CN106421663A - 一种治疗风湿骨病的药物组合物及其制备方法 - Google Patents
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Abstract
本发明涉及一种治疗风湿骨病的药物组合物,原料包括桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术、水蛭、土鳖虫、全蝎、苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,通过采用上述多种天然中草药为原料并进行适当重量配比,各原料组分发挥协同作用,共同起到活血化瘀、祛风通络、解毒消肿、清热凉血、强筋骨等功能,用于治疗各种风湿性关节炎、类风湿性关节炎、颈椎病、脊椎病、肩周炎等风湿骨病,治疗范围广,起效快,疗效好。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗风湿骨病的药物组合物及其制备方法。
背景技术
风湿和类风湿骨关节病是一切风湿和类风湿骨关节病变疾病的总称,包括13大类100多种疾患,是医学领域中最为庞大的一个类别,类风湿关节炎的系统性红斑狼疮、硬皮病、多发性肌炎、皮肌炎、干燥综合症、百塞综合症、强直性脊柱炎、痛风性关节炎、骨质性关节炎、化脓性关节炎、坐骨神经痛、关节肌萎缩、骨质增生、腰椎间盘突出、肢体性麻木、全身性的游走、骨蒸劳热、四肢全身性怕风、怕冷等上百种之多均属于风湿骨病。
风湿和类风湿骨关节是一种病因未明、滑膜炎为主的系统性、缠绵难愈的慢性全身性疾病。据统计表明,造成劳动力下降致残的第一类疾病,就是风湿骨关节病、肿瘤、心脏病。10%的病人生活不能自理,造成身体畸形,致残率也高,轻则致残,重则致死。其特征是手足骨多关节炎症,经常伴有关节外器官受累及血清类风湿因子阳性,关节畸形及功能丧失等。
风湿和类风湿骨关节病是一个世界范围内的疾病,分布于所有的种族和民族,发病率很高。据统计,轻型患者约占全人口的2.5%,全球风湿和类风湿骨关节病人数约在2000万以上,重型的也超过200万人。尤其在成人中发病率较高,每10万成年人中约有20-40%的发病率。
风湿和类风湿骨关节病,如果不及时治疗容易引起肿瘤的发生,70%左右的类风湿病人因病变侵犯心脏、血管、肺脏、视觉、神经系统等,引发相关严重并发症,让病人更加痛苦。因此,治疗风湿和类风湿骨关节并是一个迫不及待的紧急任务。
现有技术中,用于治疗风湿和类风湿骨关节病治疗的内服或外用药物非常 多,虽然大多能起到一定的治疗作用,但功能非常单一,效果不够全面。特别是外用药,虽然比口服药更安全,风险更小,但其推广应用却因为见效慢、治疗范围窄等不足而受到限制。
发明内容
为了解决现有技术存在的上述问题,本发明提供了一种治疗范围广、疗效好、见效快的治疗风湿骨病的药物组合物及其制备方法。
本发明所采用的技术方案为:
一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝25-45重量份、透骨草25-45重量份、红花25-45重量份、当归25-45重量份、白芷20-40重量份、麻黄20-40重量份、附子40-60重量份、乳香20-40重量份、没药20-40重量份、秦艽20-40重量份、海风藤25-45重量份、清风藤25-45重量份、牛膝25-45重量份、白芍20-40重量份、木瓜36-48重量份、川芎36-48重量份、丹参36-48重量份、泽兰20-40重量份、三棱20-40重量份、蓬莪术20-40重量份、水蛭8-12重量份、土鳖虫8-12重量份、全蝎2-8重量份、苏木15-35重量份、虎杖15-35重量份、血竭15-35重量份、三七15-35重量份、威灵仙15-35重量份、寻骨风25-45重量份、羌活25-45重量份、防风25-45重量份、川乌25-45重量份、白芥子25-45重量份、苍术15-35重量份、防己15-35重量份、独活15-35重量份、桃仁15-35重量份、石菖蒲10-20重量份、路路通10-20重量份、鹿衔草15-35重量份。
进一步优选所述治疗风湿骨病的药物组合物的原料组分包括:桑枝35重量份、透骨草35重量份、红花35重量份、当归35重量份、白芷30重量份、麻黄30重量份、附子50重量份、乳香30重量份、没药30重量份、秦艽30重量份、海风藤35重量份、清风藤35重量份、牛膝35重量份、白芍30重量份、木瓜42重量份、川芎42重量份、丹参42重量份、泽兰30重量份、三棱30重量份、蓬莪术30重量份、水蛭10重量份、土鳖虫10重量份、全蝎5重量份、苏木25重量份、虎杖25重量份、血竭25重量份、三七25重量份、威灵仙25重量份、寻骨风35重量份、羌活35重量份、防风35重量份、川乌35重量份、 白芥子35重量份、苍术25重量份、防己25重量份、独活25重量份、桃仁25重量份、石菖蒲15重量份、路路通15重量份、鹿衔草25重量份。
进一步优选所述治疗风湿骨病的药物组合物的原料组分还包括桂枝25-45重量份、伸筋草25-45重量份、炮姜10-20重量份、花椒8-15重量份、络石藤25-45重量份、鸡血藤25-45重量份、僵蚕2-8重量份、蜈蚣8-12重量份、穿山甲2-8重量份。
进一步优选所述治疗风湿骨病的药物组合物的原料组分中,所述桂枝为35重量份,所述伸筋草为35重量份,所述炮姜为15重量份,所述花椒为12重量份,所述络石藤为35重量份,所述鸡血藤为35重量份,所述僵蚕为5重量份,所述蜈蚣为10重量份,所述穿山甲为5重量份。
一种制备所述治疗风湿骨病的药物组合物的方法,包括如下步骤:
(1)分别称取桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入第一有机溶剂并在40-80℃回流提取1-2h,回收第一有机溶剂后得到提取液;将所述提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入水进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入第二有机溶剂并在60-90℃回流提 取1-2h,回收第二有机溶剂后得到提取液;将所述提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
另一种制备所述治疗风湿骨病的药物组合物的方法,包括如下步骤:
(1)分别称取桑枝、桂枝、伸筋草、透骨草、红花、当归、白芷、麻黄、附子、炮姜、花椒、乳香、没药、秦艽、海风藤、清风藤、络石藤、鸡血藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入第一有机溶剂并在40-80℃回流提取1-2h,回收第一有机溶剂后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎、僵蚕、蜈蚣和穿山甲,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入水进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入第二有机溶剂并在60-90℃回流提取1-2h,回收第二有机溶剂后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
步骤(1)中,所述各原料的细粉的粒度均为110-130目;步骤(2)中,所述第一有机溶剂为体积浓度50-70%的乙醇;所述第一混合料的质量与所述第一有机溶剂的体积之比为1:10-1:20g/ml。
步骤(3)中,所述各原料的细粉的粒度均为110-130目;步骤(4)中,所述第二混合料与水的质量比为1:6-1:9。
步骤(5)中,所述各原料的细粉的粒度均为110-130目;步骤(6)中,所述第二有机溶剂为体积浓度70-90%的乙醇;所述第三混合料的质量与所述第二有机溶剂的体积之比为1:5-1:15g/ml。
步骤(2)中,进行所述回流提取之前,先将所述第一混合料在所述第一有机溶剂中进行浸泡5-15min;
步骤(4)中,进行所述蒸煮蒸馏前,先将所述第二混合料在水中进行浸泡3-6h;
步骤(6)中,进行所述回流提取之前,先将所述第三混合料在所述第二有机溶剂中进行浸泡15-25min。
为了便于理解本发明,下面对本发明中的原料及药效作进一步阐述。
桑枝,味微苦,性平。祛风湿,利关节。用于肩臂、关节酸痛麻木。
桂枝,味辛、甘,性温。发汗解肌,温通经脉,助阳化气,平冲降气。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
伸筋草,味微苦、辛,性温。祛风除湿,舒筋活络。用于关节酸痛,屈伸不利。
透骨草,味辛、苦,性温。有小毒。祛风除湿,解毒止痛。用于风湿关节痛;外用治疮疡肿毒。
红花,味辛,性温。活血通经,散瘀止痛。用于经闭,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。
当归,味甘、辛,性温。补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
白芷,味辛,性温。散风除湿,通窍止痛,消肿排脓。用于感冒头痛,眉棱骨痛,鼻塞,鼻渊,牙痛,白带,疮疡肿痛。
麻黄,味辛、微苦,性温。发汗散寒,宣肺平喘,利水消肿。用于风寒感冒,胸闷喘咳,风水浮肿;支气管哮喘。蜜麻黄润肺止咳。多用于表症已解,气喘咳嗽。
附子,味辛、甘,性大热;有毒。回阳救逆,补火助阳,逐风寒湿邪。用于亡阳虚脱,肢冷脉微,阳萎,宫冷,心腹冷痛,虚寒吐泻,阴寒水肿,阳虚外感,寒湿痹痛。
炮姜,味辛,性热。温中散寒,温经止血。用于脾胃虚寒,腹痛吐泻,吐衄崩漏,阳虚失血。
花椒,味辛,性温。温中止痛,杀虫止痒。用于脘腹冷痛,呕吐泄泻,虫积腹痛,蛔虫症;外治湿疹瘙痒。
乳香,味辛、苦,性温。调气活血,定痛,追毒。治气血凝滞、心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。
没药,味苦,性平。散瘀止痛,外用消肿生肌。用于跌打淤血肿痛,痈疽肿痛,胸腹诸痛;外用治疮口久不收敛。
秦艽,味辛、苦,性平。祛风湿,清湿热,止痹痛。用于风湿痹痛,筋脉拘挛,骨节酸痛,日晡潮热,小儿疳积发热。
海风藤,味辛、苦,性微温。祛风湿,通经络,止痹痛。用于风寒湿痹,肢节疼痛,筋脉拘挛,屈伸不利。
清风藤,味苦、辛,性温。祛风利湿;活血解毒。主风湿痹痛;鹤膝风;水肿;脚气;跌打肿痛;骨折;深部脓肿;骨髓炎;化脓性关节炎;脊椎炎;疮疡肿毒;皮肤瘙痒。
络石藤,味苦,性微寒。祛风通络,凉血消肿。用于风湿热痹,筋脉拘挛,腰膝酸痛,喉痹,痈肿,跌扑损伤。
鸡血藤,味苦、甘,性温。补血,活血,通络。用于月经不调,血虚萎黄,麻木瘫痪,风湿痹痛。
牛膝,味苦、酸,性平。补肝肾,强筋骨,逐瘀通经,引血下行。用于腰膝酸痛,筋骨无力,经闭症瘕,肝阳眩晕。
白芍,味苦、酸,性微寒。平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,月经不调,自汗,盗汗。
木瓜,味酸,性温。平肝舒筋,和胃化湿。用于湿痹拘挛,腰膝关节酸重疼痛,吐泻转筋,脚气水肿。
川芎,味辛,性温。活血行气,祛风止痛。用于月经不调,经闭痛经,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
丹参,味苦,性微寒。祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛。
泽兰,味苦、辛,性微温。活血化瘀,行水消肿。用于月经不调,经闭,痛经,产后瘀血腹痛,水肿。
三棱,味辛、苦,性平。破血行气,消积止痛。用于症瘕痞块,瘀血经闭,食积胀痛。
蓬莪术,味苦、辛,性温。行气,破血,消积,止痛。治心腹胀痛,症瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛。
水蛭,味咸、苦,性平;有小毒。破血,逐瘀,通经。用于症瘕痞块,血瘀经闭,跌扑损伤。
土鳖虫,味咸,性寒;有小毒。破瘀血,续筋骨。用于筋骨折伤,瘀血经闭,症瘕痞块。
僵蚕,味咸、辛,性平。祛风定惊,化痰散结。用于惊风抽搐,咽喉肿痛,皮肤瘙痒,颌下淋巴结炎,面神经麻痹。
蜈蚣,味辛,性温;有毒。息风镇痉,功毒散结,通络止痛。用于小儿惊风,抽搐痉挛,中风口歪,半身不遂,破伤风,风湿顽痹,疮疡,瘰疬,毒蛇咬伤。
全蝎,味辛,性平;有毒。息风镇痉,攻毒散结,通络止痛。用于小儿惊 风,抽搐痉挛,中风口歪,半身不遂,破伤风,风湿顽痹,偏正头痛,疮疡,瘰疬。
穿山甲,味咸,性微寒。通经下乳,消肿排脓,搜风通络。用于经闭癓瘕,乳汁不通,痈肿疮毒,关节痹痛,麻木拘挛。
苏木,味甘、咸,性平。行血祛瘀,消肿止痛。用于经闭痛经,产后瘀阻,胸腹刺痛,外伤肿痛。
虎杖,味微苦,性微寒。祛风利湿,散瘀定痛,止咳化痰。用于关节痹痛,湿热黄疸,经闭,症瘕,水火烫伤,跌扑损伤,痈肿疮毒,咳嗽痰多。
血竭,味甘、咸,性平。祛瘀定痛,止血生肌。用于跌扑折损,内伤瘀痛;外伤出血不止。
三七,味甘、微苦,性温。散瘀止血,消肿定痛。用于咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹剌痛,跌扑肿痛。
威灵仙,味辛、咸,性温。祛风除湿,通络止痛。用于风湿痹痛,肢体麻木,筋脉拘挛,屈伸不利,骨哽咽喉。
寻骨风,味辛、苦,性平。祛风通络,止痛。用于风湿痹痛,胃痛,睪丸肿痛,跌打伤痛等症。
羌活,味辛、苦,性温。散寒,祛风,除湿,止痛。用于风寒感冒头痛,风湿痹痛,肩背酸痛。
防风,味辛、甘,性温。解表祛风,胜湿,止痉。用于感冒头痛,风湿痹痛,风疹瘙痒,破伤风。
川乌,味辛、苦,性热;有大毒。祛风除湿,温经止痛。用于风寒湿痹,关节疼痛,心腹冷痛,寒疝作痛,麻醉止痛。
白芥子,味辛,性温。利气豁痰,温中散寒,通络止痛。治痰饮咳喘,胸胁胀满疼痛,反胃呕吐,中风不语,肢体痹痛麻木,脚气,阴疽,肿毒,跌打肿痛。
苍术,味辛、苦,性温。燥湿健脾,祛风散寒,明目。用于脘腹胀满,泄泻,水肿,脚气痿躄,风湿痹痛,风寒感冒,夜盲。
防己,味苦,性寒。利水消肿,祛风止痛。用于水肿脚气,小便不利,湿疹疮毒,风湿痹痛;高血压。
独活,味辛、苦,性微温。祛风除湿,通痹止痛。用于风寒湿痹,腰膝疼痛,少阴伏风头痛。
细辛,味辛,性温。祛风散寒,通窍止痛,温肺化饮。用于风寒感冒,头痛,牙痛,鼻塞鼻渊,风湿痹痛,痰饮喘咳。
桃仁,味苦、甘,性平。活血祛瘀,润肠通便。用于经闭,痛经,癓瘕痞块,跌扑损伤,肠燥便秘。
石菖蒲,味辛、性苦,温。化湿开胃,开窍豁痰,醒神益智。用于脘痞不饥,噤口下痢,神昏癫痫,健忘耳聋。
路路通,味苦,性平。祛风活络,利水通经。用于关节痹痛,麻木拘挛,水肿胀满,乳少经闭。
姜黄,味辛、苦,性温。破血行气,通经止痛。用于胸胁剌痛,闭经,癓瘕,风湿肩臂疼痛,跌扑肿痛。
鹿衔草,味甘、苦,性温。祛风湿,强筋骨,止血。用于风湿痹痛,腰膝无力,月经过多,久咳劳嗽。
本发明的有益效果为:
本发明所述的治疗风湿骨病的药物组合物,采用上述多种天然中草药为原料并进行适当重量配比,各原料组分发挥协同作用,共同起到活血化瘀、祛风通络、解毒消肿、清热凉血、强筋骨等功能,用于治疗各种风湿性关节炎、类风湿性关节炎、颈椎病、脊椎病、肩周炎等风湿骨病,治疗范围广,起效快,疗效好。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范 围。
下面实施例中以1重量份代表1g。
实施例1
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝25重量份、透骨草45重量份、红花25重量份、当归45重量份、白芷20重量份、麻黄40重量份、附子40重量份、乳香40重量份、没药20重量份、秦艽40重量份、海风藤25重量份、清风藤45重量份、牛膝25重量份、白芍40重量份、木瓜36重量份、川芎48重量份、丹参36重量份、泽兰40重量份、三棱20重量份、蓬莪术40重量份、水蛭8重量份、土鳖虫12重量份、全蝎2重量份、苏木35重量份、虎杖15重量份、血竭35重量份、三七15重量份、威灵仙35重量份、寻骨风25重量份、羌活45重量份、防风25重量份、川乌45重量份、白芥子25重量份、苍术35重量份、防己15重量份、独活35重量份、桃仁15重量份、石菖蒲20重量份、路路通10重量份、鹿衔草35重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度50%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:10g/ml,之后在40℃回流提取2h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎,经分别干燥、粉碎处理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入6倍质量水进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度70%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:5g/ml,之后在60℃回流提取2h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实施例2
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝45重量份、透骨草25重量份、红花45重量份、当归25重量份、白芷40重量份、麻黄20重量份、附子60重量份、乳香20重量份、没药40重量份、秦艽20重量份、海风藤45重量份、清风藤25重量份、牛膝45重量份、白芍20重量份、木瓜48重量份、川芎36重量份、丹参48重量份、泽兰20重量份、三棱40重量份、蓬莪术20重量份、水蛭12重量份、土鳖虫8重量份、全蝎8重量份、苏木15重量份、虎杖35重量份、血竭15重量份、三七35重量份、威灵仙15重量份、寻骨风45重量份、羌活25重量份、防风45重量份、川乌25重量份、白芥子45重量份、苍术15重量份、防己35重量份、独活15重量份、桃仁35重量份、石菖蒲10重量份、路路通20重量份、鹿衔草15重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度70%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:20g/ml,先将所述第一混合料在乙醇中进行浸泡15min,再在80℃回流提取1h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入9倍质量水,先将所述第二混合料在水中进行浸泡6h,再进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度90%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:15g/ml,先将所述第三混合料在乙醇中进行浸泡25min,再在90℃回流提取1h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实施例3
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝35重量份、透骨草35重量份、红花35重量份、当归35重量份、白 芷30重量份、麻黄30重量份、附子50重量份、乳香30重量份、没药30重量份、秦艽30重量份、海风藤35重量份、清风藤35重量份、牛膝35重量份、白芍30重量份、木瓜42重量份、川芎42重量份、丹参42重量份、泽兰30重量份、三棱30重量份、蓬莪术30重量份、水蛭10重量份、土鳖虫10重量份、全蝎5重量份、苏木25重量份、虎杖25重量份、血竭25重量份、三七25重量份、威灵仙25重量份、寻骨风35重量份、羌活35重量份、防风35重量份、川乌35重量份、白芥子35重量份、苍术25重量份、防己25重量份、独活25重量份、桃仁25重量份、石菖蒲15重量份、路路通15重量份、鹿衔草25重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度60%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:15g/ml,先将所述第一混合料在乙醇中进行浸泡10min,再在60℃回流提取1.5h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎,经分别干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入8倍质量水,先将所述第二混合料在水中进行浸泡4.5h,再进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别 干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度80%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:10g/ml,先将所述第三混合料在乙醇中进行浸泡20min,再在75℃回流提取1.5h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实施例4
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝25重量份、桂枝45重量份、伸筋草25重量份、透骨草45重量份、红花25重量份、当归45重量份、白芷20重量份、麻黄40重量份、附子40重量份、炮姜20重量份、花椒8重量份、乳香40重量份、没药20重量份、秦艽40重量份、海风藤25重量份、清风藤45重量份、络石藤25重量份、鸡血藤45重量份、牛膝25重量份、白芍40重量份、木瓜36重量份、川芎48重量份、丹参36重量份、泽兰40重量份、三棱20重量份、蓬莪术40重量份、水蛭8重量份、土鳖虫12重量份、僵蚕2重量份、蜈蚣12重量份、全蝎2重量份、穿山甲8重量份、苏木15重量份、虎杖35重量份、血竭15重量份、三七35重量份、威灵仙15重量份、寻骨风45重量份、羌活25重量份、防风45重量份、川乌25重量份、白芥子45重量份、苍术15重量份、防己35重量份、独活15重量份、桃仁35重量份、石菖蒲10重量份、路路通20重量份、鹿衔草15重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、桂枝、伸筋草、透骨草、红花、当归、白芷、麻黄、附子、炮姜、花椒、乳香、没药、秦艽、海风藤、清风藤、络石藤、鸡血藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处 理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度50%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:10g/ml,先将所述第一混合料在乙醇中进行浸泡5min,再在40℃回流提取2h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎、僵蚕、蜈蚣和穿山甲,经分别干燥、粉碎处理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入6倍质量水,先将所述第二混合料在水中进行浸泡3h,再进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到粒度均为110目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度70%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:5g/ml,先将所述第三混合料在乙醇中进行浸泡15min,再在60℃回流提取2h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实施例5
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝45重量份、桂枝25重量份、伸筋草45重量份、透骨草25重量份、红花45重量份、当归25重量份、白芷40重量份、麻黄20重量份、附子60重量份、炮姜10重量份、花椒15重量份、乳香20重量份、没药40重量份、 秦艽20重量份、海风藤45重量份、清风藤25重量份、络石藤45重量份、鸡血藤25重量份、牛膝45重量份、白芍20重量份、木瓜48重量份、川芎36重量份、丹参48重量份、泽兰20重量份、三棱40重量份、蓬莪术20重量份、水蛭12重量份、土鳖虫8重量份、僵蚕8重量份、蜈蚣8重量份、全蝎8重量份、穿山甲2重量份、苏木35重量份、虎杖15重量份、血竭35重量份、三七15重量份、威灵仙35重量份、寻骨风25重量份、羌活45重量份、防风25重量份、川乌45重量份、白芥子25重量份、苍术35重量份、防己15重量份、独活35重量份、桃仁15重量份、石菖蒲20重量份、路路通10重量份、鹿衔草35重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、桂枝、伸筋草、透骨草、红花、当归、白芷、麻黄、附子、炮姜、花椒、乳香、没药、秦艽、海风藤、清风藤、络石藤、鸡血藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度70%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:20g/ml,先将所述第一混合料在乙醇中进行浸泡15min,再在80℃回流提取1h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎、僵蚕、蜈蚣和穿山甲,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入9倍质量水,先将所述第二混合料在水中进行浸泡6h,再进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、 川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到粒度均为130目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度90%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:15g/ml,先将所述第三混合料在乙醇中进行浸泡25min,再在90℃回流提取1h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实施例6
本实施例提供一种治疗风湿骨病的药物组合物,原料组分包括:
桑枝35重量份、桂枝35重量份、伸筋草35重量份、透骨草35重量份、红花35重量份、当归35重量份、白芷30重量份、麻黄30重量份、附子50重量份、炮姜15重量份、花椒12重量份、乳香30重量份、没药30重量份、秦艽30重量份、海风藤35重量份、清风藤35重量份、络石藤35重量份、鸡血藤35重量份、牛膝35重量份、白芍30重量份、木瓜42重量份、川芎42重量份、丹参42重量份、泽兰30重量份、三棱30重量份、蓬莪术30重量份、水蛭10重量份、土鳖虫10重量份、僵蚕5重量份、蜈蚣10重量份、全蝎5重量份、穿山甲5重量份、苏木25重量份、虎杖25重量份、血竭25重量份、三七25重量份、威灵仙25重量份、寻骨风35重量份、羌活35重量份、防风35重量份、川乌35重量份、白芥子35重量份、苍术25重量份、防己25重量份、独活25重量份、桃仁25重量份、石菖蒲15重量份、路路通15重量份、鹿衔草25重量份。
进一步,本实施例提供一种所述治疗风湿骨病的药物组合物的制备方法,包括如下步骤:
(1)分别称取桑枝、桂枝、伸筋草、透骨草、红花、当归、白芷、麻黄、附子、炮姜、花椒、乳香、没药、秦艽、海风藤、清风藤、络石藤、鸡血藤、 牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入体积浓度60%的乙醇,所述第一混合料的质量与所述乙醇的体积之比为1:15g/ml,先将所述第一混合料在乙醇中进行浸泡10min,再在60℃回流提取1.5h,回收乙醇后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎、僵蚕、蜈蚣和穿山甲,经分别干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入8倍质量水,先将所述第二混合料在水中进行浸泡4.5h,再进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到粒度均为120目的上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入体积浓度80%的乙醇,所述第三混合料的质量与乙醇的体积之比为1:10g/ml,先将所述第三混合料在乙醇中进行浸泡20min,再在75℃回流提取1.5h,回收乙醇后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
实验例
本发明人通过对临床100例患者应用该药物组合物的观察,其中男性50例,女性50例,年龄最小49岁,最大81岁。
应用方法:外贴敷用,每3-4日一贴。
疗效评定标准:
治愈:临床疗效显著,症状完全消失,68例。
有效:临床症状得以控制,症状明显改善,27例。
无效:临床症状无明显改善5例。总有效率95%。
典型临床病例:
宋某,男,53岁,患膝关节肿胀疼痛十余年,近期症状加重,医院诊断关节积液,遂收取关节液,不几日又肿胀如初。使用本发明实施例1的药物组合物贴敷六个疗程后,其疼痛感消失,继续贴敷一个疗程后,腰腿疼痛感消失,身体完全恢复正常。
王某,女,65岁,患老寒腿20年,双腿肿胀僵直沉重,不敢碰触,走路困难,自述每逢阴天下雨,提前就疼痛加重。使用本发明实施例2的药物组合物贴敷五个疗程后,疼痛感减轻,继续贴敷一个疗程后,疼痛感完全消失,身体恢复正常。
张某,男,58岁,腿部几个月前受潮,疼痛酸麻,不可名状,上下楼梯疼痛难忍,日甚一日。使用本发明实施例3的药物组合物贴敷一个疗程后,其红肿、灼热症状消失,疼痛减轻,继续贴敷一个疗程后,疼痛感消失,身体基本恢复正常。
夏某,男,55岁,患颈椎病,颈部疼痛,扭动脖子时疼痛加剧,贴敷本发明实施例4所述的药物组合物两个疗程后,颈部疼痛感消失,继续贴敷一个疗程后,扭动脖子基本没有疼痛感。
杨某,男,60岁,肩背板硬冷痛,晨起脊背僵硬,痛苦不堪,近十年到处治疗无效,使用本发明实施例5所述的药物组合物贴敷两个疗程后,即使在阴雨天其疼痛感也明显减轻。
李某,男,65岁,患退化性关节炎,关节处常出现僵硬、疼痛的感觉,使用本发明实施例6所述的药物组合物贴敷两个疗程后,疼痛感减轻,继续贴敷一个疗程后,关节处有轻微疼痛感,但可自由活动。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于 此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗风湿骨病的药物组合物,其特征在于,原料组分包括:
桑枝25-45重量份、透骨草25-45重量份、红花25-45重量份、当归25-45重量份、白芷20-40重量份、麻黄20-40重量份、附子40-60重量份、乳香20-40重量份、没药20-40重量份、秦艽20-40重量份、海风藤25-45重量份、清风藤25-45重量份、牛膝25-45重量份、白芍20-40重量份、木瓜36-48重量份、川芎36-48重量份、丹参36-48重量份、泽兰20-40重量份、三棱20-40重量份、蓬莪术20-40重量份、水蛭8-12重量份、土鳖虫8-12重量份、全蝎2-8重量份、苏木15-35重量份、虎杖15-35重量份、血竭15-35重量份、三七15-35重量份、威灵仙15-35重量份、寻骨风25-45重量份、羌活25-45重量份、防风25-45重量份、川乌25-45重量份、白芥子25-45重量份、苍术15-35重量份、防己15-35重量份、独活15-35重量份、桃仁15-35重量份、石菖蒲10-20重量份、路路通10-20重量份、鹿衔草15-35重量份。
2.根据权利要求1所述的治疗风湿骨病的药物组合物,其特征在于,原料组分包括:桑枝35重量份、透骨草35重量份、红花35重量份、当归35重量份、白芷30重量份、麻黄30重量份、附子50重量份、乳香30重量份、没药30重量份、秦艽30重量份、海风藤35重量份、清风藤35重量份、牛膝35重量份、白芍30重量份、木瓜42重量份、川芎42重量份、丹参42重量份、泽兰30重量份、三棱30重量份、蓬莪术30重量份、水蛭10重量份、土鳖虫10重量份、全蝎5重量份、苏木25重量份、虎杖25重量份、血竭25重量份、三七25重量份、威灵仙25重量份、寻骨风35重量份、羌活35重量份、防风35重量份、川乌35重量份、白芥子35重量份、苍术25重量份、防己25重量份、独活25重量份、桃仁25重量份、石菖蒲15重量份、路路通15重量份、鹿衔草25重量份。
3.根据权利要求1所述的治疗风湿骨病的药物组合物,其特征在于,原料组分还包括桂枝25-45重量份、伸筋草25-45重量份、炮姜10-20重量份、花椒8-15重量份、络石藤25-45重量份、鸡血藤25-45重量份、僵蚕2-8重量份、蜈蚣8-12重量份、穿山甲2-8重量份。
4.根据权利要求3所述的治疗风湿骨病的药物组合物,其特征在于,所述桂枝为35重量份,所述伸筋草为35重量份,所述炮姜为15重量份,所述花椒为12重量份,所述络石藤为35重量份,所述鸡血藤为35重量份,所述僵蚕为5重量份,所述蜈蚣为10重量份,所述穿山甲为5重量份。
5.一种制备权利要求1或2所述治疗风湿骨病的药物组合物的方法,其特征在于,包括如下步骤:
(1)分别称取桑枝、透骨草、红花、当归、白芷、麻黄、附子、乳香、没药、秦艽、海风藤、清风藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入第一有机溶剂并在40-80℃回流提取1-2h,回收第一有机溶剂后得到提取液;将所述提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入水进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入第二有机溶剂并在60-90℃回流提取1-2h,回收第二有机溶剂后得到提取液;将所述提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
6.一种制备权利要求3或4所述治疗风湿骨病的药物组合物的方法,其特征在于,包括如下步骤:
(1)分别称取桑枝、桂枝、伸筋草、透骨草、红花、当归、白芷、麻黄、附子、炮姜、花椒、乳香、没药、秦艽、海风藤、清风藤、络石藤、鸡血藤、牛膝、白芍、木瓜、川芎、丹参、泽兰、三棱、蓬莪术,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第一混合料,待用;
(2)向步骤(1)所述第一混合料加入第一有机溶剂并在40-80℃回流提取1-2h,回收第一有机溶剂后得到第一提取液;将所述第一提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第一预混料,待用;
(3)分别称取水蛭、土鳖虫、全蝎、僵蚕、蜈蚣和穿山甲,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第二混合料,待用;
(4)向步骤(3)所述第二混合料加入水进行蒸煮蒸馏,收取蒸馏液,将所述蒸馏液依次进行过滤、浓缩、干燥、粉碎处理,得到第二预混料,待用;
(5)分别称取苏木、虎杖、血竭、三七、威灵仙、寻骨风、羌活、防风、川乌、白芥子、苍术、防己、独活、桃仁、石菖蒲、路路通、鹿衔草,经分别干燥、粉碎处理后,得到上述各原料的细粉,将所述各原料的细粉进行充分混合,得到第三混合料,待用;
(6)向步骤(1)所述第三混合料加入第二有机溶剂并在60-90℃回流提取1-2h,回收第二有机溶剂后得到第二提取液;将所述第二提取液依次进行过滤、浓缩、干燥、粉碎处理,得到第三预混料,待用;
(7)将步骤(2)所述第一预混料、步骤(4)第二预混料、步骤(6)第三预混料进行充分混合,即得所述治疗风湿骨病的药物组合物。
7.根据权利要求5或6所述的制备方法,其特征在于,步骤(1)中,所述各原料的细粉的粒度均为110-130目;步骤(2)中,所述第一有机溶剂为体积浓度50-70%的乙醇;所述第一混合料的质量与所述第一有机溶剂的体积之比为1:10-1:20g/ml。
8.根据权利要求5或6所述的制备方法,其特征在于,步骤(3)中,所述各原料的细粉的粒度均为110-130目;步骤(4)中,所述第二混合料与水的质量比为1:6-1:9。
9.根据权利要求5或6所述的制备方法,其特征在于,步骤(5)中,所述各原料的细粉的粒度均为110-130目;步骤(6)中,所述第二有机溶剂为体积浓度70-90%的乙醇;所述第三混合料的质量与所述第二有机溶剂的体积之比为1:5-1:15g/ml。
10.根据权利要求5或6所述的制备方法,其特征在于,步骤(2)中,进行所述回流提取之前,先将所述第一混合料在所述第一有机溶剂中进行浸泡5-15min;
步骤(4)中,进行所述蒸煮蒸馏前,先将所述第二混合料在水中进行浸泡3-6h;
步骤(6)中,进行所述回流提取之前,先将所述第三混合料在所述第二有机溶剂中进行浸泡15-25min。
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