功效:回阳救逆,补火助阳,散寒止痛。本品辛热燥烈,走而不守,能通行十二经,既能追复散失之亡阳,又能资助不足之元阳,与补益药同用,可治一身上下阳气衰微、阴寒内盛之证,能上助心阳以通脉,中温脾阳以健运。
干姜:为姜科植物姜ZingiberofficinaleRosc.的干燥根茎。性味:辛、热。归脾、胃、心、肺经。功效:温中散寒,回阳通脉,燥湿消痰,温肺化饮。用于脘腹冷痛,呕吐泄泻,肢冷脉微,痰饮喘咳。干姜外用治疗外伤化脓性感染。本品辛热燥烈、主入脾胃经,长于温暖中焦脾阳而散寒,故凡中焦寒证,无论外寒内侵之实寒证,还是阳气不足之虚寒证,均为要药,常配高良姜治疗脘腹冷痛、泄泻。
马钱子:为马钱科植物马钱StrychnosnuxvomicaL.的干燥成熟种子。性味:苦,温;有大毒。归肝、脾经。功效:通络止痛,散结消肿。用于风湿顽痹,麻木瘫痪,跌扑损伤,痈疽肿痛;小儿麻痹后遗症,类风湿性关节痛。
川芎:为伞形科植物川芎LigusticumchuanxiongHort.的干燥根茎。性味:辛,温。归肝、胆、心经。功效:活血行气,祛风止痛。本品辛散温通,能上行巅顶,下达血海,外彻皮毛,旁通四肢,既能活血又能行气,昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。川芎有明显的镇静作用。抗菌作用等体外试验:川芎对大肠、痢疾(宋内氏)、变形、绿脓、伤寒、副伤寒杆菌及霍乱弧菌等有抑制作用。川芎水浸剂(1:3)在试管内对某些致病性皮肤真菌也有抑制作用。若心脉瘀阻,胸痹心痛,则常与桂枝、丹参等同用。本品含有川芎嗪能抑制血管平滑肌收缩,扩张冠状动脉,增加冠脉血流量,改善心肌缺氧状况及肠系膜微循环,增加脑及肢体血流量,降低外周血管阻力,还能抑制血小板聚集,可预防血栓的形成,对心脑血管疾病有很好的疗效。
地龙:为钜蚓科动物参环毛蚓Pheretimaaspergillum(E.Perrier)、通俗环毛蚓PheretimavulgarisChen、威廉环毛蚓Pheretimaguillelmi(Michaelsen)或栉盲环毛蚓PheretimapectiniferaMichaelsen的干燥体。性味:咸,寒。归肝、脾、膀胱经。功效:清热定惊,通经活络,清热平喘,利水通淋。本品长于通络止痛,适用于多种原因导致的经络阻滞、血脉不畅,肢节不利之症。性寒清热,尤适用于关节红肿疼痛、屈伸不利之热痹,常与防己、秦艽、忍冬藤、桑枝等除湿热、通经络药物配伍;如用治风寒湿痹,肢体关节麻木、疼痛尤甚、屈伸不利等症,则应与川乌、草乌、南星、乳香等祛风散寒,通络止痛药配伍,如小活络丹(《和剂局方》)。
黄芪:为豆科植物蒙古黄芪Astragalusmembranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao或膜荚黄芪Astragalusmembranaceus(Fisch.)Bge.的干燥根。性味:甘,微温。归肺、脾、肝、肾经。功效:补气升阳、固表敛汗、利水消肿、托疮排脓、通调水道。本品在体外对志贺氏痢疾杆菌、炭疽杆菌、甲型溶血性链球菌、乙型溶血性链球菌、白喉杆菌、假白喉杆菌、肺炎双球菌、金黄色葡萄球菌、柠檬色葡萄球菌、枯草杆菌等均有抑制作用。黄芪擅长补中益气,为补气升阳的要药,并且补气利尿,以消肿。
刘寄奴:为菊科植物奇蒿(HerbaArtemisiaeAnomalae)的带花全草。性味:味辛;微苦;性温。归心;肝;脾经。功效:破瘀通经;止血消肿;消食化积。用于经闭,痛经;产后瘀滞腹痛;恶露不尽,症瘕;跌打损伤;金疮出血;风湿痹痛;便血;尿血;痈疮肿毒;烫伤;食积腹痛;泄泻痢疾。
鸡血藤:为豆科Leguminosae植物密花豆SpatholobussuberectusDunn的干燥藤茎。性味:苦、甘,温。归肝、肾经。功效:补血,活血,通络。本品行血养血,舒筋活络,为治疗经脉不畅,络脉不和病证的常用药。治中风手足麻木,肢体瘫痪,常配伍益气活血通络药,如黄芪、太子参等药;治血虚不养筋之肢体麻木及血虚萎黄,多配益气补血药之黄芪、当归等药用。
白芥子:十字花科一年或二年生植物白芥SinapisalbaL.的干燥成熟种子。性味:辛、温。归肺、胃经。功效:利气豁痰,温中散寒,通络止痛。治痰饮咳喘,胸胁胀满疼痛,反胃呕吐,中风不语,肢体痹痛麻木,脚气,阴疽,肿毒,跌打肿痛。《本草备要》中记载:白芥子,宣,利气豁痰。辛温入肺。通行经络,温中开胃,发汗散寒,利气豁痰,消肿止痛。痰行则肿消,气行则痛止。为未醋调敷,消痈肿。治咳嗽反胃,痹木脚气,筋骨诸病。
麻黄:为麻黄科植物草麻黄EphedrasinicaStapf、中麻黄EphedraintermediaSchrenketC.A.Mey.或木贼麻黄EphedraequisetinaBge.的干燥草质茎。性味:辛、微苦,温。归肺、膀胱经。功效:发汗散寒,宣肺平喘,利水消肿。用于风寒感冒,胸闷喘咳,风水浮肿;支气管哮喘。蜜麻黄润肺止咳。多用于表症已解,气喘咳嗽。麻黄性温辛散,能发汗散寒而解表,又可散风透疹。用治外感风寒所引起的发热恶寒、无汗等症,常与桂枝相须为用,有发汗解表的作用。如治麻疹透发不畅,兼有咳嗽气急症状时,可在辛凉透疹药中酌加麻黄。
乳香:为橄榄科乳香树属植物乳香树BoswelliacarteriiBirdw.[B.sacraFluek.]、药胶香树B.bhawdajianaBirdw.及其同属植物皮部渗出的树脂。性味:辛、苦、温。归心、肝、脾经。功效:活血止痛、消肿生肌。本品用于疮疡后久不收口,常与与没药配伍,外敷于患处。
没药:为橄榄科没药属植物没药树CommiphoramyrrhaEngl.[C.molmolEngl.]及同属他种植物的树干皮部渗出的油胶树脂。性味:苦、平。入肝经。功效:散血去瘀,消肿定痛。临床上可用于治疗乳痈。
苍术:为菊科植物茅苍术Atractylodeslancea(Thunb.)DC.或北苍术Atractylodeschinensis(DC.)Koidz.的干燥根茎。性味:辛、苦,温;归脾、胃、肝经;功效:燥湿健脾、祛风散寒、明目;本品苦辛性温,芳烈燥散,可升可降,走而不守,能是湿邪除而恢复脾的运化功能。
防己:为防己科植物粉防己StephaniatetrandraS.Moore的干燥根。性味:苦,寒。归膀胱、肺经。功效:利水消肿,祛风止痛。用于水肿脚气,小便不利,湿疹疮毒,风湿痹痛;高血压。用于风湿痹痛,多配伍薏苡仁、滑石、蜇砂等清热除湿之品。对寒湿痹痛,须用温经止痛的肉桂、附子等药同用。用于水肿、小便不利等症,可与椒目、葶苈子、大枣等配伍同用,若属虚证,常与黄耆、茯苓、白朮等配伍。
延胡索:为罂粟科植物延胡索CorydalisyanhusuoW.T.Wang的干燥块茎。性味:辛、苦、温。归肝、脾经。功效:活血,利气,止痛。用于胸胁、脘腹疼痛,经闭痛经,产后瘀阻,跌扑肿痛。本品辛散温通,能行血中气滞,气中血滞,活血行气止痛,善治血瘀气滞所致的多种疼痛,其止痛作用优良。《本草求真》中记载:延胡索,不论是血是气,积而不散者,服此力能通达,以其性温,则于气血能行能畅,味辛则于气血能润能散,所以理一身上下诸痛,往往独行功多。
艾叶:为菊科植物艾ArtemisiaargyiLevl.etVant.的干燥叶。性味:辛、苦,温;有小毒。归肝、脾、肾经。功效:散寒止痛,温经止血。用于少腹冷痛,经寒不调,宫冷不孕,吐血,衄血,崩漏经多,妊娠下血;外治皮肤瘙痒。醋艾炭温经止血。用于虚寒性出血。
夏天无:为罂粟科植物伏生紫堇Corydalisdecumbens(Thunb.)Pers.的干燥块茎。性味:苦、微辛,温。归肝经。功效:活血通络,行气止痛。用于中风偏瘫,跌扑损伤,风湿性关节炎,坐骨神经痛。本品具有降压、镇静,舒筋、活络、止痛等作用。
儿茶:为豆科合欢属植物儿茶树Acaciacatechu(L.f.)Willd.的去皮枝、干的干燥煎膏。性味:苦、涩,微寒。归肺经。功效:收湿生肌敛疮。用于溃疡不敛,湿疹,口疮,跌扑伤痛,外伤出血。本发明的方解是:方中桂枝发汗解肌、温通经脉,细辛散结消肿,花椒温中止痛,当归补血活血,白芍补血柔肝、平肝止痛,以上五味共为君药,首先从疾病的根本上进行温经通脉、散结消肿,注重活血理气的效果,疏通经络,气行则血行之故也,加快气血的运行,缓解患者症状,进而达到治疗的目的。红花活血通经、散瘀止痛,姜黄通经止痛,丹参活血调经、祛瘀止痛,毛冬青活血通脉、消肿止痛,川牛膝逐瘀通经,附子散寒止痛,干姜温中散寒,以上七味共为臣药,增强君药药效的同时,还具有活血通经、散瘀止痛的效果,缓解患者因雷诺病所引起的痉挛、疼痛等现象,加快病情额的好转。马钱子通络止痛,川芎活血行气,地龙清热定惊,黄芪补气升阳,刘寄奴破瘀通经,鸡血藤补血活血,白芥子温中散寒、通络止痛,麻黄发汗散寒,乳香、没药活血止痛、消肿生肌,苍术燥湿健脾,防己利水消肿,延胡索活血理气,艾叶散寒止痛,夏天无活血通络,儿茶生肌敛疮,以上几味共为佐药,调理患者的身体,加强药物疗效,促进患者恢复。此方诸药合用,君臣协力,佐使共辅,具有温经通脉、散结消肿、活血化瘀、通络止痛的功效,能够有效缓解并治疗雷诺病。
本发明药物原料用量是经发明人进行大量摸索总结得出的,各原料用量为在下述重量份范围都具有较好的疗效:桂枝10-20g、细辛4-14g、花椒4-14g、当归10-20g、白芍10-20g、红花4-14g、姜黄10-20g、丹参15-25g、毛冬青15-25g、川牛膝10-20g、附子10-20g、干姜10-20g、马钱子1-5g、川芎7-17g、地龙4-14g、黄芪25-35g、刘寄奴15-25g、鸡血藤19-29g、白芥子4-14g、麻黄4-14g、乳香4-14g、没药5-15g、苍术10-20g、防己7-17g、延胡索19-29g、艾叶10-20g、夏天无7-17g、儿茶4-14g。
其中优选为:桂枝15g、细辛9g、花椒9g、当归15g、白芍15g、红花9g、姜黄15g、丹参20g、毛冬青20g、川牛膝15g、附子15g、干姜15g、马钱子3g、川芎12g、地龙9g、黄芪30g、刘寄奴20g、鸡血藤24g、白芥子9g、麻黄9g、乳香9g、没药10g、苍术15g、防己12g、延胡索24g、艾叶15g、夏天无12g、儿茶9g。
本发明优选的制备方法是洗剂,其制备方法如下:
步骤一:按本发明重量配比,称取花椒、马钱子、白芥子用纱布包成药包,放于冷水中浸泡15-25分钟,备用;
步骤二:按本发明重量配比,称取附子放入砂锅中,加入步骤一中剩余冷水1-2厘米,用武火煎煮20分钟,然后称取白芍、姜黄、丹参、毛冬青、川牛膝、干姜、黄芪、苍术、防己、儿茶放入砂锅中,加入步骤一浸泡后剩余的冷水,抹过药材3-5厘米,先用武火煮沸,再用文火煎30-40分钟,过滤,得滤液,在剩余药渣中加入2-3厘米的水,然后加入细辛、当归、川芎、刘寄奴、鸡血藤、麻黄、延胡索、艾叶、夏天无以及步骤一种的药包继续煎煮20分钟,最后加入桂枝、红花、乳香、没药煎煮15分钟,过滤,得滤液,合并两次滤液,弃渣,备用;
步骤三:按本发明重量配比,称取地龙进行研磨粉碎,过120目筛,备用;
步骤四:将步骤三中的粉末均匀混合到步骤二中的药液中,既得本发明所述的治疗用于缓解雷诺病的中药洗剂。
本发明药物具有温经通脉、散结消肿、活血化瘀、通络止痛等功效,且效果明显,有效率高,价格低廉,无毒副作用,使用方便,能够有效的缓解雷诺病给患者带来的痛苦,减少并发症的发生,调理患者身体,进而达到治疗的目的。
具体实施方式
实施例一、桂枝10g、细辛4g、花椒4g、当归10g、白芍10g、红花4g、姜黄10g、丹参15g、毛冬青15g、川牛膝10g、附子10g、干姜10g、马钱子1g、川芎7g、地龙4g、黄芪25g、刘寄奴15g、鸡血藤19g、白芥子4g、麻黄4g、乳香4g、没药5g、苍术10g、防己7g、延胡索19g、艾叶10g、夏天无7g、儿茶4g。
实施例二、桂枝15g、细辛9g、花椒9g、当归15g、白芍15g、红花9g、姜黄15g、丹参20g、毛冬青20g、川牛膝15g、附子15g、干姜15g、马钱子3g、川芎12g、地龙9g、黄芪30g、刘寄奴20g、鸡血藤24g、白芥子9g、麻黄9g、乳香9g、没药10g、苍术15g、防己12g、延胡索24g、艾叶15g、夏天无12g、儿茶9g。
实施例三、桂枝20g、细辛14g、花椒14g、当归20g、白芍20g、红花14g、姜黄20g、丹参25g、毛冬青25g、川牛膝20g、附子20g、干姜20g、马钱子5g、川芎17g、地龙14g、黄芪35g、刘寄奴25g、鸡血藤29g、白芥子14g、麻黄14g、乳香14g、没药15g、苍术20g、防己17g、延胡索29g、艾叶20g、夏天无17g、儿茶14g。
下面是患者使用本发明药物的临床统计资料:
一、一般资料
收治患者120例,其中男性62例,女性58例,男女比例约为1.07:1,最大年龄68岁,最小年龄20岁,病程时间不等,患者性别、年龄、病程等各项基本资料基本相同。
二、诊断标准
参照中华人民共和国《中药新药临床研究指导原则》(第二辑,1995)制定的雷诺综合征的西医诊断标准。临床表现主要有:
1、常因情绪激动或寒冷刺激诱发;
2、发作时手指皮色发白,继而青紫,逐渐变为潮红,最后恢复正常颜色,伴有手指发凉、麻木、疼痛、感觉异常等症状,遇寒加重,得暖则缓解,多为双侧上肢发病,呈对称性;
3、局部无坏死或只有很小的指(趾)端皮肤坏死;
4、甲皱微循环检测有异常;
5、排除其他疾病所致的雷诺氏现象。
三、治疗方法
按照本发明实施例二,称取原料药(一日剂量),水煎,过滤去渣,外洗患处,每天两次,10日为一个疗程。
四、疗效评定标准
参照中华人民共和国《中药新药临床研究指导原则》(第二版,1995年)制定的雷诺综合征的疗效判定标准。
痊愈:病状消失,对低温有良好的耐受性,甲皱微循环正常;
显效:主要症状消失,对低温有良好的耐受性,但遇冷后或情绪激动时,仍有皮色变化,甲皱微循环较前好转;
无效:治疗前后比较,各方面均无改善。
五、治疗结果统计
其中:总有效率=治愈率+好转率
通过治疗结果的统计表明,本发明中药在治雷诺病具有良好的临床效果,能有效提高治疗的治愈率,值得在临床应用上推广。
典型病例及疗效:
病例一、郑某,女,45岁,患者无意中发现手指接触冷水时,手指苍白,继而转为青紫色,转暖后恢复正常,严重时还具有麻木、针刺样疼痛,患者去多家医院进行检查,最终确诊为雷诺病,患者层口服西药一段时间,但是效果不明显,患者希望采用中药的治疗方法,患者采用本发明实施例二中所制制剂,以及所优选选的制备方法,使用两个疗程后,患者刺痛、麻木的现象明显好转,又坚持使用了一段时间,症状完全消失,随访一年,未见复发,痊愈。
病例二、郭某,男,30岁,患者患有雷诺病多年,四处求医,但是效果一直不明显,后来我处就诊,患者采用本发明实施例二中所制制剂,以及所优选选的制备方法,使用两个疗程后,患者刺痛、麻木的现象明显得到缓解,发作频率较以前明显的减少,为巩固疗效,患者又坚持使用了两个疗程,感觉异常的现象完全消失,麻木、刺痛的感觉一直没有出现,工作,干家务不受影响,电话随访一年,未见复发,痊愈。
Claims (4)
1.一种用于缓解雷诺病的中药制剂,其特征在于,该中药制剂是由以下重量份的药物组成:桂枝10-20g、细辛4-14g、花椒4-14g、当归10-20g、白芍10-20g、红花4-14g、姜黄10-20g、丹参15-25g、毛冬青15-25g、川牛膝10-20g、附子10-20g、干姜10-20g、马钱子1-5g、川芎7-17g、地龙4-14g、黄芪25-35g、刘寄奴15-25g、鸡血藤19-29g、白芥子4-14g、麻黄4-14g、乳香4-14g、没药5-15g、苍术10-20g、防己7-17g、延胡索19-29g、艾叶10-20g、夏天无7-17g、儿茶4-14g。
2.根据权利要求书1所述的用于缓解雷诺病的中药制剂,其特征在于,由以下重量份的药物组成:桂枝15g、细辛9g、花椒9g、当归15g、白芍15g、红花9g、姜黄15g、丹参20g、毛冬青20g、川牛膝15g、附子15g、干姜15g、马钱子3g、川芎12g、地龙9g、黄芪30g、刘寄奴20g、鸡血藤24g、白芥子9g、麻黄9g、乳香9g、没药10g、苍术15g、防己12g、延胡索24g、艾叶15g、夏天无12g、儿茶9g。
3.根据权利要求1或2所述的用于缓解雷诺病的中药制剂,其特征在于:所述中药制剂为外用洗剂。
4.一种用于缓解雷诺病的中药制剂的制备方法,其特征在于,制备方法如下:步骤一:按本发明重量配比,称取花椒、马钱子、白芥子用纱布包成药包,放于冷水中浸泡15-25分钟,备用;步骤二:按本发明重量配比,称取附子放入砂锅中,加入步骤一中剩余冷水1-2厘米,用武火煎煮20分钟,然后称取白芍、姜黄、丹参、毛冬青、川牛膝、干姜、黄芪、苍术、防己、儿茶放入砂锅中,加入步骤一浸泡后剩余的冷水,抹过药材3-5厘米,先用武火煮沸,再用文火煎30-40分钟,过滤,得滤液,在剩余药渣中加入2-3厘米的水,然后加入细辛、当归、川芎、刘寄奴、鸡血藤、麻黄、延胡索、艾叶、夏天无以及步骤一种的药包继续煎煮20分钟,最后加入桂枝、红花、乳香、没药煎煮15分钟,过滤,得滤液,合并两次滤液,弃渣,备用;步骤三:按本发明重量配比,称取地龙进行研磨粉碎,过120目筛,备用;步骤四:将步骤三中的粉末均匀混合到步骤二中的药液中,既得本发明所述的治疗用于缓解雷诺病的中药洗剂。
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