CN105412899A - 一种用于缓解红斑性肢痛病的中药制剂及其制备方法 - Google Patents
一种用于缓解红斑性肢痛病的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于缓解红斑性肢痛病的中药制剂,它是由金银花、忍冬藤、紫花地丁、玄参、当归、川芎、生地黄、白芍、牡丹皮、川牛膝、制水蛭、地龙、土鳖虫、知母、黄柏、栀子、龙胆草、侧柏叶、水牛角、丝瓜络、路路通、延胡索、姜黄、生姜、生甘草按照一定的重量配比组成,具有清热解毒、疏风通络、养阴生津的功效,能够有效缓解红斑性肢痛病的症状,减少并发症,减轻病人痛苦,进而达到治疗的目的。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种用于缓解红斑性肢痛病的中药制剂。本发明还涉及该中药制剂的制备方法。
背景技术
红斑肢痛症是一种少见的病因不明的阵发性血管扩张性周围自主神经疾病。可能是由于周围性自主神经功能障碍,使末梢血管运动功能失调,肢端小动脉极度扩张,造成局部血流障碍,局部充血,当血管内张力增加,压迫和刺激邻近的神经末梢时,产生剧烈疼痛等临床症状。临床表现:多见于中青年男女,症状以肢端,尤以双足最常见,表现足前部、足趾的红、肿、热、痛,疼痛为阵发性,非常剧烈,呈烧灼痛,针刺感,以夜间明显且发作次数较多,在温度较高环境、长时间站立、行走或双足下垂均可引起或加重疼痛,患者不愿穿袜或戴手套,因可能导致疼痛加剧,患者入睡时喜欢将双足置于被外,在冰冷的地面行走,喜欢用冷水浸足、将患肢抬高或休息均可缓解疼痛。红斑性肢痛病的化验检查可发现患肢皮肤发红、皮温增高、血管扩张、轻度肿胀、多汗、轻压可使红色暂时小腿,患肢足背动脉波动正常,无运动、感觉及反射障碍,少数患者晚期可出现营养障碍,表现肢端皮肤与指甲变厚或溃破,甚至坏疽。红斑肢痛症的治疗急性期应卧床休息,抬高患肢,局部冷敷或将肢体置于冷水中以减轻疼痛。急性期应避免任何足以引起血管扩张的局部刺激。
目前治疗这种疾病的药物较少,大多为西药,包括β受体阻滞剂、阿司匹林、5-羟色胺拮抗剂、肾上腺皮质激素冲击短期治疗能控制症状,但上述治疗的疗效尚待证实,并且西药存在着毒副作用大的现象比较严重,长期服用伤害肝肾,并且疗程长,费用高,效果也不是太理想,患者不易接受。中医在治疗此病上可以发挥优势,从整体上进行把握,缓解患者症状,进而达到治疗疾病的目的。
发明内容
本发明的目的是提供一种中药制剂,该中药制剂对于用于缓解红斑性肢痛病具有治疗效果明显,有效率高,价格低廉,无毒副作用,使用方便的特点。
本发明的另一目的是提供该用于缓解红斑性肢痛病的中药制剂的制备方法。
发明人在多年的临床医疗实践中,观察到红斑性肢痛病给患者带来的痛苦,根据该病症的发展规律,以及中药的配伍原则,并通过大量的临床验证,反复探索总结出一种用于缓解红斑性肢痛病的中药制剂的新配方,本发明选择金银花、忍冬藤、紫花地丁、玄参、当归、川芎、生地黄、白芍、牡丹皮、川牛膝、制水蛭、地龙、土鳖虫、知母、黄柏、栀子、龙胆草、侧柏叶、水牛角、丝瓜络、路路通、延胡索、姜黄、生姜、生甘草进行组合,将这些药物组合使得各药物功效产生协同作用,使之具有清热解毒、疏风通络、养阴生津的功效,能够有效缓解红斑性肢痛病的症状,减少并发症,减轻病人痛苦,进而达到治疗的目的。
本发明中药物的作用:
其中:
金银花:为忍冬科植物忍冬LonicerajaponicaThunb.、红腺忍冬LonicerahypoglaucaMiq.、山银花(毛萼忍冬)LoniceraconfusaDC.或毛花柱忍冬LoniceradasystylaRehd.的干燥花蕾或带初开的花。性味:甘、寒。归肺、心、胃经。功效:清热解毒,疏风散热。本品性味甘寒,既能清热解毒,又善散痈消肿,为治疗一切阳证痈肿疔疮的要药。临床上用于痈疽疔毒:常与紫地丁、野菊花等同用,能增强清热解毒作用,可用以痈疽疔毒,红肿疼痛。古方记载,金银花治一切肿毒,不问已溃未溃,或初起发热,并疔疮便毒,喉痹乳蛾:金银花(连茎叶)自然汁半碗,煎八分服之,以滓敷上,败毒托里,散气和血,其功独胜。
忍冬藤:为忍冬科植物忍冬LonicerajaponicaThunb.的干燥茎枝。性味:甘,寒。归肺、胃经。功效:清热解毒,疏风通络。用于温病发热,热毒血痢,痈肿疮疡,风湿热痹,关节红肿热痛。忍冬藤不仅具有解毒的作用,还具有通络之功,可以消除经络的风热而止痛,故常用于风湿热痹,关节红肿热痛等症状。
紫花地丁:为堇菜科植物紫花地丁ViolayedoensisMakino的干燥全草。性味:苦、辛,寒。归心、肝经。功效:清热解毒,凉血消肿。用于疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。本品苦泄辛散,寒能清热、入心肝经血分,个能清热解毒,消痈散结,可与金银花、蒲公英、野菊花配伍。本品对金黄色葡萄球菌、结核杆菌、痢疾杆菌、肺炎双球菌、皮肤真菌等均有不同程度的抑制作用。此外,尚有解热、消肿、消炎等作用,临床上多用于外科化脓性炎症。
玄参:为玄参科植物玄参ScrophularianingpoensisHemsl.的干燥根。性味:甘、苦、咸,微寒。归肺、胃、肾经。功效:清热凉血,泻火解毒,滋阴。有轻微的降血糖作用。用于:温热病热入营血,热病伤阴之证。有清热凉血,解毒滋阴的功效。治温热病热入营血,伤阴劫液所致的身热烦渴,夜寐不安,舌绛者,可与生地、犀角、丹参等药合用,如清营汤;治温热病热陷心包之壮热,神昏谵语者,可与犀角、连翘心、麦冬等药合用,如清宫汤;治温热病高热发斑者,可与石膏、犀角、知母等药合用,如化斑汤。
当归:为伞形科植物当归Angelicasinensis(Oliv.)Diels的干燥根。性味:甘、辛、苦,温。归肝、心、脾经。功效:补血;活血;调经止痛;润燥滑肠。当归对中枢神经系统有抑制作用,挥发油有镇静、催眠、镇痛、麻醉等作用。归能活血消肿止痛,又能补血生肌,故为外科多常用。
川芎:为伞形科植物川芎LigusticumchuanxiongHort.的干燥根茎。性味:辛,温。归肝、胆、心经。功效:活血行气,祛风止痛。本品辛散温通,能上行巅顶,下达血海,外彻皮毛,旁通四肢,既能活血又能行气,昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。川芎有明显的镇静作用。抗菌作用等体外试验:川芎对大肠、痢疾(宋内氏)、变形、绿脓、伤寒、副伤寒杆菌及霍乱弧菌等有抑制作用。川芎水浸剂(1:3)在试管内对某些致病性皮肤真菌也有抑制作用。若心脉瘀阻,胸痹心痛,则常与桂枝、丹参等同用。本品含有川芎嗪能抑制血管平滑肌收缩,扩张冠状动脉,增加冠脉血流量,改善心肌缺氧状况及肠系膜微循环,增加脑及肢体血流量,降低外周血管阻力,还能抑制血小板聚集,可预防血栓的形成,对心脑血管疾病有很好的疗效。
生地黄:为玄参科植物地黄RehmanniaglutinosaLibosch.的新鲜或干燥块根。性味:甘、寒。归心、肝、肾经。功效:清热凉血,养阴生津。可用于津伤口渴,内热消渴。本品甘寒,能于清热之中养阴生津,性寒而入血分,不仅能清营血分之热而凉血,而且味甘性寒能生津,有滋阴清热的作用,常与麦冬、沙参等同用。
白芍:为双子叶植物毛茛科植物芍药PaeonialactifloraPall.的干燥根。性味:凉,苦酸,微寒。功效:补血柔肝、平肝止痛,敛阴收汗。研究表明:白芍中含有的芍药甙有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。白芍煎剂能抑制痢疾杆菌、肺炎链球菌、大肠杆菌、伤寒杆菌、溶血性链球菌、绿脓杆菌等。
牡丹皮:为毛茛科植物牡丹PaeoniasuffruticosaAndr.的干燥根皮。性味:苦,凉。归心、肝、肾、肺经。功效:清热凉血,活血散瘀。对于疮痈肿毒、肠痈等症,本品也是常用的药物。疗疮痈可配合清热解毒药如连翘、地丁草之类;治肠痈初起未能脓者可和大黄等同用。本品通过清热凉血、活血散瘀以消痈,可用于肠痈及痈肿疮毒,肠痈初期可配伍大黄,也可配金银花、连翘等清热降火。
川牛膝:为苋科植物川牛膝CyathulaofficinalisKuan的干燥根。性味:甘、微苦、平。归肝、肾经。功效:逐瘀通经,通利关节,利尿通淋。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
制水蛭:为水蛭科动物蚂蟥WhitmaniapigraWhitman、水蛭HirudonipponicaWhitman或柳叶蚂蟥Whit-maniaacranulataWhitman的干燥体。性味:咸、苦、平,有小毒。归肝经。具有破血,逐瘀,通经的功效,用于癥瘕痞块,血瘀经闭,跌扑损伤。水蛭咸苦入血分,善于破血逐淤,且力峻效宏,近代临床用治血小板增多症,短时煎服,有一定的疗效,治脑出血、颅内血肿,有较好的疗效。
地龙:为钜蚓科动物参环毛蚓Pheretimaaspergillum(E.Perrier)、通俗环毛蚓PheretimavulgarisChen、威廉环毛蚓Pheretimaguillelmi(Michaelsen)或栉盲环毛蚓PheretimapectiniferaMichaelsen的干燥体。性味:咸,寒。归肝、脾、膀胱经。功效:清热定惊,通经活络,清热平喘,利水通淋。本品性寒,既能息风止痉,又善于清热定惊,故适用于热极生风所致的神昏谵语、痉挛抽搐及小儿惊风,或癫痫、癫狂等症。如《本草拾遗》治狂热癫痫,即以本品同盐化为水,饮服;《摄生众妙方》治小儿急慢惊风,则用本品研烂,同朱砂作丸服。
土鳖虫:为鳖蠊科昆虫地鳖EupolyphagasinensisWalker或冀地鳖Stelephagaplancyi(Boleny)的雌虫全体。性味:寒,咸;有小毒。归肝经。功效:破瘀血,续筋骨,用于治疗跌打损伤,筋伤骨折,瘀肿疼痛。本品咸寒入血,主入肝经,性善走窜,能活血消肿止痛,续筋接骨疗伤,为伤科常用药,尤多用于骨折筋伤,瘀血肿痛。
知母:为百合科植物知母AnemarrhenaasphodeloidesBunge.的干燥根茎。性味:苦、甘,寒。归肺、胃、肾经。功效:清热泻火,生津润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。知母性味苦寒而不燥,上能清肺,中能凉胃,下能泻肾火。
黄柏:为芸香科植物黄皮树PhellodendronchinenseSchneid.或黄檗PhellodendronamurenseRupr.的干燥树皮。性味:苦、寒。归肾、膀胱、大肠经。功效:清热燥湿,泻火解毒,除骨蒸清虚热。用于湿热泻痢,黄疸,带下,热淋,脚气,痿辟,骨蒸劳热,盗汗,遗精,疮疡肿毒,湿疹瘙痒。现代药理学研究:黄柏水煎剂或醇浸剂在体外对金黄色葡萄球菌、白色葡萄球菌、溶血性链球菌、肺炎双球菌、炭疽杆菌、霍乱弧菌、白喉杆菌、枯草杆菌、大肠杆菌、绿脓杆菌、伤寒杆菌、副伤寒杆菌、脑膜炎双球菌等,均有不同程度的抑制作用.实验还表明、黄柏对福氏痢疾杆菌、志贺氏痢疾杆菌有较强的抑制作用.另外,黄柏煎剂、水浸剂于体外对多种致病性皮肤真菌、阴道滴虫等均有不同程度的抑制作用。本品既能清热燥湿,又能泻火解毒,内服、外用均有效,并且黄柏具有广谱抗菌的作用。
栀子:为茜草科植物栀子GardeniajasminoidesEllis的干燥成熟果实。性味:苦,寒。归心、肺、三焦经。功效:泻火除烦,清热利尿,凉血解毒。用于热病心烦,黄疸尿赤,血淋涩痛,血热吐衄,目赤肿痛,火毒疮疡;外治扭挫伤痛。用于热毒、实火引起的吐血、鼻衄、尿血、目赤肿痛和疮疡肿毒等症。山栀又有凉血止血、清热解毒的作用,用治血热妄行,常与生地、侧柏叶、丹皮等配伍;治目赤肿痛,可与菊花、石决明等配伍;治疮疡肿毒,可与黄连、银花、连翘等同用。
龙胆草:为龙胆科植物条叶龙胆GentianamanshuricaKitag.、龙胆GentianascabraBunge、三花龙胆Gentianatriflorapall或坚龙胆GentianarigescensFranch.的干燥根及根茎。性味:苦、寒。归肝、胆经。功效:清热燥湿、泻肝胆火。用于治疗湿热黄疸,阴肿阴痒,带下,强中,湿疹瘙痒,本品大寒,清热燥湿,尤善清肝胆及下焦湿热,为清利肝胆及下焦湿热的常用药。常和黄柏、苦参等同用。本品大苦大寒,清热燥湿,尤善清肝胆及下焦湿热,为下焦湿热的常用药,用于治疗带下湿疹、阴肿阴痒常配苦参、黄芩。
侧柏叶:为柏科植物侧柏Platycladusorientalis(L.)Franco的干燥枝梢及叶。性味:苦、涩,寒。归肺、肝、脾经。功效:凉血止血,生发乌发。用于吐血衄血,咯血,便血,崩漏下血,血热脱发,须发早白。侧柏叶性寒味苦,能凉血止血,试验研究有一定的抗菌消炎的作用。
水牛角:为牛科动物水牛BubalusbubalisLinnaeus的角。性味:苦,寒。归心、肝经。功效:清热解毒,凉血,定惊。用于温病高热,神昏谵语,发斑发疹,吐血衄血,惊风,癫狂。
丝瓜络:为葫芦科植物丝瓜Luffacylindrica(L.)Roem.的干燥成熟果实的维管束。性味:甘,平。归肺、胃、肝经。功效:通络,活血,祛风。用于痹痛拘挛,胸胁胀痛,乳汁不通。《本草再新》:通经络,和血脉,化痰顺气。
路路通:为金缕梅科植物枫香树LiquidambarformosanaHance的干燥成熟果序。性味:苦,平。归肝、肾经。功效:祛风活络,利水通经。用于关节痹痛,麻木拘挛,水肿胀满,乳少经闭。《中药志》:通经利水,除湿热痹痛。治月经不调,周身痹痛、小便不利,水肿胀满等证。
延胡索:为罂粟科植物延胡索CorydalisyanhusuoW.T.Wang的干燥块茎。性味:辛、苦、温。归肝、脾经。功效:活血,利气,止痛。用于胸胁、脘腹疼痛,经闭痛经,产后瘀阻,跌扑肿痛。本品辛散温通,能行血中气滞,气中血滞,活血行气止痛,善治血瘀气滞所致的多种疼痛,其止痛作用优良。《本草求真》中记载:延胡索,不论是血是气,积而不散者,服此力能通达,以其性温,则于气血能行能畅,味辛则于气血能润能散,所以理一身上下诸痛,往往独行功多。
姜黄:为姜科植物姜黄CurcumalongaL.的干燥根茎。性味:辛、苦,温。归脾、肝经。破血行气,通经止痛。用于胸胁剌痛,闭经,癓瘕,风湿肩臂疼痛,跌扑肿痛。姜黄和郁金配合使用善治臂背痛。
生姜:为姜科植物姜ZingiberofficinaleRosc.的新鲜根茎。性味:辛、微温。归肺、脾、胃经。功效:发汗解表,温中止呕,温肺止咳,解鱼蟹毒,解药毒。特别对于鱼蟹毒,半夏、天南星等药物中毒有解毒作用。生姜可作用于交感神经及迷走神经系统,有抑制胃机能及直接兴奋胃平滑肌的作用,生姜对中枢神经系统有抑制作用。
生甘草:为豆科植物甘草GlycyrrhizauralensisFisch.,胀果甘草GlycyrrhizaInflataBat.或光果甘草GlycyrrhizaGlabraL.的干燥根及根茎。炙甘草为甘草的蜜烘制加工品。性味:甘,平。归心、肺、脾、胃经。功效:补脾和胃,益气复脉。《日华子本草》:安魂定魄。补五劳七伤,一切虚损、惊悸、烦闷、健忘。通九窍,利百脉,益精养气,壮筋骨,解冷热。
本发明的方解是:方中金银花、忍冬藤清热解毒、疏风通络,紫花地丁、玄参清热解毒、凉血消肿,当归、川芎活血行气,以上六味共为君药,首先六味要配合使用清热解毒、疏风通络、凉血消痈,红斑性肢痛病是一种血管扩张性周围自主神经疾病,君药从根本上对患者进行治疗,清热凉血,防止因血液燥热而造成的红、肿、热、痛等临床症状,进而达到完全治疗的目的。生地黄清热凉血、养阴生津,白芍敛阴收汗,牡丹皮清热凉血,川牛膝逐瘀通经,制水蛭破血逐瘀,地龙清热定惊、通经活络,土鳖虫破瘀血,以上七味共为臣药,增强君药药效的同时还具有养阴生津、破血除淤的作用,缓解患者因红斑性肢痛病所引起的针刺感、疼痛等现象,加快病情额的好转。知母清热泻火,黄柏清热燥湿,栀子清热利尿,龙胆草清热燥湿、泻肝胆火,侧柏叶凉血止血,水牛角清热解毒,丝瓜络通络活血,路路通祛风活络、利水通经,延胡索活血理气,姜黄破血行气,生姜发汗解表,以上几味共为佐药,调理患者的身体,加强药物疗效,促进患者恢复,生甘草调和诸药、引药归经,为使药。此方诸药合用,君臣协力,佐使共辅,具有清热解毒、疏风通络、养阴生津的功效,能够有效缓解并治疗红斑性肢痛病。
本发明药物原料用量是经发明人进行大量摸索总结得出的,各原料用量为在下述重量份范围都具有较好的疗效:金银花7-17g、忍冬藤15-25g、紫花地丁7-17g、玄参10-20g、当归7-17g、川芎13-23g、生地黄7-17g、白芍10-20g、牡丹皮7-17g、川牛膝13-23g、制水蛭4-14g、地龙7-17g、土鳖虫7-17g、知母7-17g、黄柏10-20g、栀子7-17g、龙胆草4-14g、侧柏叶7-17g、水牛角10-20g、丝瓜络15-25g、路路通7-17g、延胡索19-29g、姜黄10-20g、生姜10-20g、生甘草3-9g。
其中优选为:金银花12g、忍冬藤20g、紫花地丁12g、玄参15g、当归15g、川芎18g、生地黄12g、白芍15g、牡丹皮12g、川牛膝18g、制水蛭9g、地龙12g、土鳖虫12g、知母12g、黄柏15g、栀子12g、龙胆草9g、侧柏叶12g、水牛角15g、丝瓜络20g、路路通12g、延胡索24g、姜黄15g、生姜15g、生甘草6g。
本发明优选的制备方法是洗剂,其制备方法如下:
步骤一:按本发明重量配比,称取栀子、路路通用纱布包成药包,放于冷水中浸泡15-25分钟,备用;
步骤二:按本发明重量配比,称取制水蛭、地龙、土鳖虫、水牛角进行粉碎磨面,过120目筛,备用;
步骤三:按本发明重量配比,称取玄参、生地黄、白芍、牡丹皮、川牛膝、知母、黄柏、龙胆草、姜黄、生姜放入砂锅中,加入步骤一浸泡后剩余的冷水,抹过药材3-5厘米,先用武火煮沸,再用文火煎30-40分钟,过滤,得滤液,在剩余药渣中加入2-3厘米的水,然后加入忍冬藤、紫花地丁、当归、川芎、延胡索、生甘草以及步骤一种的药包继续煎煮20分钟,最后加入金银花、侧柏叶、丝瓜络煎煮15分钟,过滤,得滤液,合并两次滤液,弃渣,备用;
步骤四:将步骤二中的粉末均匀混合到步骤三中的药液中,既得本发明所述的治疗用于缓解红斑性肢痛病的中药洗剂。
本发明药物具有清热解毒、疏风通络、养阴生津等功效,且效果明显,有效率高,价格低廉,无毒副作用,使用方便,能够有效的缓解红斑性肢痛病给患者带来的痛苦,减少并发症的发生,调理患者身体,进而达到治疗的目的。
具体实施方式
实施例一、金银花7g、忍冬藤15g、紫花地丁7g、玄参10g、当归7g、川芎13g、生地黄7g、白芍10g、牡丹皮7g、川牛膝13g、制水蛭4g、地龙7g、土鳖虫7g、知母7g、黄柏10g、栀子7g、龙胆草4g、侧柏叶7g、水牛角10g、丝瓜络15g、路路通7g、延胡索19g、姜黄10g、生姜10g、生甘草3g。
实施例二、金银花12g、忍冬藤20g、紫花地丁12g、玄参15g、当归15g、川芎18g、生地黄12g、白芍15g、牡丹皮12g、川牛膝18g、制水蛭9g、地龙12g、土鳖虫12g、知母12g、黄柏15g、栀子12g、龙胆草9g、侧柏叶12g、水牛角15g、丝瓜络20g、路路通12g、延胡索24g、姜黄15g、生姜15g、生甘草6g。
实施例三、金银花17g、忍冬藤25g、紫花地丁17g、玄参20g、当归17g、川芎23g、生地黄17g、白芍20g、牡丹皮17g、川牛膝23g、制水蛭14g、地龙17g、土鳖虫17g、知母17g、黄柏20g、栀子17g、龙胆草14g、侧柏叶17g、水牛角20g、丝瓜络25g、路路通17g、延胡索29g、姜黄20g、生姜20g、生甘草9g。
下面是患者使用本发明药物的临床统计资料:
一、一般资料
收治患者120例,其中男性62例,女性58例,男女比例约为1.07:1,最大年龄68岁,最小年龄20岁,病程时间不等,患者性别、年龄、病程等各项基本资料基本相同。
二、治疗方法
按照本发明实施例二,称取原料药(一日剂量),水煎,过滤去渣,外洗患处,每天两次,10日为一个疗程。
三、疗效评定标准
痊愈:病状消失,肢端或其他部位的病症消失,烧灼痛、针刺感消失,身体状况良好;
显效:主要症状消失,肢端或其他部位的病症减轻,烧灼痛、针刺感明显好转,身体状况逐渐得到恢复;
无效:治疗前后比较,各方面均无改善。
四、治疗结果统计
其中:总有效率=治愈率+好转率
通过治疗结果的统计表明,本发明中药在治红斑性肢痛病具有良好的临床效果,能有效提高治疗的治愈率,值得在临床应用上推广。
典型病例及疗效:
病例一、郑某,男,45岁,患者无意中发现脚部经常有灼热刺痛的感觉,在温度较高的环境或者长时间站立的情况下,疼痛感加重,晚上睡觉的时候喜欢将双足放在外面,在冷水的刺激下,患者的不适感会有所减轻,患者去多家医院检查,最终确诊为红斑性肢痛病,患者采用本发明实施例二中所制制剂,以及所优选选的制备方法,使用两个疗程后,患者刺痛、麻木的现象明显好转,又坚持使用了一段时间,症状完全消失,随访一年,未见复发,痊愈。
病例二、郭某,女,50岁,患者患有红斑性肢痛病多年,四处求医,但是效果一直不明显,后来我处就诊,患者采用本发明实施例二中所制制剂,以及所优选选的制备方法,使用两个疗程后,患者刺痛、麻木的现象明显得到缓解,晚上睡觉、走路等逐渐恢复正常,为巩固疗效,患者又坚持使用了两个疗程,感觉异常的现象完全消失,麻木、刺痛的感觉一直没有出现,工作,干家务不受影响,电话随访一年,未见复发,痊愈。
Claims (4)
1.一种用于缓解红斑性肢痛病的中药制剂,其特征在于,该中药制剂是由以下重量份的药物组成:金银花7-17g、忍冬藤15-25g、紫花地丁7-17g、玄参10-20g、当归7-17g、川芎13-23g、生地黄7-17g、白芍10-20g、牡丹皮7-17g、川牛膝13-23g、制水蛭4-14g、地龙7-17g、土鳖虫7-17g、知母7-17g、黄柏10-20g、栀子7-17g、龙胆草4-14g、侧柏叶7-17g、水牛角10-20g、丝瓜络15-25g、路路通7-17g、延胡索19-29g、姜黄10-20g、生姜10-20g、生甘草3-9g。
2.根据权利要求书1所述的用于缓解红斑性肢痛病的中药制剂,其特征在于,由以下重量份的药物组成:金银花12g、忍冬藤20g、紫花地丁12g、玄参15g、当归15g、川芎18g、生地黄12g、白芍15g、牡丹皮12g、川牛膝18g、制水蛭9g、地龙12g、土鳖虫12g、知母12g、黄柏15g、栀子12g、龙胆草9g、侧柏叶12g、水牛角15g、丝瓜络20g、路路通12g、延胡索24g、姜黄15g、生姜15g、生甘草6g。
3.根据权利要求1或2所述的用于缓解红斑性肢痛病的中药制剂,其特征在于:所述中药制剂为外用洗剂。
4.一种用于缓解红斑性肢痛病的中药制剂的制备方法,其特征在于,制备方法如下:步骤一:按本发明重量配比,称取栀子、路路通用纱布包成药包,放于冷水中浸泡15-25分钟,备用;步骤二:按本发明重量配比,称取制水蛭、地龙、土鳖虫、水牛角进行粉碎磨面,过120目筛,备用;步骤三:按本发明重量配比,称取玄参、生地黄、白芍、牡丹皮、川牛膝、知母、黄柏、龙胆草、姜黄、生姜放入砂锅中,加入步骤一浸泡后剩余的冷水,抹过药材3-5厘米,先用武火煮沸,再用文火煎30-40分钟,过滤,得滤液,在剩余药渣中加入2-3厘米的水,然后加入忍冬藤、紫花地丁、当归、川芎、延胡索、生甘草以及步骤一种的药包继续煎煮20分钟,最后加入金银花、侧柏叶、丝瓜络煎煮15分钟,过滤,得滤液,合并两次滤液,弃渣,备用;步骤四:将步骤二中的粉末均匀混合到步骤三中的药液中,既得本发明所述的治疗用于缓解红斑性肢痛病的中药洗剂。
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CN106138889A (zh) * | 2016-08-18 | 2016-11-23 | 迟玉善 | 一种治疗癌症、疔疮以及无名肿瘤的中药制剂及制备方法 |
CN106266321A (zh) * | 2016-08-22 | 2017-01-04 | 吴斌 | 一种用于治疗红斑性肢痛症的药物 |
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CN106138889A (zh) * | 2016-08-18 | 2016-11-23 | 迟玉善 | 一种治疗癌症、疔疮以及无名肿瘤的中药制剂及制备方法 |
CN106266321A (zh) * | 2016-08-22 | 2017-01-04 | 吴斌 | 一种用于治疗红斑性肢痛症的药物 |
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